CN101537054A - Preparation capable of clearing blood and softening pulse, tonifying heart and protecting brain and adjusting blood fat and blood pressure, and preparation method thereof - Google Patents

Preparation capable of clearing blood and softening pulse, tonifying heart and protecting brain and adjusting blood fat and blood pressure, and preparation method thereof Download PDF

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Publication number
CN101537054A
CN101537054A CN200910061799A CN200910061799A CN101537054A CN 101537054 A CN101537054 A CN 101537054A CN 200910061799 A CN200910061799 A CN 200910061799A CN 200910061799 A CN200910061799 A CN 200910061799A CN 101537054 A CN101537054 A CN 101537054A
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blood
preparation
extract
ligustri lucidi
fructus ligustri
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CN200910061799A
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李翔
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Wuhan Daidaimu Biological Sci & Tech Co Ltd
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Individual
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Abstract

The invention discloses a preparation capable of clearing blood and softening pulse, tonifying heart and protecting brain and adjusting blood fat and blood pressure, and a preparation method thereof. The preparation is made from a glossy privet fruit extract, a lotus leaf extract, hawthorn fruit, cassia seed, prepared fleece flower root and red sage root. The preparation method comprises the following steps: the glossy privet fruit extract and the lotus leaf extract are prepared by a pure enzymolysis method and blended at high temperature; the hawthorn fruit, the cassia seed, the prepared fleece flower root and the red sage root are dried up, crushed and mixed; and the mixed mixture of the glossy privet fruit extract and the lotus leaf extract is mixed together with mixed powder thereof, and an obtained mixture is distilled by a flask and a condensation tube and added with an adjuvant for preparing a capsule to prepare the capsule. The pure enzymolysis method is adopted to prepare the glossy privet fruit extract and the lotus leaf extract, thus maximally keeping active ingredients thereof and being capable of improving medicinal value thereof. The preparation has the advantages of being capable of softening blood vessels, improving blood circulation, clearing the blood and softening the pulse, quickening lipid metabolism, adjusting the blood fat and the blood pressure and tonifying the heart and protecting the brain.

