CN101520418B - Detection device and detection method - Google Patents
Detection device and detection method Download PDFInfo
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- CN101520418B CN101520418B CN200810006372XA CN200810006372A CN101520418B CN 101520418 B CN101520418 B CN 101520418B CN 200810006372X A CN200810006372X A CN 200810006372XA CN 200810006372 A CN200810006372 A CN 200810006372A CN 101520418 B CN101520418 B CN 101520418B
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- light
- pick
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- sample
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Abstract
A detection device is used for obtaining the concentration of a sample and includes a first detection unit, a signal regulation and control unit and a shell. The first detection unit detects the intensity of a light to be detected. The signal regulation and control unit calculates the intensity and modified value of the light to be detected and obtains the concentration of the sample according to the calculation result. The shell coats the first detection unit and the signal regulation and control unit. The modified value is related to the surrounding environment of the shell. The invention also provides a detection method used for obtaining the concentration of the sample in the shell.
Description
Technical field
The present invention relates to a kind of pick-up unit and method, especially relate to a kind of pick-up unit and method that is used to measure sample solution concentration.
Background technology
The method of existing measurement sensing substrate concentration is to use a kind of crystal vibrator.When detectable concentration, form in order to adsorb the adsorbed layer of sensing thing on the surface of crystal vibrator.Utilize the sensing thing to be attached on the adsorbed layer, the frequency that makes crystal probe changes with the adhesion amount of adsorbed layer, to obtain the concentration of sensing thing.
Along with the progress of science and technology, more detection mode is developed out.In existing medical detection mode, spectroanalysis instrument is a kind of instrument commonly used, when it utilizes light to penetrate a certain material, divides the light of wavelength to be carried out quantitative test to material by the principle of this material absorbing.Spectroanalysis instrument is learnt the concentration of this material according to the light that penetrates this material.Yet, when detecting,, will influence the analysis result of spectroanalysis instrument if when extra irradiate light is arranged to this material.
Summary of the invention
The invention provides a kind of pick-up unit,, and comprise first detecting unit, signal regulation and control unit and housing in order to the concentration of acquisition sample (specimen).First detecting unit detects the intensity of light to be measured.Signal regulation and control unit is calculated the intensity and the modified value of light to be measured, and obtains the concentration of sample according to result of calculation.Housing coats first detecting unit and signal regulation and control unit.Modified value is relevant with the environment around the housing.
Described housing in this pick-up unit has selector switch, and the user is switched described selector switch according to the environment of described pick-up unit.
Described signal regulation and control unit in this pick-up unit determines that according to the state of described selector switch the position of described modified value is accurate.
Described modified value in this pick-up unit is relevant with the light around the described housing.
Light described to be measured in this pick-up unit is sent by described sample.
In this pick-up unit, chemical substance is added in the described sample, just can make described sample send described light to be measured.
This pick-up unit also comprises light-emitting component, is arranged in the described housing, and when described light-emitting component shone described sample, the light of penetrable described sample was exactly described light to be measured.
Described first detecting unit in this pick-up unit also detects the light intensity around the described housing, to produce described modified value.
Described first detecting unit in this pick-up unit detects the light intensity around the described housing earlier, and then detects the intensity of described light to be measured.
Described housing in this pick-up unit has first light hole, can receive described housing light on every side.
Described first pick-up unit in this pick-up unit is arranged on the mapping position of described first light hole.
In this pick-up unit, when described first pick-up unit detected described light to be measured, described sample was arranged between described first light hole and described first pick-up unit.
Described housing in this pick-up unit also has second light hole, can receive described housing light on every side.
This pick-up unit also comprises second detecting unit, and described second detecting unit is arranged on the mapping position of described second light hole, in order to detect described housing light intensity on every side, to produce described modified value.
In this pick-up unit, when described first detecting unit detected the intensity of described light to be measured, described second detecting unit is the described housing of synchronous detection light intensity on every side also.
Described first detecting unit in the pick-up unit is Charged Coupled Device (Charge-coupled Device; CCD) or complementary metal oxide semiconductor (CMOS) (Complementary Metal-Oxide Semiconductor; CMOS).
The present invention also provides a kind of detection method, in order to obtain the concentration of the sample in the housing.Detection method comprises the following steps: to obtain modified value, and this modified value is relevant with the environment around this housing; According to this sample, obtain the intensity of light to be measured; Calculate intensity and this modified value of this light to be measured; And, obtain the concentration of this sample according to result of calculation.
Described modified value in this detection method is also relevant with the light around the described housing.
Modified value in this detection method and described light while to be measured or obtained in regular turn.
Light described to be measured in this detection method is sent by described sample.
