CN101584972B - Emulsification device - Google Patents
Emulsification device Download PDFInfo
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- CN101584972B CN101584972B CN2009101410943A CN200910141094A CN101584972B CN 101584972 B CN101584972 B CN 101584972B CN 2009101410943 A CN2009101410943 A CN 2009101410943A CN 200910141094 A CN200910141094 A CN 200910141094A CN 101584972 B CN101584972 B CN 101584972B
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- mixing
- continuous phase
- emulsifier unit
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/41—Emulsifying
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/10—Mixing by creating a vortex flow, e.g. by tangential introduction of flow components
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/30—Injector mixers
- B01F25/31—Injector mixers in conduits or tubes through which the main component flows
- B01F25/313—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit
- B01F25/3131—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit with additional mixing means other than injector mixers, e.g. screens, baffles or rotating elements
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
- B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
- B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
- B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
- B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
- B01F25/4338—Mixers with a succession of converging-diverging cross-sections, i.e. undulating cross-section
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
- B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
- B01F25/434—Mixing tubes comprising cylindrical or conical inserts provided with grooves or protrusions
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/50—Pipe mixers, i.e. mixers wherein the materials to be mixed flow continuously through pipes, e.g. column mixers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
Abstract
There is provided an emulsification device for mixing two different liquids not dissolvable in each other, wherein (1) emulsion droplets can be reduced to micro size without reducing the channel width, which may cause degraded productivity; and wherein (2) a disperse phase can be prevented from adhering to the channel wall surface, thus allowing the device to be operated for a prolonged period of time and a uniform emulsion droplet size to be obtained. The emulsification device comprises: at least one channel (211) of a first liquid; a channel (210) of a second liquid; and a mixing channel (304) in which the first liquid is joined with the second liquid. In the mixing channel (304), the first liquid has a swirl component in the mainstream direction. The channel of the second liquid is connected to the central portion of the mixing channel, and the second liquid flows at the central portion of at least one swirl flow of the first liquid. In this way, at least one continuous-phase swirl flow is formed around the disperse phase.
Description
Technical field
The present invention relates to a kind of emulsifier unit, relate to particularly that the sort of to be suitable for for the liquid that forms continuous phase be that second liquid that will be not dissolved in continuous phase is dispersed in the emulsifier unit that carries out emulsification in the continuous phase with the decentralized photo form.
Background technology
The making of latex generally is by thereby two kinds of liquid that can not mix mutually as water and oil being applied shearing force with a kind of liquid refinement, being distributed in the another kind of liquid again.
As existing latex forming method, known a kind of batch-wise method that has adopted dispersion method.This method is to drop into water and oil in tun, utilize rotation, rabbling mechanism once to obtain a large amount of latexes, but, the problem that exists of this method is because shearing force can't impose on liquid equably thereby the latex particle size made is inhomogeneous or during production costs.So under the inhomogeneous state of the particle diameter of latex particle, its effect, performance produce and depart from and become the reason that quality reduces.
Relative with it, advocate a kind of latex of little fluid injector that adopted in recent years and make.The latex liquid nozzle be to width and a few μ m of the degree of depth to the small stream feed fluid of hundreds of μ m, in small stream, carry out emulsification.
Specifically, known is to have utilized liquid shear speed, because water and oil content are slit into a plurality of liquid streams, they are interconnected to increase the contact area between liquid, are notch cuttype and clamp-on in the stream, between the stream wall, produce liquid shear speed (for example, with reference to patent documentation 1) thus.
In addition, thus also have a kind of method be form with the decentralized photo be inboard, be the method that the combined-flow of the laminar condition in the outside is made latex with continuous phase.Be that liquor charging speed by control continuous phase applies shearing force to the interface of continuous phase and decentralized photo thereby this method is known, by sudden enlargement portion is set pressure sharply reduced soon thereafter, thus decentralized photo (for example, with reference to patent documentation 2) separately.
Patent documentation 1: TOHKEMY 2004-81924 communique
Patent documentation 2: TOHKEMY 2004-98225 communique
Yet, in the patent documentation 1 described emulsification method, distribute about the particle diameter of latex, make moderate progress though compare with batch-type, be the progress of a certain degree.
