CN115487231A - Traditional Chinese medicine composition for treating prostatitis and/or prostatic hyperplasia and application thereof - Google Patents
Traditional Chinese medicine composition for treating prostatitis and/or prostatic hyperplasia and application thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for treating prostatitis and/or prostatic hyperplasia, belonging to the technical field of traditional Chinese medicines. The composition of the present invention comprises: clematis root, medicinal cyathula root, mistletoe and liquorice. Wherein the clematis root is the monarch, can walk twelve meridians, enters bladder meridians, dredges channels and collaterals, and dispels wind by excreting dampness; the medicinal cyathula root is a minister, enters liver and kidney channels, has the functions of promoting blood circulation and removing blood stasis, is good at walking and scurrying, and helps monarch drugs to expel wind and remove dampness, promote blood circulation and promote qi; the loranthus parasiticus is used as an assistant and enters liver and kidney channels, and the loranthus parasiticus has the functions of tonifying liver and kidney, strengthening bones and muscles, nourishing blood and dispelling wind, so that the clematis root is kept in the middle and cannot be crossed too much; the liquorice is used for guiding and harmonizing the medicines; the medicines are combined to play the effects of promoting blood circulation to remove blood stasis, promoting qi circulation and dredging collaterals. Clinical test results show that the traditional Chinese medicine composition disclosed by the invention is used for treating prostatitis and prostatic hyperplasia in an enema mode, and the cure rate is up to 93.3%.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating prostatitis and/or prostatic hyperplasia and application thereof.
Background
The prostate gland is an accessory gland of the male reproductive system, is an unpaired parenchymal gland, is located between the bladder and the urogenital diaphragm, surrounds the root of the urethra, and is a chestnut with a shape and a size similar to a little flat. The upper end is wide, the lower end is sharp and thin, the back surface is flat, and the rectum can be touched by finger diagnosis of the rectum. Early prostatitis has no obvious symptoms and is mostly ignored, and attention is paid to difficult urination caused by pressing urethra in the prostate hyperplasia stage.
At present, the treatment method of the prostatic hyperplasia mainly comprises western medicine treatment, physical therapy and operation. Wherein the western medicine treatment comprises: first line drugs for the treatment of BPH today are alpha receptor blockers, 5 alpha reductase inhibitors and botanicals. The alpha receptor inhibitor has quick response, is effective to prostatic hypertrophy of different degrees at different positions, has good curative effect only on patients with light symptoms and small prostate volume, and can cause orthostatic hypotension; the 5 alpha reductase inhibitor can reduce the volume of prostate, reverse the progress of diseases and improve symptoms, but has relatively slow effect, generally needs to be taken continuously for more than 2-3 months to take effect, and can have symptoms of erectile dysfunction, hyposexuality and the like; although the combination therapy of the alpha receptor inhibitor and the 5 alpha reductase inhibitor can effectively reduce the clinical progression rate of BPH and reduce the incidence rate of acute urinary retention compared with single drug therapy, adverse reactions and cost are increased correspondingly. Physical therapy: the working principle of the field effect ablation for treating the prostatic hyperplasia is that an electric field is established in a human body, the electric field is gathered to generate high heat, so that protein is irreversibly changed, prostatic cells and smooth muscle cells are coagulated and necrotized, and fall off after a period of time, and the pressure on the urethra is relieved. However, the pain of the field effect ablation therapy increases with the increase of the temperature, the treatment time is long and the effect is poor when the temperature is low, and the probe is easy to scab and calcify when contacting the surface of the tissue. And (3) operation: the operation for treating the prostatic hyperplasia is suitable for severe patients, namely the operation is only used under the condition that the medical treatment and the physical therapy can not relieve the disease condition. The operation has certain risks, may cause various complications, and has a high probability of recurrence of the focus within a period of time after the operation. Therefore, the treatment methods have various defects. Therefore, a medicine which has no side effect and takes effect quickly for treating prostatitis and prostatic hyperplasia is urgently needed.
Disclosure of Invention
In view of this, the present invention aims to provide a traditional Chinese medicine composition for treating prostatitis and/or prostatic hyperplasia and an application thereof, and the traditional Chinese medicine composition has the effects of small side effect, quick effect and good effect.
