CN101579256A - Concentric, detachable and replaceable multifunctional targeted tumor scalpel - Google Patents
Concentric, detachable and replaceable multifunctional targeted tumor scalpel Download PDFInfo
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- CN101579256A CN101579256A CNA2008100433604A CN200810043360A CN101579256A CN 101579256 A CN101579256 A CN 101579256A CN A2008100433604 A CNA2008100433604 A CN A2008100433604A CN 200810043360 A CN200810043360 A CN 200810043360A CN 101579256 A CN101579256 A CN 101579256A
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Abstract
The invention discloses a concentric, detachable and freely replaceable multifunctional targeted tumor scalpel used for treating various tumor treatments, which comprises an inner ring pipe and an inner pipe that are concentric. The mutual locations of the inner pipe and the outer ring pipe can be axially adjusted, and the inner pipe can be fixed on a handle through a connecting bar and can be detached from the outer ring pipe. The invention includes multifunctional applications of cold therapy, radio frequency ablation therapy, microwave ablation therapy, endothermknife therapy, laser ablation therapy, chemical therapy, radiation therapy, immunization therapy, gene therapy, photodynamic therapy, electrochemotherapy and the like. Meanwhile, the inner pipe of the multifunctional targeted tumor scalpel can also be used as a diagnosis monitoring device, such as a temperature sensor, a biopsy needle, a micro ultrasonic probe, an endoscope and the like. The multifunctional targeted tumor scalpel can realize the combination of single and/or multiple therapy methods.
Description
Technical field
The present invention relates to a kind of concentric, removable, replaceable multifunctional targeted tumor scalpel, can implement the use of uniting of therapy such as hot and cold, electric, light, chemistry, radiation, immunity, gene or said method various combination by this scalpel to pathological tissues, also can be used as temperature sensor, biopsy needle, miniature ultrasonic probe and endoscope target tissue is carried out diagnostic monitoring.
Background technology
Tumor is acknowledged as one of main reason that threatens human body health.Along with the continuous development of science and technology and medical level, people explore the method for multiple treatment tumor, mainly are divided into operative treatment, naturopathy, chemotherapy, radiotherapy, Biotherapeutics (immunization therapy and gene therapy) etc.
Cold therapy in the naturopathy claims cryosurgery again, is meant to utilize cryosurgery tool, thereby making lesion tissue experience cooling, freezing and rewarming causes irreversible damage so that a downright bad clinical medicine of control arranged.The cold therapy of tumor is that cryoprobe or conduit are inserted tumor tissues, imposes low temperature at cryoprobe or catheter head then tumor is killed.The ultimate principle of cold therapy tumor is: on the cell aspect, ice crystal forms and the mechanical injuries of ice crystal in the cell, cell dehydration and shrinkage and the chemical injury that causes; And at tissue, on the organ aspect, cause blood stagnation and microthrombusis and and then blocked the nutrient substance supply of tumor thereby refrigerated effect has also destroyed the blood microcirculation system.Generally speaking, various clinical researches show by tumor being implemented be aided with the destroyed tumor tissue to greatest extent of rewarming thawing at a slow speed again after the quick cryogenic refrigeration.But in practical clinical,, conveniently scalpel is withdrawn from from focus as early as possible thereby preferably can implement initiatively heating after refrigerating process finishes to scalpel in order to shorten operating time.This rewarming that initiatively heats also helps to slow down the initiatively freezing harmful inertia expansion that stops freezing zone, back to a certain extent.Cryosurgery has been widely used treats carcinoma of prostate, hepatocarcinoma, renal carcinoma, breast carcinoma and other multiple diseases.Be applied to cold therapy at present and mainly contain two kinds of systems: liquid nitrogen system and argon helium High-Pressure Gas System.Liquid nitrogen system mainly is to utilize the principle of boiling heat transfer (need absorb a large amount of gasification latent heats when material becomes gas by liquid) and heat convection that tissue temperature is reduced rapidly.In the operation liquid nitrogen is fed in the cryoprobe, gasification heat absorption when its contact target tumor tissues, the temperature of treatment scalpel is reduced rapidly, make and organize fast cooling, freeze, in scalpel, pass to room temperature or heated nitrogen then and make and organize rewarming, tumor is killed through the one or many freeze-thaw cycle.Argon helium system utilizes the adiabatic throttling effect of gas to finish the therapeutic process of cooling and rewarming, when the higher gas of pressure is flowed through the aperture adiabatic throttling, along with the decline temperature of pressure tends to change, some gas temperature descends, and some gas temperature rises, the adiabatic throttling effect is also referred to as joule-Thomson (Joule-Thomson is called for short J-T) effect.As when the cryoprobe internal recycle argon, argon is rapid expansion in point of a knife, drop to about-150 ℃ of degree in a short period of time and realization liquefaction under ideal state, thereby the same boiling heat transfer and the heat convection of utilizing with liquid nitrogen system realizes that fast cooling to target tumor is (during rewarming, helium is withdrawn from cryoprobe thereby temperature increase is convenient in the point of a knife rapid expansion in target tumor).For the designer of two systems, its design concept is consistent: promptly with inside, target tumor contacted cryoprobe top at the short as far as possible pre-cooling after date of experience, do one's utmost to realize that working medium is in the liquid stateization under the alap temperature.Liquid nitrogen system is that with the fundamental difference of High-Pressure Gas System the former is that the working medium that will liquefy in advance is transported to the cryoprobe top through relative long distance, and the latter makes gases at high pressure working medium realize liquefaction at the cryoprobe top.Only relatively from operation principle, liquid nitrogen system because of discharge pressure lower (tens of PSI) thus the refrigeration work consumption when causing that boiling temperature is lower to make stable state improves, but the long shortcoming of pre-cool time is arranged; High-Pressure Gas System has overcome the long shortcoming of pre-cool time, but because of discharge pressure higher (thousands of PSI) thus the freezing power when causing that boiling temperature is higher to make stable state is relatively low.
Another thermotherapy method radio-frequency (RF) ablation also has been widely used in treatment and has comprised multiple diseases such as liver's tumor, mastadenoma, prostate tumor and brain tumor or cancer.It is that electrode needle is inserted pathological tissues that tumor is carried out radio-frequency (RF) ablation, back pole plate or another electrode contact human body, the frequency electromagnetic waves of using the alternation that produces between the two makes ion motion direction alternate in the tumor tissues, ion kinetic energy is converted to heat energy and causes the pathological tissues temperature to raise, thereby reaches therapeutic purposes.Direct heat melts effect and organizes suffered temperature correlation, and temperature is to be determined by the speed of the energy that applies, heating and the heat sensitivity of tissue.General heating-up temperature is 43 ℃-45 ℃, just can cause irreversible cell injury.Inactivation at this temperature range endoenzyme is the main factor that causes tissue injury.When tissue temperature was elevated to 60 ℃, the time that makes cell produce irreversible damage shortened greatly.After temperature raise and surpasses 60 ℃, protein denaturation in this temperature range, had and condenses between the necrotic area.In this way, pathological tissues is melted, and reaches therapeutic purposes.
The dominant mechanism of another thermotherapy method micro-wave therapeutic is that the energy with microwave is transformed into heat energy, with the tumor tissues rapid solidification, stops blooding and burns tumor tissues.The tissue injury of microwave coagulation is characterized as tissue coagulation degeneration and necrosis, its clear border, and pathological study shows that its tumor cell is the characteristic damage and changes.Body can produce certain immunology effect behind the microwave coagulation tumor tissues.Characteristics such as microwave applications is since clinical, and is fast to the tissue heating with it, and it is high to heat up, and tissue coagulation is reliable, and haemostatic effect is thorough, and heated perimeter is easily grasped, and is easy to use and being accepted.Along with the development of high frequency transmission line and improving constantly of antenna technology, the microwave radiation mode is from external radiation, develop in the tissue the direct radiation that gets involved in radiation and blood vessel, the tract, range of application constantly enlarges, and its effect more and more is subjected to people's attention and attention.
