CN103767783B - Hot and cold knife and a system with drug delivery capabilities - Google Patents

Hot and cold knife and a system with drug delivery capabilities Download PDF

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CN103767783B
CN103767783B CN201410058249.8A CN201410058249A CN103767783B CN 103767783 B CN103767783 B CN 103767783B CN 201410058249 A CN201410058249 A CN 201410058249A CN 103767783 B CN103767783 B CN 103767783B
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cartridge
guide
cold
knife
hot
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CN201410058249.8A
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CN103767783A (en
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赵刚
朱凯旋
沈凌霄
王震
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中国科学技术大学
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Abstract

本发明提供了一种带药物输送功能的冷热刀及系统,其中带药物输送功能的冷热刀包括冷热刀主体、导药管和注射单元;所述导药管的一端开口,另一端封闭,所述导药管的底壁和/或侧壁上设置有出药孔,所述注射单元与所述导药管开口的一端相连接;所述冷热刀主体上设置有导药管通道,所述导药管位于所述导药管通道中。 The present invention provides a system and a cold knife with a drug delivery function, wherein the knife with hot and cold drug delivery function includes a cold knife body, an injection unit and a cartridge guide; end of the guide opening of the cartridge, and the other end closing the bottom wall of the cartridge guide and / or is provided with a hole on a sidewall of the drug, the injection unit and an end of the guide tube opening is connected to the drug; is provided with a cartridge guide the cold blade body channel, the guide guides the cartridge located in the cartridge channel. 本发明提供的带药物输送功能的冷热刀在传统冷热刀的结构基础上增加了可输送药物的导药管,使得冷热刀在能够完成冷热治疗的同时,还能够完成抗肿瘤药物的输送,提高了冷热刀的治疗效果及适用范围,使冷热刀不但对直径小且形状规则的肿瘤有更好地治疗效果,而且也适用于治疗直径大及形状不规则的肿瘤。 The present invention provides a knife with hot and cold drug delivery function based on the structure of a conventional cold knife guide on the cartridge can be increased drug delivery, such that the hot and cold cold knife treatment can be completed at the same time, it is also possible to complete the antineoplastic delivery, improved patient outcomes and scope of the cold knife the knife not only better cold treatment of small and regular shape of the tumor size, but also for the treatment of irregular shape and a diameter larger tumors.

Description

一种带药物输送功能的冷热刀及系统 Hot and cold knife and a system with drug delivery capabilities

技术领域 FIELD

[0001] 本发明涉及医疗器械领域,特别涉及一种带药物输送功能的冷热刀及系统。 [0001] The present invention relates to the field of medical devices, and particularly relates to a system for hot and cold knife with drug delivery capabilities.

背景技术 Background technique

[0002] 肿瘤是机体在各种致癌因素作用下,局部组织的某一个细胞在基因水平上失去对其生长的正常调控,导致其克隆性异常增生而形成的异常病变,一般将肿瘤分为良性和恶性肿瘤两大类。 [0002] The tumor is the body under the action of various carcinogenic factors, one of the local tissue cells to lose their normal regulation of growth, resulting in abnormal proliferation of clonal formation of an abnormality in the gene level, generally divided into benign tumors and malignant tumors into two categories. 肿瘤是威胁人类生命和健康的一种常见的疾病,近年来,全世界由肿瘤引发的癌症的发病率和死亡率呈逐年上升的趋势,已跃居全世界人类生命健康的首要敌人。 Cancer is a threat to human life and health is a common disease in recent years, the world caused by the tumor incidence and mortality of cancer showed an increasing trend, it has leapt to the world's most important enemy of human life and health.