In order to achieve the above object, the present invention provides the following technical solutions:
a traditional Chinese medicine composition for treating prostatitis and/or prostatic hyperplasia comprises the following raw materials in parts by weight: 3-10 parts of clematis root, 8-18 parts of medicinal cyathula root, 8-18 parts of parasitic loranthus and 3-10 parts of liquorice.
Preferably, the feed comprises the following raw materials in parts by weight: 4-8 parts of clematis root, 10-15 parts of medicinal cyathula root, 10-15 parts of parasitic loranthus and 4-8 parts of liquorice.
Preferably, the dosage form of the composition comprises an enema.
Preferably, the preparation method of the enema comprises the following steps: pulverizing the Chinese medicinal composition, and mixing with water.
Preferably, the pulverized particle size is 80 to 150 mesh.
Preferably, the mass volume ratio of the traditional Chinese medicine composition to the water is (10-20) to (5-15) g/mL.
Preferably, the temperature of the water is 35-45 ℃.
The invention also provides application of the traditional Chinese medicine composition in preparing a medicine for treating prostatitis and/or prostatic hyperplasia.
Compared with the prior art, the invention has the following beneficial effects:
the invention provides a traditional Chinese medicine composition for treating prostatitis and/or prostatic hyperplasia, which comprises the following components: clematis root, cyathula root, chinese taxillus twig and liquorice. Wherein the clematis root is the monarch and can go through twelve meridians, enter bladder meridian, dredge channels and collaterals, and expel dampness and wind; the medicinal cyathula root is used as a minister, enters liver and kidney channels, has the functions of promoting blood circulation and removing blood stasis, is good at running and fleeing, helps monarch drugs to expel wind and remove dampness, and promotes blood circulation and qi circulation; the loranthus parasiticus is used as an assistant and enters liver and kidney channels, and the loranthus parasiticus has the functions of tonifying liver and kidney, strengthening bones and muscles, nourishing blood and dispelling wind, so that the clematis root is kept in the middle and cannot be crossed too much; the liquorice is used for guiding and harmonizing the medicines; the medicines are combined to play the effects of promoting blood circulation to remove blood stasis, promoting qi circulation and dredging collaterals. Clinical test results show that the traditional Chinese medicine composition disclosed by the invention is used for treating prostatitis and prostatic hyperplasia in an enema mode, and the cure rate is up to 93.3%.
The composition of the invention for treating prostate diseases is non-invasive and has no complications compared with surgical treatment; compared with western medicines, the composition has little side effect and no drug resistance; compared with oral traditional Chinese medicine, the traditional Chinese medicine is injected into rectum, prostate is tightly attached to rectum, medicine directly reaches focus through intestinal membrane, focus medicine concentration is high, and the effect is quicker and better. Rectal administration does not involve blood circulation, and does not increase the burden on liver and kidney.
Detailed Description
The invention provides a traditional Chinese medicine composition for treating prostatitis and/or prostatic hyperplasia, which comprises the following raw materials in parts by weight: 3-10 parts of clematis root, 8-18 parts of medicinal cyathula root, 8-18 parts of parasitic loranthus and 3-10 parts of liquorice.
In the invention, the raw materials preferably comprise the following components in parts by weight: 4-8 parts of clematis root, 10-15 parts of medicinal cyathula root, 10-15 parts of parasitic loranthus and 4-8 parts of liquorice, and more preferably 6 parts of clematis root, 12 parts of medicinal cyathula root, 12 parts of parasitic loranthus and 6 parts of liquorice.
