CN101569699A

CN101569699A - Pharmaceutical composition for treating prostatitis and preparation method thereof

Info

Publication number: CN101569699A
Application number: CNA2009100860878A
Authority: CN
Inventors: 张洪瀑
Original assignee: Individual
Current assignee: Individual
Priority date: 2009-06-10
Filing date: 2009-06-10
Publication date: 2009-11-04
Anticipated expiration: 2029-06-10
Also published as: CN101569699B

Abstract

The invention discloses a pharmaceutical composition for treating prostatitis, and the pharmaceutical composition is composed of more than 20 traditional Chinese medicines of clematis root, quilled cinnamon bark, white paeony root, belvedere fruit, longhairy antenoron herb, cowherb seed, grassleaf sweelflag rhizome, pangolin scales, south dodder seed and the like. The pharmaceutical composition adopts the application method on navel for treating the prostatitis by treating the internal disease by the external therapy, namely the traditional Chinese medicines are made into an ointment or a medicine cake to be applied on the navel, thereby not only having the stimulating effect on an acupuncture point, but also having the penetration effect of the drug, avoiding the defect that antibiotics and other drugs easily cause drug-induced diseases and not causing patients to generate the drug dependence. The pharmaceutical composition has the advantages of capability of treating the internal disease by the external therapy, simplicity, easy operation, no wounds and no pains, the patients are ready to accept and the popularization is convenient.

Description

Prostatitic pharmaceutical composition of a kind of treatment and preparation method thereof

Technical field

The present invention relates to a kind of pharmaceutical composition, particularly relate to prostatitic pharmaceutical composition of a kind of treatment and preparation method thereof.

Background technology

Prostatitis is a kind of common and multiple urology department illness, divides acute and chronic two kinds.Clinically, prostatitis accounts for 25%～30% of urology department outpatient service disease.Prostatitis patient surpasses several hundred million people in the world at present, and the trend that increases is year by year arranged.In years, prostatitis morbidity focused mostly on two stages: 25-32 year and climacteric, have a strong impact on patient's live and work after the morbidity.Prostatitis origin cause of formation more complicated, sitting, irregular sexual life, mechanical irritation, masturbation, excessive consumption of alcohol, in a large number foods excitatory such as edible Fructus Capsici, Bulbus Allii, often suppress urine, influence mentally, often the phase stays up late, is nervous, is in a very depressed state etc. and all might cause prostatosis.Now prostatitic medicine of treatment and method are a lot of both at home and abroad, and the overwhelming majority is various antibiotics oral medicine.Take the antibiotic therapy prostatitis, sterilization is not radically reformed, is cured the symptoms, not the disease, and not only unsatisfactory curative effect also might cause the pathogenic bacteria drug resistance to strengthen, and the state of an illness constantly worsens.

Summary of the invention

The object of the present invention is to provide the prostatitic pharmaceutical composition of a kind of treatment; Another object of the present invention is to provide this preparation of drug combination method.

The present invention is achieved through the following technical solutions:

The crude drug of pharmaceutical composition of the present invention consists of:

Radix Clematidis 5-35 weight portion Cortex Cinnamomi 4-26 weight portion Radix Paeoniae Alba 4-26 weight portion

Fructus Kochiae 4-26 weight portion Herba Lysimachiae 2-18 weight portion Semen Vaccariae 2-18 weight portion

Rhizoma Acori Graminei 2-18 weight portion Squama Manis 4-26 weight portion Semen Cuscutae 4-26 weight portion

Herba Leonuri 4-26 weight portion Natrii Sulfas 5-35 weight portion Concha Ostreae (calcined) 2-10 weight portion

Radix Astragali 4-26 weight portion is fried Spina Gleditsiae 2-10 weight portion Fructus Lycii 4-26 weight portion

Radix Salviae Miltiorrhizae 2-18 weight portion Herba Cistanches 5-35 weight portion Rhizoma Cimicifugae 2-14 weight portion

Talcum 4-26 weight portion Semen Plantaginis 6-44 weight portion Carapax et Plastrum Testudinis 4-26 weight portion

Radix Achyranthis Bidentatae 5-35 weight portion Radix Glycyrrhizae 5-35 weight portion Semen Litchi 5-35 weight portion

Medulla Tetrapanacis 2-14 weight portion Herba Epimedii 4-26 weight portion Semen Phaseoli 4-26 weight portion

Spora Lygodii 2-18 weight portion.

