CN101569695A - Medicament composition for curing cardiovascular and cerebrovascular diseases - Google Patents
Medicament composition for curing cardiovascular and cerebrovascular diseases Download PDFInfo
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- CN101569695A CN101569695A CNA2008101053867A CN200810105386A CN101569695A CN 101569695 A CN101569695 A CN 101569695A CN A2008101053867 A CNA2008101053867 A CN A2008101053867A CN 200810105386 A CN200810105386 A CN 200810105386A CN 101569695 A CN101569695 A CN 101569695A
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- salviae miltiorrhizae
- stigma croci
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Abstract
The invention discloses a medicament composition for curing cardiovascular and cerebrovascular diseases, which is characterized by comprising saffron, panax notoginseng and Salvia miltiorrhiza, wherein the saffron is a monarch drug, and the panax notoginseng and the Salvia miltiorrhiza are ministerial drugs; and the saffron, the panax notoginseng and the Salvia miltiorrhiza are all 1-10 according to the parts by weight. The pharmacological experiment proves that the medicament composition has better pharmacological action than the prior preparation.
Description
Technical field
The present invention relates to medical technical field, be specifically related to a kind of pharmaceutical composition, promptly comprise the pharmaceutical composition of Stigma Croci, Radix Notoginseng, Radix Salviae Miltiorrhizae;
Background technology
Cardiovascular and cerebrovascular disease seizes up to ten million people's life every year, become the No.1 formidable enemy of human health, today in the world, cardiovascular and cerebrovascular disease kills more people than other any diseases, and millions upon millions of people are disabled, along with social senilization and growth in the living standard, the sickness rate and the case fatality rate of cerebrovascular disease rise day by day, the investigation that comprises both developed and developing country in 8 major areas, the whole world shows that ischemic heart desease and cerebrovascular disease have become the main cause of death.As in the U.S., cardiovascular and cerebrovascular disease far surpasses cancer, accounts for 42% of whole death, becomes underlying cause of death.In China, there are 1.1 hundred million people to suffer from cerebrovascular disease approximately, 7,000 ten thousand people suffer from cerebral infarction or cerebral hemorrhage, and the philtrum more than 40 years old has 57% people to suffer from various degree cerebrovascular disease approximately.Cerebrovascular disease also becomes one of old people's common frdquently encountered disease, cerebral infarction especially, and prevalence is up to 491.8/10 ten thousand people, apparently higher than western countries.Therefore, the medicine of exploitation treatment cardiovascular and cerebrovascular disease is medical worker's the most important thing.
Consult document, though the report that has medical material compatibilities such as Stigma Croci, Radix Notoginseng, Radix Salviae Miltiorrhizae to use does not find with the Stigma Croci to be monarch drug, Radix Notoginseng, Radix Salviae Miltiorrhizae are ministerial drug, the report that compatibility uses.
Summary of the invention
For these reasons, our scientific research personnel is monarch drug by the modern Chinese medicine theory with the Stigma Croci, and Radix Notoginseng, Radix Salviae Miltiorrhizae are ministerial drug, and other Chinese medicine of compatibility is formed pharmaceutical composition; Pharmacological evaluation shows that pharmaceutical composition of the present invention and preparation are according to the effect that good treatment cardiovascular and cerebrovascular disease is arranged.
The present invention is achieved through the following technical solutions.
A kind of pharmaceutical composition for the treatment of cardiovascular and cerebrovascular disease, it comprises Stigma Croci, Radix Notoginseng, Radix Salviae Miltiorrhizae.
Stigma Croci 1-10 weight portion wherein, Radix Notoginseng 1-10 weight portion, Radix Salviae Miltiorrhizae 1-10 weight portion.
Pharmaceutical composition also comprises Rhizoma Chuanxiong, Borneolum Syntheticum.Can also comprise medicines such as Radix Ginseng, the Radix Astragali, Flos Carthami.
Wherein preparation of pharmaceutical compositions becomes tablet, capsule, granule, soft capsule, pellet, drop pill, oral liquid.
Wherein the preparation method of tablet, capsule, granule, soft capsule, pellet, drop pill, oral liquid also can be prepared according to following method for being prepared according to prior art:
Get Stigma Croci, Radix Notoginseng, Radix Salviae Miltiorrhizae, pulverize, use the 50%-95% ethanol extraction, extracting solution concentrates, and drying obtains dry thing;
Above-mentioned dry thing mixes, and is prepared according to the conventional dose requirement of tablet, capsule, granule, soft capsule, pellet, drop pill, oral liquid.