Description

Preparation of a kind of energy clearing blood and softening pulse, tonifying heart and protecting brain, blood lipid regulation blood pressure and preparation method thereof
Technical field
The present invention relates to preparation of a kind of energy clearing blood and softening pulse, tonifying heart and protecting brain, blood lipid regulation blood pressure and preparation method thereof.
Background technology
Fructus Ligustri Lucidi always is regarded as first-class good medicine, has the effect of cholesterol reducing.Traditional instructions of taking is that it grind into powder is directly edible, because its serum cholesterol content and serum triglycerides content are obviously reduced. to the consumption that is formed with of the formation of experimental aorta lipid speckle and crown atherosclerotic plaque. there is report to point out, oleanolic acid has the effect that atherosclerosis forms that suppresses. the salt acidolysis water law of continuing to use in the past, shortcoming is that reaction is violent, complex process, production cycle is long, and loss of effective components is big.
Now the medicine of making blood fat-reducing blood pressure-decreasing with Fructus Ligustri Lucidi, Folium Nelumbinis has " a kind of lipid lowerers " (Chinese patent application number 96102687), is that Rhizoma Polygoni Cuspidati, Radix Curcumae, Pericarpium Citri, Folium Nelumbinis, Fructus Crataegi, Radix Astragali, Fructus Schisandrae Chinensis, Rhizoma Atractylodis Macrocephalae (parched), Fructus Ligustri Lucidi, Herba Cistanches, Herba Epimedii, Radix Et Rhizoma Rhei, the above component of Rhizoma Alismatis are formed via pulverizing, mix, decoct, concentrating." a kind of powder for lowering lipid and reducing obesity " (Chinese patent application number 97106087) is to be prepared from by Folium Nelumbinis, Fructus Crataegi, Poria, Herba Epimedii, Radix Salviae Miltiorrhizae, the Radix Polygoni Multiflori, Semen Coicis, Fructus Ligustri Lucidi, the Rhizoma Atractylodis Macrocephalae, Semen Cassiae and fructus zizaniae caduciflorae." a kind of Chinese herbal medicine that prevents to effect a radical cure hypertension " (Chinese patent application number 200410010340) made by rice vinegar, Mel, Sucus Zingberis, Succus Bambusae, Folium Nelumbinis, Fructus Ligustri Lucidi (processed with vinegar), Magnetitum (processed with vinegar) etc.
Summary of the invention
The objective of the invention is at above-mentioned present situation, aim to provide preparation of a kind of energy clearing blood and softening pulse, tonifying heart and protecting brain, blood lipid regulation blood pressure and preparation method thereof.
The implementation of the object of the invention is that the preparation of a kind of energy clearing blood and softening pulse, tonifying heart and protecting brain, blood lipid regulation blood pressure is made up of following components by weight proportion:
Fructus Ligustri Lucidi extract 5-7 Folium Nelumbinis extract 5-7
Fructus Crataegi 8-12 Semen Cassiae 5-7
Radix Polygoni Multiflori Preparata 5-7 Radix Salviae Miltiorrhizae 8-12.
The preparation method of a kind of energy clearing blood and softening pulse, tonifying heart and protecting brain blood lipid regulation blood pressure preparation, concrete steps are as follows:
1) preparation of Fructus Ligustri Lucidi extract:
1. Fructus Ligustri Lucidi is cleaned,
2. Fructus Ligustri Lucidi is put into container, press the thing amount, add two parts of CHCL for a 3: CH 3OH=1: 2 mix reagent, stir half an hour, add a CHCL 3, stirred again one hour, add a distilled water again, stirred one hour,
3. vacuum filtration, and use 30%CHCL 3Wash residue once more,
4. filtrate places vacuum, and 30~40 ℃ of constant temperature, daylight lamp shine down, treat CHCL 3, CH 3OH volatilizees fully, and high temperature is isolated docosahexaenoic acid and eicosapentaenoic acid highly unsaturated fatty acid again,
5., separating obtained docosahexenoic acid and eicosapentaenoic acid highly unsaturated fatty acid are placed in the sterilizing room, disinfection by ultraviolet light sterilization 3-5 hour,
6. extract and add the dense HCL of equivalent in filtering residue and the layering funnel upper solution water solublity product, fully reaction, HCL volatilization, get the water solublity product, alkaline solution is transferred pH value 6.5-7.5, gets the protein precipitation layer, amount by the 0.8-1.2% of protein precipitation amount adds protease, places vacuum, 58-65 ℃ of constant temperature, hydrolysis 24 hours, sucking filtration, concentrate, carry out nitrogen content and measure, nitrogen content surpasses 2.4%, disinfection by ultraviolet light sterilization 3-5 hour, get Fructus Ligustri Lucidi extract