The laser therapy pathological tissues mainly utilizes heat effect (the laser energy density height of laser to biological tissue, under bombardment with laser beams, the local temperature of biological tissue is raise), (optical pressure of laser itself adds the tissue bulking that is caused by hyperpyrexia and the secondary pulse ripple that produces to the optical pressure effect, the tumor tissues that has produced heat effect is destroyed, albuminolysis) and galvanomagnetic-effect (laser also is a kind of electromagnetic wave, the electromagnetic field that it produces can make tumor tissues ionization, nuclear decomposition).
The immunization therapy of tumor is to attempt to utilize immune strength and specific treatment malignant tumor.Although tumor cell is not immunogenic but pathogenic former, immune system still can be discerned it also with it removing.But tumor usually can be disturbed immunoreactive function, and the challenge of immunization therapy is that the anti-tumor method of safety can inject immunoreagent to human body in the reality tumor is treated by the sophisticated method exploitation of using cellular immunization and molecular immune is effective.
Chemotherapy (abbreviation chemotherapy) is a kind of drug treatment that is used for the treatment of tumor or cancer.Multiple different chemotherapeutics has been arranged at present.According to type, progress degree and the patient's of disease general health, use these medicines in a different manner.All chemotherapeutics all work by attacking quick splitted cell.Normal cell divides with a kind of speed by the health strict control.Yet in cancerous cell, cell division makes a mistake, and causes producing uncontrollably new cell, forms tumor or cancer.Chemotherapy agents can disturb the division growth of these cells, can cause cancerous cell dead fully.Chemotherapy can be carried out in one or more periods, was used for treating the entity tumor (carcinous lump) of mammary gland or intestinal etc., remained in intravital cancerous cell such as be used for dwindling tumor or guarantee after the kill tumor excision.
Photodynamic therapy (Photodynamic Therapy, PDT) also claim photoirradiation therapy (Photoradiation Therapy, PRT) or photochemotherapy (Photochemotherapy, PCT), compare with traditional remedies, the sharpest edges of optical dynamic therapy method just are its high efficiency and safety.Its principle is: at first select a kind of to target body photosensitizer selectively, be introduced in the body and distribution between tissue by means such as injections, then when the concentration ratio of photosensitizer in target body and non-target body reaches maximum, with the rayed target body tissue that is complementary with sensitiser absorption, by a series of optical physicss, photochemistry, photo bio process, in the presence of oxygen, produce the deleterious active oxygen of target body cell function, make the target body disorganization until death.Therefore photodynamic therapy has advantages such as determined curative effect, general toxicity are low.In optical dynamic therapy, singlet oxygen that in the luminous energy conversion process, produces and the free radical energy direct killing sick cell, also, further cause the ischemic necrosis of pathological tissues because of the local microcirculation obstacle that capillary endothelium damages and blood vessel embolism causes of this process initiation.
X-ray therapy is that radion implantation tumour tissue is killed and wounded it.In operation process, with the special apparatus of a cover with in these particle implantation tumours or be subjected to comprise among the tissue of tumor lympha diffusion path between the tissue of tumor-infiltrated infringement.Be planted in that mini-radioactive resource continues to discharge the gamma-rays that energy photons produces among the tumor body, irradiated tumor cell makes tumor tissues killed and wounded by destructiveness.
Electroporation treatment is a kind of oncotherapy new technique, studies show that rational control electric pulse, can be temporarily, reversibly make cell membrane micropore occur, permeability strengthens, micropore can be closed mostly after electric field disappeared, and pair cell does not have any impact, this phenomenon is called electroporation (electroporation, EP), utilizing the electroporation phenomenon of cell membrane to carry out oncotherapy is the oncotherapy new technique that occurs in recent years, it can overcome the barrier action of cell membrane to medicine, obviously change the curative effect of cytotoxic drug to tumor, overcome the drug resistance of tumor to medicine, this technology is applied to clinical tumor, has produced electroporation therapy, oncotherapy new techniques such as electricity gene therapy.By use in conjunction electroporation technology and chemotherapy to tumor treat be called electroporation therapy (electroporation therapy, EPT or electrochemotherapy, EIC).After the instantaneous electric pulse of high strength caused cell membrane generation electroporation, the electrical conductivity and the permeability of cell membrane sharply increased, and promoted chemicals to intracellular transport, had improved cell internalizing greatly and had learned drug concentrations, had strengthened the lethal effect of medicine.Electroporation therapy is not with the direct kill tumor cell of pulse, but strengthens the curative effect of chemicals by electroporation.Electroporation therapy still belongs to topical therapeutic, and its therapeutic domain only limits to the electrode target area, and the tumor cell that exceeds the target area is not had effect.In addition, (electeo-gene therapy is to use electroporation technology ETG) to electric gene therapy, carries out the method that high efficiency gene shifts in vivo by the electroosmosis of cell membrane.On oncotherapy, electric gene therapy utilizes electroporation technology importing range gene to strengthen the antineoplastic curative effect.
Gene therapy is meant that generally the hereditary material that will limit changes the specific target cell of patient over to, to reach the method for preventing or treating the target of disease.Therapy of tumor is to correct or displacement Disease-causing gene or introducing have a kind of Therapeutic Method of other source gene of therapeutic value with normal or wild type gene.At present, therapy of tumor can become the part of combined therapy of tumour, may be to improving the sensitivity of chemotherapy, radiotherapy, and the recurrence and the transfer that reduce tumor are played a role, or even significantly effect.Gene transfer can be adopted methods such as electroporation, particle gun.
Ultrasonic sensor is the pick off that utilizes hyperacoustic characteristic to develop.Ultrasound wave is the mechanical wave that a kind of frequency of vibration is higher than sound wave, is taken place under the excitation of voltage by the transducing wafer that vibration produces, and it has the frequency height, wavelength is short, the diffraction phenomenon is little, particularly good directionality, can become ray and characteristics such as direction propagation.Ultrasound wave is very big to liquid, solid penetrating power, especially in the opaque solid of sunlight, and the degree of depth that it is penetrable tens meters.Ultrasound wave is run into impurity or separating surface and can be produced significantly to reflect to form and be reflected into echo, runs into the live animal physical ability and produces Doppler effect.Therefore ultrasound wave is widely used in aspects such as industry, national defence, biomedicine as detection means.