One, pharmacological evaluation
Experiment 1
Protective effect to rat cerebral infarction
Experiment medicine: pharmaceutical composition of the present invention; XUESHUANTONG PIAN;
Laboratory animal: SD rat, 250-300g, male and female half and half.
Experimental technique: get rat, chloral hydrate 300mg/kgip anesthesia, cervical incision, separate and the ligation right carotid, behind the suture muscles skin, right lateral position is fixed, and cuts skin at auris dextra and right eye outer canthus line mid point, separate temporalis, expose zygomatic process and temporal bone, open the bone window of about a 3 * 3mm at head end 1～2mm place of zygomatic process, expose middle cerebral artery (MCA), it is disconnected that MCA is burnt, and sews up the incision.With reference to the administration of Bederson method, put to death animal, get right cerebral hemisphere, be cut into 5, place 37 ℃ of incubation 15min dyeing of 2g/LNPT, the white infarct cerebral tissue that carefully takes and weigh and do not dyed blue color, experimental result sees Table 1.
Table 1 different pharmaceutical is protected situation to rat cerebral infarction
Annotate: compare with the normal saline group
*P＜0.01; Compare #P＜0.05 with the XUESHUANTONG PIAN group
Experiment 2
To the protective effect of Cor Canitis myocardial ischemia
Laboratory animal: Beagle Canis familiaris L., body weight 7.5-10kg.
Experiment medicine: pharmaceutical composition of the present invention; FUFANG DANSHEN DIWAN;
Proved recipe method: get experimental dogs, be divided into the normal saline group, Composite Salvia Dropping Pill group, pharmaceutical composition group of the present invention, administration group gastric infusion, the each 300mg/kg of pharmaceutical composition dosage of the present invention, Composite Salvia Dropping Pill group dosage 300mg/kg, normal saline groups etc. are held inequality, administration every day 3 times, successive administration 7 days, administration are used pentobarbital sodium 25mg/kg intravenous anesthesia, tracheal intubation after the 7th day, connect artificial respirator positive pressure respiration in addition, the 5th rib is opened breast from the left side, cuts off pericardium, exposes heart, the pericardial incision edge is sewn in thoracic wall, divide the second stage of ligation at ramus descendens anterior arteriae coronariae sinistrae, and slow iv lignocaine 8mg/kg is in case the ventricular fibrillation that may cause before the ligation is sewed up pericardium and thoracic wall subsequently.24h behind the heart infarction, Canis familiaris L. is put to death after pentobarbital sodium anesthesia, take out heart rapidly, excision trunk and fatty tissue, check the position of anterior descending branch ligation point, claim heavy whole-heartedly, excise right ventricle and left atrium then, stay interventricular septum and left atrium, claim to such an extent that left ventricle is heavy, from the apex of the heart and beginning and anterior descending branch vertical direction left ventricle is cut into the thick flesh sheet of 2-3mm, be dipped in dyeing 30min in the nitro tetrazolium blue solution (NBT), cut ischemic region two cardiac muscular tissues and weigh the calculating myocardium infarction size, that is: heart infarction scope=ischemic region weight/left ventricle is heavy by * 100%, the results are shown in Table 2.
The influence of table 2 pair Cor Canitis chamber infarction size
Annotate: compare with the normal saline group,
*P＜0.01; Compare #P＜0.05 with the positive controls Composite Salvia Dropping Pill group
Experiment conclusion: show that by pharmacological evaluation pharmaceutical composition of the present invention and existing preparation relatively have better pharmacological action, prove absolutely that pharmaceutical composition of the present invention has practical significance.
Preparation embodiment
Embodiment 1
Stigma Croci 1 gram, Radix Notoginseng 1 gram, Radix Salviae Miltiorrhizae 1 gram;
Get Stigma Croci, Radix Notoginseng, Radix Salviae Miltiorrhizae, pseudo-ginseng, pulverize, 50% ethanol extraction, the extracting solution concentrate drying is pulverized, and is prepared into tablet, capsule, granule, pellet, drop pill, oral liquid according to the conventional requirement of pharmaceutics.
Embodiment 2
Stigma Croci 10 grams, Radix Notoginseng 10 grams, Radix Salviae Miltiorrhizae 10 grams;
Get Stigma Croci, Radix Notoginseng, Radix Salviae Miltiorrhizae, medical material, pulverize, 95% ethanol extraction, the extracting solution concentrate drying, pulverize standbyly, Lignum Dalbergiae Odoriferae extracts volatile oil, volatile oil beta cyclodextrin inclusion compound, clathrate mixes with above-mentioned standby extract, is prepared into tablet, capsule, granule, pellet, drop pill, oral liquid according to the conventional requirement of pharmaceutics.