2) extracting method by Fructus Ligustri Lucidi extract prepares Folium Nelumbinis extract,
3) get 5-7g Fructus Ligustri Lucidi extract, 2-7g Folium Nelumbinis extract 80-100 ℃ of fusion,
4) get 5-7g Fructus Crataegi, 5-7g Semen Cassiae, 5-7g Radix Polygoni Multiflori Preparata, 8-12g Radix Salviae Miltiorrhizae and dry, pulverize, mix,
5) Fructus Ligustri Lucidi extract of step 3) gained and the mixing fusions of Folium Nelumbinis extract and the mixture of step 4) gained are mixed, distill, add the capsular adjuvant of system and make capsule by flask and condensing tube.
The present invention extracts Fructus Ligustri Lucidi extract, Folium Nelumbinis extract with pure enzymatic isolation method, has preserved effective ingredient wherein to greatest extent, can fully improve its medical value.This preparation energy energy vessel softening improves blood circulation, and clearing blood and softening pulse quickens lipid metabolism, and the blood lipid regulation blood pressure can tonifying heart and protecting brain.
The specific embodiment
This preparation is made up of Fructus Ligustri Lucidi extract, Folium Nelumbinis extract, Fructus Crataegi, Semen Cassiae, Radix Polygoni Multiflori Preparata and Radix Salviae Miltiorrhizae.This pharmaceutical formulation is reasonable, wherein Fructus Ligustri Lucidi extract energy cholesterol reducing; The blood fat reducing of Folium Nelumbinis energy, antiviral; Fructus Crataegi has the effect of anti-cancer, anticancer, heart tonifying, blood fat reducing, blood pressure lowering, and is can prevention of arterial atherosis, strengthens the function of heart; Semen Cassiae is often used in diseases such as treatment acute conjunctivitis, central retina choroiditis, hypertension, habitual constipation, hyperlipemia; The Radix Polygoni Multiflori has blood fat reducing, reduces the effect of thrombosis; Radix Polygoni Multiflori Preparata can increase coronary flow, reduce myocardial excitability; Radix Salviae Miltiorrhizae energy blood circulation promoting and blood stasis dispelling, the removing heat from blood eliminating carbuncle, relieving restlessness is calmed the nerves.The effect of share clearing blood and softening pulse, tonifying heart and protecting brain, blood lipid regulation blood pressure is better.
The concrete steps of the preparation method of this preparation are as follows:
1) preparation of Fructus Ligustri Lucidi extract:
1. Fructus Ligustri Lucidi is cleaned,
2. Fructus Ligustri Lucidi is put into container, press the thing amount, add two parts of CHCL for a 3: CH 3OH=1: 2 mix reagent, stir half an hour, add a CHCL 3, stirred again one hour, add a distilled water again, stirred one hour,
3. vacuum filtration, and use 30%CHCL 3Wash residue once more,
4. filtrate places vacuum, and 30~40 ℃ of constant temperature, daylight lamp shine down, treat CHCL 3, CH 3OH volatilizees fully, and high temperature is isolated docosahexaenoic acid and eicosapentaenoic acid highly unsaturated fatty acid again,
5., separating obtained docosahexenoic acid and eicosapentaenoic acid highly unsaturated fatty acid are placed in the sterilizing room, disinfection by ultraviolet light sterilization 3-5 hour,
6. extract and add the dense HCL of equivalent in filtering residue and the layering funnel upper solution water solublity product, fully reaction, HCL volatilization, get the water solublity product, alkaline solution is transferred pH value 6.5-7.5, gets the protein precipitation layer, amount by the 0.8-1.2% of protein precipitation amount adds protease, places vacuum, 58-65 ℃ of constant temperature, hydrolysis 24 hours, sucking filtration, concentrate, carry out nitrogen content and measure, nitrogen content surpasses 2.4%, disinfection by ultraviolet light sterilization 3-5 hour, get Fructus Ligustri Lucidi extract
2) extracting method by Fructus Ligustri Lucidi extract prepares Folium Nelumbinis extract
3) get 5-7g Fructus Ligustri Lucidi extract, 2-7g Folium Nelumbinis extract 80-100 ℃ of fusion,
4) get 5-7g Fructus Crataegi, 5-7g Semen Cassiae, 5-7g Radix Polygoni Multiflori Preparata, 8-12g Radix Salviae Miltiorrhizae and dry, pulverize, mix,
5) Fructus Ligustri Lucidi extract of step 3) gained and the mixing fusions of Folium Nelumbinis extract and the mixture of step 4) gained are mixed, distill, add the capsular adjuvant of system and make capsule by flask and condensing tube.