The indication difference of above-mentioned different treatment methods, handling characteristics is different with medical effect, and the doctor is also different to the preference of some method.Several different treatment methods are gathered on leader's art apparatus, not only make the doctor select Therapeutic Method to become possibility fast according to the focus situation at operative site, simultaneously to same focus in same operation process, under the situation that keeps the former invariant position of operating theater instruments, implement the different methods of killing and wounding one by one, then can play the effect of learning from other's strong points to offset one's weaknesses, improving curative effect.Example 1: if the interior pipe of this multifunction surgical cutter, can realize then that the oneself of multifunction surgical cutter accurately locatees as the passage of guide wire/puncture needle.Example 2: if the interior pipe of this multifunction surgical cutter is as the passage of carrying other medical device, after some operation is as breast carcinoma cryosurgery and/or radio-frequency (RF) therapy, carry out immediately in the focus zone of receiving treatment, biopsy and place and to be used for the opaqueness heavy metal gauge point (as platinum or peptide alloy hoop etc.) of definite treatment position in the future exactly.Example 3: if the interior pipe of this multifunction surgical cutter is as the passage of carrying other medical treatment device, then can be after finishing freezing operation or the operation of other associativity, thus placed radion in the past and strengthened lethal effect withdrawing from the multifunction surgical cutter tumor.Example 4: if the interior pipe of this multifunction surgical cutter is as drug conveying/perfusion guide duct, then cold therapy and chemotherapy can be combined, by injecting some specific targeted anticancer medicine, thereby kill liver neoplasm to greatest extent, effectively reduce the postoperative recurrence rate.Miguel A. etc. adopt the comprehensive treatment of freezing-chemotherapy, discover that cold therapy can be played the effect of catching the cancer therapy drug in the tumor in the Comprehensive Treatment process, thereby reduce the release of cancerous cell secretin, promote the curative effect of chemotherapy.Example 5: because single the deficiency of the freezing power of cryoprobe, cryosurgery often is limited to treat the liver lesion less than 5 centimeters diameters.Though many problems that can effectively solve freezing power of using side by side cryoprobe the time manyly can cause the puncture of cryoprobe unnecessary mechanicalness to damage to the diseased region tissue and tumor cell is squeezed and spreads.With two cryoprobes fix a point, coaxial, use one by one in the same way, simultaneously and/or at times, not only can solve single the freezing underpower of cryoprobe with avoid many mechanical damage problems that cryoprobe is used side by side, and can be by regulating two or many relative position between the coaxial cryoprobe freezing function district and freezing power are separately controlled freezing hazard boundary and shape effectively.Example 6: if the interior pipe of this multifunction surgical cutter as the guide duct of carrying radio-frequency electrode, then can be realized the Synergistic treatment of freezing-radio-frequency (RF) ablation.Promptly carry out the one or many freeze cycle earlier, use radiofrequency ablation therapy according to patient's practical situation again.Though because the freezing most of cancerous issue of cryosurgery energy, can't be freezing to the cancerous cell that is hidden in the blood vessel depths, be in the cancerous cell very easily breeding again of this environment.Thereby the reuse radiofrequency ablation therapy not only can be strengthened the effect of cold therapy after carrying out cryosurgery, and radiofrequency ablation therapy is carried out under a kind of more advantageous conditions, because the liver neoplasm volume is littler after the cryosurgery, cancerous cell is more responsive to heat radiofrequency, and the energy that will use during treatment is still less corresponding.When adopting single radio-frequency (RF) ablation, when being elevated to 100 ℃ of left and right sides as if temperature control is improper, moisture ebullition, gasification in the tissue.If temperature continues to raise, organize the phenomenon that carbonization then can take place and produce cigarette.In case carbonization produces, temperature can raise rapidly.Simultaneously, hindered the degree that tissue damaged hinders, and carbonization increased interstice's pressure, may cause cancerous cell diffusion and deeply tissue and blood vessel owing to thermal resistance restriction phenomenon occurred.Because electric current density is the highest around electrode needle, so temperature is the highest.Along with the distance electrode needle is gradually far away, temperature reduces gradually.Enlarge temperature range if improve power, then the tissue near electrode needle is easy to carbonization.Therefore, under temperature can not too high prerequisite, improve ablation range and become a difficult point, and just can address this problem by refrigerative method.
Having used freezing, heating, chemistry, immunity or therapy such as interosculate in some equipment is treated pathological tissues.
U.S. Pat 7097641 discloses a kind of cold and hot ablation conduit, and this catheter tip can be by injecting the freezing perienchyma of cooling fluid, and it also has a radio frequency heating to bring in heat tissue simultaneously.Dual mode can be operated separately, but also binding operation is controlled size, the scope of damaged tissue, thereby increases the multiformity on the modus operandi.
U.S. Pat 6506189 discloses a kind of cold junction electrode thermal therapy system, and radio-frequency electrode is used to heat pathological tissues in this system, and the cold fluid injecting electrode makes that the scope of heating ablation is bigger simultaneously, treats more effective.
U.S. Pat 5938659 discloses a kind of cooling multistylus electrode conduit system, and this system adopts multistylus electrode at catheter tip, and cold fluid injects and improves heating ablation efficient simultaneously.
U.S. Pat 6316007 discloses a kind of physiotherapy treatment method for cancer that combines with immunotherapy.This invention is at first used immunotherapy to pathological tissues, then destroys pathological tissues by physical method.
A kind of cryosurgery surgery systems and method of removing pathological tissues disclosed in the U.S. Pat 6395715.In this invention, treatment reagent can import to area for treatment after cryosurgery finishes.
A kind of cold therapy system is disclosed in the U.S. Pat 7083612, system adopts spininess freezing, every scalpel is included freezing tip and freezing chamber, and scalpel punctures into behind the human body, cryogen is passed through behind the freezing chamber tip to be cooled off, thereby reaches the purpose of treatment disease.Inventor Peter J.Littrup mentions chemotherapy agents or other drug reagent can be expelled to area for treatment in freezing front and back, can enlarge therapeutic domain like this, makes tumour ablation more thorough.
U.S. Pat 7118566 discloses a kind of ablation procedure that accurate amounts of fluids promotes heart tissue that injects under certain pressure.Fluid can be cytotoxicity liquid or high heat-conducting liquid, fluid can inject target tissue by the discharge orifice of needle point under certain pressure, radiofrequency ablation procedures can be carried out in injection process, uses injection device as electrode, also can adopt independent electrode to melt after injection.
U.S. Pat 1011606 discloses a kind of device of using cold or hot method treatment body system, and this device is a concentric double channel catheter, treats urethra or bladder disease by cold or hot mode.
U.S. Pat 4244377 discloses a kind of concentric double channel catheter that is used to heat ear inside.
U.S. Pat 5437673 discloses a kind of closed loop that is applied in the prostate surgery operation and has organized heater.This device adopts concentric three cavities conduit pipe, and hot salt brine flows into from outermost intracavity, flows out from concentric second layer conduit, is positioned at the discharge that the 3rd layer of the most inboard conduit is used for urine.This conduit is mainly used in when prostate is frozen scalpel and melts the heating urethra and avoids its damaged.
The saline that U.S. Pat 5257977 discloses a kind of application of heat comes prostate is carried out the device of thermotherapy.Similar to last patent is, this device has adopted three cavities conduit pipe equally, and intermediary conduit is used for the discharge of urine.
Summary of the invention
Technical problem to be solved by this invention is to propose a kind ofly can to implement therapies such as hot and cold, electric, light, chemistry, radiation, immunity, gene to pathological tissues, or above-mentioned different therapy combination, unite the concentric removable of use and can freely exchange, be used for the multifunctional targeted scalpel that kinds of tumors is treated, this scalpel also can be used as temperature sensor, biopsy needle, miniature ultrasonic is popped one's head in and endoscope carries out diagnostic monitoring to target tissue.For example, when the outer endless tube that includes spiral fin coil during as cryoprobe, interior pipe can be used as the guide channel of another apparatus.This apparatus including, but not limited to other one cryoprobe, heat pipe, single electrode radio frequency scalpel, the radio frequency scalpel of popping one's head in, microwave antenna, optical fiber, electrode, resistance wire, scope carrier pipe, temperature sensor, miniature ultrasonic probe, various drug conveying and perfusion cannula, guide wire, puncture needle, biopsy needle or input probe etc. more.Again for example, when the interior pipe that includes finned tube during as cryoprobe, outer endless tube can be used as the guide channel of above-mentioned any apparatus; Interior pipe also can constitute a bipolar ablation device, two-tube conveyer device or two-tube diagnostic monitoring device with outer endless tube.This with different treatment methods separately and/or distinct methods in conjunction with and alternately the treatment means used of property not only provide an operation platform that possesses multi-selection as the doctor, and the whole bag of tricks in order, accurately, reasonably is used in combination and may produces significant mutual and synergistic effect, thereby reaches the optimum efficiency of killing tumor cells.
For solving the problems of the technologies described above, the concentric removable multifunction surgical cutter that the present invention proposes comprises outer endless tube and interior pipe.Interior pipe, outer endless tube can be done axially pulling relatively, and interior pipe can take apart from outer endless tube.