Embodiment 3
Stigma Croci 8 grams, Radix Notoginseng 2 grams, Radix Salviae Miltiorrhizae 7 grams;
Get Stigma Croci, Radix Notoginseng, Radix Salviae Miltiorrhizae, medical material, pulverize, 60% ethanol extraction, the extracting solution concentrate drying is pulverized, and mixes with Moschus, is prepared into tablet, capsule, granule, pellet, drop pill, oral liquid according to the conventional requirement of pharmaceutics.
Embodiment 4
Stigma Croci 3 grams, Radix Notoginseng 9 grams, Radix Salviae Miltiorrhizae 5 grams, Herb Gynostemmae Pentaphylli 2 grams, Radix Panacis Quinquefolii 1 gram, Semen Ginkgo 2 grams;
Get Stigma Croci, Radix Notoginseng, Radix Salviae Miltiorrhizae, Herb Gynostemmae Pentaphylli, Radix Panacis Quinquefolii, Semen Ginkgo medical material, pulverize, 75% ethanol extraction, the extracting solution concentrate drying is pulverized, and is prepared into tablet, capsule, granule, pellet, drop pill, oral liquid according to the conventional requirement of pharmaceutics.
Embodiment 5
Stigma Croci 100 grams, Radix Notoginseng 100 grams, Radix Salviae Miltiorrhizae 100 grams, Rhizoma Chuanxiong 100 grams, Borneolum Syntheticum 1 gram
Get Stigma Croci, Radix Notoginseng, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, pulverize, use 50% ethanol extraction, extracting solution concentrates, and drying obtains dry thing;
Get Borneolum Syntheticum, beta-cyclodextrin inclusion compound mixes Borneolum Syntheticum clathrate, above-mentioned dry thing, is prepared according to the conventional dose requirement of tablet, capsule, granule, soft capsule, pellet, drop pill, oral liquid.
Embodiment 6
Stigma Croci 1000 grams, Radix Notoginseng 1000 grams, Radix Salviae Miltiorrhizae 1000 grams, Rhizoma Chuanxiong 1000 grams, Borneolum Syntheticum 20 grams
Get Stigma Croci, Radix Notoginseng, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, pulverize, use 95% ethanol extraction, extracting solution concentrates, and drying obtains dry thing;
Get Borneolum Syntheticum, beta-cyclodextrin inclusion compound mixes Borneolum Syntheticum clathrate, above-mentioned dry thing, is prepared according to the conventional dose requirement of tablet, capsule, granule, soft capsule, pellet, drop pill, oral liquid.
Embodiment 7
Stigma Croci 900 grams, Radix Notoginseng 150 grams, Radix Salviae Miltiorrhizae 200 grams, Rhizoma Chuanxiong 180 grams, Borneolum Syntheticum 12.2 grams;
Get Stigma Croci, Radix Notoginseng, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, pulverize, use 55% ethanol extraction, extracting solution concentrates, and drying obtains dry thing;
Get Borneolum Syntheticum, beta-cyclodextrin inclusion compound mixes Borneolum Syntheticum clathrate, above-mentioned dry thing, is prepared according to the conventional dose requirement of tablet, capsule, granule, soft capsule, pellet, drop pill, oral liquid.
Embodiment 8
Stigma Croci 300 grams, Radix Notoginseng 100 grams, Radix Salviae Miltiorrhizae 300 grams, Rhizoma Chuanxiong 300 grams, Borneolum Syntheticum 1 gram;
Get Stigma Croci, Radix Notoginseng, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, pulverize, use 85% ethanol extraction, extracting solution concentrates, and drying obtains dry thing;
Get Borneolum Syntheticum, beta-cyclodextrin inclusion compound mixes Borneolum Syntheticum clathrate, above-mentioned dry thing, is prepared according to the conventional dose requirement of tablet, capsule, granule, soft capsule, pellet, drop pill, oral liquid.
Embodiment 9
Stigma Croci 800 grams, Radix Notoginseng 500 grams, Radix Salviae Miltiorrhizae 800 grams;
Get Stigma Croci, Radix Notoginseng, Radix Salviae Miltiorrhizae, pulverize, use 90% ethanol extraction, extracting solution concentrates, and drying obtains dry thing;
Above-mentioned dry thing requires to be prepared according to the conventional dose of tablet, capsule, granule, soft capsule, pellet, drop pill, oral liquid.