[0003] 随着科学技术的不断发展,治疗肿瘤的方法有很多种,如肿瘤手术治疗、肿瘤化疗、肿瘤放疗等。 [0003] With the continuous development of science and technology, there are many methods of treating cancer, such as cancer surgery, chemotherapy, radiation therapy and other cancer. 通常早期患者可以通过手术切除,但由于手术常常无法彻底清除癌细胞且无法控制转移,因此手术治疗肿瘤可能会在若干年后存在会复发和转移可能性,并且传统手术治疗还存在创伤大、出血多、病人恢复慢、住院时间长等缺点。 Typically patients with early stage can be removed by surgery, but often not completely due to surgical removal of cancer cells and can not be controlled, and accordingly the surgical treatment of tumor recurrence and metastasis likelihood may be present in a few years, and there are conventional surgery trauma, bleeding many patients recover drawback slow, and long time hospitalization. 肿瘤化疗是通过化疗药物杀死肿瘤组织,达到治疗效果,由于化疗常常是全身用药,化疗药物通常对人体正常细胞也具有一定伤害,特别是身体虚弱的病人不宜采用化疗方法。 Chemotherapy is to kill tumor by chemotherapy drugs, therapeutic effect, often due to chemotherapy is systemic treatment, chemotherapy drugs are often normal human cells also have some damage, especially in frail patients should not use chemotherapy. 放疗是通过高能量射线杀死肿瘤组织,比较适合治疗皮肤性、鳞癌等表皮癌症,对于人体内脏器官癌症效果不明显,且也会对正常组织造成很大伤害,同时放疗和化疗在杀伤癌细胞的同时,也将对正常细胞和免疫(抵抗)细胞一同杀死,易出现毒副作用。 Radiotherapy is by high-energy rays to kill tumor tissue, more suitable for the treatment of cutaneous squamous cell carcinoma and other skin cancers, cancers of internal organs of the human body effect is not obvious, and will cause great damage to normal tissue, while radiation and chemotherapy in cancer killer Meanwhile cells and normal cells will also have immunity (resistance) cell together killed, prone to side effects. 因此传统疗法不仅成功率不高,而且严重影响病人的正常生活,大部分人丧失劳动能力。 So not only traditional therapy success rate is not high, but also seriously affect the normal life of patients, most people lose the ability to work.

[0004] 为了更好更安全地治疗肿瘤,近年来冷热刀技术得到了快速的发展。 [0004] In order to better and safer treatment of cancer, hot and cold knife technique in recent years has been rapid development. 冷热刀是一种用于治疗肿瘤的新兴医疗器械,其可对肿瘤组织实施快速降温冻结和骤然升温,从而有效地摧毁肿瘤组织。 Hot and cold knife is a new medical device for the treatment of tumors which may be tumor tissue embodiment rapid cooling and freezing sudden warming to effectively destroy the tumor tissue. 但现有的冷热刀只适用于治疗直径小(一般指直径小于4cm)且形状规则的肿瘤,对于直径较大或者形状不规则的肿瘤则很难全部杀死,这样往往会导致术后易复发。 However, the existing hot and cold knife is only applicable to the treatment of small diameter (generally a diameter less than 4cm) and regular shape of the tumor, for large or irregularly shaped tumor diameter is difficult to kill all, this often leads to postoperative relapse.

发明内容 SUMMARY

[0005] 本发明要解决的技术问题在于提供一种不仅适用于治疗直径小且形状规则的肿瘤,对直径大及形状不规则的肿瘤也能够起到良好治疗效果的带药物输送功能的冷热刀及冷热刀系统。 [0005] The present invention is to provide a technical problem not only applicable to the treatment of small and regular shape of the tumor diameter, and the irregular shape of the large diameter of the tumor can also achieve an effective therapeutic effect with cold drug delivery function knife and cold knife system.

[0006] 为解决上述技术问题,本发明提供了一种带药物输送功能的冷热刀,包括冷热刀主体、导药管和注射单元;所述导药管的一端开口,另一端封闭,所述导药管的底壁和/或侧壁上设置有出药孔,所述注射单元与所述导药管开口的一端相连接;所述冷热刀主体上设置有导药管通道,所述导药管位于所述导药管通道中。 [0006] In order to solve the above technical problem, the present invention provides a drug delivery cold knife A tape function including hot and cold knife body, an injection unit and a cartridge guide; end of the guide opening of the cartridge, and the other end is closed, the cartridge guiding bottom wall and / or the drug is provided on the side wall aperture, the injection unit and an end of the guide tube opening is connected to the drug; provided with a guide channel on the cartridge body cold knife, the cartridge guide is located in the cartridge guide passage.

