CN101579112B - Throat relieving drink and preparation method thereof - Google Patents
Throat relieving drink and preparation method thereof Download PDFInfo
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- CN101579112B CN101579112B CN2008100476703A CN200810047670A CN101579112B CN 101579112 B CN101579112 B CN 101579112B CN 2008100476703 A CN2008100476703 A CN 2008100476703A CN 200810047670 A CN200810047670 A CN 200810047670A CN 101579112 B CN101579112 B CN 101579112B
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Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a throat relieving drink and a preparation method thereof, belonging to the field of health drink. The throat relieving drink comprises primary materials and the formulation content as follows: 15-20 parts of ebony, 15-20 parts of hawthorn, 3-8 parts of seed of boat-fruited sterculia, 30-45 parts of roxburgh rose, 3-8 parts of shizandra berry, 3-8 parts of Fructus Canarii, 3-8 parts of Lophatherum gracile, 3-8 parts of fructus momordicae and 3-8 parts of Gynostemma pentaphylla; the auxiliary material extracting solution is grape seed extracting solution and weights 1 percent to 3percent of the primary material extracting solution. The drink has the health care functions of relieving cough and wetting throat and plays a role of health care for smokers by relieving the discomfort in throats during smoking. The invention is suitable for smokers and various groups as an ordinary drink. The drink comes from nature completely and contains no additive. The grape seed extract has functions of resisting bacteria and guaranteeing the quality and has no toxic side effect.
Description
Technical field
The invention belongs to field of health drinks, particularly relate to a kind of beverage with uncomfortable function of throat that releiving smokes causes.
Background technology
As everyone knows, the normal people who smokes often feels throat's drying, expectoration, jagged sense, and this mainly is that nicotine stimulates the physiology that causes uncomfortable.The research of throat's comfortableness is more and more paid attention in the exploitation of tobacco product at present, even but high-grade cigarette, throat stimulates and dried thorn sense still exists.Thereby it is uncomfortable also can't to solve the physiology that causes because of smoking at the cigarette technical elements at present.
Summary of the invention
To the above-mentioned deficiency of prior art, the purpose of this invention is to provide and a kind ofly can alleviate the beverage that the throat cause of smoking stimulates, increases throat's comfort level, can be used as daily drink, the protection throat.
Technical scheme of the present invention is: throat relieving drink of the present invention is made up of major ingredient material extract and auxiliary material material extract,
Major ingredient material composition and content prescription thereof in the major ingredient material extract are: dark plum 15-20 part, hawthorn 15-20 part, sterculia seed 3-8 part, Rosa roxburghii 30-45 part, fruit of Chinese magnoliavine 3-8 part, Chinese olive 3-8 part, lophatherum gracile 3-8 part, Momordica grosvenori 3-8 part, gynostemma pentaphylla 3-8 part; Auxiliary material material extract is the grape pip extract.
Major ingredient material extract extracts according to the following steps:
(1), gets the dry material of following weight: dark plum 15-20 part, hawthorn 15-20 part, sterculia seed 3-8 part, Rosa roxburghii 30-45 part, fruit of Chinese magnoliavine 3-8 part, Chinese olive 3-8 part, lophatherum gracile 3-8 part, Momordica grosvenori 3-8 part, gynostemma pentaphylla 3-8 part; Reject the impurity in the medicinal material; Be crushed to the 20-40 order; The pure water that adds 30 times of above-mentioned mixing dry matter weights boils, and keeps boiling 30 minutes, and the 200 order filter clothes of filtrating are collected filtrating; The pure water that filter residue adds 20 times of above-mentioned mixing dry matter weights again boils, and keeps boiling 30 minutes, and the 200 order filter clothes of filtrating are collected filtrating, and filter residue discards;
(2), above-mentioned twice filtrating is merged, the pure water that adds 0.8~1.2 times of filtrate volume fully stirs, and with its rapid cooling to 4 ℃, deposits 5 hours at 4 ℃;
Auxiliary material material extract extracts according to the following steps: get grape pip, extracted 5 hours with 95% alcohol reflux, extract refrigeration 4~6 hours is concentrated into 1/40~1/30 of original volume with it again, and is for use;
Auxiliary material material extract is 1%~3% of a major ingredient material extract weight in throat relieving drink.