Embodiment 10
Stigma Croci 750 grams, Radix Notoginseng 200 grams, Radix Salviae Miltiorrhizae 700 grams, Radix Ginseng;
Get Stigma Croci, Radix Notoginseng, Radix Salviae Miltiorrhizae, Radix Ginseng, pulverize, use 75% ethanol extraction, extracting solution concentrates, and drying obtains dry thing;
Above-mentioned dry thing mixes, and is prepared according to the conventional dose requirement of tablet, capsule, granule, soft capsule, pellet, drop pill, oral liquid.
Embodiment 11
Stigma Croci 350 grams, Radix Notoginseng 450 grams, Radix Salviae Miltiorrhizae 320 grams, the Radix Astragali, Flos Carthami
Get Stigma Croci, Radix Notoginseng, Radix Salviae Miltiorrhizae, the Radix Astragali, Flos Carthami, pulverize, use 50% ethanol extraction, extracting solution concentrates, and drying obtains dry thing;
Above-mentioned dry thing mixes, and is prepared according to the conventional dose requirement of tablet, capsule, granule, soft capsule, pellet, drop pill, oral liquid.
Embodiment 12
Stigma Croci 500 grams, Radix Notoginseng 300 grams, Radix Salviae Miltiorrhizae 500 grams, Rhizoma Chuanxiong, Radix Ginseng;
Get Stigma Croci, Radix Notoginseng, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Radix Ginseng, pulverize, use 60% ethanol extraction, extracting solution concentrates, and drying obtains dry thing;
Get Borneolum Syntheticum, beta-cyclodextrin inclusion compound, the blood dragon exhausts pulverizing, with Borneolum Syntheticum clathrate, blood dragon exhaust ground product, above-mentioned dry thing mixes, be prepared according to the conventional dose requirement of tablet, capsule, granule, soft capsule, pellet, drop pill, oral liquid.
Embodiment 12
Stigma Croci 500 grams, Radix Notoginseng 300 grams, Radix Salviae Miltiorrhizae 500 grams, Rhizoma Chuanxiong 300 grams, Borneolum Syntheticum 5 grams, Sanguis Draxonis 20 grams;
Get Stigma Croci, Radix Notoginseng, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, pulverize, use 65% ethanol extraction, extracting solution concentrates, and drying obtains dry thing;
Get Borneolum Syntheticum, beta-cyclodextrin inclusion compound, the blood dragon exhausts pulverizing, with Borneolum Syntheticum clathrate, blood dragon exhaust ground product, above-mentioned dry thing mixes, be prepared according to the conventional dose requirement of tablet, capsule, granule, soft capsule, pellet, drop pill, oral liquid.
Embodiment 12
Stigma Croci 250 grams, Radix Notoginseng 550 grams, Radix Salviae Miltiorrhizae 150 grams, Rhizoma Chuanxiong 250 grams, Borneolum Syntheticum 6 grams, Sanguis Draxonis 12 grams;
Get Stigma Croci, Radix Notoginseng, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, pulverize, use 60% ethanol extraction, extracting solution concentrates, and drying obtains dry thing;
Above-mentioned dry thing mixes, and is prepared according to the conventional dose requirement of tablet, capsule, granule, soft capsule, pellet, drop pill, oral liquid.
Embodiment 13
Stigma Croci 900 grams, Radix Notoginseng 540 grams, Radix Salviae Miltiorrhizae 950 grams, Radix Ginseng, the Radix Astragali;
Get Stigma Croci, Radix Notoginseng, Radix Salviae Miltiorrhizae, Radix Ginseng, the Radix Astragali, pulverize, use 95% ethanol extraction, extracting solution concentrates, and drying obtains dry thing;
Above-mentioned dry thing mixes, and is prepared according to the conventional dose requirement of tablet, capsule, granule, soft capsule, pellet, drop pill, oral liquid.
Embodiment 14
Stigma Croci 1000 grams, Radix Notoginseng 1000 grams, Radix Salviae Miltiorrhizae 1000 grams, the Rhizoma Anemarrhenae 390 grams;
Get Stigma Croci, Radix Notoginseng, Radix Salviae Miltiorrhizae, rhizoma ane marrhenae, pulverize, 75% ethanol extraction, the extracting solution concentrate drying is pulverized, and is prepared into tablet, capsule, granule, pellet, drop pill, oral liquid according to the conventional requirement of pharmaceutics.
Claims (5)
1, a kind of pharmaceutical composition for the treatment of cardiovascular and cerebrovascular disease is characterized in that it comprises Stigma Croci, Radix Notoginseng, Radix Salviae Miltiorrhizae.
