CN101516879A - 具有催眠作用的取代的咪唑并吡啶化合物的制备及用途 - Google Patents

具有催眠作用的取代的咪唑并吡啶化合物的制备及用途 Download PDF

Info

Publication number
CN101516879A
CN101516879A CNA2007800290943A CN200780029094A CN101516879A CN 101516879 A CN101516879 A CN 101516879A CN A2007800290943 A CNA2007800290943 A CN A2007800290943A CN 200780029094 A CN200780029094 A CN 200780029094A CN 101516879 A CN101516879 A CN 101516879A
Authority
CN
China
Prior art keywords
enantiomorph
compound
weight
formula
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2007800290943A
Other languages
English (en)
Chinese (zh)
Inventor
T·G·甘特
S·萨沙
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Auspex Pharmaceuticals Inc
Original Assignee
Auspex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Auspex Pharmaceuticals Inc filed Critical Auspex Pharmaceuticals Inc
Publication of CN101516879A publication Critical patent/CN101516879A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CNA2007800290943A 2006-06-05 2007-05-30 具有催眠作用的取代的咪唑并吡啶化合物的制备及用途 Pending CN101516879A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81093506P 2006-06-05 2006-06-05
US60/810,935 2006-06-05

Publications (1)

Publication Number Publication Date
CN101516879A true CN101516879A (zh) 2009-08-26

Family

ID=38802216

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2007800290943A Pending CN101516879A (zh) 2006-06-05 2007-05-30 具有催眠作用的取代的咪唑并吡啶化合物的制备及用途

Country Status (8)

Country Link
US (3) US7772248B2 (https=)
EP (1) EP2024365A4 (https=)
JP (1) JP5528105B2 (https=)
CN (1) CN101516879A (https=)
AU (1) AU2007256893A1 (https=)
BR (1) BRPI0711491A2 (https=)
CA (1) CA2654445A1 (https=)
WO (1) WO2007143468A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104447555A (zh) * 2009-10-26 2015-03-25 大塚制药株式会社 苯并氮杂*化合物
CN107982375A (zh) * 2017-12-04 2018-05-04 黑龙江参鸽药业有限公司 一种风寒双离拐片的制备方法
CN111423456A (zh) * 2020-04-03 2020-07-17 南京昊绿生物科技有限公司 一种利福昔明-d6的合成工艺

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007256893A1 (en) * 2006-06-05 2007-12-13 Auspex Pharmaceuticals, Inc. Preparation and utility of substituted imidazopyridine compounds with hypnotic effects
US20090076007A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched aprepitant
US20090076066A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched zolpidem
US20110053968A1 (en) 2009-06-09 2011-03-03 Auspex Pharmaceuticals, Inc. Aminopyrimidine inhibitors of tyrosine kinase
EP2483406A2 (en) 2009-09-30 2012-08-08 President and Fellows of Harvard College Methods for modulation of autophagy through the modulation of autophagy-inhibiting gene products
WO2011059080A1 (ja) * 2009-11-16 2011-05-19 第一三共株式会社 同位体置換されたジアミン誘導体
US10166183B2 (en) 2014-02-07 2019-01-01 Auspex Pharmaceuticals, Inc. Pharmaceutical formulations
US20210009583A1 (en) * 2018-03-12 2021-01-14 University Of Notre Dame Du Lac Deuterated imidazopyridines