On the other hand, shown in patent documentation 2, owing to be to make latex particle one by one, thereby particle diameter can be evened up dispersion value 20% with interior uniformity coefficient.But, in the combined-flow structure, must when refinement latex particle particle diameter, reduce the diameter d of microfluidic circuit., the problem of existence is along with reducing flow path width, and 4 powers of the pressure loss and d are inversely and increase, thereby the flow of liquid stream tails off.Have, in the patent documentation 2 described combined-flow structures, the structure of formation is on the both direction that continuous phase flows into again, continuous phase is in the flows outside of decentralized photo, thereby decentralized photo can directly not contact with stream, and on two other direction, decentralized photo directly contacts with stream.Thereby if long-time the use, then decentralized photo is attached in the stream, becomes liquid-drop diameter reason devious as can be known.
Summary of the invention
The objective of the invention is to, a kind of emulsifier unit that is mixed with two kinds of immiscible liquid is provided, this emulsifier unit, (1) can not dwindle into the flow path width that reduces reason into productivity ratio, particle diameter that can the refinement latex particle, (2) avoid decentralized photo to be attached on the stream, can use for a long time, can obtain uniform latex particle.
(1) to achieve these goals, the invention provides and a kind of immiscible two kinds of liquid are mixed and emulsifications, it is characterized in that, comprising: the stream of first liquid; The stream of second liquid; And the mixing stream at described first liquid and described second liquid interflow, in the described mixing stream, described first liquid has the revolution composition with respect to main flow direction, the stream of described second liquid is connected with the central portion of described mixing stream, the flow through centre of gyration portion of rotating described first liquid of described second liquid.
Constitute according to this, this emulsifier unit that is mixed with two kinds of immiscible liquid can not dwindle into the flow path width that reduces reason into productivity ratio, particle diameter that can the refinement latex particle, also avoid decentralized photo to be attached on the stream in addition, can use for a long time, can obtain uniform latex particle.
(2) preferably in above-mentioned (1), the central shaft of the stream of described first liquid is with respect to the central shaft bias configuration of described mixing stream.
(3) preferably in above-mentioned (2), the stream of described first liquid forms by many, and the stream of described many first liquid is respectively with respect to the central shaft axial symmetry configuration of described mixing stream.
(4) preferably in above-mentioned (1), the central shaft arrangement of the stream of described second liquid is in the perspective plane of described mixing stream.
(5) preferably in above-mentioned (1), the wall of described mixing stream possesses spiral helicine protuberance, makes described first liquid produce turning power.
(6) preferably in above-mentioned (1), the stream of described first liquid forms the double pipe shape on every side of the stream that is configured in described second liquid, and described emulsifier unit possesses the rotation wing in the stream that is configured in described first liquid and drives the rotating mechanism of the described rotation wing.
The invention effect
According to the present invention, this emulsifier unit that is mixed with two kinds of immiscible liquid, (1) can not dwindle into the flow path width that reduces reason into productivity ratio, particle diameter that can the refinement latex particle, (2) avoid decentralized photo to be attached on the stream, can use for a long time, can obtain uniform latex particle.
Description of drawings
Fig. 1 is that expression comprises system's pie graph that the system of the emulsifier unit of the present invention's the 1st embodiment constitutes.
Fig. 2 is the exploded perspective view that the emulsifier unit of expression the present invention the 1st embodiment constitutes.
Fig. 3 is the exploded perspective view that the emulsifier unit of expression the present invention the 1st embodiment constitutes.
Fig. 4 is the major part enlarged drawing that the emulsifier unit of expression the present invention the 1st embodiment constitutes.
Fig. 5 is the cutaway view that the emulsifier unit of expression the present invention the 1st embodiment constitutes.
Fig. 6 is the key diagram that carries out emulsification in the emulsifier unit of the present invention's the 1st embodiment.
Fig. 7 is the stereogram that latex is derived other formations of stream in the emulsifier unit of expression the present invention the 1st embodiment.
Fig. 8 is the major part amplification stereogram that the emulsifier unit of expression the present invention the 2nd embodiment constitutes.
Fig. 9 is the major part amplification stereogram that the emulsifier unit of expression the present invention the 3rd embodiment constitutes.
Figure 10 is when adopting the emulsifier unit of the present invention's the 1st embodiment, when not turning round continuous phase under the identical liquor charging condition and the key diagram of the experimental result during revolution continuous phase.