2, pharmaceutical composition according to claim 1, Stigma Croci 1-10 weight portion wherein, Radix Notoginseng 1-10 weight portion, Radix Salviae Miltiorrhizae 1-10 weight portion.
3, pharmaceutical composition according to claim 1 and 2, pharmaceutical composition also comprises Rhizoma Chuanxiong, Borneolum Syntheticum.
4, according to claim 1,2 each described pharmaceutical compositions, wherein preparation of pharmaceutical compositions becomes tablet, capsule, granule, soft capsule, pellet, drop pill, oral liquid.
5, pharmaceutical composition according to claim 1 and 2, wherein the preparation method of tablet, capsule, granule, soft capsule, pellet, drop pill, oral liquid is:
Get Stigma Croci, Radix Notoginseng, Radix Salviae Miltiorrhizae, pulverize, use the 50%-95% ethanol extraction, extracting solution concentrates, and drying obtains dry thing;
Above-mentioned dry thing mixes, and is prepared according to the conventional dose requirement of tablet, capsule, granule, soft capsule, pellet, drop pill, oral liquid.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101053867A CN101569695A (en) | 2008-04-30 | 2008-04-30 | Medicament composition for curing cardiovascular and cerebrovascular diseases |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101053867A CN101569695A (en) | 2008-04-30 | 2008-04-30 | Medicament composition for curing cardiovascular and cerebrovascular diseases |
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| CN101569695A true CN101569695A (en) | 2009-11-04 |
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| CNA2008101053867A Pending CN101569695A (en) | 2008-04-30 | 2008-04-30 | Medicament composition for curing cardiovascular and cerebrovascular diseases |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103735617A (en) * | 2013-12-13 | 2014-04-23 | 王树林 | Compound red sage root orally-disintegrating tablet and preparation method thereof |
| CN103767966A (en) * | 2014-01-06 | 2014-05-07 | 洛阳市汉本草生物工程有限公司 | Whitening and tendering moisturizing essence |
| CN103948882A (en) * | 2014-02-27 | 2014-07-30 | 香港嘉峰医药血栓科技开发有限公司 | Traditional Chinese medicine for treating thrombus |
| CN107496876A (en) * | 2017-09-19 | 2017-12-22 | 韦家福 | A kind of eliminating embolism and invigorating blood circulation Chinese medicine preparation and preparation method thereof |
| CN107596273A (en) * | 2017-10-19 | 2018-01-19 | 山东省千佛山医院 | A kind of Chinese medicine composition for being used to treat cardiovascular and cerebrovascular |
| CN107714857A (en) * | 2017-12-01 | 2018-02-23 | 王章琳 | A kind of Chinese medicine composition for treating cardiovascular and cerebrovascular diseases and preparation method thereof |
| CN111973725A (en) * | 2020-08-31 | 2020-11-24 | 项城市贾岭镇沁园春颐养苑 | Compound medicine for treating cardiovascular and cerebrovascular diseases and preparation method thereof |
-
2008
- 2008-04-30 CN CNA2008101053867A patent/CN101569695A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103735617A (en) * | 2013-12-13 | 2014-04-23 | 王树林 | Compound red sage root orally-disintegrating tablet and preparation method thereof |
| CN103767966A (en) * | 2014-01-06 | 2014-05-07 | 洛阳市汉本草生物工程有限公司 | Whitening and tendering moisturizing essence |
| CN103767966B (en) * | 2014-01-06 | 2019-06-14 | 洛阳市汉本草生物工程有限公司 | Delicate moisturizing stoste |
| CN103948882A (en) * | 2014-02-27 | 2014-07-30 | 香港嘉峰医药血栓科技开发有限公司 | Traditional Chinese medicine for treating thrombus |
| CN107496876A (en) * | 2017-09-19 | 2017-12-22 | 韦家福 | A kind of eliminating embolism and invigorating blood circulation Chinese medicine preparation and preparation method thereof |
| CN107596273A (en) * | 2017-10-19 | 2018-01-19 | 山东省千佛山医院 | A kind of Chinese medicine composition for being used to treat cardiovascular and cerebrovascular |
| CN107714857A (en) * | 2017-12-01 | 2018-02-23 | 王章琳 | A kind of Chinese medicine composition for treating cardiovascular and cerebrovascular diseases and preparation method thereof |
| CN111973725A (en) * | 2020-08-31 | 2020-11-24 | 项城市贾岭镇沁园春颐养苑 | Compound medicine for treating cardiovascular and cerebrovascular diseases and preparation method thereof |
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Open date: 20091104 |