The preparation method of throat relieving drink carries out according to the following steps:
[1], preparation major ingredient material extract:
(1), gets the dry material of following weight: dark plum 15-20 part, hawthorn 15-20 part, sterculia seed 3-8 part, Rosa roxburghii 30-45 part, fruit of Chinese magnoliavine 3-8 part, Chinese olive 3-8 part, lophatherum gracile 3-8 part, Momordica grosvenori 3-8 part, gynostemma pentaphylla 3-8 part; Reject the impurity in the medicinal material; Be crushed to the 20-40 order; The pure water that adds 30 times of above-mentioned mixing dry matter weights boils, and keeps boiling 30 minutes, and the 200 order filter clothes of filtrating are collected filtrating; The pure water that filter residue adds 20 times of above-mentioned mixing dry matter weights again boils, and keeps boiling 30 minutes, and the 200 order filter clothes of filtrating are collected filtrating, and filter residue discards;
(2), above-mentioned twice filtrating is merged, the pure water that adds 0.8~1.2 times of filtrate volume fully stirs, and with its rapid cooling to 4 ℃, deposits 5 hours at 4 ℃;
[2], preparation auxiliary material material extract:
Get grape pip, extracted 5 hours with 95% alcohol reflux, extract refrigeration 4~6 hours is concentrated into 1/40~1/30 of original volume with it again, and is for use;
[3], preparation throat relieving drink:
Auxiliary material material extract is mixed with major ingredient material extract with 1%~3% ratio of major ingredient material extract weight; Stir, and after crossing 0.8 micron filter membrane with flame filter press, in 121 ℃ of pressure sterilizings 30 minutes; Naturally cool to room temperature, can gets product.
The health care that beverage of the present invention has antibechic, wets one's whistle.Its innovation part is: the throat that having solved first smokes brings is uncomfortable, for the smoker plays a role in health care; The present invention not only is merely smoking personage development, also can be used as daily beverage, is applicable to various crowds, both is fit to hot drink, also is fit to cold drink, and sweet mouthfeel is tasty and refreshing, and voiceless sound relieve sore throat, clearing heat and detoxicating effect are arranged; This beverage comes from natural fully, does not contain any additives, and the effect of grape seed extract in these article is antibiotic guaranteeing the quality, and be without any side effects.
The specific embodiment
Following specific embodiments of the invention and relevant technologies problem are described in further detail.The effect of each component of throat relieving drink of the present invention is respectively:
Dark plum: be the almost ripe fruit of rosaceae plant deciduous tree plum, smoke through pyrotechnics and form that temperature remains on about 40 ℃, roasting 2-3 vexed then 2-3 days, makes it become black round the clock.Contain compositions such as citric acid, malic acid, butanedioic acid, carbohydrate, sitosterol, vitamin c; Can promote the production of body fluid cough-relieving, improve liver function, softening blood vessel, anti-senility; And have desirable antibacterial action, also have a very important effect to provide the mouthfeel of acid acid in the present invention.
Hawthorn: be the fruit of rose family defoliation bush plant hawthorn; Contain compositions such as multivitamin, chlorogenic acid, caffeic acid, crataegolic acid, neat chrysanthemum tartaric acid, Quercetin, hyperin, epicatechin, the treatment for relieving indigestion and constipation of being good for the stomach is arranged, multiple efficacies such as softening blood vessel are relievingd asthma, detoxified to the cholagogic that promotes the production of body fluid, expectoration.Select hawthorn to be rich in multiple organic acid among the present invention, and vitamin c, and under the situation of heating, can ruined effect yet.
The sterculia seed: be the dry mature seed of the Sterculiaceae plant sterculia seed, contain galacturonic acid, arabinose, galactolipin, sterculin, the sticking element of tragcanth etc., the present invention selects the effect of its clearing heat and moistening lung that have, liyan jiedu, the voiceless sound that reduces phlegm.
Rosa roxburghii: be a kind of fruit of rosaceous plant rosa roxburghii, main component has dimension c, dimension b, superoxide dismutase, compositions such as glycocide that it is contained and tannic acid, and the present invention selects it that effect of expelling phlegm and arresting coughing, maintenance throat is arranged.
The fruit of Chinese magnoliavine: the fruit for the perennial defoliation liana of the Magnoliaceae fruit of Chinese magnoliavine, contain compositions such as schizandrin, deoxyschisandrin, schisandrol, schisantherin, the present invention selects its nourishing generate fluid, restrains effect astringent or styptic treatment for spontaneous sweating, kidney calming.