The crude drug composition of pharmaceutical composition of the present invention is preferably:

The Radix Clematidis 20 weight portion Cortex Cinnamomi 15 weight portion Radix Paeoniae Albas 15 weight portions

The Fructus Kochiae 15 weight portion Herba Lysimachiaes 10 weight portion Semen Vaccariae 10 weight portions

Rhizoma Acori Graminei 10 weight portion Squama Maniss 15 weight portion Semen Cuscutae 15 weight portions

Herba Leonuri 15 weight portion Natrii Sulfas 20 weight portion Concha Ostreae (calcined)s 6 weight portions

The Radix Astragali 15 weight portions are fried Spina Gleditsiae 6 weight portion Fructus Lycii 15 weight portions

Radix Salviae Miltiorrhizae 10 weight portion Herba Cistanches 20 weight portion Rhizoma Cimicifugaes 8 weight portions

Talcum 15 weight portion Semen Plantaginiss 25 weight portion Carapax et Plastrum Testudiniss 15 weight portions

Radix Achyranthis Bidentatae 20 weight portion Radix Glycyrrhizaes 20 weight portion Semen Litchis 20 weight portions

Medulla Tetrapanacis 8 weight portion Herba Epimedii 15 weight portion Semen Phaseolis 15 weight portions

Spora Lygodii 10 weight portions.

The Radix Clematidis 10 weight portion Cortex Cinnamomi 20 weight portion Radix Paeoniae Albas 8 weight portions

The Fructus Kochiae 22 weight portion Herba Lysimachiaes 4 weight portion Semen Vaccariae 16 weight portions

Rhizoma Acori Graminei 5 weight portion Squama Maniss 20 weight portion Semen Cuscutae 8 weight portions

Herba Leonuri 20 weight portion Natrii Sulfas 10 weight portion Concha Ostreae (calcined)s 8 weight portions

The Radix Astragali 6 weight portions are fried Spina Gleditsiae 8 weight portion Fructus Lycii 6 weight portions

Radix Salviae Miltiorrhizae 15 weight portion Herba Cistanches 10 weight portion Rhizoma Cimicifugaes 12 weight portions

Talcum 8 weight portion Semen Plantaginiss 35 weight portion Carapax et Plastrum Testudiniss 10 weight portions

Radix Achyranthis Bidentatae 30 weight portion Radix Glycyrrhizaes 10 weight portion Semen Litchis 30 weight portions

Medulla Tetrapanacis 4 weight portion Herba Epimedii 22 weight portion Semen Phaseolis 8 weight portions

Spora Lygodii 15 weight portions.

The Radix Clematidis 30 weight portion Cortex Cinnamomi 10 weight portion Radix Paeoniae Albas 20 weight portions

The Fructus Kochiae 10 weight portion Herba Lysimachiaes 15 weight portion Semen Vaccariae 5 weight portions

Rhizoma Acori Graminei 15 weight portion Squama Maniss 10 weight portion Semen Cuscutae 20 weight portions

Herba Leonuri 10 weight portion Natrii Sulfas 30 weight portion Concha Ostreae (calcined)s 4 weight portions

The Radix Astragali 20 weight portions are fried Spina Gleditsiae 4 weight portion Fructus Lycii 20 weight portions

Radix Salviae Miltiorrhizae 5 weight portion Herba Cistanches 30 weight portion Rhizoma Cimicifugaes 4 weight portions

Talcum 20 weight portion Semen Plantaginiss 10 weight portion Carapax et Plastrum Testudiniss 20 weight portions

Radix Achyranthis Bidentatae 10 weight portion Radix Glycyrrhizaes 30 weight portion Semen Litchis 10 weight portions

Medulla Tetrapanacis 12 weight portion Herba Epimedii 10 weight portion Semen Phaseolis 20 weight portions

Spora Lygodii 5 weight portions.

Preparation of drug combination method of the present invention is:

The above-mentioned raw materials medicine is processed into fine powder, stirs evenly with the wine and the vinegar of crude drug 1.5 times of weight, and the ratio of wine and vinegar is 1: 1, adds vaseline furnishing paste again and is advisable, and is standby.

Pharmaceutical composition of the present invention adds conventional adjuvant by practice of pharmacy and makes the ointment of clinical acceptance, emplastrum or powder.

