CN101583622A - 用于破坏与泛素化相关的酶的相互作用的抑制剂和其应用 - Google Patents
用于破坏与泛素化相关的酶的相互作用的抑制剂和其应用 Download PDFInfo
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- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/93—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Indole Compounds (AREA)
Abstract
Description
Claims (11)
Applications Claiming Priority (3)
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US85612506P | 2006-11-02 | 2006-11-02 | |
US60/856,125 | 2006-11-02 | ||
PCT/CN2007/003105 WO2008052441A1 (en) | 2006-11-02 | 2007-11-01 | Inhibitors for disrupting the interaction of ubiquitination related enzymes and uses thereof |
Publications (2)
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CN101583622A true CN101583622A (zh) | 2009-11-18 |
CN101583622B CN101583622B (zh) | 2012-11-07 |
Family
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CN2007800409346A Expired - Fee Related CN101583622B (zh) | 2006-11-02 | 2007-11-01 | 用于破坏与泛素化相关的酶的相互作用的抑制剂和其应用 |
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US (1) | US20100189648A1 (zh) |
EP (1) | EP2086999B1 (zh) |
JP (1) | JP2010516227A (zh) |
CN (1) | CN101583622B (zh) |
WO (1) | WO2008052441A1 (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105061288A (zh) * | 2015-08-07 | 2015-11-18 | 武汉华素康生物科技有限公司 | 化合物及其制备方法和应用 |
CN107158387A (zh) * | 2017-06-08 | 2017-09-15 | 吉林大学第医院 | 阻断UBE2M介导Neddylation修饰在肾细胞癌治疗中的应用 |
CN111544595A (zh) * | 2020-05-29 | 2020-08-18 | 中山大学 | 泛素结合酶e2抑制剂和溶瘤病毒在制备抗肿瘤药物的应用 |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2334380B1 (en) | 2008-05-30 | 2021-09-01 | Mitologics | Ant-ligands molecules and biological applications |
EP2367798B1 (en) * | 2008-11-20 | 2018-02-28 | Northwestern University | Pyrazolone derivatives useful in the treatment of amyotrophic lateral sclerosis |
US9145424B2 (en) | 2008-11-20 | 2015-09-29 | Northwestern University | Treatment of amyotrophic lateral sclerosis |
WO2011160016A2 (en) * | 2010-06-17 | 2011-12-22 | The Trustees Of Columbia University In The City Of New York | E3 binding pockets and identification and use of e3 ligase inhibitors |
CN104144707B (zh) | 2011-12-14 | 2018-09-14 | 得克萨斯系统大学董事会 | 用于癌症疗法的连带基因失活生物标志和靶标 |
CN103091498B (zh) * | 2013-01-08 | 2014-12-31 | 中国科学院遗传与发育生物学研究所 | 植物体外泛素蛋白降解系统及其应用 |
US10267145B2 (en) | 2014-10-17 | 2019-04-23 | Halliburton Energy Services, Inc. | Increasing borehole wall permeability to facilitate fluid sampling |
MX2021002818A (es) * | 2018-09-10 | 2021-07-15 | Berg Llc | Métodos para tratar el cáncer mediante la inhibición de la enzima conjugadora de ubiquitina e2 k (ube2k). |
AU2020417293A1 (en) * | 2020-01-03 | 2022-09-01 | Berg Llc | Polycyclic amides as UBE2K modulators for treating cancer |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7915293B2 (en) * | 2003-05-30 | 2011-03-29 | Rigel Pharmaceuticals, Inc. | Ubiquitin ligase inhibitors |
WO2005000876A2 (en) * | 2003-06-27 | 2005-01-06 | Proteologics, Inc. | Ring finger family proteins and uses related thereto |
US20050130974A1 (en) * | 2003-10-17 | 2005-06-16 | Rigel Pharmaceuticals, Inc. | Benzothiazole compositions and their use as ubiquitin ligase inhibitors |
JP2008503591A (ja) * | 2004-06-22 | 2008-02-07 | ライジェル ファーマシューティカルズ, インコーポレイテッド | ユビキチンリガーゼ阻害剤 |
WO2006074262A1 (en) * | 2005-01-05 | 2006-07-13 | Rigel Pharmaceuticals, Inc. | Ubiquitin ligase inhibitors |
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2007
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- 2007-11-01 WO PCT/CN2007/003105 patent/WO2008052441A1/en active Application Filing
- 2007-11-01 US US12/513,154 patent/US20100189648A1/en not_active Abandoned
- 2007-11-01 JP JP2009534976A patent/JP2010516227A/ja active Pending
- 2007-11-01 CN CN2007800409346A patent/CN101583622B/zh not_active Expired - Fee Related
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105061288A (zh) * | 2015-08-07 | 2015-11-18 | 武汉华素康生物科技有限公司 | 化合物及其制备方法和应用 |
CN107158387A (zh) * | 2017-06-08 | 2017-09-15 | 吉林大学第医院 | 阻断UBE2M介导Neddylation修饰在肾细胞癌治疗中的应用 |
CN111544595A (zh) * | 2020-05-29 | 2020-08-18 | 中山大学 | 泛素结合酶e2抑制剂和溶瘤病毒在制备抗肿瘤药物的应用 |
Also Published As
Publication number | Publication date |
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EP2086999A4 (en) | 2010-08-04 |
US20100189648A1 (en) | 2010-07-29 |
CN101583622B (zh) | 2012-11-07 |
EP2086999B1 (en) | 2013-01-09 |
EP2086999A1 (en) | 2009-08-12 |
JP2010516227A (ja) | 2010-05-20 |
WO2008052441A1 (en) | 2008-05-08 |
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