Chinese olive: be the fruit of Burseraceae aiphyllium olive, contain compositions such as cresols, thymol, vitamin c, citrene, amphene, nerol, olivetol, the effect that the present invention selects its heat-clearing, relieve sore throat, promotes the production of body fluid, detoxifies.
Lophatherum gracile: the dry herb in perennial grass lophatherum gracile ground, all herbal medicine, refrigerant analgesic, the present invention selects it to eliminate the effect of swelling and aching of gum, stomatitis.
Momordica grosvenori: the dry fruit for Curcurbitaceae herbaceous perennial vine plant Momordica grosvenori, contain compositions such as mogroside, fructose, amino acid, flavones, the present invention selects the effect of its clearing heat and moistening lung, voiceless sound relieve sore throat.
Gynostemma pentaphylla: be the herb of cucurbitaceous plant gynostemma pentaphylla; Mainly contain outside sterol, sugar part, the pigment; Also have more than 50 kind of saponin to comprise tetracyclic triterpenoids compound, wherein seven leaf courage saponin III, IV, VII, XII are four kinds, are same substances with sanchinoside E1, Rb3, Rd, F2 respectively; Its acid hydrolysis products and panaxoside acid hydrolysis products---panoxadiol has identical physicochemical property.This is very rare in the plant of non-Araliaceae, thereby is described as " second genseng ".The present invention selects Herb Gynostemmae Pentaphylli extract that reducing blood lipid, hypotensive is arranged, relieving cough and reducing sputum effect, and the effect of clearing heat and detoxicating, clearing lung and eliminating phlegm, boosting qi and nourishing yin.
Grape seed extract: grape originates in and adds this than marine site, Asia Minor; Its plantation concentrates on the zone, warm temperate zone in the Northern Hemisphere, and mainly in Europe and south, the Central Asia, the grape seed extract OPC is a pure natural substance; It is one of efficient antioxidants of the plant origin found so far; Shows that the antioxidant effect of grape seed extract is vitamin C and vitamin E 30-50 a times in the body with in vitro test.Prove through experiment: grape seed extract can have good protective effect to brain and nervous system smoothly through the blood-brain barrier of human body.Owing to can obviously remove interior free yl, improve body immunity, increase the elasticity of artery and vein, prevent atherosclerotic, through strengthening blood circulation and reducing blood viscosity and come prevention of cardiac and other illness.In addition, can also make skin keep its elasticity and moisture, delay the generation of wrinkle.The present invention selects the anti-oxidation efficacy of its grape seed extract.
Beverage of the present invention has been cooked safety testing, i.e. the gene mutation test of drink soln---Salmonella reversion test.Make an experiment by standard GB 15193.4-94 and " new drug pharmacology, toxicological study specification requirement ", suitably with reference to Bruce N.Ames original work and U.S. food drug control administration (FDA), national toxicological study center (NCTR) operational procedure.
Bacterial strain: histidine defect type salmonella typhimurium (Salmonella typhimurium) TA97, TA98, TA100, TA102 introduce a fine variety from Ames Lab, all identify through bacterial classification to meet the requirements.
(the S of metabolism activation enzyme system
9): Sprague Dawley rat liver microsomes (S after derivant is handled
9) by above-mentioned rules preparation, each dose groups is all adding or do not adding S during test
9Parallel testing under the mixture conditions.
Method: be aided with " cultivating in advance " operation by above-mentioned national standard and Ames method routine, promptly in each test tube upper strata culture medium, add quantitative bacterium liquid, add test solution and S again
9The back is cultivated 30 minutes impouring minimal medium plates in advance in 45 ℃ of water-baths, to improve the sensitiveness of test.Each tests ware, and all cultivation is after 72 hours down at 37 ℃, and every ware that counts returns the change clump count.Each test all attaches the solvent negative control.The result judges: returned that to become clump count be that solvent control is returned and become the clump count twice or more than the twice if try thing, and have dosage-return to become reaction relation person, then be decided to be the positive.Experimental result is seen table 1.
Every ware that table 1 solution brings out in the Ames bacterial strain returns and becomes clump count *
* X ± SD is that 3 experimental results amount to, i.e. n=3 * 3=9
Evaluation of result: beverage of the present invention does not all bring out positive mutagenesis reaction to TA97, TA98, TA100 and four bacterial strains of TA102 in the various concentration ranges that this experiment condition allows.