Above-mentioned concentric, removable, the replaceable multifunctional targeted tumor scalpel of the present invention main feature be: comprise outer endless tube and interior pipe.Outer endless tube is freezing endless tube scalpel, and interior pipe is the radio frequency scalpel.The heat conduction of outer shroud tube wall face, the centre is a cavity, the front end sealing.Spiral finned heat exchanger is arranged in the scalpel, it enters pipeline with gas respectively and links to each other with the J-T nozzle, the J-T effect takes place after by the J-T nozzle and expands in endless tube front end cavity in gas, and the cold fluid that the back of expanding forms is by the conduction cooling surrounding tissue of endless tube wall.Wherein be provided with temperature sensor and come collecting temperature.The instlated tubular of annulus hollow is put into ring pipe, and when refrigerating gas flowed out, instlated tubular played heat-blocking action, avoids healthy tissue damaged to hinder.Outer endless tube and handle join, and in the handle connecting leg on the handle air inlet pipe and escape pipe are arranged, and temperature sensor line and radio frequency line can pass from escape pipe.Interior pipe unit is the pipe of a middle cavity, front end sealing.Its tip can be electrode, melts by providing frequency electromagnetic waves to make surrounding tissue be heated.The interior rear end of managing links to each other with a connecting rod, and connecting rod and handle rear side are provided with gripping mechanism, and with convenient fixing interior the pipe, when connecting rod was tightened, the outer endless tube of annular also can be along interior tubular axis to moving.Interior pipe rear end surface is marked with scale, with the relative position of pipe in representing with outer endless tube, makes things convenient for the operation in the operation process.Can use interior pipe separately in actual applications, outer endless tube is treated tissue, also can regulate the temperature of tissue or form size, the shape of ice hockey by the power of controlling pipe in freezing outer endless tube and the radio frequency.When freezing end, can carry out rewarming to freezing tissue by pipe in the radio frequency, expose interior pipe by the outer endless tube that slides afterwards, next by the heating of pipe in the radio frequency to causing hemorrhage needle track tissue to stop blooding owing to puncture.When interior pipe carries out radio-frequency (RF) therapy, can control the effects of reduced temperature of outer endless tube, pipe radio frequency pin is controlled its temperature in cooling off.Because refrigerative effect, pressing close to organizing not of radio frequency pin can carbonization, and the ablation procedure that carries out simultaneously organizing around making still heated, and causes scope to increase greatly.
Above-mentioned another characteristics concentric, removable, replaceable multifunctional targeted tumor scalpel of the present invention are: outer endless tube is freezing endless tube scalpel, and interior pipe can be the spininess radio-frequency unit.A plurality of radio frequency pins can enlarge therapeutic domain, make that the not dead sick cell in freezing edge is dead fully.Another characteristics of the present invention, interior pipe can be treated pathological tissues for microwave antenna, optical fiber, electroporation electrode, electrochemical electrode, resistance wire, heat pipe etc., also can enlarge ablation range by the temperature of pipe in the cooling control of outer endless tube simultaneously.Another characteristics of the present invention, interior pipe can be carrier pipe, not only can be used as the transmission channel of endoscope, can also be as the radion implanting device in the X-ray therapy, also can be used as simultaneously the passage of light power reagent, chemotherapy, immunity, gene reagent or other treatment reagent, pipe in reagent injects under certain pressure is by the tip aperture, reagent such as cytotoxic reagent or cause apoptotic reagent to inject target tissue, the performance therapeutical effect.Some heat-conducting liquids also can inject and strengthen heat-conduction effect, and the variation of injection direction can change shape and the size that forms ice hockey.Input process can be before freezing, carry out in the refrigerating process or after freezing.In addition, can use cavity looper delivering therapeutic material to target tissue, particularly the tissue of freezing edge.Another characteristics of the present invention, interior pipe can be the diagnostic monitoring device, when as temperature sensor, can be in various process tissue temperature monitoring; When as biopsy needle, can diagnose degree and scope that the structure of evaluation of tissue, form etc. change by taking out the target tissue sample; When popping one's head in, can detect tissue or in-house apparatus as miniature ultrasonic.
Above-mentioned another characteristics concentric, removable, replaceable multifunctional targeted tumor scalpel of the present invention are: interior pipe is a cryoprobe, and outer endless tube is a radio frequency annular pin.The heat conduction of inner tubal wall face, the centre is a cavity, the front end sealing.In the interior pipe finned tube exchanger is arranged, it enters pipeline with gas respectively and links to each other with the J-T nozzle, and gas the J-T effect takes place after by the J-T nozzle and expands in interior pipe front end cavity, and the cold fluid that the back of expanding forms is by the conduction cooling surrounding tissue of inner tubal wall.By the pulling of foregoing connecting rod, the length that pipe enters tissue in can controlling, thus regulate length, the shape that forms ice hockey.Outer endless tube is the ring tube of middle cavity, front end sealing, and the electromagnetic energy that send at its tip is converted into heat energy, and surrounding tissue is heated.Effects of reduced temperature by pipe scalpel in controlling cools off outer endless tube radio frequency pin, controls its temperature.Because refrigerative effect, pressing close to organizing not of radio frequency pin outer wall can carbonization, and the ablation procedure that carries out simultaneously organizing around making still heated, so heated perimeter increases greatly.
Above-mentioned another characteristics concentric, removable, replaceable multifunctional targeted tumor scalpel of the present invention are: interior pipe is a cryoprobe, in the outer endless tube spiral finned heat exchanger is arranged, described in main feature of the present invention.Feed the gas with contrary burnt soup effect in serpentine pipe, as helium etc., outer like this endless tube can play heat effect, not only can be applicable to freezing back rewarming heat, and can also play the effect of protecting vital tissue in the refrigerating process.Outer endless tube inner helix pipe also can feed the gas of positive burnt soup effect, plays refrigeration, by adjusting the position of inside and outside endless tube, can adjust the shape and the size that form ice hockey.
Above-mentioned another characteristics concentric, removable, replaceable multifunctional targeted tumor scalpel of the present invention are: interior pipe is a cryoprobe, outer endless tube can be microwave antenna, optical fiber, electroporation electrode, electrochemical electrode, pathological tissues is treated, also can control the temperature of outer endless tube simultaneously by the cooling of interior pipe, enlarge ablation range.Another characteristics of invention, outer endless tube can be carrier pipe, not only can be used as the transmission channel of endoscope, can also also can be used as the passage of light power reagent, chemotherapy, immunity, gene reagent or other treatment reagent simultaneously as the radion implanting device in the X-ray therapy.Input process can be before freezing, carry out in the refrigerating process or after freezing.Another characteristics of invention, outer endless tube can detect tissue or in-house apparatus for the miniature ultrasonic probe.
Above-mentioned another characteristics concentric, removable, replaceable multifunctional targeted tumor scalpel of the present invention are: interior pipe can constitute a bipolar ablation device with outer endless tube.Electric insulation between inner and outer pipes.Two pipes both can be applied to tissue surface, also can puncture in the tissue.Come tissue is carried out in various degree the melting of diverse location by the distance that changes between two pipes.
Above-mentioned another characteristics concentric, removable, replaceable multifunctional targeted tumor scalpel of the present invention are: interior pipe can constitute a two-tube conveyer device with outer endless tube.Interior pipe or outer endless tube can be imported light power reagent, chemotherapy, immunity, gene reagent or other treatment reagent simultaneously or in difference constantly, also can be used as the radion implanting device in the X-ray therapy.
Above-mentioned another characteristics concentric, removable, replaceable multifunctional targeted tumor scalpel of the present invention are: interior pipe can constitute a two-tube monitoring diagnosis device with outer endless tube.Interior pipe or outer endless tube can be respectively as temperature sensor, miniature ultrasonic probe or biopsy needles.
Description of drawings
Fig. 1 is that the present invention is concentric, removable, the sketch map of replaceable multifunctional targeted tumor scalpel.
Fig. 2 is the profile that concentric, removable, the replaceable multifunctional targeted tumor scalpel of pipe in outer endless tube of helical fin heat exchanger and the radio frequency is arranged.
Fig. 3 is that interior pipe is the profile of concentric, removable, the replaceable multifunctional targeted tumor scalpel of microwave antenna.
Fig. 4 is the application sketch map that concentric, removable, the replaceable multifunctional targeted tumor scalpel of pipe in outer endless tube of helical fin heat exchanger and the radio frequency is arranged.
Fig. 5 is the sketch map that concentric, removable, the replaceable multifunctional targeted tumor scalpel of pipe in outer endless tube of helical fin heat exchanger and the multi-electrode is arranged.