[0007] 优选地,所述导药管的直径为0.5mm〜1.0mm。 [0007] Preferably, the diameter of the cartridge guide 0.5mm~1.0mm.

[0008] 优选地,所述导药管通道位于所述冷热刀主体的刀杆上。 [0008] Preferably, the guide channel is located on the cartridge body cold knife arbor.

[0009] 更优选地,所述导药管的直径为所述刀杆直径的1/10〜1/5。 [0009] More preferably, the diameter of the cartridge to guide the shank diameter of 1 / 10~1 / 5.

[0010] 更优选地,所述导药管通道为所述刀杆外表面上的凹槽。 [0010] More preferably, the guide groove of the cartridge channel to the outer surface of the arbor.

[0011] 更优选地,所述凹槽的截面形状为大于1/2圆周的圆弧,且所述导药管通道的直径比所述导药管的直径大0.0lmm〜0.05mm。 [0011] More preferably, the sectional shape of the groove is greater than half the diameter of the circumference arc, and the cartridge guide passage than the diameter of the guide tube 0.0lmm~0.05mm drug.

[0012] 优选地,所述注射单元为注射栗。 [0012] Preferably, the injection means is an injection Li.

[0013] 本发明还提供了一种冷热刀系统,包括上述带药物输送功能的冷热刀、信息采集单元、导药管移动控制单元以及控制单元;所述控制单元根据所述信息采集单元采集到的肿瘤信息,输出导药管移动速率信号及注射速率信号;所述注射单元根据注射速率信号控制药物的输出速率,所述导药管移动控制单元根据导药管移动速率信号控制所述导药管在所述导药管通道中的移动速率。 [0013] The present invention further provides a cold knife system comprising a drug delivery function described above with cold knife, the information acquisition unit, the control unit moves the cartridge guide and a control unit; the control unit according to the information collection unit tumor collected information, the output rate of movement of the cartridge guide and the signal injection rate signal; output rate of the injection unit according to the drug injection rate control signal, the pilot signal control unit cartridge movement control in accordance with the rate of movement of the cartridge guide rate of movement of the cartridge guide in the cartridge of the guide channel.

[0014] 优选地,所述信息采集单元为核磁共振仪。 [0014] Preferably, the information collection unit is a NMR spectrometer.

[0015] 优选地,所述导药管移动控制单元为微电机。 [0015] Preferably, the cartridge guide movement control unit is a micro-motor.

[0016] 本发明提供的带药物输送功能的冷热刀在传统冷热刀的结构基础上增加了可输送药物的导药管,使得冷热刀在能够完成冷热治疗的同时,还能够完成抗肿瘤药物的输送,提高了冷热刀的治疗效果及适用范围,使冷热刀不但对直径小且形状规则的肿瘤有更好地治疗效果,而且也适用于治疗直径大及形状不规则的肿瘤。 [0016] The present invention provides a knife with hot and cold drug delivery function based on the structure of a conventional cold blade can increase the delivery of a drug cartridge guide, so that the hot and cold cold knife treatment can be completed at the same time, it is also possible to complete the delivery of anticancer drugs, to improve therapeutic effect and scope cold knife the knife not only better cold treatment of small and regular shape of the tumor size, but also for the treatment of large diameter and irregular shape tumors.

[0017] 本发明提供的冷热刀系统通过对注射单元和导药管移动控制单元的控制,可保证抗肿瘤药物更均匀的渗透到肿瘤组织中,从而对肿瘤起到更好的治疗效果,且易于实现全自动化,便于冷热刀系统的推广使用。 [0017] Hot and cold blade system of the present invention is provided by the injection unit and the cartridge guide the movement control of the control unit, ensures a more even penetration into tumor tissue antineoplastic tumor thus play a better therapeutic effect, fully automated and easy to implement, easy to promote the use of hot and cold knife system.

