CN101530094A - Vitamin D reactive compound rodenticide and method of preparing the same - Google Patents
Vitamin D reactive compound rodenticide and method of preparing the same Download PDFInfo
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- CN101530094A CN101530094A CN200910097783A CN200910097783A CN101530094A CN 101530094 A CN101530094 A CN 101530094A CN 200910097783 A CN200910097783 A CN 200910097783A CN 200910097783 A CN200910097783 A CN 200910097783A CN 101530094 A CN101530094 A CN 101530094A
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- vitamin
- reactive compound
- rodenticide
- microcapsule raw
- attractant
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Abstract
The invention relates to rodenticide and method of preparing the same, aiming to provide a vitamin D reactive compound rodenticide and method of preparing the same. The rodenticid comprises vitamin D reactive compound microcapsule active compound and accessories; the active compound comprises core vitamin D reactive compound, grease, oil soluble emulsifying agent and wall materials. The preparing method comprises the steps of: (1) evenly mixing vitamin D reactive compound microcapsule active compound, attractant and water in appropriate amount; (2) adding the mixture into foodstuffs taking 80%-95% of the total amount of the rodenticide, fully stirring and kneading, pelleting and drying to obtain the product granular formulation. After microencapsulation processing the active compound, the prepared granular formulation products improve the stability, prolong the shelf life of the products, strengthen the palatability; the microencapsulation processing covers the bad orod and taste of the vitamin D reactive compound; and after microencapsulation processing, the active compound is easily dispered in water and has convenient use and is easier for using.
Description
Technical field
The present invention relates to a kind of rodenticide and preparation method thereof, particularly vitamin D reactive compound rodenticide and preparation method thereof.
Background technology
The plague of rats is the serious harm problem that exists in farmland, grassland, vegetable garden, orchard, forestry and plant, grain and food processing and store place, the dwelling house.Using the raticide agent is the important means of the control plague of rats.But at present the raticide agent toxicity of using is big, and easily secondary poisoning does not meet environment protection requirement, and country forbids that this class raticide agent uses in the pollution-free food production processing site.
The rodenticide that vitamin D reactive compound is formed, Environmental Protection Agency's registration in 1984 is made rodenticide and is used.It kills the mouse mechanism of action for by destroying the dynamic equilibrium of calcium in the muroid body, strengthens the absorption of small intestine to calcium, and the calcium in the bone is transferred in the serum, reduces the drainage of kidney to calcium simultaneously, cause blood mineral materialization, thereby the damage heart causes death muroid.Vitamin D reactive compound uses as rodenticide, kills the mouse spectrum extensively, and is all effective to mouse kinds such as house mouse, borwn rat, egyptian rats.State's external preparation has poison baits such as 0.075% granule, kind granula, dead in 3～5 days after once taking food or repeatedly taking food, vitamin D reactive compound is low to birds toxicity, no secondary poisoning phenomenon, to the person poultry safety, absorption to animal capable promotion calcium belongs to the necessary nutrition adding ingredient of people and animals, meets environment protection requirement.Because toxicity is low, so can be used for family, commerce area, farm, means of transport, harbour airport, reach the food processing place.And approval is used for organic farming, mouse is killed in the food production place.Existing American and Britain, Australia, add, developed country such as New Zealand all used for many years, developing countries such as India, Philippine have also introduced application, and register use in China.
By looking into new relevant patent both at home and abroad and document result demonstration, external at present existing patent report is used for rodenticide with vitamin D reactive compound to be used, and makes former medicine but not mentioned its vitamin D reactive compound carries out the microcapsules processing earlier.
Summary of the invention
The object of the present invention is to provide the raticide agent efficiently of a kind of green safety, not only can be used for the conventional mouse that kills, more can be used for the pollution-free food production processing site and kill mouse.In order to overcome deficiency of the prior art, the invention provides a kind of vitamin D reactive compound rodenticide and preparation method thereof.
Vitamin D reactive compound rodenticide provided by the invention comprises vitamin D reactive compound microcapsule raw medicine and auxiliary material;
Described vitamin D reactive compound microcapsule raw cartridge bag is drawn together core vitamin D reactive compound, grease, oil soluble emulsifying agent and wall material, and the scope of its weight percent content is:
Vitamin D reactive compound 0.1%～15%;
Grease 3%～30%;
Oil soluble emulsifying agent 0.5%～5%;
Wall material 50%～95%;
Described vitamin D reactive compound is a vitamin D
2, vitamin D
3, the 1a-hydroxy-vitamine D
3, 25-hydroxy-vitamin D
3Or 1,25-two dihydroxyvitamin Ds
3Wherein at least a;
Described wall material is any one or a few in maltodextrin, gum Arabic, carragheen, gelatin, casein, casein sodium, soybean protein or the modified starch;
Described auxiliary material comprises grain.