The traditional Chinese medicine for treating prostatic hyperplasia distinguishes between qi stagnation and blood stasis, or dampness-heat evil cannot be cleared away for a long time, ministerial fire is blocked for a long time, and essence is lost and stasis is blocked in the essence channel; obstructed qi and blood circulation, obstructed meridians, qi and blood stasis; or the disease occurs due to cold pathogen attack, blood circulation, collateral damage of jueyin, qi stagnation and blood stasis, and unsmooth operation. The clematis root in the composition is the monarch drug, can walk twelve meridians, enter bladder meridians, dredge channels and collaterals, and eliminate dampness and wind; the cyathula root is used as a minister and is in charge of liver, kidney and channel, has the functions of promoting blood circulation and removing blood stasis, is good for walking and fleeing, helps monarch drugs to expel wind and remove dampness, and promotes blood and qi; the loranthus parasiticus is used as an adjuvant and enters liver and kidney and meridians, and the loranthus parasiticus has the effects of tonifying liver and kidney, strengthening muscles and bones, nourishing blood and dispelling wind, so that the clematis root is kept in the middle of the walking and cannot be crossed too much; the liquorice is used for guiding and harmonizing the medicines; the medicines are combined to play the effects of promoting blood circulation to remove blood stasis, promoting qi circulation and dredging collaterals.
In the present invention, the dosage form of the composition preferably includes an enema; the preparation method of the enema preferably comprises the following steps: pulverizing the Chinese medicinal composition, and mixing with water; the particle size of the crushed powder is preferably 80-150 meshes, and more preferably 100 meshes; the mass volume ratio of the traditional Chinese medicine composition to water is preferably (10-20) to (5-15) g/mL, and more preferably 15; the water is preferably plain boiled water, and the temperature of the water is preferably 35-45 ℃, and more preferably 40 ℃.
In the invention, the enema is connected with an enema tube by a syringe for rectal perfusion once every two days, and 25g is taken each time, and 10 times is taken as a treatment course. The prostate is tightly attached to the rectum, the composition adopts a rectal perfusion method, the medicine directly reaches the focus through the intestinal membrane, the concentration of the medicine at the focus is high, the effect is quicker, and the effect is better.
The invention also provides application of the traditional Chinese medicine composition in preparing a medicine for treating prostatitis and/or prostatic hyperplasia. 60 patients with the semen liquefaction time of more than 30min aged 25-45 are randomly divided into 2 groups, each group has 30 patients, the composition is adopted in an experimental group, and the quinolone medicament levofloxacin is orally taken in a comparative example. Clinical test results show that the traditional Chinese medicine composition disclosed by the invention is used for treating prostatitis and prostatic hyperplasia in an enema mode, and after 60 days, the cure rate is as high as 93.3%, which is obviously higher than that of western medicines. Therefore, the traditional Chinese medicine composition has positive effects on the aspect of medicines for treating prostatitis and/or prostatic hyperplasia.
The sources of the raw materials are not particularly limited in the invention, and products sold in the field can be adopted.
The technical solutions provided by the present invention are described in detail below with reference to examples, but they should not be construed as limiting the scope of the present invention.
Example 1
Weighing 6g of radix clematidis, 12g of medicinal cyathula root, 12g of parasitic loranthus and 6g of liquorice, mixing, crushing, sieving by a 100-mesh sieve, and mixing with 24mL of boiled water at 40 ℃ for dissolving.
Example 2
Weighing 3g of clematis root, 8g of medicinal cyathula root, 8g of parasitic loranthus and 3g of liquorice, mixing, crushing, sieving with a 80-mesh sieve, and mixing with 11mL of boiled water with the temperature of 35 ℃ for dissolving.
Example 3
Weighing 10g of radix clematidis, 18g of radix cyathulae, 18g of parasitic loranthus and 10g of liquorice, mixing, crushing, sieving with a 150-mesh sieve, and mixing with 42mL of boiled water at 45 ℃ for dissolving.
Comparative example 1
Weighing 14.4g of medicinal cyathula root, 14.4g of parasitic loranthus and 7.2g of liquorice, mixing, crushing, sieving by a 100-mesh sieve, and mixing with 24mL of boiled water at 40 ℃ for dissolving.
Comparative example 2
Weighing 9g of radix clematidis, 18g of parasitic loranthus and 9g of liquorice, mixing, crushing, sieving with a 100-mesh sieve, and mixing with 24mL of boiled water at 40 ℃ for dissolving.
Comparative example 3
Weighing 9g of radix clematidis, 18g of radix cyathulae and 9g of liquorice, mixing, crushing, sieving with a 100-mesh sieve, and mixing with 24mL of boiled water at 40 ℃ for dissolving.
