CN101535312B - 吡咯并三嗪激酶抑制剂 - Google Patents
吡咯并三嗪激酶抑制剂 Download PDFInfo
- Publication number
- CN101535312B CN101535312B CN2007800405379A CN200780040537A CN101535312B CN 101535312 B CN101535312 B CN 101535312B CN 2007800405379 A CN2007800405379 A CN 2007800405379A CN 200780040537 A CN200780040537 A CN 200780040537A CN 101535312 B CN101535312 B CN 101535312B
- Authority
- CN
- China
- Prior art keywords
- alkyl
- substituted
- aryl
- group
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 *Nc1nc(Nc2n[n]c(C3CC3)c2)n[n]2c1ccc2 Chemical compound *Nc1nc(Nc2n[n]c(C3CC3)c2)n[n]2c1ccc2 0.000 description 4
- VFNAOKHYMBACPS-OCGAEPIXSA-N C[C@@H](c(cc1)ccc1F)NC1=NC(Nc2n[nH]c(C3CC3)c2)=NN(C)/C1=C\C Chemical compound C[C@@H](c(cc1)ccc1F)NC1=NC(Nc2n[nH]c(C3CC3)c2)=NN(C)/C1=C\C VFNAOKHYMBACPS-OCGAEPIXSA-N 0.000 description 1
- KSCXJMRUDMOOEN-LBPRGKRZSA-N C[C@@H](c(cc1)ccc1F)Nc1nc(Nc2n[nH]c(C3CC3)c2)n[n]2c1ccc2 Chemical compound C[C@@H](c(cc1)ccc1F)Nc1nc(Nc2n[nH]c(C3CC3)c2)n[n]2c1ccc2 KSCXJMRUDMOOEN-LBPRGKRZSA-N 0.000 description 1
- BSZGZNRUUJXKKQ-UHFFFAOYSA-N Clc1nc(Cl)n[n]2c1ccc2 Chemical compound Clc1nc(Cl)n[n]2c1ccc2 BSZGZNRUUJXKKQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86417506P | 2006-11-03 | 2006-11-03 | |
| US60/864,175 | 2006-11-03 | ||
| PCT/US2007/083436 WO2008057994A2 (en) | 2006-11-03 | 2007-11-02 | Pyrrolotriazine kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101535312A CN101535312A (zh) | 2009-09-16 |
| CN101535312B true CN101535312B (zh) | 2013-04-24 |
Family
ID=39365255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007800405379A Expired - Fee Related CN101535312B (zh) | 2006-11-03 | 2007-11-02 | 吡咯并三嗪激酶抑制剂 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7982033B2 (enExample) |
| EP (1) | EP2081936B1 (enExample) |
| JP (1) | JP5180967B2 (enExample) |
| CN (1) | CN101535312B (enExample) |
| NO (1) | NO20091374L (enExample) |
| WO (1) | WO2008057994A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2041138E (pt) | 2006-07-07 | 2014-10-07 | Bristol Myers Squibb Co | Inibidores de pirrolotriazina quinase |
| US8268998B2 (en) * | 2006-11-03 | 2012-09-18 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| CN102105150B (zh) | 2008-05-21 | 2014-03-12 | 阿里亚德医药股份有限公司 | 用作激酶抑制剂的磷衍生物 |
| JP5592890B2 (ja) * | 2008-10-08 | 2014-09-17 | ブリストル−マイヤーズ スクイブ カンパニー | ピロロトリアジンキナーゼ阻害剤 |
| TW201035100A (en) | 2008-12-19 | 2010-10-01 | Cephalon Inc | Pyrrolotriazines as ALK and JAK2 inhibitors |
| JP5093527B2 (ja) * | 2010-02-10 | 2012-12-12 | 日本電気株式会社 | 複合光導波路、波長可変フィルタ、波長可変レーザ、および光集積回路 |
| CA2809331C (en) * | 2010-08-27 | 2018-09-25 | Merck Patent Gmbh | Triazolopyrazine derivatives |
| CN103848833B (zh) * | 2012-11-28 | 2016-08-31 | 上海希迈医药科技有限公司 | 吡咯并三嗪类衍生物、其制备方法及其在医药上的应用 |
| RU2650512C2 (ru) | 2013-09-18 | 2018-04-16 | Бейджин Ханми Фармасьютикал Ко., Лтд. | Соединение, ингибирующее активности киназ ВТК и/или JAK3 |
| CN104974163B (zh) * | 2014-04-14 | 2017-11-07 | 广东东阳光药业有限公司 | 取代的杂芳基化合物及其组合物和用途 |
| FR3025717A1 (fr) * | 2014-09-16 | 2016-03-18 | Univ Lille Sciences Tech | Utilisation conjointe d'un inhibiteur de trka et d'un inhibiteur de epha2 pour une utilisation dans le traitement de cancers |