As a kind of improvement, the weight percent content of described vitamin D reactive compound is 0.1%～15%.
As a kind of improvement, described grease is edible oil or fat.
As a kind of improvement, described oil soluble emulsifying agent is any one or two kinds in glycerin monostearate, stearoyl lactate or the soybean lecithin.
As a kind of improvement, comprise that also weight percent content is 0.1%～2% antioxidant.
As a kind of improvement, described antioxidant is any one in BHT, BHA or the DL-alpha-tocopherol.
As a kind of improvement, described auxiliary material also comprises at least a in attractant or the white sugar.
The present invention also provides a kind of preparation method of vitamin D reactive compound rodenticide, may further comprise the steps:
(1) the described vitamin D reactive compound microcapsule raw of claim 1 medicine, attractant and suitable quantity of water are mixed; Vitamin D reactive compound microcapsule raw medicine accounts for 0.1%～5% of rodenticide gross weight, and attractant accounts for 0.1%～4% of gross weight;
(2) said mixture is joined in the grain that accounts for rodenticide gross weight 83%～95%, fully stir and mediate, behind granulating and drying, get the finished particle agent.
As a kind of improvement, abovementioned steps also comprises the step that adds white sugar in (1), and white sugar accounts for 1%～8% of rodenticide gross weight.
Among the present invention, also vitamin D reactive compound microcapsule raw medicine directly can be mixed the system use with grain.
Beneficial effect of the present invention is:
Compared with prior art, advantage of the present invention be mainly reflected in following some:
(1) former medicine is after microencapsulation is handled, and the stability of the granule product of making has obtained enhancing, has prolonged the shelf-life of product;
(2) palatability has obtained enhancing, because of handling through microencapsulation, has covered the bad smell and the mouthfeel of vitamin D reactive compound itself;
(3) former medicine easily is scattered in the water after microencapsulation is handled equably, uses conveniently, needn't dissolve easier promoting the use of with the solvent that peasant household is difficult to obtain.
Embodiment
Below by specific embodiment the present invention is described in further detail, but not as a limitation of the invention.
Among the present invention, the method for the vitamin D reactive compound microcapsules of preparation may further comprise the steps:
(1) with core vitamin D reactive compound, grease and oil soluble emulsifying agent as oil phase, the control temperature makes its dissolving and mixes at 50～70 ℃;
(2) add proper amount of deionized water in the wall material, its solid concentration is controlled between 40%～60%, stirring and dissolving, solution temperature are controlled at 50～90 ℃, with it as water;
(3) oil phase is joined aqueous phase, carry out homogeneous after the mixing and stirring, it is emulsified into the microcapsules that diameter is 1～100 μ m;
(4) microcapsules to step (3) gained carry out atomized drying, and EAT is controlled at 160 ℃～180 ℃, and outlet temperature is controlled at 80 ℃～95 ℃, and spraying forms vitamin D
3Microcapsules;
(5) sieve, mix, check, pack and make finished product.
The pressure of the homogenizing process in the step (3) is: first class pressure is 20～60MPa, and secondary pressure is 10～20MPa.
In the step (1), can also comprise the step of antioxidant, its weight percent content is 0.1%～2%, and described antioxidant is any one in BHT, BHA or the DL-alpha-tocopherol.
Described step (4) can also comprise the step that adds flowable tricalcium phosphate or silica afterwards, and its weight percent content is 0.5%～2%, to strengthen the flowability of microscapsule powder.
Embodiment 1
(1) will contain 7.5% vitamin D
3Vitamin D reactive compound microcapsule raw medicine 9g, white sugar 40g, attractant trace 1g put into 250g water to stir the back standby;
(2) get corn flour 850g, wheat flour 100g puts into container, and standby waterside edged is stirred until mixing;
(3), promptly get the rodenticide finished product after the drying with the material that mixes comminutor granulation.
Embodiment 2
To contain 15% vitamin D
3Vitamin D reactive compound microcapsule raw medicine 5g put into 250g water and stir, add rice 995g then, mix again, can use.
Embodiment 3
(1) will contain 5% vitamin D
2Vitamin D reactive compound microcapsule raw medicine 50g, white sugar 80g, attractant 40g put into 250g water stir the back standby;
(2) get paddy 830g and put into container, standby water even spraying on paddy, is promptly got the rodenticide finished product after the drying.
Embodiment 4
(1) will contain 5%1, the 25-dihydroxyvitamin D
3Vitamin D reactive compound microcapsule raw medicine 1g, white sugar 10g, attractant 40g put into 250g water stir the back standby;
(2) get paddy 949g and put into container, standby water even spraying on paddy, is promptly got the rodenticide finished product after the drying.