Among the figure, the former hopper of 101-, 102-pump, the 103-import pipe, 104-emulsifier unit, 105-import pipe, 106-latex case, 107-thermostat, 201-liquid introduction part, 202-interflow stream portion, 203-mixing stream portion, 204-liquid leading-out portion, the 205-screwed hole, 206-sealing groove, 207-continuous phase introducing port, 208-decentralized photo introducing port, the vertical stream of 209-continuous phase, the vertical stream of 210-decentralized photo, the horizontal stream of 211-continuous phase, the 212-latex is derived stream, 213-alignment pin, 301-continuous phase imports stream, and the 302-decentralized photo imports stream, 303-continuous phase branch stream, 304-mixing stream, 305-latex export mouth, 401-rotary current, 601-latex particle, the spiral helicine protuberance of 801-, 901-continuous phase is mixed the vertical stream of stream portion, and 902-rotates the wing, 903-rotating mechanism.
The specific embodiment
Below, utilize Fig. 1～Fig. 7 to describe for formation and the action of the emulsifier unit of the present invention's the 1st embodiment.
At first utilize Fig. 1 to illustrate that the system of the emulsifier unit that comprises present embodiment constitutes.
Fig. 1 is that expression comprises system's pie graph that the system of the emulsifier unit of the present invention's the 1st embodiment constitutes.
Storage of water in former hopper 101A.In addition, store oil in former hopper 101B.The water that is stored among the former hopper 101A is carried to emulsifier unit 104 via pump 102A.In addition, the oil that is stored among the former hopper 101B is carried to emulsifier unit 104 via pump 102B.At this, pump 102A, 102B preferably use syringe pump or gear pump etc. respectively according to purpose.
Each liquid of carrying via pump 102A, 102B flow into emulsifier unit 104 by import pipe 103A and 103B, makes latex in this emulsifier unit 104.The latex of making is stored in the latex case 106 by import pipe 105.
Also have, when the making latex need be adjusted temperature, for example emulsifier unit 104 can be set in thermostat 107, be full of thermostat 107 inside with heating agent, carry out the temperature adjustment.Perhaps can be at the arranged outside Peltier's element of emulsifier unit 104.
Next, utilize Fig. 2～Fig. 6 that the formation of the emulsifier unit of present embodiment is described.
Fig. 2 and Fig. 3 are the exploded perspective views that the emulsifier unit of expression the present invention the 1st embodiment constitutes.Also have, Fig. 2 is the decomposition texture of representing emulsifier unit 104 from the introduction part side of continuous phase and decentralized photo, and Fig. 3 represents from latex leading-out portion side.
In addition, Fig. 4 is the major part enlarged drawing of the emulsifier unit formation of expression the present invention the 1st embodiment.Also have, Fig. 4 A is the vertical view that the enlarging section in the zone that is impaled by broken circle B of Fig. 2 is seen from liquid introduction part side.Fig. 4 B is the stereogram that the enlarging section in the zone that is impaled by broken circle B of Fig. 2 is seen from liquid introduction part side.Fig. 5 is the cutaway view that the emulsifier unit of expression the present invention the 1st embodiment constitutes.Also have, Fig. 5 represents to be parallel to the flow direction of decentralized photo by the cross section at center.Fig. 6 is the key diagram that carries out emulsification in the emulsifier unit of the present invention's the 1st embodiment.
As shown in Figures 2 and 3, emulsifier unit 104 is made of liquid introduction part 201, interflow stream portion 202, mixing stream portion 203 and liquid leading-out portion 204.Become the screwed hole 205 of perforation at the quadrangle of liquid introduction part 201.In addition, interflow stream portion 202, mix stream portion 203 and liquid leading-out portion 204 with screwed hole 205 same positions of liquid introduction part 201 on also form 4 screwed holes respectively.Liquid leading-out portion 204 forms 2 dowel holes 213 that the end is arranged.As shown in Figure 3, liquid introduction part 201 with dowel hole 213 same positions of liquid leading-out portion 204 on also form 2 dowel holes that the end is arranged.Thereby, in dowel hole 213, insert alignment pin (not diagram), can carry out precision positioning thus, utilize the screw (not diagram) that connects screwed hole 205 to tighten.Fig. 5 represents Fig. 2 and liquid introduction part 201 shown in Figure 3, interflow stream portion 202, mixes the state that stream portion 203 and liquid leading-out portion 204 usefulness screws (not having to illustrate) are tightened.
