CN101574389A - Dripping pill for treating pharyngeal and laryngeal diseases and preparation method thereof - Google Patents
Dripping pill for treating pharyngeal and laryngeal diseases and preparation method thereof Download PDFInfo
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- CN101574389A CN101574389A CNA2008101061755A CN200810106175A CN101574389A CN 101574389 A CN101574389 A CN 101574389A CN A2008101061755 A CNA2008101061755 A CN A2008101061755A CN 200810106175 A CN200810106175 A CN 200810106175A CN 101574389 A CN101574389 A CN 101574389A
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- drop pill
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- laryngopharyngeal diseases
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Abstract
The invention discloses a dripping pill for treating pharyngeal and laryngeal diseases and a preparation method thereof. Raw materials of ridonin and sarcandra are combined in proper proportion, extracted, and then added with accessories to prepare the dripping pill. The dripping pill is used through medicinal compatibility of the two raw materials, adopts the modern technology of quick release, and has obvious curative effect on symptoms of uncomfortable pharynx such as acpuei and chronic pharyngitis, abscess of throat, dry throat and the like.
Description
Technical field
The present invention relates to a kind of drop pill for the treatment of laryngopharyngeal diseases and preparation method thereof.
Background technology
Pharyngeal disease such as pharyngolaryngitis, pharyngeal discomfort influences quality of life of people, has influence on work sometimes, as teacher, announcer etc. with the more occupation of throat.The western medical treatment method often adopts the antibiotic method, but medicine reaches pharyngeal less, and takes for a long time, can produce drug resistance and toxic and side effects.In recent years, adopt the kind of crude drug treatment existing many, shown special advantages.
Summary of the invention
The object of the invention is to provide a kind of drop pill for the treatment of laryngopharyngeal diseases.
Another purpose of the present invention is to provide a kind of preparation method for the treatment of the drop pill of laryngopharyngeal diseases.
The present invention is implemented by the following technical programs.
Drop pill of the present invention can be made by the raw material of following weight portion: Rabdosia rubescens 4-10 Herba Pileae Scriptae 5-12.
Raw material of the present invention can add one or more in Oleum Blumeae Balsamiferae, Mentholum, Oleum menthae, glycyrrhizic acid, Radix Scrophulariae, Radix Platycodonis, Borneolum Syntheticum, the Blumeae preparatum Tabellae.
Raw material of the present invention also can add one or more raw materials in Bulbus Lilii, Radix Ophiopogonis, Folium Mori, Radix Notoginseng, Bulbus Fritillariae Cirrhosae, Bulbus Fritillariae Thunbergii, Radix Puerariae, tea polyphenols, the Flos Chrysanthemi.
The present invention treats the preparation method of the drop pill of laryngopharyngeal diseases, can take following steps: Rabdosia rubescens 4-10 Herba Pileae Scriptae 5-12 weight portion adds 4-8 times of 50-95% ethanol, can adopt percolation, ultrasonic, a kind of in refluxing, the extracting solution decompression recycling ethanol, can adopt a kind of drying in microwave, decompression, spraying, the lyophilization mode, get Rabdosia rubescens extract; Get extract, add 4-18 weight portion drop pill substrate adjuvant, stir, heating and melting, medicinal liquid 50-90 ℃ insulation splashes in the liquid coolant, drips to make ball.
Rabdosia rubescens 4-10 Herba Pileae Scriptae 5-12 weight portion also can add 6-12 times of water in the invention described above preparation method, decocts to extract 1-2 hour, extract 1-3 time, and the extracting solution concentrating under reduced pressure, vacuum drying must mix extract.
Adjuvant can comprise lactose in the preparation method of drop pill of the present invention, dextrin, calcium sulfate, calcium carbonate, calcium hydrogen phosphate, hydroxypropyl cellulose, carboxymethyl starch sodium, xylitol, mannitol, sorbitol, microcrystalline Cellulose, oil with hydrogenated soybean, olive oil, edible vegetable oil, Polyethylene Glycol, poloxamer, stearic acid, sodium stearate, glycerin gelatine, polyoxyethylene stearate fat, Lac, the polyoxyethylene monostearate, glyceryl monostearate, sugar esters, a kind of in the Polysorbate or with more than one.
Beneficial effect of the present invention below is described.