Claims (2)

1, the preparation of a kind of energy clearing blood and softening pulse, tonifying heart and protecting brain, blood lipid regulation blood pressure is characterized in that doing to be made up of following components by weight proportion:
Fructus Ligustri Lucidi extract 5-7 Folium Nelumbinis extract 5-7
Fructus Crataegi 8-12 Semen Cassiae 5-7
Radix Polygoni Multiflori Preparata 5-7 Radix Salviae Miltiorrhizae 8-12.
2, the preparation method of the described a kind of energy clearing blood and softening pulse of claim 1, tonifying heart and protecting brain blood lipid regulation blood pressure preparation is characterized in that concrete steps are as follows:
1) preparation of Fructus Ligustri Lucidi extract:
1. Fructus Ligustri Lucidi is cleaned,
2. Fructus Ligustri Lucidi is put into container, press the thing amount, add two parts of CHCL for a 3: CH 3OH=1: 2 mix reagent, stir half an hour, add a CHCL 3, stirred again one hour, add a distilled water again, stirred one hour,
3. vacuum filtration, and use 30%CHCL 3Wash residue once more,
4. filtrate places vacuum, and 30~40 ℃ of constant temperature, daylight lamp shine down, treat CHCL 3, CH 3OH volatilizees fully, and high temperature is isolated docosahexaenoic acid and eicosapentaenoic acid highly unsaturated fatty acid again,
5., separating obtained docosahexenoic acid and eicosapentaenoic acid highly unsaturated fatty acid are placed in the sterilizing room, disinfection by ultraviolet light sterilization 3-5 hour,
6. extract and add the dense HCL of equivalent in filtering residue and the layering funnel upper solution water solublity product, fully reaction, HCL volatilization, get the water solublity product, alkaline solution is transferred pH value 6.5-7.5, gets the protein precipitation layer, amount by the 0.8-1.2% of protein precipitation amount adds protease, places vacuum, 58-65 ℃ of constant temperature, hydrolysis 24 hours, sucking filtration, concentrate, carry out nitrogen content and measure, nitrogen content surpasses 2.4%, disinfection by ultraviolet light sterilization 3-5 hour, get Fructus Ligustri Lucidi extract
2) extracting method by Fructus Ligustri Lucidi extract prepares Folium Nelumbinis extract,
3) get 5-7g Fructus Ligustri Lucidi extract, 2-7g Folium Nelumbinis extract 80-100 ℃ of fusion,
4) get 5-7g Fructus Crataegi, 5-7g Semen Cassiae, 5-7g Radix Polygoni Multiflori Preparata, 8-12g Radix Salviae Miltiorrhizae and dry, pulverize, mix,
5) Fructus Ligustri Lucidi extract of step 3) gained and the mixing fusions of Folium Nelumbinis extract and the mixture of step 4) gained are mixed, distill, add the capsular adjuvant of system and make capsule by flask and condensing tube.
CN200910061799A 2009-04-29 2009-04-29 Preparation capable of clearing blood and softening pulse, tonifying heart and protecting brain and adjusting blood fat and blood pressure, and preparation method thereof Pending CN101537054A (en)

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Application Number Priority Date Filing Date Title
CN200910061799A CN101537054A (en) 2009-04-29 2009-04-29 Preparation capable of clearing blood and softening pulse, tonifying heart and protecting brain and adjusting blood fat and blood pressure, and preparation method thereof

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101904925A (en) * 2010-08-24 2010-12-08 苏丹 Traditional Chinese medicine composite for treating hyperlipidaemia
CN102920786A (en) * 2012-11-16 2013-02-13 武汉代代木生物科技有限公司 Method for preparing preparation capable of protecting liver, resisting tumors, reducing blood lipid and regulating immunity
CN103301220A (en) * 2013-05-19 2013-09-18 张家界金鲵生物工程股份有限公司 Traditional Chinese medicine for treating hyperlipidemia and preparation method thereof

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101904925A (en) * 2010-08-24 2010-12-08 苏丹 Traditional Chinese medicine composite for treating hyperlipidaemia
CN102920786A (en) * 2012-11-16 2013-02-13 武汉代代木生物科技有限公司 Method for preparing preparation capable of protecting liver, resisting tumors, reducing blood lipid and regulating immunity
CN103301220A (en) * 2013-05-19 2013-09-18 张家界金鲵生物工程股份有限公司 Traditional Chinese medicine for treating hyperlipidemia and preparation method thereof
CN103301220B (en) * 2013-05-19 2014-10-22 张家界金鲵生物工程股份有限公司 Traditional Chinese medicine for treating hyperlipidemia and preparation method thereof

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Owner name: WUHAN DAIDAIMU BIOLOGICAL SCI. + TECH CO., LTD.

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Address before: 430070 Hubei Province, Wuhan city Wuchang District Wuluo Road No. 460 Golden Horse Home Furnishing 2709

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Application publication date: 20090923