For above and other objects of the present invention, feature and advantage can be become apparent, cited below particularlyly go out preferred embodiment, and conjunction with figs., be described in detail below.
Description of drawings
Fig. 1 is that of pick-up unit of the present invention may embodiment.
Fig. 2 is that of housing may embodiment.
Fig. 3 is another possibility embodiment of pick-up unit of the present invention.
Fig. 4 a～4e is the schematic appearance of housing.
Fig. 5 a～5d is another possibility embodiment of housing.
Fig. 6 is another possibility embodiment of pick-up unit of the present invention.
Fig. 7 a～7c is another possibility embodiment of housing.
Fig. 8 is another possibility embodiment of housing.
Fig. 9 is the process flow diagram of detection method of the present invention.
Embodiment
Fig. 1 is that of pick-up unit of the present invention may embodiment.Pick-up unit 110 is in order to the concentration of test samples 120.As shown in the figure, pick-up unit 110 comprises, detecting unit 111, signal regulation and control unit 112, housing 113, selector switch 114 and light-emitting component 115.Can utilize the sample box (not shown) to place sample 120.When the sample box with sample 120 inserted housing 113, pick-up unit 110 just can detect sample 120, in order to obtain the concentration of sample 120.
Detecting unit 111 detects light L to be measured
1Intensity.Detecting unit 111 can be Charged Coupled Device (Charge-coupled Device, CCD) or complementary metal oxide semiconductor (CMOS) (Complementary Metal-Oxide Semiconductor, CMOS).Detecting unit 111 detected light L to be measured
1From sample 120.In the present embodiment, light L to be measured
1Be the light that penetrates sample 120.When light-emitting component 115 irradiation samples 120, the light that penetrates sample 120 is light L to be measured
1
In other embodiments, light L to be measured
1Be the light that sample 120 is sent.When sample and chemical substance mix, just can send light L to be measured
1For example, if compound is added in the sample 120, just can produce hydrogen peroxide.Chemical change by hydrogen peroxide and tracer and peroxidase (peroxidase) just can produce cold light, fluorescence, visible light or ultraviolet light etc.Therefore, sample 120 just can be luminous.Tracer can be luminol (Luminol) or dimethyl indole (2-methyl Indole) etc.And can be mixing of uricase (Uricase), phosphatidase and choline enzyme or lipolytic enzyme and mixing of glycerine enzyme etc. with compound that sample produces hydrogen peroxide.
Signal regulation and control unit 112 is calculated light L to be measured
1Intensity and modified value, and obtain the concentration of sample 120 according to result of calculation, wherein modified value is relevant with housing 113 environment (as light) on every side.Because the influence of extraneous light, when the concentration of pick-up unit 110 test samples 120 under the different light rays environment, its resulting testing result may be subjected to the influence of aforementioned external environment.Yet signal regulation and control unit 112 is with light L to be measured
1Intensity and modified value calculate, and the environment around this modified value and the housing 113 is relevant, therefore, can get rid of the influence that housing 113 surrounding environment are caused.
In a possibility embodiment, signal regulation and control unit 112 can have built-in environmental impact database.When the environmental change around the housing 113, signal regulation and control unit 112 can be obtained corresponding modified value from the environmental impact database, in order to revise the result that detecting unit 111 is detected.
For example, if pick-up unit 110 is placed in when outdoor, the user can switch to outdoor state with selector switch 114, and therefore, signal regulation and control unit 112 just can be according to the state of selector switch 114, and from the environmental impact database, obtains corresponding modified value.If pick-up unit 110 is placed in when indoor, the user can switch to indoor design condition with selector switch 114, and therefore, signal regulation and control unit 112 just can be obtained corresponding to indoor modified value from the environmental impact database.
Housing 113 is in order to coat detecting unit 111, signal regulation and control unit 112 and light-emitting component 115, and wherein selector switch 114 is arranged at the surface of housing 113, switches to make things convenient for the user.The possible pattern of housing 113 below will be described.Fig. 2 is the possible embodiment of housing, and as shown in the figure, housing 113 has slot 210 and selector switch SW
1～SW
n
Slot 210 is in order to place sample box.When the sample box with sample places slot 210, cooperate selector switch SW
1～SW
nSwitching state, just can record the concentration of sample, wherein the result of Jian Ceing has got rid of the influence that housing 113 surrounding environment are caused.
In the present embodiment, selector switch SW
1Have indoor design condition and outdoor state; Selector switch SW
2Have fine state, rainy day state and cloudy state; Selector switch SW
nHas daystart state, high noon state and state at dusk.By switching selection switch SW
1～SW
nState, even pick-up unit is under the different environment,, still can obtain identical testing result at same sample.
