CN101518510A - Method for preparing tanshinone micelle - Google Patents
Method for preparing tanshinone micelle Download PDFInfo
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- CN101518510A CN101518510A CN200910115120A CN200910115120A CN101518510A CN 101518510 A CN101518510 A CN 101518510A CN 200910115120 A CN200910115120 A CN 200910115120A CN 200910115120 A CN200910115120 A CN 200910115120A CN 101518510 A CN101518510 A CN 101518510A
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- tanshinone
- micelle
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- tanshinones
- cosurfactant
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Abstract
The invention relates to a method for preparing tanshinone micelle, which is characterized by comprising the following raw materials according to the parts by weight: 0.01-50 of tanshinone, 0.01-50 of surface active agent, 0.01-50 of cosurfactant and the balanced deionized water. The invention has the advantages that the obtained tanshinone micelle has an average particle diameter below 10 nm, good dispersion, stable nature and convenient preparation, is transparent and Turkey red, and can solve the problem of insolubility of tanshinone extractive in water and provide a preference for the development of tanshinone liquid products.
Description
Technical field
The present invention relates to the preparation method of tanshinone micelle
Background technology
TANSHINONES (Tanshinoes) is from the root of salviamiltiorrhizabung (Salviamiltiorrhiza Bunge), extracts the fat-soluble phenanthrenequione active component that obtains.TANSHINONES mainly shows as antiplatelet aggregation, antithrombotic, anti-oxidative damage, atherosclerosis, dwindle myocardial infarction area, reduce effects such as myocardial oxygen consumption and control myocardial ischemia reperfusion injury, now be widely used in the treatment of cardio-cerebrovascular diseases.But,, also be simultaneously the focus of studying both at home and abroad at present because poorly soluble, the problems such as bioavailability is low, character instability of this active component in water have restricted its applicating and exploitation greatly.Micelle volume is meant under certain condition, when the concentration of surfactant in water surpasses critical micelle concentration, by the association of surfactant, spontaneous formation mean diameter below 10nm, the dispersion transparent, that thermodynamics and kinetics is stable.Utilize this technology, can solve the problem of the poorly water-soluble of TANSHINONES well, important effect is played in these research and development for TANSHINONES active ingredient solution series products.
Summary of the invention
The object of the present invention is to provide a kind of preparation method of tanshinone micelle, this method can solve the insoluble problem of tanshinone extract in water well.
The present invention is achieved like this, and it is characterized in that its preparation method is:
With 0.01-50 parts of 0.01-50 parts of TANSHINONES, 0.01-50 parts in surfactant, cosurfactant behind part mix homogeneously, slowly join in the deionized water, process stirring and sonic oscillation combined effect prepare tanshinone micelle after 3 seconds-30 minutes.
Surfactant of the present invention is the mixture of a kind of in sad tricaprin, sad capric acid polyethyleneglycol glyceride, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hydrogenated Oleum Ricini, the polyoxyethylene castor oil or some kinds.
Cosurfactant of the present invention is the mixture of a kind of in ethanol, isopropyl alcohol, TC, 1, the 2-propylene glycol or some kinds.
The weight ratio of surfactant of the present invention and cosurfactant is 1:0.1-10.
Advantage of the present invention is: resulting tanshinone micelle mean diameter below 10nm, good dispersion, transparent, be cerise, stable in properties, easy to prepare, can solve the insoluble problem of tanshinone extract in water well, the exploitation of this solution series products is played a role in promoting.
The specific embodiment
Embodiment one
Get TANSHINONES 0.01g, polyoxyethylene hydrogenated Oleum Ricini 12g, ethanol 2g behind the TANSHINONES of above-mentioned weight, polyoxyethylene hydrogenated Oleum Ricini, ethanol mix homogeneously, slowly join in the deionized water, stir, and ultrasonic concussion 10 minutes promptly makes tanshinone micelle.
Embodiment two
Get TANSHINONES 0.1g, polyoxyethylene castor oil 2g, isopropyl alcohol 12g behind the TANSHINONES of above-mentioned weight, polyoxyethylene castor oil, isopropyl alcohol mix homogeneously, slowly join in the deionized water, stir, and ultrasonic concussion 5 minutes promptly makes tanshinone micelle.