Side's medicine decomposes: Radix Clematidis: expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, expectorant water, the hypochondriac lump of loosing; Cortex Cinnamomi: both helped functioning of bladder, but guiding fire to origin again; The Radix Paeoniae Alba: lung is grown in nourishing the liver, to support kidney yin; The Fructus Kochiae: clearing away heat and promoting diuresis eliminating dampness by diuresis, tonneau bladder; Semen Vaccariae: dampness removing, promoting blood circulation to restore menstrual flow; Rhizoma Acori Graminei: eliminate phlegm for resuscitation, the refreshment Fructus Alpiniae Oxyphyllae; Squama Manis: invigorating kidney, promoting blood circulation is sensible; Herba Lysimachiae: clear damp-heat in lower-JIAO, lead the bladder stasis of blood and stagnate; Semen Cuscutae: nourishing the liver and kidney, the controlling nocturnal emission with astringent drugs reducing urination, antiabortive, make eye bright antidiarrheal.Being used for impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen suffers from a deficiency of the kidney and rushes down; Carapax et Plastrum Testudinis: replenishing kidney-YIN, strong water are controlled fire, and with the training the congenital foundation, mutual generation between metal and water, The liver and the kidney have a common source; Radix Achyranthis Bidentatae: the through sick institute of energy priming; Radix Glycyrrhizae: can and all medicines and protect the moon; Semen Litchi: the eliminating stagnation of regulating the flow of vital energy; Medulla Tetrapanacis: clearing away heat and promoting diuresis; Herba Epimedii: invigorating kidney, promoting blood circulation is sensible; Natrii Sulfas: remove pathogen, broken stagnant blood diuresis, drench, push away Chen Zhixin the fifth day of the first lunar month; Herba Leonuri: remove aqueous vapor, make light of one's life by commiting suicide, treat the contrary big heat of blood, invigorating middle warmer gas promoting blood circulation; Concha Ostreae (calcined): can ooze profit lead wet, divide clean turbid; The Radix Astragali: angry invigorating middle warmer, supporing yang activating QI; Fry Spina Gleditsiae: repercussive; Fructus Lycii: enriching kidney essence, nourishing YIN for harmonizing YANG; Radix Salviae Miltiorrhizae: promoting blood circulation to remove obstruction in the collateral, eliminating blood stasis to promote regeneration of blood; Herba Cistanches: kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.Be used for sexual impotence, infertile, soreness of the waist and knees, muscles and bones is unable, the dryness of the intestine constipation; Rhizoma Cimicifugae: can go up circulation of qi promoting, rise then that water falls; Talcum: energy is wet, puckery painful can the removing of urethra of the exterior and the interior up and down; Semen Plantaginis: clearing away heat and promoting diuresis, eliminating dampness by diuresis is treating stranguria.

The present invention adopts umbilical compress therapy inner disease outer treat treatment prostatitis, be about to Chinese medicine and make ointment or medicine cake, be attached on the umbilicus, do existing stimulation (being similar to acupuncture) like this to the acupuncture point, the osmosis of medicine is arranged again, also avoided antibiotic etc to cause the drawback of drug-induced disease easily, the patient has been produced medicine rely on.Pharmaceutical composition of the present invention has inner disease outer treat, and is simple and easy to do, no wound, no pain advantage, and the patient takes like a shot, and is convenient to promote.

Following experimental example is used to further specify the present invention but is not limited to the present invention.

Experimental example:

One, physical data

This group is randomly drawed prostatitis patient 100 examples, and wherein the oldest 65 years old, minimum 28 years old, 51 years old mean age; Medical history is the longest 21 years, the shortest half a year, average 4 years.

Two, curative effect determinate standard

Clinical cure:

(1) subjective symptoms disappears.

(2) the prostate tenderness disappears during palpation, quality deliquescing or improvement.

(3) test of location segmentation urine is normal.

(4) prostatic fluid microscopy leukocyte count＜10/HPF, the antibacterial culturing feminine gender, and continuous review is normal more than 2 times.

Produce effects:

(1) subjective symptoms disappears.

(2) the normal or improvement of palpation prostate.

(3) prostatic fluid microscopy leukocyte count＞10/HPF, or antibacterial culturing is still positive.

Effectively:

(1) partial symptoms is improved or is disappeared.

(2) prostatic fluid microscopy leukocyte count take a favorable turn before the treatment, and antibacterial culturing is still positive.