Fig. 6 is the sketch map that concentric, removable, the replaceable multifunctional targeted tumor scalpel of pipe in outer endless tube of helical fin heat exchanger and the carrier pipe is arranged.
Fig. 7 is the sketch map that concentric, removable, the replaceable multifunctional targeted tumor scalpel of outer endless tube of helical fin heat exchanger and cavity looper carrier pipe is arranged.
Fig. 8 is the sketch map that concentric, removable, the replaceable multifunctional targeted tumor scalpel of the outer endless tube of helical fin heat exchanger and a kind of carrier pipe is arranged.
Fig. 9, the 10th has the sketch map of concentric, removable, the replaceable multifunctional targeted tumor scalpel of outer endless tube of helical fin heat exchanger and biopsy needle.
Figure 11 is the sketch map that concentric, removable, the replaceable multifunctional targeted tumor scalpel of pipe in outer endless tube of helical fin heat exchanger and the diagnostic detection is arranged.
Figure 12 is the profile that concentric, removable, the replaceable multifunctional targeted tumor scalpel of pipe in outer endless tube of radio frequency and the finned heat exchanger is arranged.
Figure 13 is the profile that concentric, removable, the replaceable multifunctional targeted tumor scalpel of pipe in outer endless tube of helical fin heat exchanger and the finned heat exchanger is arranged.
Figure 14 is the profile that concentric, removable, the replaceable multifunctional targeted tumor scalpel that can annotate pipe in outer endless tube of treatment reagent and the finned heat exchanger is arranged.
Figure 15 is the profile of concentric, removable, the replaceable multifunctional targeted tumor scalpel of bipolar ablation electrode.
Figure 16 is the profile of concentric, removable, the replaceable multifunctional targeted tumor scalpel of two-tube conveying.
Figure 17,18,19 is profiles of three kinds of handles and interior pipe connecting structure.
The specific embodiment
Below in conjunction with the drawings and specific embodiments, further set forth the present invention.These embodiment are interpreted as only being used to the present invention is described and are not used in restriction protection scope of the present invention.After the content of having read the present invention's record, those skilled in the art can make various changes or modifications the present invention, and these equivalences change and modify and fall into claim of the present invention institute restricted portion equally.
Fig. 1 has shown that the present invention is concentric, removable, the concrete form of replaceable multifunctional targeted tumor scalpel 20 and the form of critical piece wherein.Scalpel 20 mainly is made up of outer endless tube 30, interior pipe 70, handle 40 and connecting rod 50.Outer endless tube 30 Front-end Design become pointed sealing, are convenient to insert pathological tissues, and the back is the hollow circular ring body.The heat conduction of outer shroud tube wall face, its length and diameter adopt the mode of operation to decide by the size of wanting treated tissue, the degree of depth that will insert tissue and doctor.Make material and can use materials such as rustless steel, Nitinol or titanium.Interior pipe 70 lumps together with outer endless tube 30 concentric sets, the front end sealing, and tip can be made difformity, as tip or round end, is convenient to insert pathological tissues.The back is a hollow circular cylinder, wall heat conduction.Make material and can use materials such as rustless steel, Nitinol or titanium.Interior pipe 70 can axially spur along sliding tray 81, also can take apart from outer endless tube 30.Outer endless tube 30 joins with handle 40, and handle connecting leg 41 is arranged on the handle 40, and handle 40 mainly plays a part to connect, fixing and operation.In pipe 70 link to each other with connecting rod 50,40 on connecting rod 50 and handle are provided with snap ring 82,83,84,85,86, with convenient fixing interior pipe 70, when connecting rod is fixed in a certain position of snap ring, interior pipe and outer endless tube fixed-site, and when connecting rod was not tightened, outer endless tube 30 also can move axially along interior pipe 70.
Fig. 2 has shown that the present invention is concentric, removable, the main feature of replaceable multifunctional targeted tumor scalpel 20.Outer endless tube 30 is a cryoprobe, and interior pipe 70 is the radio frequency scalpel.In the endless tube 30, spiral fin coil 62 spirals along outer endless tube 30 inwalls, and is concentric with outer endless tube outside.After flowing into appendix 66 and spiral fin coil 62 by appendix interface 67, gas enters J-T nozzle 61.When applying high voltage gas such as argon, then the J-T cooling effect takes place in 63 places of the expansion chamber outside J-T nozzle 61.The cooling fluid that obtain this moment riddles the cavity of outer endless tube front end 33, the spiral fin coil 62 of flowing through subsequently, with process that it fully contacts in disturbance takes place, therefore sufficient heat exchange takes place in the wall with spiral fin coil 62 and outer endless tube front end 33, on the one hand pre-cooling the gas in the spiral fin coil 62, make the pin wall cool off rapidly on the other hand, reach the purpose of cooling surrounding tissue.Expellant gas is discharged from exhaustor 91 through discharge chamber 69.The tissue penetration of outer endless tube 30 rear ends has comprised that partly outer shroud pipe insulation coating 92 is to avoid electromagnetic wave energy to have influence on surrounding health tissue.Be provided with circular instlated tubular 93 at spiral fin coil 62 rear sides, the head and the tail two ends are connected with outer endless tube 30 inwalls by welding or other connected modes, but other positions do not contact with tube wall, thereby have sealed one deck air layer.Material can be selected rustless steel or other materials for use.When refrigerative gas flowed out, instlated tubular 93 and air layer can avoid cold air directly to contact with tube wall, organized the influence that is not subjected to flow out cold air with protection and the contacted health of pipe.Endless tube 30 front ends outside, temperature sensor 64 can be joined with it by welding or other thermo-contact modes.It can be thermocouple, thermal resistance or other forms of pick off.The temperature signal that is collected by it can reflect temperature of tissue surrounding or the degree that melts indirectly.Temperature sensor joint 68 can outwards transmit temperature signal.Outer endless tube 30 outer walls are connected by junction point 34 with handle 40.Outer shroud inside pipe wall 39 is connected with closed-loop 43, and closed-loop 43 is connected with handle 40, has formed discharge chamber 69.
Include connecting rod 50 in the handle 40, outside the pipe 70, the other end extended the handle outer wall in connecting rod 50 1 end ring covers were fixed in, and end has spheroidal connecting rod medicated cap 52, is convenient to manual operation.Can drive interior tubular axis to moving or pulling out by mobile link.Move forward and backward along the track of interior pipe 70 and also can spur outer endless tube 30 by pulling handle connecting leg 41.Interior pipe rear end surface is marked with scale, with the relative position of pipe in representing with outer endless tube, makes things convenient for the operation in the operation process.
Fig. 3 has shown that the present invention is concentric, removable, characteristics of replaceable multifunctional targeted tumor scalpel 20.Outer endless tube is a cryoprobe, and interior pipe is a microwave therapy equipment.Microwave antenna 303 couples together by junction 304 and radiation head 301, and the energy of microwave is transformed into heat energy, with the tumor tissues rapid solidification, burn or tissue is stopped blooding.Insulating barrier 302 is fixed on microwave antenna 303 outsides, and the health tissues around avoiding sustains damage.
Fig. 4 has shown a kind of operational approach of the present invention.With one heart, removable, replaceable multifunctional targeted tumor scalpel is made of pipe in freezing outer endless tube and the radio frequency, shown in Fig. 4 the first half, interior pipe 70 is fixed in snap ring 86 on the handle 40 by connecting rod 50.Concentric scalpel 20 is punctured into 101 pairs of lesion region 102 of tissue when treating, at first start the freezing function of outer endless tube 30, formation ice hockey 103 comes the cryoablation pathological tissues.After the freezing end, the radio-frequency enabled of pipe 70 in starting is carried out rewarming and even heating ablation comes destroyed tumor tissue to greatest extent to tissue.Freezing and two processes of radio frequency can back and forth start use.After treatment finishes, connecting rod 52 is discharged into sliding cavity 81, spur handle connecting leg 41 gently, outer endless tube is pulled back out until releasing tissue 101, can be fixed in snap ring 82 this moment with connecting rod 52, and shown in Fig. 4 the latter half, the pipe radio-frequency enabled is stopped blooding to needle track 104 in starting then, behind hemostatic closure, concentric scalpel 20 is taken out.In operation process, because the needle track that puncture causes is hemorrhage to be inevitable, utilize packing, as applying starch sponge, absorbable gelatin sponge or fibrin silk floss needle track being stopped blooding is method relatively more commonly used, but for severe haemorrhage, especially the massive hemorrhage after refrigerating process finishes, packing has little effect sometimes.Can make freezing back needle track blood coagulation even make needle track organize the blood capillary sealing by the radio frequency hemostasis, make effectively hemostasis of tissue.