The applicant has carried out functionality of drink test of the present invention, and beverage promptly of the present invention is to observation (ammoniacal liquor draws the method for the coughing) test of small white mouse antitussive effect, and the test situation brief account is following:
Drawing with ammoniacal liquor and to cough, so as to observing the antitussive effect of beverage of the present invention, is to use one of antitussive screening technique.This experiment is with reference to the screening technique of antitussive, and with ICR kind mouse, 30, body weight 20 ± 2 restrains, and male and female are regardless of.Divide three groups at random; Be respectively water control group, heavy dose of group (6g/g), small dose group (2g/g); Irritate stomach respectively for 3 groups and give beverage or water, continuous irrigation stomach three days, fasting is 12 hours after three days; Through 25%-28% ammoniacal liquor 0.2ml vaporization, observation is respectively organized ammoniacal liquor and is caused cough latent period and the cough number of times in 2 minutes in bell jar.The result sees table 2.
Table 2 beverage of the present invention is to the antitussive effect of small white mouse
The result shows, to before giving beverage, comparing the water control group after the beverage; Cough latent period and cough number of times have no significant change; Heavy dose of group beverage can make cough latent period prolong, and the cough number of times reduces, and gives before the beverage relatively; The difference significance shows: this beverage is heavy dose of to be used and mouse ammoniacal liquor is drawn the cough that the method for coughing causes the obvious suppression effect is arranged.This beverage is not a medicine, and it can be used as daily drink, uses the health care that above test proves that just this beverage has antibechic, wets one's whistle.
Throat relieving drink of the present invention is solicited frequent smoking personage's suggestion and evaluation with the mode of application form; To 300 surveyees drinkable 2 months this beverage (every day is by 355 milliliters) is provided respectively; When drink arbitrarily; Regain 258 of effective application forms after 3 months, tabulate like following table through the situation of statistical analysis:
Table 3, throat relieving drink application form
Several embodiments of the present invention are described below.
Embodiment 1:
Get grape pip 100 grams, extracted 5 hours with 95% alcohol reflux, extract refrigeration was concentrated into 10 grams in 24 hours.Get the dry material of following weight: dark plum 15 grams, hawthorn 15 grams, the sterculia seed 3 grams, Rosa roxburghii 30 grams, the fruit of Chinese magnoliavine 3 grams, Chinese olive 3 grams, lophatherum gracile 3 grams, Momordica grosvenori 3 grams, gynostemma pentaphylla 3 grams; Reject the impurity in the medicinal material; Be crushed to the 20-40 order; After adding 30 times of pure water and boiling, keep boiling 30 minutes, the 200 order filter clothes of filtrating are collected.Filter residue adds 20 times of pure water of dried medicinal material again and boils, and keeps boiling 30 minutes, and the 200 order filter clothes of filtrating are collected, and filter residue discards; Twice filtrating is merged, about 4000 milliliters altogether, add pure water and be diluted to 8000 milliliters, fully stir, change it over to freezer rapid cooling to 4 ℃, and deposited 5 hours; Grape seed extract is pressed 2% of mixed extract weight add in the mixed extract, stir, and cross 0.8 micron filter membrane with flame filter press, in 121 ℃ of pressure sterilizings 30 minutes, naturally cool to room temperature afterwards, can gets product.
Embodiment 2:
Get grape pip 100 grams, extracted 2 hours with 95% alcohol reflux, extract refrigeration was concentrated into 10 grams in 4 hours; Get the dry material of following weight: dark plum 15 grams, hawthorn 20 grams, the sterculia seed 6 grams, Rosa roxburghii 35 grams, the fruit of Chinese magnoliavine 8 grams, Chinese olive 5 grams, lophatherum gracile 5 grams, Momordica grosvenori 5 grams, gynostemma pentaphylla 5 grams, reject the impurity in the medicinal material, be crushed to the 20-40 order; After adding 30 times of pure water and boiling, keep boiling 30 minutes, the 200 order filter clothes of filtrating are collected; Filter residue adds 20 times of pure water of dried medicinal material again and boils; Keep boiling 30 minutes, the 200 order filter clothes of filtrating are collected, and filter residue discards; Twice filtrating is merged, about 4000 milliliters altogether, add pure water and be diluted to 8000 milliliters, fully stir, cool off naturally, change it over to freezer rapid cooling to 4 ℃, and deposited 5 hours; Grape seed extract is pressed 2% of mixed extract weight add in the mixed extract, stir, and cross 0.8 micron filter membrane with flame filter press, in 121 ℃ of pressure sterilizings 30 minutes, naturally cool to room temperature afterwards, can gets product.