Example 4
Prostatitis is the leading cause of no liquefaction of semen. Prostatitis is suffered from 90 percent of patients who do not liquefy semen. Semen does not liquefy and the sperm's free movement is affected. The movement of the sperms in the non-liquefied semen in the female genital tract is obviously hindered, and the sperms cannot go upwards to enter the cervical canal, the uterine cavity and the oviduct and meet the ovum, so that the fertilization is hindered. After the normal semen is ejected out of the body, the semen is in a thick jelly shape under the action of coagulase secreted by a seminal vesicle, and is liquefied and thinned under the action of fibrinolytic enzyme secreted by prostate after being ejected out of the body for 10-20 min. The optimal liquefaction time is as follows: less than 30min; the abnormal liquefaction refers to the phenomenon that the semen can not be completely liquefied or begins to be liquefied in more than one hour after the ejaculation, and can influence the movement of the semen and the fertilization. It includes no liquefaction of semen and delayed liquefaction of semen, which are commonly referred to as no liquefaction of semen. Semen liquefaction does not affect conception within 30min; the semen liquefaction for 30-60min is called semen liquefaction delay, the possibility of conception is existed, but the conception probability is reduced, and the longer the liquefaction time is, the lower the conception probability is; the semen is not liquefied after the semen begins to liquefy for more than 60min, and the conception probability is close to zero. Therefore, the present invention uses the semen liquefaction time exceeding 30min as a criterion for judging prostate diseases.
80 patients with semen liquefaction time of more than 30min in a county sister hospital aged 25-45 are randomly divided into 4 groups, each group has 20 patients, and the age, sex and severity of prostate disease of each group have no statistical difference.
The curative effect standard is as follows: the liquid can be liquefied within 30min for curing, the liquid can be liquefied within 30-60min for obvious effect, and the liquid can be liquefied only after 60min for ineffective effect.
Cure rate = number of heals/total number of treatments x 100%; the significant efficiency = the number of significant persons/the total number of treated persons × 100%; inefficiency = number of null/total number of treatments x 100%.
Treatment 1: example 1 enema treatment; the liquefaction time of 30-60min in the group is 15 cases, and the liquefaction time of more than 60min is 5 cases;
and (3) treatment 2: enema treatment with the composition of comparative example 2; the liquefaction time of 30-60min in the group is 14 cases, and the liquefaction time of more than 60min is 6 cases;
and (3) treatment: enema treatment with the composition of comparative example 3, where the liquefaction time was 30-60min for 14 cases and the liquefaction time was over 60min for 6 cases;
and (4) treatment: the composition enema of comparative example 4 was used for the treatment, and the liquefaction time was 13 cases at 30-60min and 7 cases at more than 60 min.
Each treatment enema is connected with an enema tube by a syringe for rectal perfusion once every two days, each time is 25g,10 times of a treatment course, the enema is not continued after one treatment course, a patient is rechecked after 30 days, and the results are counted, wherein the results are shown in table 1.
TABLE 1 Recall the results of the treatment effect (%), 30 days after the treatment of 1-4 groups
Treatment of | Cure rate | Display efficiency | Inefficiency of |
Example 1 | 80 | 15 | 5 |
Comparative example 1 | 5 | 65 | 30 |
Comparative example 2 | 15 | 55 | 30 |
Comparative example 3 | 15 | 50 | 35 |
As can be seen from table 1, the composition of the present invention can significantly improve the therapeutic effect of treating prostatitis and/or prostatic hyperplasia, compared to enema without adding clematis root, cyathula root, and loranthus parasiticus, respectively. Therefore, the clematis root, the medicinal cyathula root, the parasitic loranthus and the liquorice in the composition have the effect of synergistically treating the prostate diseases.
Example 5
60 patients with semen liquefaction time of more than 30min in a county sister hospital aged 25-45 are randomly divided into 2 groups, each group contains 30 patients, and the age, sex and severity of prostate disease of each group have no statistical difference.
And (4) treatment 5: example 1 enema treatment, enema is connected with an enema tube by a syringe for rectal perfusion once every two days, each time is 25g,10 times of treatment course; the liquefaction time of the group is 24 cases within 30-60min, and the liquefaction time exceeds 60min and is 6 cases;
and (6) treatment: orally taking the quinolone drug levofloxacin, 0.5 g/day, 20 days as a treatment course; the liquefaction time of the group is 25 cases at 30-60min, and the liquefaction time of the group is 5 cases at more than 60 min.