| WO2016190847A1 (en) * | 2015-05-26 | 2016-12-01 | Calitor Sciences, Llc | Substituted heteroaryl compounds and methods of use |
| WO2017004134A1 (en) * | 2015-06-29 | 2017-01-05 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000071129A1 (en) * | 1999-05-21 | 2000-11-30 | Bristol-Myers Squibb Company | Pyrrolotriazine inhibitors of kinases |
| WO2002040486A2 (en) * | 2000-11-17 | 2002-05-23 | Bristol-Myers Squibb Company | METHODS OF TREATING p38 KINASE-ASSOCIATED CONDITIONS AND PYRROLOTRIAZINE COMPOUNDS USEFUL AS KINASE INHIBITORS |
| WO2003090912A1 (en) * | 2002-04-23 | 2003-11-06 | Bristol-Myers Squibb Company | Pyrrolo-triazine aniline compounds useful as kinase inhibitors |
| US6982265B1 (en) * | 1999-05-21 | 2006-01-03 | Bristol Myers Squibb Company | Pyrrolotriazine inhibitors of kinases |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6670357B2 (en) | 2000-11-17 | 2003-12-30 | Bristol-Myers Squibb Company | Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors |
| AU2003265349A1 (en) | 2002-08-02 | 2004-02-23 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| CA2425123C (en) * | 2003-01-16 | 2010-09-21 | Decoma International Inc. | Lightweight composite tailgate |
| WO2008021859A1 (en) | 2006-08-09 | 2008-02-21 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| US7531539B2 (en) | 2006-08-09 | 2009-05-12 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| WO2008131050A1 (en) | 2007-04-18 | 2008-10-30 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
-
2007
- 2007-11-02 US US12/447,751 patent/US7982033B2/en active Active
- 2007-11-02 JP JP2009536401A patent/JP5180967B2/ja not_active Expired - Fee Related
- 2007-11-02 EP EP07844826.3A patent/EP2081936B1/en active Active
- 2007-11-02 WO PCT/US2007/083436 patent/WO2008057994A2/en not_active Ceased
- 2007-11-02 CN CN2007800405379A patent/CN101535312B/zh not_active Expired - Fee Related
-
2009
- 2009-04-03 NO NO20091374A patent/NO20091374L/no not_active Application Discontinuation
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000071129A1 (en) * | 1999-05-21 | 2000-11-30 | Bristol-Myers Squibb Company | Pyrrolotriazine inhibitors of kinases |
| US6982265B1 (en) * | 1999-05-21 | 2006-01-03 | Bristol Myers Squibb Company | Pyrrolotriazine inhibitors of kinases |
| WO2002040486A2 (en) * | 2000-11-17 | 2002-05-23 | Bristol-Myers Squibb Company | METHODS OF TREATING p38 KINASE-ASSOCIATED CONDITIONS AND PYRROLOTRIAZINE COMPOUNDS USEFUL AS KINASE INHIBITORS |
| WO2003090912A1 (en) * | 2002-04-23 | 2003-11-06 | Bristol-Myers Squibb Company | Pyrrolo-triazine aniline compounds useful as kinase inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| US20100081662A1 (en) | 2010-04-01 |
| NO20091374L (no) | 2009-07-21 |
| CN101535312A (zh) | 2009-09-16 |
| WO2008057994A2 (en) | 2008-05-15 |
| JP5180967B2 (ja) | 2013-04-10 |
| JP2010509348A (ja) | 2010-03-25 |
| US7982033B2 (en) | 2011-07-19 |
| WO2008057994A3 (en) | 2008-09-12 |
| EP2081936B1 (en) | 2014-04-02 |
| EP2081936A2 (en) | 2009-07-29 |
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| US8268998B2 (en) | Pyrrolotriazine kinase inhibitors |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130424 Termination date: 20161102 |