附图说明 BRIEF DESCRIPTION

[0018]图1为本发明带药物输送功能的冷热刀实施例的结构示意图; [0018] FIG. 1 cold knife with drug delivery capabilities schematic structural diagram of the embodiment of the present invention;

[0019]图2为本发明带药物输送功能的冷热刀的导药管实施例的结构示意图; [0019] FIG 2 cold knife with drug delivery capabilities of the present invention the cartridge guide schematic structural diagram of the embodiment;

[0020]图3为本发明冷热刀系统实施例的信号传输示意图。 [0020] Fig 3 a schematic view of hot and cold knife signal transmission system according to an embodiment of the present invention.

[0021] 图中标示如下: [0021] FIG labeled as follows:

[0022] 带药物输送功能的冷热刀-1,冷热刀主体-11,刀柄-11a,刀杆-11b,刀头-11c,导药管通道-110,导药管-12,出药孔-120,注射单元-13,信息采集单元-2,导药管移动控制单元-3,控制单元-4。 [0022] Hot and cold knife -1 with drug delivery function, body -11 cold knife, shank -11A, -11B Arbor, head-11C, guide channel -110 cartridge, the cartridge guide 12, the drugs hole -120, -13 injection unit, an information acquisition unit -2 cartridge guide movement control unit -3, -4 control unit.

具体实施方式 Detailed ways

[0023] 为使发明的上述目的、特征和优点能够更加明显易懂,下面对本发明的具体实施方式做详细的说明。 [0023] For the above-described objects, features and advantages of the invention can be more fully understood by reading the following detailed description of specific embodiments of the present invention.

[0024] 在下面的描述中阐述了很多具体细节以便于充分理解本发明,但是本发明还可以采用其他不同于在此描述的其它方式来实施,本领域技术人员可以在不违背本发明内涵的情况下做类似推广,因此本发明不受下面公开的具体实施例的限制。 [0024] numerous specific details are set forth in the following description in order to provide a thorough understanding of the present invention, but the present invention may also be in other ways other than described in the embodiment to employ skilled in the art without departing from the intension may present invention promotion do similar case, therefore invention is not limited to the specific embodiments disclosed below.

[0025] 如图1和图2所示,带药物输送功能的冷热刀I包括冷热刀主体11、导药管12和注射单元13,其中冷热刀主体11由依次连接地刀柄11a、刀杆Ilb和刀头Ilc组成;所述导药管12的一端开口,另一端封闭,所述导药管12的底壁和/或侧壁上设置有出药孔120,所述注射单元13与所述导药管12开口的一端相连接,上述底壁是指导药管12封闭的一端的面形成的壁,侧壁是指导药管12侧面形成的壁,注射单元13将抗肿瘤药物自导药管12开口的一端注入后,抗肿瘤药物再自出药孔120输出;所述冷热刀主体11上设置有导药管通道110,所述导药管12位于所述导药管通道110中,导药管通道110与外界相通使导药管12输出的抗肿瘤药物能够进入肿瘤组织,更重要的是起到保护导药管12的作用,从而延长导药管12的使用寿命。 [0025] FIGS. 1 and 2, with a cold knife function I comprising the drug delivery cold knife body 11, the cartridge guide 12 and the injection unit 13, wherein the cold blade body 11 are connected in succession by a shank 11a , head and shank Ilb Ilc composition; end of the cartridge guide 12 open, the other closed end of the guide 120, said injection unit is provided with a drug-delivery port and / or on the side wall 12 of the bottom wall of the cartridge 13 is connected to one end of the guide opening 12 of the cartridge, the bottom wall is a wall surface of the closed end of the cartridge guide 12 is formed, the side wall is a side wall formed to guide the cartridge 12, the injection unit 13 antitumor agent since the open end 12 of the guide tube is injected drug, an antineoplastic drug and then from the output aperture 120; cartridge provided with a guide channel 110 on the cold blade body 11, the guide guiding the cartridge 12 located in cartridge channel 110, cartridge guide passage 110 communicated with the outside of the guide cartridge 12 outputs antineoplastic agents into the tumor tissue can be, more importantly serves to protect the cartridge guide 12, thereby extending the life of the cartridge guide 12 .