Embodiment three
Get TANSHINONES 0.05g, sad capric acid polyethyleneglycol glyceride 10.0g, TC 1.0g, behind the TANSHINONES of above-mentioned weight, sad capric acid polyethyleneglycol glyceride, TC mix homogeneously, slowly join in the deionized water, stir, ultrasonic concussion 30 seconds promptly makes tanshinone micelle.
Embodiment four
Get TANSHINONES 0.02g, sad tricaprin 5.0g, 1,2-propylene glycol 5.0g, with the TANSHINONES of above-mentioned weight, sad tricaprin, 1,2-mixed with propylene glycol evenly after, slowly join in the deionized water, stir, ultrasonic concussion 1 minute promptly makes tanshinone micelle.
Embodiment five
Get TANSHINONES 2.0g, sorbitan fatty acid ester 10.0g, isopropyl alcohol 1.0g are behind the TANSHINONES of above-mentioned weight, sorbitan fatty acid ester, isopropyl alcohol mix homogeneously, slowly join in the deionized water, stir, ultrasonic concussion 5 seconds promptly makes tanshinone micelle.
Embodiment six
Get TANSHINONES 5.0g, sad capric acid polyethyleneglycol glyceride 1.0g, ethanol 10.0g are behind the TANSHINONES of above-mentioned weight, sad capric acid polyethyleneglycol glyceride, ethanol mix homogeneously, slowly join in the deionized water, stir, ultrasonic concussion 30 minutes promptly makes tanshinone micelle.
Embodiment seven
Get TANSHINONES 0.5g, polyoxyethylene sorbitan fatty acid ester 8.0g, isopropyl alcohol 4.0g, behind the TANSHINONES of above-mentioned weight, polyoxyethylene sorbitan fatty acid ester, isopropyl alcohol mix homogeneously, slowly join in the deionized water, stir, ultrasonic concussion 15 minutes promptly makes tanshinone micelle.
Experimental result
The mean diameter (the equal particle diameter of Z) that adopts Zetasizer Nano S type Ma Erwen nano particle size analyzer to measure in the tanshinone micelle the results are shown in the nm of following table unit
| Sample number into spectrum | Press strength detection | Polydispersity index (PDI value) |
| 1 | 7.70 | 0.276 |
| 2 | 6.10 | 0.221 |
| 3 | 8.12 | 0.301 |
| 4 | 6.74 | 0.251 |
| 5 | 8.55 | 0.283 |
| 6 | 6.30 | 0.238 |
| 7 | 6.52 | 0.246 |
Claims (4)
1, a kind of preparation method of tanshinone micelle, with 0.01-50 parts of 0.01-50 parts of TANSHINONES, 0.01-50 parts in surfactant, cosurfactant behind part mix homogeneously, slowly join in the deionized water, process stirring and sonic oscillation combined effect prepare tanshinone micelle after 3 seconds-30 minutes.
2, the preparation method of tanshinone micelle according to claim 1 is characterized in that surfactant is the mixture of a kind of in sad tricaprin, sad capric acid polyethyleneglycol glyceride, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hydrogenated Oleum Ricini, the polyoxyethylene castor oil or some kinds.
3, the preparation method of tanshinone micelle according to claim 1 is characterized in that cosurfactant is the mixture of a kind of in ethanol, isopropyl alcohol, TC, 1, the 2-propylene glycol or some kinds.
4, the preparation method of tanshinone micelle according to claim 1, the weight ratio that it is characterized in that surfactant and cosurfactant is 1:0.1-10.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910115120A CN101518510A (en) | 2009-03-30 | 2009-03-30 | Method for preparing tanshinone micelle |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910115120A CN101518510A (en) | 2009-03-30 | 2009-03-30 | Method for preparing tanshinone micelle |
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| Publication Number | Publication Date |
|---|---|
| CN101518510A true CN101518510A (en) | 2009-09-02 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200910115120A Pending CN101518510A (en) | 2009-03-30 | 2009-03-30 | Method for preparing tanshinone micelle |
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| CN (1) | CN101518510A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117487154A (en) * | 2023-10-31 | 2024-02-02 | 暨南大学 | Tanshinone derivative and preparation method and application thereof |
-
2009
- 2009-03-30 CN CN200910115120A patent/CN101518510A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117487154A (en) * | 2023-10-31 | 2024-02-02 | 暨南大学 | Tanshinone derivative and preparation method and application thereof |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
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Open date: 20090902 |