Embodiment 5
(1) will contain the 0.1%25-hydroxy-vitamine D
3Vitamin D reactive compound microcapsule raw medicine 25g, attractant 40g put into 250g water stir the back standby;
(2) get paddy 935g and put into container, standby water even spraying on paddy, is promptly got the rodenticide finished product after the drying.
Embodiment 6
(1) will contain the 5%1a-hydroxy-vitamine D
3Vitamin D reactive compound microcapsule raw medicine 25g, white sugar 45g, attractant 40g put into 250g water stir the back standby;
(2) get paddy 890g and put into container, standby water even spraying on paddy, is promptly got the rodenticide finished product after the drying.
Embodiment 7
To compare according to the variation that the stability of the several vitamins D reactive compound rodenticide of embodiment preparation and prior art products is measured its active component content (percentage composition of labelled amount) by accelerated test, accelerated test condition temperature is 40 ℃ ± 2 ℃, and relative moisture is 75%RH+5%RH.
Its result of the test is as shown in the table:
| Testing time | Embodiment 1 preparation contain vitamin D 3Vitamin D reactive compound rodenticide | Embodiment 5 preparation contain 25-hydroxy-vitamin D 3Vitamin D reactive compound rodenticide | Prior art products |
| 0 month | 101.2％ | 100.9％ | 101.1％ |
| 3 months | 100.5％ | 100.2％ | 78.2％ |
| 6 months | 99.8％ | 99.5％ | 65.1％ |
From table, can significantly find out, the vitamin D reactive compound rodenticide that the former medicine of this patent is made after microencapsulation is handled again, its stability has obtained very big enhancing.
Embodiment 8
Will be according to the vitamin D that contains of embodiment 1 preparation
3Vitamin D reactive compound rodenticide and conventional rodenticide 0.005% Bromadiolone granule do the farmland raticide and imitate comparative trial, its method and result are as follows:
Test method:
Test site is positioned at oranges and tangerines garden, rice gulf village, kind cities and towns, Jiangbei District, next-door neighbour village and rice field.
Mouse density measurement before method was done and killed August 1～2, the mousetrap adopts the medium size standard mousetrap, with the shelled peanut is bait, 54 of the mousetraps are placed in the every district of each treatment region respectively, keep certain distance (folder is apart from 25 meters of 10 meters * line-spacings) between folder and the folder, cloth clamp trapping two is put folder round the clock before the darkness continuously, receives folder morning next day.
August 4, above-mentioned poison bait is thrown in, throw in 10 Poison bait stations for every mu, every Poison bait station is placed 10 gram poison baits, every mu of consumption 100 grams.Receive poison bait afternoon August 8.
Did August 9～10 and kill back mouse density measurement, concrete operations are the same.
Result of the test:
From test effect: contain vitamin D
3Vitamin D reactive compound rodenticide to kill the mouse effect more satisfactory, what significantly be better than contrast medicament 0.005% Bromadiolone granule kills the mouse effect.
Embodiment 9
Will be according to embodiment 6 preparation contain the 1a-hydroxy-vitamine D
3Vitamin D reactive compound rodenticide do application test, its method and result are as follows:
Test method:
Testing ground: company dining room, staff quarters, warehouse
(1) mouse density survey before the test: investigation method adopts powder mark method.
(2) dispensing: in the trial stretch of determining, offer medicine each standard room (15m
2) bait 3 heaps of poisoning, the per 3～5m in big room or goods yard throws a pile.The every 5m of building external environment throws a pile.
(3) kill the mouse effect assessment: dispensing finishes back 15 days, carries out the mouse density survey once more, and statistics is killed the mouse effect.
Result of the test:
Result of the test shows that this rodenticide kills the mouse rate and reaches more than 90%, and the mouse effect is obvious extremely.
At last, it is also to be noted that, obviously the invention is not restricted to above embodiment, many distortion can also be arranged, all distortion that those of ordinary skill in the art can directly derive or associate from content disclosed by the invention all should be thought protection scope of the present invention.
Claims (9)
1, a kind of vitamin D reactive compound rodenticide comprises vitamin D reactive compound microcapsule raw medicine and auxiliary material;
Described vitamin D reactive compound microcapsule raw cartridge bag is drawn together core vitamin D reactive compound, grease, oil soluble emulsifying agent and wall material, and the scope of its weight percent content is:
Vitamin D reactive compound 0.1%～15%;
Grease 3%～30%;
Oil soluble emulsifying agent 0.5%～5%;
Wall material 50%～95%;
Described vitamin D reactive compound is a vitamin D
2, vitamin D
3, the 1a-hydroxy-vitamine D
3, 25-hydroxy-vitamin D
3Or 1, the 25-dihydroxyvitamin D
3Wherein at least a;
Described wall material is any one or a few in maltodextrin, gum Arabic, carragheen, gelatin, casein, casein sodium, soybean protein or the modified starch;
Described auxiliary material comprises grain.