[0026] 其中,导药管12上出药孔120的数量和大小根据具体需求设置,本发明对此并没有进一步限定,导药管12的底壁和侧壁上可同时设置有出药孔120,也可仅位于底壁或侧壁上。 [0026] wherein the drug cartridge guide hole 12 and the size of the number 120 is provided according to particular needs, the present invention does not further defined, the bottom and side walls 12 of the cartridge guide may be simultaneously provided with an aperture drugs 120, may be located only in the bottom wall or the side wall.

[0027] 在上述带药物输送功能的冷热刀I实施例的操作过程中,导药管12随着冷热刀主体11 一起进入肿瘤组织,注射单元13将抗肿瘤药物自导药管12开口的一端注入,抗肿瘤药物再自导药管12的出药孔120输出,通过导药管通道110与外界相通处进入肿瘤组织,这时再进行冷热刀的冷热治疗。 [0027] During operation of said cold-knife with a drug delivery function I of the Examples, the cartridge guide 12 as the blade body 11 with hot and cold into tumor tissue, the injection unit 13 antitumor drugs from the cartridge guide opening 12 the end of the injection, an antineoplastic drug and then the guide tube from an output 12 of the drug-delivery port 120, into the tumor tissue by turning the cartridge passage 110 and the outside world, the treatment time then cold cold knife. 导药管12上的出药孔120的设置不仅可有效地减小药物在导药管12中的流动阻力,而且有利于使抗肿瘤药物更均匀快速地进入肿瘤组织。 A medicine guiding hole provided on the cartridge 12, 120 can not only effectively reduce the flow resistance in the drug cartridge 12 of the guide, but also help to make a more antineoplastic agents into the tumor tissue rapidly and uniformly. 抗肿瘤药物的输送时间可在冷热治疗前或冷热治疗后或冷热治疗中,优选地在冷热治疗中,这样药物治疗和冷热治疗同时进行,可起到更好地肿瘤治疗效果。 After the time of delivery of anticancer drugs can be cold treatment prior to cold or cold therapy or treatment, preferably the treatment of cold, hot and cold medications such treatment simultaneously, it can play a better effect of tumor treatment .

[0028] 本发明公开的导药管12的直径优选地可为0.5mm〜1.0mm,以方便在导药管12上设置出药孔120。 Preferably the diameter of the [0028] present invention disclosed cartridge guide 12 may be 0.5mm~1.0mm, to facilitate the agent hole 120 is provided in the cartridge guide 12.

[0029] 需要说明的是,导药管通道110的具体设置位置根据实际需求设置,当然为了方便导药管通道110的形成,所述导药管通道110位于所述冷热刀主体11的刀杆Ilb上。 [0029] Incidentally, the specific set position of the guide passage 110 of the cartridge is provided according to actual needs, of course, in order to facilitate formation of the guide passage 110 of the cartridge, the cartridge guide 110 is located in the channel of the cold knife blade body 11 bar Ilb. 为了便于将导药管12装配在冷热刀主体11的导药管通道110内,所述导药管12的直径优选地为所述冷热刀主体11的刀杆Ilb直径的1/10〜1/5。 Ilb shank diameter 12 to facilitate assembly of the cartridge guide in the guide channel 110 cold blade cartridge body 11, the guide diameter of the cartridge 12 is preferably for the blade main body 11 of a cold / 10~ 1/5.