In addition, as shown in Figure 2, liquid leading-out portion 204 forms sealing groove 206A around latex is derived stream 212.In addition, as shown in Figure 3, import the sealing of the formation on every side groove 206B of stream 301 on the liquid introduction part 201 in continuous phase, formation seals and uses groove 206C around decentralized photo importing stream 302.Have, interflow stream portion 202 forms sealing groove 206D around continuous phase branch stream 303 again.By sandwiching containment member (not illustrating) in groove 206 in sealing, thereby improve the connecting airtight property between each member, can prevent leak of liquid.As required can be with bonding between each member or the use that is bonded together.
Material about each member of constituting emulsifier unit 104 according to the kind of the liquid of carrying, adopts metal or resin, glass etc.In addition, the material of each member need not be all identical, can change material according to each member according to the characteristic of processing, heat conductivity etc.
The continuous phase introducing port 207 of liquid introduction part 201 shown in Figure 2 imports stream 301 with the continuous phase of liquid introduction part 201 shown in Figure 3 and is communicated with.The decentralized photo introducing port 208 of liquid introduction part 201 shown in Figure 2 imports stream 302 with the decentralized photo of liquid introduction part 201 shown in Figure 3 and is communicated with.
The vertical stream 209 of continuous phase of interflow stream portion 202 shown in Figure 2 is communicated with the continuous phase branch stream 303 of interflow stream portion 202 shown in Figure 3.Continuous phase branch stream 303 is made of with near the stream that is branched off into two strands the vertical stream 210 of decentralized photo line part.The vertical stream 209 of continuous phase of interflow stream portion 202 shown in Figure 2 is communicated with the end of the line part of continuous phase branch stream 303.The vertical stream 210 of decentralized photo of interflow stream portion 202 shown in Figure 2 is communicated with the vertical stream 210 of decentralized photo of interflow stream portion 202 shown in Figure 3.
The horizontal stream 211 of continuous phase of mixing stream portion 203 shown in Figure 2 is communicated with the mixing stream 304 of mixing stream portion 203 shown in Figure 3.Also have, utilize Fig. 4 aftermentioned about the detailed formation of the horizontal stream 211 of continuous phase.
The latex derivation stream 212 of liquid leading-out portion 204 shown in Figure 2 is communicated with the latex export mouth 305 of liquid leading-out portion 204 shown in Figure 3.
Shown in Fig. 4 (A), the horizontal stream 211 of continuous phase that mixes stream portion 203 is made of the horizontal stream 211A of continuous phase, 211B and columnar revolution stream 211Z.With respect to the central shaft of revolution stream 211Z, the horizontal stream 211A of continuous phase is to a direction bias configuration, and the horizontal stream 211B of continuous phase is to the other direction bias configuration.That is, the horizontal stream 211A of continuous phase, 211B are with respect to turning round stream 211Z bias configuration axisymmetrically.
Continuous phase branch stream 303 shown in Figure 3 be branched off in two strands the stream, a stream is connected with the end of the horizontal stream 211A of continuous phase, form to flow to the liquid that turns round stream 211Z and flow.Continuous phase branch stream 303 shown in Figure 3 be branched off in two strands the stream, another stream is connected with the end of the horizontal stream 211B of continuous phase, form to flow to the liquid that turns round stream 211Z and flow.Flow to the liquid stream that turns round stream 211Z and the liquid stream that flows to revolution stream 211Z from the end of the horizontal stream 211B of continuous phase from the end of the horizontal stream 211A of continuous phase, in turning round stream 211Z, become rotary current.
Shown in Fig. 4 (B), with respect to the central shaft of revolution stream 211Z, the central shaft of the vertical stream 210 of decentralized photo is consistent the configuration with it, and in addition, the central shaft of mixing stream 304 is consistent the configuration with it.
Next, utilize Fig. 5 to illustrate that the whole liquid in the emulsifier unit 104 flows.
Be not directed to liquid introduction part 201 from continuous phase introducing port 207 and decentralized photo introducing port 208 as the water of continuous phase and as the oil content of decentralized photo.Utilize joint (not diagram), connect import pipe 103 shown in Figure 1 at continuous phase introducing port 207 and decentralized photo introducing port 208, utilize pump 102 that each liquid is transported in the emulsifier unit 104.
Water in continuous phase introducing port 207 imports to emulsifier unit 104 imports stream 301 via continuous phase and the vertical stream 209 of continuous phase distributes continuous phase branch stream 303, flows into to mixing stream 304.In this continuous phase revolution.