Fig. 5 has shown that the present invention is concentric, removable, characteristics of replaceable multifunctional targeted tumor scalpel 20.Outer endless tube is a cryoprobe, and interior pipe is many probe radio frequency scalpels.Interior tip end 71 can be the radio frequency scalpel, other radio frequency scalpels can stretch out from the aperture 111 of interior tip end 71, after starting radio-frequency enabled, can selectively treat in the different lesions zone, because the pathological tissues of ice hockey marginal area can not thoroughly be killed sometimes during cryosurgery, can kill this regional pathological tissues fully by place radio frequency scalpel 112 at marginal position 113 places.Can kill liver neoplasm by freezing to greatest extent with the radio frequency coupling, effectively reduce the postoperative recurrence rate.
Fig. 6,7 has shown that the present invention is concentric, removable, characteristics of replaceable multifunctional targeted tumor scalpel 20.Outer endless tube is a cryoprobe, and interior pipe can be for injecting the passage of treatment reagent.As shown in Figure 6, input equipment 123 manages 70 in reagent is injected, and infiltrates through target tissue 122 at interior pipe 70 tips by tip aperture 121.Can regulate the position and the zone of feed liquor by the length of pipe 70 in regulating.Liquid injects can be before freezing, refrigerating process or freezing after carry out.As shown in Figure 7, interior pipe can be the multitube injection device.Tubule 124 can be punctured in the tissue by the aperture 121 of interior pipe 70 front ends, can selectively treat the different lesions zone.The situation that the pathological tissues of ice hockey marginal area can not thoroughly be killed sometimes during especially to cryosurgery can be eliminated pathological tissues by be injected into treatment reagent at marginal position 126 places.Target cell death can be quickened by freezing with the coupling of injection treatment reagent, and target cell might be wiped out.
Fig. 8 has shown that the present invention is concentric, removable, characteristics of replaceable multifunctional targeted tumor scalpel 20.Outer endless tube is a cryoprobe, and interior pipe can be carrier pipe.Endoscope can send into assigned address by this carrier pipe 127, and target tissue is monitored; In addition, also can during treatment, this scalpel be inserted in the tissue, under the effect of device outside 128, particle is delivered to target tissue by carrier pipe 127 carrier pipe as the radion implanting device.The detection of freezing preceding tissue or the effect of definite target tissue site can be played by endoscope.Combine and will radiate, more fully kill cancer cell with freezing.
Fig. 9,10 has shown that the present invention is concentric, removable, another characteristics of replaceable multifunctional targeted tumor scalpel 20.Outer endless tube is a cryoprobe, and interior pipe is a biopsy device.Include two kinds of different biopsy device forms among Fig. 9,10.Biopsy needle tip 129,120 can be taken out target tissue easily, for analyzing and diagnosing.
Figure 11 has shown that the present invention is concentric, removable, another characteristics of replaceable multifunctional targeted tumor scalpel 20.Outer endless tube is a cryoprobe, and interior pipe can be optical fiber, electrode, temperature sensor or miniature ultrasonic probe.Optical fiber, electrode 401 can stretch into from interior pipe pathological tissues is treated.Temperature sensor can be goed deep into the variation that tissue temperature in the refrigerating process is removed to monitor in the target tissue center.The miniature ultrasonic probe then can detect tissue or in-house apparatus.
Figure 12 has shown that the present invention is concentric, removable, characteristics of replaceable multifunctional targeted tumor scalpel 20, and interior pipe 70 is a cryoprobe, and outer endless tube 30 is the radio frequency scalpel.In pipe finned tube 132 and concentric with interior pipe 70 is arranged in 70.After flowing into air inlet pipe 136 and finned tube 132 by appendix interface 138, gas enters J-T nozzle 131.When applying high voltage gas such as argon, then the J-T cooling effect takes place in 133 places of the expansion chamber outside J-T nozzle 131.The cavity of tip end 71 in the refrigerating gas that obtain this moment riddles, the finned tube 132 of flowing through subsequently, with process that it fully contacts in disturbance takes place, therefore sufficient heat exchange takes place in the wall with finned tube 132 and interior tip end 71, on the one hand pre-cooling the gas in the finned tube 132, make the pin wall cool off rapidly on the other hand, reach the purpose of cooling surrounding tissue.Expellant gas is discharged from gas outlet 137.Be furnished with outer endless tube radio frequency line 141 in the outer endless tube 30, link to each other with radio frequency line outlet 142.By the pulling of connecting rod 52, can regulate the length that pipe enters tissue in the control, thereby regulate length, the shape that forms ice hockey.Outer endless tube is a radio frequency annular pin, and its electromagnetic energy of sending is converted into heat energy, and surrounding tissue is heated.Effects of reduced temperature by pipe scalpel in controlling cools off outer endless tube radio frequency pin.Because refrigerative effect, pressing close to organizing not of radio frequency pin outer wall can carbonization, and the ablation procedure that carries out simultaneously organizing around making still heated, so heated perimeter increases greatly.
Figure 13 has shown that the present invention is concentric, removable, characteristics of replaceable multifunctional targeted tumor scalpel 20, interior pipe 70 includes appendix 136, finned tube 132 and J-T nozzle 131, and outer endless tube 30 includes air inlet pipe 66, spiral fin coil 62 and J-T nozzle 61.In the gas used both can be for having had the gas of positive J-T effect in pipe 70 and the outer endless tube 30, as nitrogen, argon or other gas, also can be for having the gas of contrary J-T effect, as helium, hydrogen etc.When all importing positive J-T effect gas in two pipes, two pipes are cryoprobe, can form the ice hockey of difformity, size by the position that changes between two pipes, thereby play therapeutical effect.When all importing against J-T effect gas in two pipes, two pipes are the heating scalpel, can control different heated perimeters by the position that changes between two pipes.When interior pipe is imported the gas of positive J-T effect, the gas of the contrary J-T effect of outer endless tube input, interior pipe is a cryoprobe, outer endless tube is the heating scalpel; Otherwise interior pipe is the heating scalpel, and outer endless tube is a cryoprobe.Combining of freezing and heating both can be used for rewarming, heating after freezing, also can the time be used to control temperature in heating, increased the multiformity of operative treatment like this.
Figure 14 has shown that the present invention is concentric, removable, characteristics of replaceable multifunctional targeted tumor scalpel 20.Interior pipe is cryoprobe, and outer endless tube can be the passage that injects treatment reagent.Reagent injects feed tube 151 under certain pressure, and infiltrates through target tissue by inlet 152 by tip delivery hole 153.Remaining liq can flow out from liquid outlet 156 by going out sap cavity 155.Liquid injects can be before freezing, refrigerating process or freezing after carry out.Target cell death can be quickened by freezing with the coupling of injection treatment reagent, and target cell might be wiped out.
Figure 15 has shown that the present invention is concentric, removable, characteristics of replaceable multifunctional targeted tumor scalpel 20.Interior pipe has constituted a bipolar ablation device with outer endless tube.The both positive and negative polarity of the anodal high-frequency line 72 that links to each other with interior pipe and the negative pole high-frequency line 141 formation ablating device devices 161 that link to each other with outer endless tube carries out electric insulation by interior pipe insulation layer 76 and outer shroud pipe insulation layer 92 between inner and outer pipes.Two pipes both can be applied to tissue surface, also can puncture in the tissue.Tissue is carried out in various degree the heating ablation of diverse location by the distance that changes between two pipes.