Rabdosia rubescens has another name called Rabdosia rubescens, and LINGCAO is spent, frozen to ice slush.Its main inclusions is Rabdosia rubescens first element, second element, third element and fourth element, also contains volatile oil alkaloid, bitter principle, lactone and flavone etc.Wherein Rabdosia rubescens first element and second element are its antitumor effective ingredient, and the obvious sterilization effect is arranged, and various carninomatosis are all had certain curative effect, and be more obvious with early stage esophageal carcinoma curative effect especially.In addition, it also has stronger lethal effect to upper respiratory tract bacterial strains such as staphylococcus aureus, alpha streptococcuss, now be widely used in the clinical treatment of pharyngitis, tonsillitis and stomatitis, acute laryngitis, acute suppurative tonsillitis there are significant curative effect, chronic bronchitis and chronic pharyngitis etc. is also had good result.
Herba Pileae Scriptae is the herb of Chloranthaceae Herba Pileae Scriptae Sarcandra glabra (Thunb.) Nakai.Acrid in the mouth, hardship, property is flat.Effects such as anti-inflammation, heat-clearing and toxic substances removing, expelling wind and removing dampness, promoting blood circulation and stopping pain, the synthetism of stimulating the menstrual flow are arranged, be used for the treatment of various diseases associated with inflammation, rheumatic arthritis, sore swollen toxin, traumatic injury, fracture etc.
In the present composition, Rabdosia rubescens, Herba Pileae Scriptae have tangible curative effect to oral cavity, laryngopharyngeal diseases, extensive use clinically, the two compatibility is used and be yet there are no report, and the two compatibility is used, the energy Synergistic, be used for pharyngeal drying, scorching hot, the improvement of pain symptom has obvious curative effects to oral cavity, laryngopharyngitis etc.
The specific embodiment
The present invention is described further by embodiment.
Embodiment 1
Rabdosia rubescens 4 Herba Pileae Scriptaes 5 weight portions add 4 times of ethanol, percolation, and the percolate decompression recycling ethanol, vacuum drying gets extract; Get extract, add 4 weight portion Macrogol 4000s, stir, heating and melting, 80 ℃ of insulations of medicinal liquid splash in 10 ℃ of liquid paraffin liquid coolants, drip apart from 15cm, drip and make ball.
Embodiment 2
Rabdosia rubescens 10 Herba Pileae Scriptaes 12 weight portions add 8 times of ethanol, percolation, and the percolate decompression recycling ethanol, vacuum drying gets extract; Get extract, add 18 weight portion polyethylene glycol 6000s, stir, heating and melting, 80 ℃ of insulations of medicinal liquid splash in 5 ℃ of methyl-silicone oil liquid coolants, drip apart from 10cm, drip and make ball.
Embodiment 3
Rabdosia rubescens 6 Herba Pileae Scriptaes 8 weight portions add 6 times of ethanol, refluxed 2 hours, and the extracting solution decompression recycling ethanol, vacuum drying gets extract; Get extract, add 8 weight portion sucrose fatty acid ester, stir, heating and melting, 65 ℃ of insulations of medicinal liquid splash in 15 ℃ of hydrogenated vegetable oil liquid coolants, drip apart from 12cm, drip and make ball.
Embodiment 4
Rabdosia rubescens 5 Herba Pileae Scriptaes 6 weight portions add 8 times of ethanol, and ultrasonic 1 hour, the extracting solution decompression recycling ethanol, spray drying gets extract; Get extract, add 4.5 weight portion stearic acid, stir, heating and melting, 75 ℃ of insulations of medicinal liquid splash in 3 ℃ of liquid paraffin liquid coolants, drip apart from 11cm, drip and make ball.
Embodiment 5
Rabdosia rubescens 8 Herba Pileae Scriptaes 6 weight portions add 9 times of water, decocted 1 hour, and the extracting solution concentrating under reduced pressure, spray drying gets extract; Get extract, add 8 weight portion Lac, 4 weight portion carboxymethyl starch sodium, stir, heating and melting, 80 ℃ of insulations of medicinal liquid splash in 13 ℃ of liquid paraffin liquid coolants, drip apart from 8cm, drip and make ball.
Embodiment 6
Rabdosia rubescens 7 Herba Pileae Scriptaes 8 weight portions add 6 times of 70% ethanol, refluxed 1 hour, and the extracting solution concentrating under reduced pressure, spray drying gets extract; Get extract, add 10 weight portion polyoxyethylene 8 stearate fat, stir, heating and melting, 70 ℃ of insulations of medicinal liquid splash into 7 ℃ of liquid paraffin: the methyl-silicone oil volume ratio is in 1: 1 liquid coolant, drips apart from 9cm, drips and makes ball.