Invalid:

(1) symptom and prostatic fluid microscopy all do not have improvement.

Three, Therapeutic Method:

1, medicine is formed: Radix Clematidis 20g, Cortex Cinnamomi 15g, Radix Paeoniae Alba 15g, Fructus Kochiae 15g, Herba Lysimachiae 10g, Semen Vaccariae 10g, Rhizoma Acori Graminei 10g, Squama Manis 15g, Semen Cuscutae 15g, Herba Leonuri 15g, Natrii Sulfas 20g, Concha Ostreae (calcined) 6g, Radix Astragali 15g, stir-fry Spina Gleditsiae 6g, Fructus Lycii 15g, Radix Salviae Miltiorrhizae 10g, Herba Cistanches 20g, Rhizoma Cimicifugae 8g, Talcum 15g, Semen Plantaginis 25g, Carapax et Plastrum Testudinis 15g, Radix Achyranthis Bidentatae 20g, Radix Glycyrrhizae 20g, Semen Litchi 20g, Medulla Tetrapanacis 8g, Herba Epimedii 15g, Semen Phaseoli 15g, Spora Lygodii 10g;

2, preparation method:

The above-mentioned raw materials medicine is processed into fine powder, stirs evenly with the wine and the vinegar of 1.5 times of weight of crude drug total amount, and the ratio of wine and vinegar is 1: 1, adds vaseline furnishing paste again and is advisable, and divides 40 equal portions standby.

3, using method: adopt umbilical compress therapy.The cleaning umbilical part is cleaned dirt in the umbilicus with ethanol, gets to mix up the ointment portion and fill up umbilicus, fixes with medical proof fabric, takes off after 24 hours.10 days courses of treatment, 2 days at interval per course of treatment.

Four, therapeutic outcome:

Through clinical 100 prostatitis patients are observed, cured 47 examples, account for 47% with pharmaceutical composition of the present invention; 25 examples that take a turn for the better account for 25%; Effective 21 examples account for 21%; Invalid 7 examples account for 7%.

Five, model case:

Case 1: open * *, man, 46 years old, trade.In October, 2006, feel that perineal position often has twinge, burning on urination, urine retention, lower abdominal distention pain etc.The demonstration lecithin of going to see a doctor ++, WBCO-4 is diagnosed as prostatitis.Taking medicine that hospital opens can respite but recurrence often.

Course of treatment of application unguentum of the present invention, the self-induction symptom obviously alleviates, continue application three courses of treatment after, the self-induction transference cure.To examination in hospital, every index is all normal.Follow up a case by regular visits to and do not have recurrence.

Case 2: appoint * *, 35 years old, certain section chief of bank.In July, 2006, that the patient urinates is unable, the urine line attenuates, bifurcated, not to the utmost dripping, and few abdomen weighs down and expands, testis is taken out pain, constipation.Be diagnosed as chronic bacterial prostatitis through the prostatic fluid routine examination.Priority arrives how tame hospitalize but effect is not good, and time has repeatedly, has a strong impact on physical and mental health, and directly involves sexual function.

Application powder of the present invention is after four courses of treatment, ultrasound diagnosis, the complete obiteration of prostatitis symptom.The every index of follow-up examination prostate is all normal, does not have recurrence.

Following embodiment all can realize the effect of above-mentioned experimental example.

The specific embodiment

Embodiment 1: the preparation of ointment

Radix Clematidis 20kg Cortex Cinnamomi 15kg Radix Paeoniae Alba 15kg Fructus Kochiae 15kg

Herba Lysimachiae 10kg does not stay capable 10kg Rhizoma Acori Graminei 10kg Squama Manis 15kg

Semen Cuscutae 15kg Herba Leonuri 15kg Natrii Sulfas 20kg Concha Ostreae (calcined) 6kg

Radix Astragali 15kg fries Spina Gleditsiae 6kg Fructus Lycii 15kg Radix Salviae Miltiorrhizae 10kg

Herba Cistanches 20kg Rhizoma Cimicifugae 8kg Talcum 15kg Semen Plantaginis 25kg

Carapax et Plastrum Testudinis 15kg Radix Achyranthis Bidentatae 20kg Radix Glycyrrhizae 20kg Semen Litchi 20kg

Medulla Tetrapanacis 8kg Herba Epimedii 15kg Semen Phaseoli 15kg Spora Lygodii 10kg;