On the other hand, the oil that imports from decentralized photo introducing port 208 imports stream 302 and the vertical stream 210 of decentralized photo via the decentralized photo that forms perpendicular to liquid introduction part 201 stacked in-planes, flow into the place, interflow of mixing stream 304.In this place, interflow, two kinds of liquid interflow.
Fig. 6 represents that two kinds of liquid are in the activity in place, interflow.Water and the oil at interflow in mixing stream 304 encase oil based on water and form the effect of rotary current 401 on every side, and stably generates latex particle 601.
The latex particle 601 that generates is derived stream 212, is stored in the latex case 106 via import pipe 105 from latex export mouth 305 via latex.
At this, be not limited to the shape shown in the present embodiment about each stream shape, for example also can be rectangular shape.
At this, be specifically described about embodiments of the invention.
As embodiment, adopt the situation of silicone oil to describe about the hydromining that is stored among the former hopper 101A with the water of sneaking into interfacial agent, the oil that is stored among the former hopper 101B.
The experimental result that Figure 10 represents is the central shaft of the central shaft of the horizontal stream 211A of continuous phase, 211B and rotating part to be intersected the situation (not have revolution: do not have to illustrate) that do not have continuous phase revolution composition and with the situation (revolution is arranged) of the central shaft bias configuration of the central shaft of the horizontal stream 211A of continuous phase, 211B and rotating part.At this, the discharge of the horizontal stream 211A of the continuous phase of flowing through, 211B and the silicone oil flow of the liquid introduction part 201 of flowing through are carried out various variations, carry out 5 kinds of results under the transport condition relatively.Example 1～the example 5 of Figure 10 under these 5 kinds of transport conditions is arranged according to the big order of the total flow of the continuous phase of carrying and decentralized photo.
Can confirm that in the above conditions, emulsifier unit when work, the particle diameter of the latex particle in the produced latex has reduced about 10% than average grain diameter under the no revolving conditions having under the revolving conditions.In addition, average dispersion value be with no revolving conditions under equal extent 10% in, the particle diameter deviation is little.
Next, other formations of utilizing Fig. 7 to derive stream about latex in the emulsifier unit of present embodiment describe.
Fig. 7 is the stereogram that latex is derived other formations of stream in the emulsifier unit of expression the present invention the 1st embodiment.Also has the part that the symbolic representation identical with Fig. 4 is identical.
Expression imports 4 horizontal streams 211 of continuous phase of stream 210 configurations, the shape that continuous phase flows into from 4 directions with respect to decentralized photo in this example.That is, except the horizontal stream 211A of continuous phase shown in Figure 4,211B and columnar revolution stream 211Z, also possess the horizontal stream 211C of continuous phase, 211D.The horizontal stream 211C of continuous phase, 211D are also with respect to the central shaft bias configuration of turning round stream 211Z.That is, the horizontal stream 211A of continuous phase, 211B, 211C, 211D are with respect to revolution stream 211Z bias configuration axisymmetrically on the position of every skew 90 degree.
As this example, owing to continuous phase flows into from 4 directions, thereby the turning power of continuous phase strengthens.In addition, owing to shearing force applies from 4 direction equalizations, thereby compare from Fig. 4 that 2 directions flow into continuous phase, can make drop generate stabilisation.
Also have, in the example shown in Fig. 4 (B), central shaft with respect to revolution stream 211Z, the central shaft of the vertical stream 210 of decentralized photo is consistent the configuration with it, in addition, the central shaft of mixing stream 304 is consistent the configuration with it, but, and the central shaft of the vertical stream 210 of decentralized photo and general consistent the getting final product of central shaft of mixing stream 304.For example, the central shaft of the vertical stream 210 of decentralized photo is positioned at the cross section of mixing stream 304 and gets final product.
As described above, according to present embodiment, because continuous phase is granted rotating effect shearing, thereby compare with laminar condition, to relative enhancing of power of the interface interaction of continuous phase and decentralized photo.Thereby, can not dwindle the particle diameter of flow path width ground refinement latex particle.And, can select than existing big flow path width for the latex particle that obtains same particle size, can boost productivity.Have again, by surround with continuous phase decentralized photo around, thereby the stream that can avoid causing the decentralized photo of particle diameter deviation adheres to, thereby does not clean and also can carry out long-time emulsification uniformly.
Next, utilize Fig. 8 to describe about the formation of the emulsifier unit of the present invention's the 2nd embodiment.Also have, comprise that the system of the emulsifier unit of present embodiment constitutes with device shown in Figure 1 same.In addition, the formation of the emulsifier unit of present embodiment and Fig. 2 and device shown in Figure 3 are same.