Claims (7)
1, a kind of drop pill for the treatment of laryngopharyngeal diseases is characterized in that comprising the raw material of following weight portion:
Rabdosia rubescens 4-10 Herba Pileae Scriptae 5-12.
2, treat the drop pill of laryngopharyngeal diseases according to claim 1, it is characterized in that: also can add one or more raw materials in Oleum Blumeae Balsamiferae, Mentholum, Oleum menthae, glycyrrhizic acid, Radix Scrophulariae, Radix Platycodonis, Borneolum Syntheticum, the Blumeae preparatum Tabellae.
3, treat the drop pill of laryngopharyngeal diseases according to claim 1, it is characterized in that: one or more raw materials in Bulbus Lilii, Radix Ophiopogonis, Folium Mori, Radix Notoginseng, Bulbus Fritillariae Cirrhosae, Bulbus Fritillariae Thunbergii, Radix Puerariae, tea polyphenols, the Flos Chrysanthemi.
4, treat according to claim 1 laryngopharyngeal diseases the preparation method of drop pill, it is characterized in that comprising the steps: that Rabdosia rubescens 4-10 Herba Pileae Scriptae 5-12 weight portion adds 4-8 times of 50-95% ethanol, can adopt percolation, ultrasonic, a kind of in refluxing, the extracting solution decompression recycling ethanol, can adopt a kind of drying in microwave, decompression, spraying, the lyophilization mode, get Rabdosia rubescens extract; Get extract, add 4-18 weight portion drop pill substrate adjuvant, stir, heating and melting, medicinal liquid 50-90 ℃ insulation splashes in the liquid coolant, drips to make ball.
5, as the preparation method of the drop pill of treatment laryngopharyngeal diseases as described in the claim 4, it is characterized in that comprising the steps: that Rabdosia rubescens 4-10 Herba Pileae Scriptae 5-12 weight portion also can add 6-12 times of water, decoct and extracted 1-2 hour, extract 1-3 time, the extracting solution concentrating under reduced pressure, vacuum drying must mix extract.
6, preparation method as the drop pill of treatment laryngopharyngeal diseases as described in the claim 4 is characterized in that adjuvant can comprise lactose, dextrin, calcium sulfate, calcium carbonate, calcium hydrogen phosphate, hydroxypropyl cellulose, carboxymethyl starch sodium, xylitol, mannitol, sorbitol, microcrystalline Cellulose, oil with hydrogenated soybean, olive oil, edible vegetable oil, Polyethylene Glycol, poloxamer, stearic acid, sodium stearate, glycerin gelatine, polyoxyethylene stearate fat, Lac, the polyoxyethylene monostearate, glyceryl monostearate, sugar esters, a kind of in the Polysorbate or with more than one.
7, as the preparation method of the drop pill of treatment laryngopharyngeal diseases as described in the claim 4, it is characterized in that: liquid coolant can be one or more in liquid paraffin, vegetable oil, the methyl-silicone oil.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101061755A CN101574389A (en) | 2008-05-09 | 2008-05-09 | Dripping pill for treating pharyngeal and laryngeal diseases and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101061755A CN101574389A (en) | 2008-05-09 | 2008-05-09 | Dripping pill for treating pharyngeal and laryngeal diseases and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101574389A true CN101574389A (en) | 2009-11-11 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008101061755A Pending CN101574389A (en) | 2008-05-09 | 2008-05-09 | Dripping pill for treating pharyngeal and laryngeal diseases and preparation method thereof |
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| CN (1) | CN101574389A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104116734A (en) * | 2014-07-15 | 2014-10-29 | 贵州大学 | Pharmaceutical composition and pharmaceutical preparation for treating oral and throat diseases, and applications and preparation method of the pharmaceutical composition and pharmaceutical preparation |
| CN104800616A (en) * | 2015-04-07 | 2015-07-29 | 范永启 | Compound essential oil for preventing and curing stomatitis |
-
2008
- 2008-05-09 CN CNA2008101061755A patent/CN101574389A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104116734A (en) * | 2014-07-15 | 2014-10-29 | 贵州大学 | Pharmaceutical composition and pharmaceutical preparation for treating oral and throat diseases, and applications and preparation method of the pharmaceutical composition and pharmaceutical preparation |
| CN104800616A (en) * | 2015-04-07 | 2015-07-29 | 范永启 | Compound essential oil for preventing and curing stomatitis |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20091111 |