Embodiment 3:
Get grape pip 100 grams, extracted 5 hours with 95% alcohol reflux, the sedimentation of extract normal temperature was concentrated into 10 grams in 24 hours; Get the dry material of following weight: dark plum 20 grams, hawthorn 20 grams, the sterculia seed 5 grams, Rosa roxburghii 30 grams, the fruit of Chinese magnoliavine 8 grams, Chinese olive 5 grams, lophatherum gracile 5 grams, Momordica grosvenori 5 grams, gynostemma pentaphylla 5 grams, reject the impurity in the medicinal material, be crushed to the 20-40 order; After adding 30 times of pure water and boiling, keep boiling 30 minutes, the 200 order filter clothes of filtrating are collected; Filter residue adds 20 times of pure water of dried medicinal material again and boils; Keep boiling 30 minutes, the 200 order filter clothes of filtrating are collected, and filter residue discards; Twice filtrating is merged, about 4000 milliliters altogether, add pure water and be diluted to 8000 milliliters; Fully stir, change it over to freezer rapid cooling to 4 ℃, and deposited 5 hours; Grape seed extract is pressed 2% of mixed extract weight add in the mixed extract, stir, and cross 0.8 micron filter membrane with flame filter press; In 121 ℃ of pressure sterilizings 30 minutes, naturally cool to room temperature afterwards, can gets product.
Embodiment 4:
Get grape pip 100 grams, extracted 5 hours with 95% alcohol reflux, extract refrigeration was concentrated into 10 grams in 4 hours; Get the dry material of following weight: dark plum 20 grams, hawthorn 20 grams, the sterculia seed 8 grams, Rosa roxburghii 45 grams, the fruit of Chinese magnoliavine 3 grams, Chinese olive 3 grams, lophatherum gracile 3 grams, Momordica grosvenori 3 grams, gynostemma pentaphylla 3 grams, reject the impurity in the medicinal material, be crushed to the 20-40 order; After adding 30 times of pure water and boiling, keep boiling 30 minutes, the 200 order filter clothes of filtrating are collected; Filter residue adds 20 times of pure water of dried medicinal material again and boils; Keep boiling 30 minutes, the 200 order filter clothes of filtrating are collected, and filter residue discards; Twice filtrating is merged, about 4000 milliliters altogether, add pure water and be diluted to 8000 milliliters, fully stir; Naturally cooling changes it over to freezer rapid cooling to 4 ℃, and deposited 5 hours; Grape seed extract is pressed 2% of mixed extract weight add in the mixed extract, stir, and cross 0.8 micron filter membrane with flame filter press; In 121 ℃ of pressure sterilizings 30 minutes, naturally cool to room temperature afterwards, can gets product.
Claims (2)
1. throat relieving drink, it is characterized in that: throat relieving drink is made up of major ingredient material extract and auxiliary material material extract, and auxiliary material material extract is 1%~3% of a major ingredient material extract weight in the throat relieving drink;
Major ingredient material composition and content prescription thereof in the major ingredient material extract are: dark plum 15-20 part, hawthorn 15-20 part, sterculia seed 3-8 part, Rosa roxburghii 30-45 part, fruit of Chinese magnoliavine 3-8 part, Chinese olive 3-8 part, lophatherum gracile 3-8 part, Momordica grosvenori 3-8 part, gynostemma pentaphylla 3-8 part;
Major ingredient material extract extracts according to the following steps:
(1), gets the dry material of following weight: dark plum 15-20 part, hawthorn 15-20 part, sterculia seed 3-8 part, Rosa roxburghii 30-45 part, fruit of Chinese magnoliavine 3-8 part, Chinese olive 3-8 part, lophatherum gracile 3-8 part, Momordica grosvenori 3-8 part, gynostemma pentaphylla 3-8 part; Reject the impurity in the medicinal material; Be crushed to the 20-40 order; The pure water that adds 30 times of above-mentioned mixing dry matter weights boils, and keeps boiling 30 minutes, and the 200 order filter clothes of filtrating are collected filtrating; The pure water that filter residue adds 20 times of above-mentioned mixing dry matter weights again boils, and keeps boiling 30 minutes, and the 200 order filter clothes of filtrating are collected filtrating, and filter residue discards;
(2), above-mentioned twice filtrating is merged, the pure water that adds 0.8~1.2 times of filtrate volume fully stirs, and with its rapid cooling to 4 ℃, deposits 5 hours at 4 ℃;
Auxiliary material material extract is the grape pip extract, and auxiliary material material extract extracts according to the following steps: get grape pip, extracted 5 hours with 95% alcohol reflux, extract refrigeration 4~6 hours is concentrated into 1/40~1/30 of original volume with it again, and is for use.