Figure 16 has shown that the present invention is concentric, removable, characteristics of replaceable multifunctional targeted tumor scalpel 20.Interior pipe has constituted a two-tube conveyer device with outer endless tube.In pipe 605 input pipe that can be used as light power reagent, chemotherapy, immunity, gene reagent or other treatment reagent, also light power reagent, chemotherapy, immunity, gene reagent or other treatment reagent can be delivered to target tissue by most advanced and sophisticated 603 and put into carrier pipe 602 in the endless tube 601 outside.Inner and outer pipes can inject different reagent simultaneously or in difference constantly, increases the multiformity of operation.
Figure 17,18,19 has shown that the present invention is concentric, removable, characteristics of replaceable multifunctional targeted tumor scalpel 20.Pipe 201 closely links together with connector 202 rear ends among Figure 17.There is female thread 204 connector 202 inboards.Handle 203 ends have external screw thread 205.On axial location, relatively move with outer endless tube by pipe in can making female thread 204 and cooperating of external screw thread 205.Handle 203 ends have graduation mark 206, the distance that pipe, outer endless tube relatively move in concrete the demonstration.Pipe 211 closely links together with connector 212 among Figure 18.There is external screw thread 214 in connector 212 outsides.Handle 213 inner wall at end have female thread 215.Relatively move at axial location with outer endless tube by pipe in can making external screw thread 214 and cooperating of female thread 215.Connector 212 outer walls have graduation mark 216, the distance that pipe, outer endless tube relatively move in concrete the demonstration.On the pipe 221 screw thread 222 is arranged among Figure 19.Connector 223 has annular projection 225 and block-shaped protrusion 224.By cooperating of annular projection 225 and handle 226 inboard scrobicular rings, connector 223 can rotate in handle 226.By the rotation of connector 223, drive the rotation of block-shaped protrusion 224, because block-shaped protrusion 224 cooperatively interacts with screw thread 222, pipe can move axially in making like this.On the interior pipe 221 graduation mark is arranged, the distance that manage in concrete the demonstration, outer endless tube relatively moves.
Claims (37)
1. concentric, removable, replaceable multifunctional targeted tumor scalpel is characterized in that, this scalpel comprises:
It is the outer endless tube of hollow circular ring body that one front end becomes pointed sealing, back, and the effective rustless steel of this outer shroud, Nitinol or titanium material are made, most advanced and sophisticated conductive and heat-conductive;
One can insert outer endless tube and with outer endless tube concentric in pipe, effective rustless steel, Nitinol or titanium material are made in this, the front end sealing, tip is tip or round end, the back is a hollow circular cylinder, most advanced and sophisticated heat-conductivity conducting;
One be used to connect, the hands handle of fixing and operation;
One is used to the handle connecting leg operated on handle;
One sliding tray in handle end;
One snap ring in the sliding tray lower edge;
One connecting rod in handle end, this connecting rod one end ring cover is fixed in inner tube outer surface, and the other end extends sliding tray;
One sealing ring, sealing circle are positioned at outer shroud tip end inwall and pipe junction.
2. concentric, removable, replaceable multifunctional targeted tumor scalpel according to claim 1 is characterized in that this scalpel further comprises:
One spiral fin coil, this spiral fin coil spirals along the outer shroud inside pipe wall, and is concentric with outer endless tube;
One J-T nozzle, this J-T nozzle is positioned at outer endless tube front end, links to each other with spiral fin coil;
One is positioned at the outer shroud pipe insulation coating of outer endless tube rear end;
The circular instlated tubular of one applying outer shroud inside pipe wall;
One is positioned at the temperature sensor of outer shroud tube head.
3. concentric, removable, replaceable multifunctional targeted tumor scalpel according to claim 1 is characterized in that this scalpel further comprises:
The one interior pipe radio frequency line that links to each other with inner tube wall;
One is positioned at the pipe insulation coating of pipe rear end;
Scale in one on the pipe rear end surface.
4. concentric, removable, replaceable multifunctional targeted tumor scalpel according to claim 1 is characterized in that this scalpel further comprises:
One microwave antenna that penetrates by interior pipe rear end;
One radiation head, this radiation head stretch out interior tip end, and are fixed in interior pipe;
One connects the junction of microwave antenna and radiation head;
One is fixed on the insulating barrier in the microwave antenna outside.
5. concentric, removable, replaceable multifunctional targeted tumor scalpel according to claim 1 is characterized in that this scalpel further comprises:
One laser fiber by interior pipe importing, this laser fiber passes interior tip end, and is fixed in interior pipe.
6. concentric, removable, replaceable multifunctional targeted tumor scalpel according to claim 1 is characterized in that this scalpel further comprises:
One electrode needle by interior pipe importing, this electrode needle passes interior tip end, and is fixed in interior pipe.
7. concentric, removable, replaceable multifunctional targeted tumor scalpel according to claim 1 is characterized in that this scalpel further comprises:
The one particle implant needle by interior pipe importing, this particle implant needle passes interior tip end, and is fixed in interior pipe.
8. concentric, removable, replaceable multifunctional targeted tumor scalpel according to claim 1 is characterized in that this scalpel further comprises:
One miniature ultrasonic probe by interior pipe importing, tip end in this miniature ultrasonic probe passes, and be fixed in interior pipe.
9. concentric, removable, replaceable multifunctional targeted tumor scalpel according to claim 1 is characterized in that this scalpel further comprises:
One biopsy needle by interior pipe importing, this biopsy needle biopsy needle passes interior tip end, and is fixed in interior pipe.
10. concentric, removable, replaceable multifunctional targeted tumor scalpel according to claim 1 is characterized in that this scalpel further comprises:
One radio frequency primary probe, this radio frequency primary probe is positioned at the tip end, and is furnished with aperture on the primary probe;
One rf probe, this rf probe passes from radio frequency primary probe aperture.
11. concentric, removable, replaceable multifunctional targeted tumor scalpel according to claim 10 is characterized in that, rf probe is 2 to 10.
12., it is characterized in that this scalpel further comprises according to described concentric, removable, the replaceable multifunctional targeted tumor scalpel of claim 1:
One priming device that links to each other with interior pipe end, interior tip end has delivery hole.
13. concentric, removable, replaceable multifunctional targeted tumor scalpel according to claim 12 is characterized in that, this priming device is single tube injection device or multitube injection device.
14. concentric, removable, replaceable multifunctional targeted tumor scalpel according to claim 1 is characterized in that this scalpel further comprises:
One spiral fin coil, this spiral fin coil are in interior pipe, and be and concentric with interior pipe;
One J-T nozzle, this J-T nozzle are positioned at the pipe front end, and link to each other with spiral fin coil;
One is positioned at the pipe insulation coating of pipe rear end.
15. concentric, removable, replaceable multifunctional targeted tumor scalpel according to claim 1 is characterized in that this scalpel further comprises:
One radio frequency line, this radio frequency line are positioned at outer endless tube front end, and are connected with the outer shroud inside pipe wall;
One is positioned at the outer shroud pipe insulation coating of outer endless tube rear end;
One is positioned at the temperature sensor of outer endless tube front end.
16. concentric, removable, replaceable multifunctional targeted tumor scalpel according to claim 1 is characterized in that this scalpel further comprises:
One priming device that is connected with outer endless tube rear end, outer endless tube front end has delivery hole.
17. concentric, removable, replaceable multifunctional targeted tumor scalpel according to claim 1 is characterized in that this scalpel further comprises:
One microwave antenna that penetrates by outer endless tube rear end;
One radiation head, this radiation head stretch out outer shroud tip end, and are fixed in outer endless tube;
One connects the junction of microwave antenna and radiation head;
One is fixed on the insulating barrier in the microwave antenna outside.
18. concentric, removable, replaceable multifunctional targeted tumor scalpel according to claim 1 is characterized in that this scalpel further comprises:
One laser fiber by outer endless tube importing, this laser fiber passes outer shroud tip end, and is fixed in outer endless tube.