Embodiment 2: the preparation of powder

Radix Clematidis 10kg Cortex Cinnamomi 20kg Radix Paeoniae Alba 8kg Fructus Kochiae 22kg

Herba Lysimachiae 4kg Semen Vaccariae 16kg Rhizoma Acori Graminei 5kg Squama Manis 20kg

Semen Cuscutae 8kg Herba Leonuri 20kg Natrii Sulfas 10kg Concha Ostreae (calcined) 8kg

Radix Astragali 6kg fries Spina Gleditsiae 8kg Fructus Lycii 6kg Radix Salviae Miltiorrhizae 15kg

Herba Cistanches 10kg Rhizoma Cimicifugae 12kg Talcum 8kg Semen Plantaginis 35kg

Carapax et Plastrum Testudinis 10kg Radix Achyranthis Bidentatae 30kg Radix Glycyrrhizae 10kg Semen Litchi 30kg

Medulla Tetrapanacis 4kg Herba Epimedii 22kg Semen Phaseoli 8kg Spora Lygodii 15kg;

The above-mentioned raw materials medicine is made the powder of clinical acceptance according to the conventional adjuvant that common process adds on the pharmaceutics.

Embodiment 3: the preparation of emplastrum

Radix Clematidis 30kg Cortex Cinnamomi 10kg Radix Paeoniae Alba 20kg Fructus Kochiae 10kg

Herba Lysimachiae 15kg Semen Vaccariae 5kg Rhizoma Acori Graminei 15kg Squama Manis 10kg

Semen Cuscutae 20kg Herba Leonuri 10kg Natrii Sulfas 30kg Concha Ostreae (calcined) 4kg

Radix Astragali 20kg fries Spina Gleditsiae 4kg Fructus Lycii 20kg Radix Salviae Miltiorrhizae 5kg

Herba Cistanches 30kg Rhizoma Cimicifugae 4kg Talcum 20kg Semen Plantaginis 10kg

Carapax et Plastrum Testudinis 20kg Radix Achyranthis Bidentatae 10kg Radix Glycyrrhizae 30kg Semen Litchi 10kg

Medulla Tetrapanacis 12kg Herba Epimedii 10kg Semen Phaseoli 20kg Spora Lygodii 5kg;

The above-mentioned raw materials medicine is made the emplastrum of clinical acceptance according to the conventional adjuvant that common process adds on the pharmaceutics.

Claims

1, the prostatitic pharmaceutical composition of a kind of treatment is characterized in that the crude drug of this pharmaceutical composition consists of:

Spora Lygodii 2-18 weight portion.

2, pharmaceutical composition as claimed in claim 1 is characterized in that the crude drug of this pharmaceutical composition consists of:

Spora Lygodii 10 weight portions.

3, pharmaceutical composition as claimed in claim 1 is characterized in that the crude drug of this pharmaceutical composition consists of:

Spora Lygodii 15 weight portions.

4, pharmaceutical composition as claimed in claim 1 is characterized in that the crude drug of this pharmaceutical composition consists of:

Spora Lygodii 5 weight portions.

5,, it is characterized in that the conventional adjuvant on this pharmaceutical composition adding pharmaceutics is made the dosage form of clinical acceptance as claim 1,2,3 or 4 arbitrary described pharmaceutical compositions.

6, pharmaceutical composition as claimed in claim 5 is characterized in that described dosage form is ointment, emplastrum or powder.

7, as claim 1,2,3 or 4 described preparation of drug combination methods, it is characterized in that this method is:

Get crude drug and be processed into fine powder, stir evenly with the wine and the vinegar of crude drug 1.5 times of weight, the ratio of wine and vinegar is 1: 1, adds vaseline furnishing paste again and is advisable.

8, preparation of drug combination method as claimed in claim 5 is characterized in that this method is:

Get crude drug and be processed into fine powder, stir evenly with the wine and the vinegar of crude drug 1.5 times of weight, the ratio of wine and vinegar is 1: 1, and the conventional adjuvant that adds on the pharmaceutics is made ointment, emplastrum or the powder of clinical acceptance.

9, as claim 1,2, the application of 3 or 4 described pharmaceutical compositions in the prostatitic medicine of preparation treatment.

10, the application of pharmaceutical composition as claimed in claim 5 in the prostatitic medicine of preparation treatment.