[0030] 对本领域技术人员而言,导药管通道110的具体形状及大小根据实际需求有多种实现方式,如导药管通道110为贯通孔,即导药管通道110为冷热刀主体11的刀杆Ilb上一个两端开口的孔,导药管12位于上述孔中,更优地还可采用如下具体实施方式:所述导药管通道110为所述刀杆Ilb外表面上的凹槽,更优选地,所述凹槽的截面形状为大于1/2圆周的圆弧,且所述导药管通道110的直径比所述导药管12的直径大0.0lmm〜0.05mm,这样导药管通道110在保证导药管12顺滑移动的前提下,可对导药管12起到包覆作用,从而有效防止导药管12在刀杆Ilb插入人体的过程中与组织碰撞受到损伤,而且抗肿瘤药物自导药管12中输出后,再通过导药管通道110的开口处进入肿瘤组织,增大了抗肿瘤药物与肿瘤组织的接触面积,使抗肿瘤药物更迅速地进入到肿瘤组织中。 [0030] to those skilled in the art, the specific shape and size of the guide channel 110 has a cartridge according to the actual needs of a variety of implementations, such as the cartridge guide passage is a through-hole 110, i.e., guide channel 110 of the cartridge body cold knife Ilb arbor hole. 11 open at both ends of a guide cartridge 12 positioned in the hole, more preferably the specific embodiments may be as follows: the cartridge guide passage 110 to the outer surface of said arbor Ilb grooves, more preferably, the cross-sectional shape of the groove is greater than half the circumference of an arc, and the diameter of the guide channel cartridge 110 than the large diameter 0.0lmm~0.05mm cartridge guide 12, such cartridge guide passage 110 in the premise of ensuring smooth guiding movement of the cartridge 12, 12 may play a role in guiding the cartridge cover, so as to effectively prevent the lead cartridge 12 is inserted in the shank of the body during a collision with tissue Ilb damage, and antineoplastic drugs since the guide tube 12 is output, and then into the tumor tissue by opening the cartridge guide channel 110, increases the contact area of ​​the tumor tissue with anticancer drugs, antineoplastic agents was more rapidly into the tumor tissue.

[0031] 注射单元13可采用本领域常用的装置,优选地,所述注射单元13为可实现自动化的注射栗,在一个具体地实施例中,为了更方便地将注射单元13和导药管12连接,注射单元13与导药管12开口的一端之间通过导管连接。 [0031] The injection unit 13 can be used in this field means, preferably, the injection unit 13 can be automated injection Li, in a particular embodiment, to make it easier to guide the injection unit 13 and the cartridge 12 is connected, via a conduit connected between one end of the cartridge and the guide opening 12 of the injection unit 13.

[0032] 本发明还提供了一种冷热刀系统,其包括上述带药物输送功能的冷热刀1、信息采集单元2、导药管移动控制单元3以及控制单元4 ;所述控制单元4根据所述信息采集单元2采集到的肿瘤信息,输出导药管移动速率信号及注射速率信号;所述注射单元13根据注射速率信号控制药物的输出速率,所述导药管移动控制单元3根据导药管移动速率信号控制所述导药管12在所述导药管通道110中的移动速率。 [0032] The present invention further provides a cold knife system, including the above function with the drug delivery cold knife 1, the information acquisition unit 2, the cartridge guide movement control unit 3, and a control unit 4; the control unit 4 2 according to the information collection unit to collect information of the tumor, the cartridge guide output signal and the rate of movement of the injection rate signal; the output rate of the injection unit 13 to control the drug injection rate signal, the control unit moves the cartridge guide 3 rate of movement of the cartridge guide signal for controlling the rate of movement of the cartridge guide 12 in the guide channel 110 of the cartridge.

[0033] 导药管移动控制单元3控制导药管12在所述导药管通道110内的移动,使得导药管12能够在导药管通道110内朝向冷热刀主体11刀头Ilc的方向运动,或朝向远离冷热刀主体11刀头Ilc的方向运动,具体的运动方向根据实际需求选择。 [0033] guide the cartridge control unit 3 controls the moving guide 12 moves the cartridge within the cartridge guide channel 110, such that the cartridge 12 can be turned toward the cold heat Ilc blade tip body 11 in the cartridge guide passage 110 direction, toward or away from the blade body 11 direction cold tip Ilc, the particular direction of motion based on the actual needs.