2, vitamin D reactive compound rodenticide according to claim 1 is characterized in that, in the vitamin D reactive compound microcapsule raw medicine that described rodenticide comprises, the weight percent content of vitamin D reactive compound is 0.1%～15%.
3, vitamin D reactive compound rodenticide according to claim 1 is characterized in that, the grease in the vitamin D reactive compound microcapsule raw medicine that described rodenticide comprises is edible oil or fat.
4, vitamin D reactive compound rodenticide according to claim 1, it is characterized in that, in the vitamin D reactive compound microcapsule raw medicine that described rodenticide comprises, oil soluble emulsifying agent is any one or two kinds in glycerin monostearate, stearoyl lactate or the soybean lecithin.
5, vitamin D reactive compound rodenticide according to claim 1 is characterized in that, in the vitamin D reactive compound microcapsule raw medicine that described rodenticide comprises, comprises that also weight percent content is 0.1%～2% antioxidant.
6, vitamin D reactive compound rodenticide according to claim 5 is characterized in that, described antioxidant is any one in BHT, BHA or the DL-alpha-tocopherol.
According to described any one vitamin D reactive compound rodenticide of claim 1 to 6, it is characterized in that 7, described auxiliary material also comprises at least a in attractant or the white sugar.
8, a kind of preparation method of vitamin D reactive compound rodenticide may further comprise the steps:
(1) the described vitamin D reactive compound microcapsule raw of claim 1 medicine, attractant and suitable quantity of water are mixed; Vitamin D reactive compound microcapsule raw medicine accounts for 0.1%～5% of rodenticide gross weight, and attractant accounts for 0.1%～4% of gross weight;
(2) said mixture is joined in the grain that accounts for rodenticide gross weight 83%～95%, fully stir and mediate, behind granulating and drying, get the finished particle agent.
9, the preparation method of vitamin D reactive compound rodenticide according to claim 8 is characterized in that, described step also comprises the step that adds white sugar in (1), and white sugar accounts for 1%～8% of rodenticide gross weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910097783A CN101530094A (en) | 2009-04-21 | 2009-04-21 | Vitamin D reactive compound rodenticide and method of preparing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910097783A CN101530094A (en) | 2009-04-21 | 2009-04-21 | Vitamin D reactive compound rodenticide and method of preparing the same |
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| Publication Number | Publication Date |
|---|---|
| CN101530094A true CN101530094A (en) | 2009-09-16 |
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ID=41101111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200910097783A Pending CN101530094A (en) | 2009-04-21 | 2009-04-21 | Vitamin D reactive compound rodenticide and method of preparing the same |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106109443A (en) * | 2016-07-01 | 2016-11-16 | 武汉华扬动物药业有限责任公司 | A kind of animal ciprofloxacin slow-releasing microcapsule and preparation method thereof |
| CN106455546A (en) * | 2014-06-16 | 2017-02-22 | 巴斯夫农业公司 | Aqueous pesticide concentrates containing paraffinic oils and methods of use |
| CN109674062A (en) * | 2019-02-01 | 2019-04-26 | 浙江花园营养科技有限公司 | A kind of preparation method of stability vitamine D3 nano freeze-dried powder |
| CN111066786A (en) * | 2019-12-20 | 2020-04-28 | 广州市益高有害生物防治有限公司 | Vitamin D3 rice product for deratization, and preparation process and use method thereof |
| CN113875755A (en) * | 2021-12-09 | 2022-01-04 | 广州市益高有害生物防治有限公司 | Raticide, preparation method and putting method thereof |
-
2009
- 2009-04-21 CN CN200910097783A patent/CN101530094A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106455546A (en) * | 2014-06-16 | 2017-02-22 | 巴斯夫农业公司 | Aqueous pesticide concentrates containing paraffinic oils and methods of use |
| CN106109443A (en) * | 2016-07-01 | 2016-11-16 | 武汉华扬动物药业有限责任公司 | A kind of animal ciprofloxacin slow-releasing microcapsule and preparation method thereof |
| CN106109443B (en) * | 2016-07-01 | 2019-08-16 | 武汉华扬动物药业有限责任公司 | A kind of animal Ciprofloxacin Hydrochloride slow-releasing microcapsule and preparation method thereof |
| CN109674062A (en) * | 2019-02-01 | 2019-04-26 | 浙江花园营养科技有限公司 | A kind of preparation method of stability vitamine D3 nano freeze-dried powder |
| CN111066786A (en) * | 2019-12-20 | 2020-04-28 | 广州市益高有害生物防治有限公司 | Vitamin D3 rice product for deratization, and preparation process and use method thereof |
| CN113875755A (en) * | 2021-12-09 | 2022-01-04 | 广州市益高有害生物防治有限公司 | Raticide, preparation method and putting method thereof |
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Application publication date: 20090916 |