19. concentric, removable, replaceable multifunctional targeted tumor scalpel according to claim 1 is characterized in that this scalpel further comprises:
One electrode needle by outer endless tube importing, this electrode needle passes outer shroud tip end, and is fixed in outer endless tube.
20. concentric, removable, replaceable multifunctional targeted tumor scalpel according to claim 1 is characterized in that this scalpel further comprises:
The one particle implant needle by outer endless tube importing, this particle implant needle passes outer shroud tip end, and is fixed in outer endless tube.
21. concentric, removable, replaceable multifunctional targeted tumor scalpel according to claim 1 is characterized in that this scalpel further comprises:
The one miniature ultrasonic probe by outer endless tube importing, this miniature ultrasonic probe passes outer shroud tip end, and is fixed in outer endless tube.
22. concentric, removable, replaceable multifunctional targeted tumor scalpel according to claim 1 is characterized in that this scalpel further comprises:
One radio frequency primary probe, this radio frequency primary probe is positioned at outer shroud tip end, and is furnished with aperture on the primary probe;
One rf probe, this rf probe passes from radio frequency primary probe aperture.
23. concentric, removable, replaceable multifunctional targeted tumor scalpel according to claim 10 is characterized in that, rf probe is 2 to 10.
24., it is characterized in that this scalpel further comprises according to described concentric, removable, the replaceable multifunctional targeted tumor scalpel of claim 1:
One priming device that links to each other with outer endless tube end, outer shroud tip end has delivery hole.
25. a bipolar ablation device is characterized in that, is made of interior pipe and outer endless tube, the both positive and negative polarity of link to each other with interior pipe radio frequency line and the radio frequency line formation radio-frequency unit that links to each other with outer endless tube carries out electric insulation by interior pipe insulation layer and outer shroud pipe insulation layer between inner and outer pipes.
26. a two-tube conveyer device is characterized in that, is made of interior pipe and outer endless tube, interior pipe, outer endless tube are all as the input pipe of reagent.
27. a two-tube monitoring diagnosis device is characterized in that, is made of interior pipe and outer endless tube, interior pipe or outer endless tube are respectively as temperature sensor, miniature ultrasonic probe or biopsy needle.
28. concentric, removable, replaceable multifunctional targeted tumor scalpel according to claim 1 is characterized in that, pipe with the connected mode of handle is in this scalpel:
Interior pipe closely links together with the connector rear end;
There is female thread the connector inboard;
Handle end has external screw thread;
By female thread and externally threaded the cooperation interior pipe is linked together with handle;
Handle end has graduation mark.
29. concentric, removable, replaceable multifunctional targeted tumor scalpel according to claim 1 is characterized in that, pipe with the connected mode of handle is in this scalpel:
Interior pipe closely links together with connector;
There is external screw thread in the connector outside;
The handle end inwall has female thread;
Link together with handle by pipe in making external screw thread and cooperating of female thread;
The connector outer wall has graduation mark.
30. concentric, removable, replaceable multifunctional targeted tumor scalpel according to claim 1 is characterized in that, pipe with the connected mode of handle is in this scalpel:
On the interior pipe screw thread is arranged;
Connector has annular projection and block-shaped protrusion;
There is scrobicular ring the handle inboard;
Connector cooperates Internal Pipe Thread to make it to link together by annular projection;
Connector cooperates handle to make it to link together by block-shaped protrusion;
On the interior pipe graduation mark is arranged.
31. an application is concentric, removable, the using method of replaceable multifunctional targeted tumor scalpel, it is characterized in that step is as follows:
With interior pipe and outer endless tube relative position fixing after, scalpel with one heart is punctured to the lesion region present position, the freezing function of the outer endless tube of startup at first, the formation ice hockey comes the cryoablation pathological tissues;
After the freezing end, radio frequency, microwave, laser, the electric knife ablation functionality of pipe in starting are carried out rewarming and even the next further destroyed tumor tissue of heating ablation to tissue; Freezing and two processes of heating back and forth start use;
After treatment finishes, outer endless tube is pulled back out until pulling out tissue, pipe radio frequency, microwave, laser, electric knife ablation functionality in the fixing startup then of connecting rod are stopped blooding to needle track;
Behind hemostatic closure, concentric scalpel is taken out.
32. an application is concentric, removable, the using method of replaceable multifunctional targeted tumor scalpel, it is characterized in that step is as follows:
With interior pipe and outer endless tube relative position fixing after, scalpel with one heart is punctured to the lesion region present position, the freezing function of the outer endless tube of startup at first, the formation ice hockey comes the cryoablation pathological tissues;
After the freezing end, feed the heating function that contrary burnt soup effect gas starts outer endless tube, tissue is carried out rewarming and even the next further destroyed tumor tissue of heating ablation; Freezing and two processes of heating back and forth start use;
Freezing heat to treat end after, outer endless tube pulls back out until releasing tissue, with connecting rod is fixing start then in the pipe input function will treat reagent and import lesion region; Perhaps carry out the reagent input process earlier, carry out cold and hot treatment again;
After the end, concentric scalpel is taken out.
33. an application is concentric, removable, the using method of replaceable multifunctional targeted tumor scalpel, it is characterized in that step is as follows:
With interior pipe and outer endless tube relative position fixing after, scalpel with one heart is punctured to the lesion region present position, at first start the freezing function of interior pipe, the formation ice hockey comes the cryoablation pathological tissues;
After the freezing end, start the heating function of outer endless tube or feed contrary burnt soup effect gas, tissue is carried out rewarming and even the next further destroyed tumor tissue of heating ablation; Freezing and two processes of heating back and forth start use;
The pulling connecting rod to be managing in the axial drive, and pipe carries out cryoablation at in-house treatment position to the pathological tissues of diverse location in changing;
After utilizing outer endless tube rewarming or heating to finish, concentric scalpel is taken out.
34. an application is concentric, removable, the using method of replaceable multifunctional targeted tumor scalpel, it is characterized in that step is as follows:
With interior pipe and outer endless tube relative position fixing after, scalpel with one heart is punctured to the lesion region present position, at first start the heating function of outer endless tube or feeding against burnt soup effect gas, pathological tissues is carried out heating ablation;
When outer endless tube temperature is elevated to design temperature, start the freezing function of interior pipe, limit or control the rate of heat addition, temperature, the power of outer endless tube;
After treatment finishes, concentric scalpel is taken out.
35. an application is concentric, removable, the using method of replaceable multifunctional targeted tumor scalpel, it is characterized in that step is as follows:
With interior pipe and outer endless tube relative position fixing after, scalpel with one heart is punctured to the lesion region present position, the freezing function of pipe and outer endless tube in starting, size, position and the shape of regulating the formation ice hockey;
After the freezing end, start the radio-frequency enabled of outer endless tube or feed contrary burnt soup effect gas, tissue is carried out rewarming and even the next further destroyed tumor tissue of heating ablation;
After treatment finishes, concentric scalpel is taken out.
36. an application is concentric, removable, the using method of replaceable multifunctional targeted tumor scalpel, it is characterized in that step is as follows:
With interior pipe and outer endless tube relative position fixing after, scalpel with one heart is punctured to the lesion region present position, manage the heating function with outer endless tube in starting, control heating location and shape;
After treatment finishes, concentric scalpel is taken out.
37. an application is concentric, removable, the using method of replaceable multifunctional targeted tumor scalpel, it is characterized in that step is as follows:
With interior pipe and outer endless tube relative position fixing after, scalpel with one heart is punctured to the lesion region present position, at first start the freezing function of interior pipe, the formation ice hockey comes the cryoablation pathological tissues;
After cold therapy finishes, start outer endless tube input function and will treat reagent injection lesion region; Perhaps carry out the reagent injection process earlier, carry out cold therapy again.
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| CNA2008100433604A CN101579256A (en) | 2008-05-13 | 2008-05-13 | Concentric, detachable and replaceable multifunctional targeted tumor scalpel |
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| CNA2008100433604A CN101579256A (en) | 2008-05-13 | 2008-05-13 | Concentric, detachable and replaceable multifunctional targeted tumor scalpel |
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