The criteria for efficacy are the same as in example 4.
Treatment 5 and treatment 6 were not continued after one treatment period, and the patients were reviewed after 30 days and 60 days, respectively, and the results were counted, as shown in table 2.
Table 2 Recall the results of the treatment effect after 30 days and 60 days (%)
Although oral antibiotics can grow bacteria and can treat prostate diseases in a short time, the oral antibiotics can not completely kill the bacteria, the bacteria are reduced during taking the medicine, the disease condition is relieved, the bacteria grow and reproduce after stopping taking the medicine, the disease condition is aggravated, the diseases are repeated, the regenerated bacteria generate drug resistance to the antibiotics, the medicine dosage needs to be increased or other types of antibiotics need to be replaced or the antibiotics of different types need to be combined in the next treatment, and the repeated attack of chronic inflammation can not be radically cured. As can be seen from Table 2, the cure rate is 36.7% when the treatment 6 is stopped for 10 days, and the cure rate is reduced to 3.3% after the treatment is stopped, so that the oral antibiotics have the defects of difficult control of the disease condition and incapability of radical treatment. Compared with orally taken quinolone drug levofloxacin, the composition of the invention has better effect on treating prostate diseases.
Case 1
When a man is in 36 years old, the man suffers from infertility, has the problems of low sperm quantity, low vitality and the like, the semen is not completely liquefied within 50min, the enema is used for 10 times by the method for 2021-1-2, the examination is repeated within 20 days, the semen is completely liquefied within 30min, the sperm quantity is increased, the vitality is improved, the examination is repeated after 30 days of stopping the medicine, the recurrence is avoided, and the wife can be diagnosed with pregnancy for 6 weeks after 2022-7-9.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and amendments can be made without departing from the principle of the present invention, and these modifications and amendments should also be considered as the protection scope of the present invention.
Claims (8)
1. A traditional Chinese medicine composition for treating prostatitis and/or prostatic hyperplasia is characterized by comprising the following raw materials in parts by weight: 3-10 parts of clematis root, 8-18 parts of medicinal cyathula root, 8-18 parts of parasitic loranthus and 3-10 parts of liquorice.
2. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 4-8 parts of clematis root, 10-15 parts of medicinal cyathula root, 10-15 parts of parasitic loranthus and 4-8 parts of liquorice.
3. The composition of claim 1 or 2, wherein the composition is in the form of an enema.
4. The Chinese medicinal composition as claimed in claim 3, wherein the preparation method of the enema comprises: pulverizing the Chinese medicinal composition, and mixing with water.
5. The Chinese medicinal composition according to claim 4, wherein the pulverized particle size is 80-150 mesh.
6. The Chinese medicinal composition according to claim 4, wherein the mass-to-volume ratio of the Chinese medicinal composition to water is (10-20): (5-15) g/mL.
7. The Chinese medicinal composition according to claim 4, wherein the temperature of the water is 35-45 ℃.
8. Use of the Chinese medicinal composition of any one of claims 1-7 in the preparation of a medicament for treating prostatitis and/or prostatic hyperplasia.
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101569699A (en) * | 2009-06-10 | 2009-11-04 | 张洪瀑 | Pharmaceutical composition for treating prostatitis and preparation method thereof |
CN104043087A (en) * | 2014-06-25 | 2014-09-17 | 梁黎明 | Traditional Chinese medicine composition for treating Raynaud syndrome |
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Publication number | Priority date | Publication date | Assignee | Title |
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CN101569699A (en) * | 2009-06-10 | 2009-11-04 | 张洪瀑 | Pharmaceutical composition for treating prostatitis and preparation method thereof |
CN104043087A (en) * | 2014-06-25 | 2014-09-17 | 梁黎明 | Traditional Chinese medicine composition for treating Raynaud syndrome |
Non-Patent Citations (1)
Title |
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王修锋: "中药内外合治慢性前列腺炎87例", 甘肃中医学院学报 * |
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