[0034] 在上述冷热刀系统的实施例中,带药物输送功能的冷热刀I插入肿瘤组织内部,信息采集单元2采集肿瘤信息,并将肿瘤信息传送给控制单元4,控制单元4根据信息采集单元2采集到的肿瘤信息,输出导药管移动速率信号及注射速率信号,注射单元13接收到注射速率信号后控制药物的输出速率,同时导药管移动控制单元3接收到导药管移动速率信号后控制导药管12的移动速率,优选地导药管12可选择匀速地向远离冷热刀主体11刀头Ilc的方向运动,以更好地保护导药管12,这样即完成了冷热刀系统合理而有效地输送药物的过程。 [0034] In the embodiment of blade system cold, cold knife with drug delivery capabilities I inserted into tumor tissue, the tumor collect information acquisition unit 2 information, and information to tumor control unit 4, the control unit 4 after the information acquisition unit 2 collected tumor information output guide the cartridge movement speed signal and the injection rate signal, the injection unit 13 receives the injection rate signal to control the output rate of the drug, while guiding the cartridge movement control unit 3 receives pilot cartridge rate of movement of the control pilot signal rate of movement of the cartridge 12, the cartridge guide 12 is preferably uniform selectively movable to a direction away from the cold tip Ilc blade body 11, in order to better protect the cartridge guide 12, so that complete the process of cold blade system rational and effective delivery of the drug. 冷热刀系统实施例的信号传输示意图具体地如图3所示。 Example signal transmission system diagram of the hot and cold knife specifically shown in FIG.

[0035] 对于本领域技术人员而言,控制单元4的实现方式可采用中央处理器,控制单元4根据信息采集单元2采集到的肿瘤信息,得到导药管移动速率和注射速率的过程可根据实际需求确定,或通过下述方式实现:肿瘤信息为肿瘤的形状信息,控制单元4根据信息采集单元2采集到的肿瘤信息生成一个最小且能包围肿瘤组织的椭球或者球,控制单元4根据椭球的赤道半径和极半径数据或球的半径数据,以及导药管出药孔120至肿瘤边界的距离数据来查表得到导药管移动速率和注射速率,通常肿瘤越大,导药管移动速率越低,随着导药管移动速率的增大,注射速率增大,随着导药管的药物输出端至肿瘤边界的距离的增大,注射速率增大。 [0035] to those skilled in the art, implementation of the control unit 4 may employ a central processor, the control unit 4 according to the information acquisition unit 2 to collect information about the tumor, the rate of movement of the cartridge guide to give and injection rate according to the process determining the actual demand, or implemented in the following manner: the tumor, tumor information shape information, the control unit 4 capable of generating a minimum of tissue surrounding the tumor ellipsoid or sphere. the information acquisition unit 2 to collect information of the tumor, the control unit 4 data from the radii of the ellipsoid equatorial radius and a polar radius data or the ball, and the drug cartridge guide hole 120 to the tumor border look-up table to the cartridge guide and the moving speed of the injection rate, the larger the tumor is usually, the cartridge guide the lower the rate of movement, with the increase rate of movement of the cartridge guide, the injection rate increases, the output end of the guide with the drug cartridge to the distance from the boundary of the tumor is increased, the injection rate increases. 当然为了得出更合适地导药管移动速率和注射速率,对肿瘤产生更好地治疗效果,上述肿瘤信息中还可包括肿瘤位置、肿瘤的类型、肿瘤的时期等相关信息,控制单元4根据椭球的赤道半径和极半径数据或球的半径数据、导药管出药孔120至肿瘤边界的距离数据、肿瘤的位置数据、肿瘤的类型数据,以及肿瘤的时期数据来查表得到导药管的移动速率和注射速率。 Of course, in order to obtain more appropriate rate of movement of the cartridge guide and the rate of injection, produce better therapeutic effect on tumors, the above-described tumor-related information may also include information tumor location, tumor type, tumor and the like period, the control unit 4 radii equatorial radius and a polar radius of the sphere or ellipsoid data, the distance data cartridge guide hole 120 drug to the tumor boundary, the position data of the tumor, the tumor type data, and time data look-up table to guide tumor drugs injection rate and rate of movement of the tube.