2. the preparation method of the described throat relieving drink of claim 1, it is characterized in that: the preparation method carries out according to the following steps:
[1], preparation major ingredient material extract:
(1), gets the dry material of following weight: dark plum 15-20 part, hawthorn 15-20 part, sterculia seed 3-8 part, Rosa roxburghii 30-45 part, fruit of Chinese magnoliavine 3-8 part, Chinese olive 3-8 part, lophatherum gracile 3-8 part, Momordica grosvenori 3-8 part, gynostemma pentaphylla 3-8 part; Reject the impurity in the medicinal material; Be crushed to the 20-40 order; The pure water that adds 30 times of above-mentioned mixing dry matter weights boils, and keeps boiling 30 minutes, and the 200 order filter clothes of filtrating are collected filtrating; The pure water that filter residue adds 20 times of above-mentioned mixing dry matter weights again boils, and keeps boiling 30 minutes, and the 200 order filter clothes of filtrating are collected filtrating, and filter residue discards;
(2), above-mentioned twice filtrating is merged, the pure water that adds 0.8~1.2 times of filtrate volume fully stirs, and with its rapid cooling to 4 ℃, deposits 5 hours at 4 ℃;
[2], preparation auxiliary material material extract:
Get grape pip, extracted 5 hours with 95% alcohol reflux, extract refrigeration 4~6 hours is concentrated into 1/40~1/30 of original volume with it again, and is for use;
[3], preparation throat relieving drink:
Auxiliary material material extract is mixed with major ingredient material extract with 1%~3% ratio of major ingredient material extract weight; Stir, and after crossing 0.8 micron filter membrane with flame filter press, in 121 ℃ of pressure sterilizings 30 minutes; Naturally cool to room temperature, can gets product.
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CN102784248B (en) * | 2012-09-03 | 2014-07-02 | 赵全成 | Chinese medicine composition for preventing and treating alcoholic liver injury |
CN103721101A (en) * | 2013-12-23 | 2014-04-16 | 广西博科药业有限公司 | Buccal tablet for clearing heat and soothing throat and preparation method of buccal tablet |
CN104116080B (en) * | 2014-07-31 | 2015-10-21 | 赵兰 | A kind of pharynx-clearing throat-benefiting health food and preparation method thereof |
CN105029596A (en) * | 2015-01-19 | 2015-11-11 | 王汝辉 | Throat clearing and soothing plant functional beverage |
CN104922280A (en) * | 2015-07-14 | 2015-09-23 | 江西中医药大学附属医院 | Granular formulation for treating sphagitis |
CN105341930B (en) * | 2015-12-03 | 2018-06-01 | 山东禹王制药有限公司 | A kind of throat-clearing throat-moistening oral liquid and its preparation process |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1129126A (en) * | 1995-07-24 | 1996-08-21 | 喜杨 | Tea of prolonging life |
CN1135908A (en) * | 1995-12-20 | 1996-11-20 | 铁萱 | Medical food for curing acute and chronic pharyngitis |
CN101073433A (en) * | 2007-06-22 | 2007-11-21 | 上海新康制药厂 | Blackthorn pear fruit-juice solid product and its production |
CN101081092A (en) * | 2007-04-25 | 2007-12-05 | 肖自力 | beverage for expelling toxin and treating melancholy |
-
2008
- 2008-05-12 CN CN2008100476703A patent/CN101579112B/en not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1129126A (en) * | 1995-07-24 | 1996-08-21 | 喜杨 | Tea of prolonging life |
CN1135908A (en) * | 1995-12-20 | 1996-11-20 | 铁萱 | Medical food for curing acute and chronic pharyngitis |
CN101081092A (en) * | 2007-04-25 | 2007-12-05 | 肖自力 | beverage for expelling toxin and treating melancholy |
CN101073433A (en) * | 2007-06-22 | 2007-11-21 | 上海新康制药厂 | Blackthorn pear fruit-juice solid product and its production |
Non-Patent Citations (1)
Title |
---|
刘秀凤.润喉保健饮料的研制.《食品工业科技》.2004,第25卷(第08期),第101-103页. * |
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