Fig. 3 is another possibility embodiment of pick-up unit of the present invention.As shown in the figure, pick-up unit 310 has detecting unit 311,312, signal regulation and control unit 313 and housing 314.Detecting unit 311 is in order to detect the light L from sample 320
2Because housing 314 has light hole 421, so light L
2Be subjected to housing 314 light L on every side
E Influence.Detecting unit 312 detects housing 314 light L on every side by light hole 422
EIntensity.Signal regulation and control unit 313 is calculated the testing result of detecting unit 311 and 312, in order to compensation light L
EThe influence that is caused.In the present embodiment, signal regulation and control unit 313 with the testing result of detecting unit 312 as modified value, in order to revise the testing result of detecting unit 311.
Another possibility embodiment of housing below will be described.Fig. 5 a is the vertical view (sample box does not insert) of housing.As shown in the figure, frame of broken lines 510 is the lay down location of sample box.Fig. 5 b is the vertical view (sample box inserts) of housing.Symbol 531 is a sample.Fig. 5 b is different from the size that 4c figure part is sample box.Though the sample box of Fig. 5 b is greater than the sample box shown in Fig. 4 c, sample 531 only places a side of the sample box of 5b figure.Fig. 5 c is the side view (sample box does not insert) of housing.Fig. 5 d is the side view (sample box inserts) of housing.As shown in the figure, though sample box 541 can only have sample 531 across the top to detecting unit 312 above detecting unit 311.
Fig. 6 is another possibility embodiment of pick-up unit of the present invention.Fig. 6 is similar in appearance to Fig. 4, and difference is that the pick-up unit 610 of Fig. 6 only has detecting unit, and housing 613 only has single light hole.Please refer to Fig. 6, when the sample box with sample 620 did not place pick-up unit 610 as yet, detecting unit 611 detected the light L around the housing 613 earlier
EIntensity, then testing result is sent to signal regulation and control unit 612.When sample box placed pick-up unit 610 places, detecting unit detected light L to be measured again
3Intensity, and testing result is sent to signal regulation and control unit 612.Signal regulation and control unit 612 is calculated twice testing result, in order to obtain the luminous intensity of sample 620.In another possibility embodiment, also can detect light L earlier
3Intensity, and then detect light L around the housing 613
EIntensity.
Fig. 7 a is another possibility embodiment of housing.In the present embodiment, housing 613 has slot 721 and light hole 722.Fig. 7 b is the vertical view (sample box does not insert) of housing.
During time t0～ts, owing to sample box does not insert, so detect light L earlier
EIntensity.Fig. 7 c is the vertical view (sample box inserts) of housing.During time ts～te, owing to sample box inserts, so can detect L
3Intensity.Signal regulation and control unit 612 with detecting unit 611 during time t0～ts detected result as modified value, in order to revise detecting unit 611 detected result during time ts～te.
Fig. 8 is another possibility of housing embodiment.In this embodiment,, has another detecting element 731 on the surface of housing 810, in order to detect the intensity of the light around the housing 810 except the mapping position of light hole 722 has the detecting unit (not shown).
Fig. 9 is the process flow diagram of detection method of the present invention.Detection method of the present invention can obtain the concentration of the sample in the housing.At first, obtain modified value (step S910), wherein this modified value is relevant with the environment around the housing.In a possibility embodiment, this modified value can be a detected value.When the environment (as light) around the housing changed, modified value also can change thereupon.In other embodiments, can store a plurality of modified values in advance.The user can be according to the environment around the housing and the state of switching selection switch in order to from a plurality of modified values, obtains suitable modified value.
Then, according to this sample, obtain the intensity (step S920) of light to be measured.This light to be measured is from this sample.In a possibility embodiment, sample and chemical substance can be mixed, make that this sample is luminous.In another possibility embodiment, can utilize light-emitting component (as light emitting diode) irradiation sample, wherein the light of penetrable sample is this light to be measured.In other may embodiment, can obtain the intensity of light to be measured earlier after, the modified value of reentrying, or obtain the intensity of modified value and light to be measured simultaneously.
Then, calculate the intensity and the modified value (step S930) of light to be measured.Because modified value is relevant with the environmental factor around the housing, so can utilize modified value to revise light to be measured.At last, according to result of calculation, just can obtain the concentration (step S940) of this sample.Because modified value is relevant with the environment around the housing, therefore, when the intensity of calculating light to be measured and modified value, just can get rid of because of the influence that environmental factor caused around the housing.Therefore, just can obtain the concentration of sample exactly according to result of calculation.
In sum, when measuring the concentration of sample, because pick-up unit surrounding environment (as light) may influence the result of measurement, therefore, by pick-up unit of the present invention and method, just can remove the influence of measurement environment, and then obtain measurement result comparatively accurately.