[0036] 由于治疗过程中的给药量是由药物注射速率和导药管移动速率来共同确定的,因此有利于减少抗肿瘤药物渗透到正常组织细胞中的量,降低抗肿瘤药物对肿瘤周边的正常组织细胞的损伤,并且保证抗肿瘤药物均匀的渗透到肿瘤组织中。 [0036] Since the dose during treatment and the rate of drug injection by the cartridge guide moves jointly determine the rate, and therefore helps to reduce the amount of anticancer drugs to penetrate into normal tissue cells, anticancer drugs reduced the tumor periphery cells of normal tissue damage, and to ensure uniform penetration of the tumor tissue to anticancer drugs.

[0037] 信息采集单元2和导药管移动控制单元2的实现方式可有多种,优选地,信息采集单元2为核磁共振仪,导药管移动控制单元3为微电机,且导药管移动控制单元3可直接设置在导药管12的外壁上,或是冷热刀主体11的刀柄Ila内。 [0037] The information collection unit 2 and the cartridge guide movement of the control unit 2 may be implemented a variety of ways, preferably, the information acquisition unit 2 is a nuclear magnetic resonance apparatus, the cartridge guide movement of the micro-motor control unit 3, and the drug conduit a movement control unit 3 may be disposed directly within the outer wall of the shank Ila cartridge guide 12, or the blade body 11 is cold.

[0038] 虽然本发明是结合以上实施例进行描述的,但本发明并不被限定于上述实施例,而只受所附权利要求的限定,本领域普通技术人员能够容易地对其进行修改和变化,但并不离开本发明的实质构思和范围。 [0038] While the present invention has been described in conjunction with the above embodiments, but the present invention is not limited to the above embodiments, but defined only by the appended claims, one of ordinary skill in the art can easily modify and changes, but not departing from the spirit and scope of the spirit of the present invention.

Claims (3)

1.一种冷热刀系统,其特征在于,包括带药物输送功能的冷热刀、信息采集单元、导药管移动控制单元以及控制单元;所述控制单元根据所述信息采集单元采集到的肿瘤信息,输出导药管移动速率信号及注射速率信号;所述注射单元根据注射速率信号控制药物的输出速率,所述导药管移动控制单元根据导药管移动速率信号控制所述导药管在所述导药管通道中的移动速率;其中, 所述带药物输送功能的冷热刀包括冷热刀主体、导药管和注射单元;所述导药管的一端开口,另一端封闭,所述导药管的底壁和/或侧壁上设置有出药孔,所述注射单元与所述导药管开口的一端相连接;所述冷热刀主体上设置有导药管通道,所述导药管位于所述导药管通道中。 A hot and cold blade system, characterized in that it comprises a knife with hot and cold drug delivery function, the information acquisition unit, the control unit moves the cartridge guide and a control unit; the control unit to collect the information collection unit according to the tumor information, and outputs pilot signal and the rate of movement of the cartridge injection rate signal; output rate of the injection unit according to the drug injection rate control signal, said control guiding movement of the cartridge guide unit according to the rate of movement of the cartridge guide signal control cartridge the rate of movement of the cartridge guide channel; wherein said cold knife with drug delivery capabilities include hot and cold knife body, the injection unit and the cartridge guide; end of the guide opening of the cartridge, and the other end is closed, the cartridge guiding bottom wall and / or the drug is provided on the side wall aperture, the injection unit and an end of the guide tube opening is connected to the drug; provided with a guide channel on the cartridge body cold knife, the cartridge guide is located in the cartridge guide passage.
2.根据权利要求1所述的冷热刀系统,其特征在于,所述信息采集单元为核磁共振仪。 The hot and cold knife system according to claim 1, wherein said information collection unit is a NMR spectrometer.
3.根据权利要求1所述的冷热刀系统,其特征在于,所述导药管移动控制单元为微电机。 The hot and cold knife system according to claim 1, wherein said cartridge guide movement control unit is a micro-motor.
CN201410058249.8A 2014-02-20 2014-02-20 Hot and cold knife and a system with drug delivery capabilities CN103767783B (en)

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Publication number Priority date Publication date Assignee Title
US20030073988A1 (en) * 1999-05-04 2003-04-17 Afx Inc. Microwave ablation instrument with insertion probe
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