Fig. 8 is the major part amplification stereogram that the emulsifier unit of expression the present invention the 2nd embodiment constitutes.
Example shown in Figure 8 mainly is the mixing stream portion 203 that has changed in Fig. 2 and the example shown in Figure 4.Mixing stream 304 among Fig. 8 is at the stream wall spiral helicine protuberance 801 to be set.Spiral helicine protuberance 801 forms as internal thread.
At the entrance side that mixes stream 304, connect revolution stream 211 from being orthogonal to the direction of mixing stream 304 central shafts.In addition, make the central shaft of the vertical stream 210 of decentralized photo as one man be connected the vertical stream 210 of decentralized photo with the central shaft that mixes stream 304.
Owing to form such formation, the continuous phase of supplying with from revolution stream 211 forms along spiral helicine liquid stream 401 in the periphery of the decentralized photo of supplying with from the vertical stream 210 of decentralized photo, and can turn round.
According to present embodiment, also because continuous phase is granted rotating effect in shearing, thereby can not dwindle the particle diameter of flow path width ground refinement latex particle.And, can select than existing big flow path width for the latex particle that obtains same particle size, can boost productivity.Have again, by surround with continuous phase decentralized photo around, thereby the stream that can avoid causing the decentralized photo of particle diameter deviation adheres to, thereby does not clean and also can carry out long-time emulsification uniformly.
Next, utilize Fig. 9 to describe about the formation of the emulsifier unit of the present invention's the 3rd embodiment.Also have, comprise that the system of the emulsifier unit of present embodiment constitutes with device shown in Figure 1 same.In addition, the formation of the emulsifier unit of present embodiment and Fig. 2 and device shown in Figure 3 are same.
Fig. 9 is the major part amplification stereogram that the emulsifier unit of expression the present invention the 3rd embodiment constitutes.
Example shown in Figure 8 mainly is the mixing stream portion 203 that has changed in Fig. 2 and the example shown in Figure 4.This example is to utilize external energy to produce the structure of rotary current.Specifically, the upstream side that mixes stream 304 be that to mix the vertical stream 901 of stream portion with continuous phase be the outside, with the vertical stream 210 of the decentralized photo double pipe structure that is the inboard.Continuous phase is mixed the vertical stream 901 of stream portion and is possessed the rotation wing 902.And, utilize rotating mechanism 903 to make the rotation of the rotation wing 902, thereby the continuous phase that the continuous phase of flowing through is mixed the vertical stream 901 of stream portion is subjected to turning power, form rotary current and flow into to mixing stream 304.
According to present embodiment, also because continuous phase is granted rotating effect in shearing, thereby can not dwindle the particle diameter of flow path width ground refinement latex particle.And, can select than existing big flow path width for the latex particle that obtains same particle size, can boost productivity.Have again, by surround with continuous phase decentralized photo around, thereby the stream that can avoid causing the decentralized photo of particle diameter deviation adheres to, thereby does not clean and also can carry out long-time emulsification uniformly.
In addition, owing to utilize external energy, thus do not rely on the feed flow of continuous phase, can both make the continuous phase revolution reliably.
Claims (4)
1. emulsifier unit, it mixes two kinds of immiscible liquid and emulsifications, it is characterized in that, comprising:
Liquid introduction part (201), it is provided with first stream (301) of first liquid and first stream (302) of second liquid;
Interflow stream portion (202), itself and described liquid introduction part (201) disposed adjacent, be provided with from the face of described liquid introduction part (201) side penetrate into opposition side face second liquid second stream (210) and be arranged at the face of described opposition side and be branched off into first branch's stream of two strands by line part with near second stream (210) of described second liquid and branch's stream (303) that second branch's stream constitutes;
Mix stream portion (203), itself and described interflow stream portion (202) disposed adjacent, be provided with second stream (211A) of first liquid of the described first branch's stream of connection of the face that is arranged at described interflow stream portion side and the 3rd stream (211B) of first liquid that is connected described second branch's stream, also be provided with from the face of described interflow stream portion side and penetrate into the face of opposition side and make described first liquid and the mixing stream (304) at described second liquid interflow;
Liquid leading-out portion (204), itself and described stream portion (203) disposed adjacent of mixing are provided with latex and derive stream (212),
In described mixing stream (304), described first liquid of supplying with from the 3rd stream (211B) of second stream (211A) of first liquid that connects described first branch's stream and first liquid that is connected described second branch's stream has the revolution composition with respect to main flow direction
Second stream (210) that is arranged at described second liquid of described interflow stream portion (202) is connected with the central portion of described mixing stream,
The flow through revolution stream (211Z) of rotating described first liquid of described second liquid,
The central shaft of the central shaft of second stream (211A) of described first liquid and the 3rd stream (211B) of described first liquid is with respect to the central shaft bias configuration of described mixing stream (304),
Second stream of described first liquid and the 3rd stream of described first liquid form many respectively,
Second stream of many described first liquid and the 3rd stream of many described first liquid dispose with respect to the central shaft axial symmetry of described mixing stream (304) respectively.