Though the present invention has disclosed above preferred embodiment; but it is not in order to limit the present invention; technical field those of ordinary skill under any; without departing from the spirit and scope of the present invention; should do some changes and modify, so protection scope of the present invention should be according to appended being as the criterion that claim limited.
The primary clustering symbol description
110,310,610: checkout gear;
111,311,312,611,731: detecting unit;
112,313,612: signal regulation and control unit;
113,314,613,810: housing;
114、SW
1～SW
n: selector switch;
115: light-emitting component;
120,320,531,620: sample;
210,410,721: slot;
421,422,521,522,722: loophole;
431,511: frame of broken lines;
441,541: sample box;
S910～S940: step.
Claims (18)
1. pick-up unit, in order to obtain the concentration of sample, described pick-up unit comprises:
First detecting unit detects the intensity of light to be measured;
Signal regulation and control unit is calculated the intensity and the modified value of described light to be measured, and obtains the concentration of described sample according to result of calculation; And
Housing, in order to coat described first detecting unit and described signal regulation and control unit, wherein said modified value is relevant with the light around the described housing.
2. pick-up unit according to claim 1, wherein said housing has selector switch, and the user is switched described selector switch according to the environment of described pick-up unit.
3. pick-up unit according to claim 2, wherein said signal regulation and control unit determine that according to the state of described selector switch the position of described modified value is accurate.
4. pick-up unit according to claim 1, wherein said light to be measured is sent by described sample.
5. pick-up unit according to claim 4 wherein adds chemical substance in the described sample, just can make described sample send described light to be measured.
6. pick-up unit according to claim 1 also comprises light-emitting component, is arranged in the described housing, and when described light-emitting component shone described sample, the light of penetrable described sample was described light to be measured.
7. pick-up unit according to claim 1, wherein said first detecting unit also detect the light intensity around the described housing, to produce described modified value.
8. pick-up unit according to claim 7, wherein said first detecting unit detect the light intensity around the described housing earlier, and then detect the intensity of described light to be measured.
9. pick-up unit according to claim 8, wherein said housing has first light hole, can receive described housing light on every side.
10. pick-up unit according to claim 9, wherein said first detecting unit is arranged on the mapping position of described first light hole.
11. pick-up unit according to claim 10, wherein when described first detecting unit detected described light to be measured, described sample was arranged between described first light hole and described first detecting unit.
12. pick-up unit according to claim 11, wherein said housing also has second light hole, can receive described housing light on every side.
13. pick-up unit according to claim 12 also comprises second detecting unit, described second detecting unit is arranged on the mapping position of described second light hole, in order to detect described housing light intensity on every side, to produce described modified value.
14. pick-up unit according to claim 13, wherein when described first detecting unit detected the intensity of described light to be measured, described second detecting unit is the described housing of synchronous detection light intensity on every side also.
15. pick-up unit according to claim 1, wherein said first detecting unit is Charged Coupled Device or complementary metal oxide semiconductor (CMOS).
16. a detection method in order to obtain the concentration of the sample in the housing, comprising:
Obtain modified value, described modified value is relevant with the light around the described housing;
According to described sample, obtain the intensity of light to be measured;
Calculate the intensity and the described modified value of described light to be measured; And
According to result of calculation, obtain the concentration of described sample.
17. detection method according to claim 16, wherein modified value and described light while to be measured or obtained in regular turn.
18. detection method according to claim 16, wherein said light to be measured is sent by described sample.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810006372XA CN101520418B (en) | 2008-02-29 | 2008-02-29 | Detection device and detection method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810006372XA CN101520418B (en) | 2008-02-29 | 2008-02-29 | Detection device and detection method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101520418A CN101520418A (en) | 2009-09-02 |
| CN101520418B true CN101520418B (en) | 2011-06-15 |
Family
ID=41081123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200810006372XA Expired - Fee Related CN101520418B (en) | 2008-02-29 | 2008-02-29 | Detection device and detection method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101520418B (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4684252A (en) * | 1982-12-01 | 1987-08-04 | Hitachi, Ltd. | Automated analyzing apparatus |
| CN1754505A (en) * | 2004-09-29 | 2006-04-05 | 株式会社日立制作所 | Method and apparatus for measuring blood sugar levels |
-
2008
- 2008-02-29 CN CN200810006372XA patent/CN101520418B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4684252A (en) * | 1982-12-01 | 1987-08-04 | Hitachi, Ltd. | Automated analyzing apparatus |
| CN1754505A (en) * | 2004-09-29 | 2006-04-05 | 株式会社日立制作所 | Method and apparatus for measuring blood sugar levels |
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| Publication number | Publication date |
|---|---|
| CN101520418A (en) | 2009-09-02 |
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