2. emulsifier unit according to claim 1 is characterized in that,
The central shaft arrangement of second stream of described second liquid is in the perspective plane of described mixing stream.
3. emulsifier unit according to claim 1 is characterized in that,
The wall of described mixing stream possesses spiral helicine protuberance, makes described first liquid produce turning power.
4. emulsifier unit according to claim 1 is characterized in that,
The 4th stream of described first liquid forms the double pipe shape on every side of second stream that is configured in described second liquid,
Described emulsifier unit possesses the rotation wing in the 4th stream that is configured in described first liquid and drives the rotating mechanism of the described rotation wing.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008-133549 | 2008-05-21 | ||
| JP2008133549 | 2008-05-21 | ||
| JP2008133549A JP4798174B2 (en) | 2008-05-21 | 2008-05-21 | Emulsifying device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101584972A CN101584972A (en) | 2009-11-25 |
| CN101584972B true CN101584972B (en) | 2013-08-21 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2009101410943A Expired - Fee Related CN101584972B (en) | 2008-05-21 | 2009-05-20 | Emulsification device |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP2123349B1 (en) |
| JP (1) | JP4798174B2 (en) |
| CN (1) | CN101584972B (en) |
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| JP5143082B2 (en) | 2009-05-22 | 2013-02-13 | 株式会社日立製作所 | Liquid-liquid extraction system |
| JP2012024313A (en) * | 2010-07-23 | 2012-02-09 | Nitto Denko Corp | Device for forming droplets, and method for forming droplets |
| AU2011346139B2 (en) | 2010-12-22 | 2016-07-14 | Institute Of National Colleges Of Technology, Japan | Fluid mixer and fluid mixing method |
| KR101334905B1 (en) | 2012-02-13 | 2013-12-02 | 인하대학교 산학협력단 | Vortex micro T-mixer with non-aligned inputs |
| DE102012104053B3 (en) * | 2012-05-09 | 2013-09-26 | Karlsruher Institut für Technologie | emulsifying |
| CN105148758B (en) * | 2015-08-20 | 2017-11-14 | 扬州大学 | A kind of quick method for preparing nanoemulsions |
| GB2555658A (en) * | 2016-11-01 | 2018-05-09 | Cambridge Consultants | Microparticle production |
| CN112946302B (en) | 2018-01-16 | 2022-05-03 | 株式会社爱蓓儿 | Cartridge for measuring blood coagulation time and blood coagulation time measuring device |
| JP6415775B1 (en) * | 2018-07-26 | 2018-10-31 | 株式会社アペレ | Blood coagulation time measurement cartridge and blood coagulation time measurement device |
| JP6407468B1 (en) * | 2018-05-24 | 2018-10-17 | 株式会社アペレ | Blood coagulation time measurement cartridge and blood coagulation time measurement device |
| WO2020160430A1 (en) * | 2019-01-31 | 2020-08-06 | Modernatx, Inc. | Vortex mixers and associated methods, systems, and apparatuses thereof |
| CN110152516B (en) * | 2019-05-30 | 2021-11-12 | 河海大学 | Liquid-liquid dual continuous preparation device |
| WO2023193002A1 (en) * | 2022-04-01 | 2023-10-05 | Modernatx, Inc. | Cross mixers for lipid nanoparticle production, and methods of operating the same |
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Also Published As
| Publication number | Publication date |
|---|---|
| EP2123349A3 (en) | 2010-10-27 |
| JP2009279507A (en) | 2009-12-03 |
| JP4798174B2 (en) | 2011-10-19 |
| CN101584972A (en) | 2009-11-25 |
| EP2123349B1 (en) | 2013-01-02 |
| EP2123349A2 (en) | 2009-11-25 |
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