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2492382A1 (fr) 1980-10-22 1982-04-23 Synthelabo Derives d'imidazo (1,2-a) pyridine, leur preparation et leur application en therapeutique
US6221335B1 (en) 1994-03-25 2001-04-24 Isotechnika, Inc. Method of using deuterated calcium channel blockers
CN1087725C (zh) 1994-03-25 2002-07-17 同位素技术有限公司 用氘代方法增强药物效果
EP1005863A1 (en) 1998-12-04 2000-06-07 Synthelabo Controlled-release dosage forms comprising a short acting hypnotic or a salt thereof
US6440710B1 (en) 1998-12-10 2002-08-27 The Scripps Research Institute Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds
PT1104760E (pt) 1999-12-03 2003-06-30 Pfizer Prod Inc Compostos de sulfamoil-heteroarilpirazole como agentes analgesicos e anti-inflamatorios
EP1134290A3 (en) 2000-03-14 2004-01-02 Pfizer Products Inc. Pharmacophore models for the identification of the CYP2D6 inhibitory potency of selective serotonin reuptake inhibitors
DE10121638A1 (de) * 2001-05-03 2002-11-14 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Imidazopyridinen
TW200413273A (en) 2002-11-15 2004-08-01 Wako Pure Chem Ind Ltd Heavy hydrogenation method of heterocyclic rings
WO2004064832A2 (en) * 2003-01-22 2004-08-05 Pfizer Products Inc. Methods for treating joint pain or improving sleep using an estrogen agonist/antagonist
US8703099B2 (en) 2005-02-24 2014-04-22 Dr Pharma Nova, Llc Registry method and control system for DEA schedule II-V medicines
US20080033011A1 (en) 2005-07-29 2008-02-07 Concert Pharmaceuticals Inc. Novel benzo[d][1,3]-dioxol derivatives
US7750168B2 (en) 2006-02-10 2010-07-06 Sigma-Aldrich Co. Stabilized deuteroborane-tetrahydrofuran complex
AU2007256893A1 (en) 2006-06-05 2007-12-13 Auspex Pharmaceuticals, Inc. Preparation and utility of substituted imidazopyridine compounds with hypnotic effects
US20080058351A1 (en) 2006-06-30 2008-03-06 Concert Pharmaceuticals Inc. Novel heterobicyclic compounds
WO2008024481A2 (en) 2006-08-24 2008-02-28 Concert Pharmaceuticals Inc. 3,4-dihydro-2 (1h) - quinolinone and 2 (1h)-quinolinone derivatives
US20080318964A1 (en) 2007-06-19 2008-12-25 Protia, Llc Deuterium-enriched eszopiclone
US20090062312A1 (en) 2007-08-29 2009-03-05 Protia, Llc Deuterium-enriched indiplon
US20090076066A1 (en) 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched zolpidem
US8501738B2 (en) 2009-06-23 2013-08-06 Concert Pharmaceuticals, Inc. Substituted triazolo-pyridazine derivatives
WO2011002451A1 (en) 2009-06-30 2011-01-06 Hewlett-Packard Development Company, L.P. Optimizing file block communications in a virtual distributed file system
US20110082147A1 (en) 2009-07-24 2011-04-07 Concert Pharmaceuticals, Inc. Substituted imidazotriazines
US8278460B2 (en) 2009-10-15 2012-10-02 Concert Pharmaceuticals, Inc. Substituted benzimidazoles

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104447555A (zh) * 2009-10-26 2015-03-25 大塚制药株式会社 苯并氮杂*化合物
CN104829531A (zh) * 2009-10-26 2015-08-12 大塚制药株式会社 苯并氮杂*化合物
CN107982375A (zh) * 2017-12-04 2018-05-04 黑龙江参鸽药业有限公司 一种风寒双离拐片的制备方法
CN111423456A (zh) * 2020-04-03 2020-07-17 南京昊绿生物科技有限公司 一种利福昔明-d6的合成工艺

Also Published As

Publication number Publication date
JP5528105B2 (ja) 2014-06-25
EP2024365A2 (en) 2009-02-18
US20100105720A1 (en) 2010-04-29
AU2007256893A1 (en) 2007-12-13
US8101633B2 (en) 2012-01-24
CA2654445A1 (en) 2007-12-13
WO2007143468A3 (en) 2008-11-27
JP2009539863A (ja) 2009-11-19
US20100121067A1 (en) 2010-05-13
WO2007143468A2 (en) 2007-12-13
BRPI0711491A2 (pt) 2012-07-10
EP2024365A4 (en) 2010-08-25
US7772248B2 (en) 2010-08-10
US20070281965A1 (en) 2007-12-06

Similar Documents

Publication Publication Date Title
KR101767849B1 (ko) 섬유증 저해제로서의 치환된 ｎ-아릴 피리디논
CN101765582A (zh) 氘标记的氯胺酮
CN101516879A (zh) 具有催眠作用的取代的咪唑并吡啶化合物的制备及用途
US7872013B2 (en) Preparation and utility of opioid analgesics
JP2009539866A (ja) 置換エリスロマイシンアナログの調製および有用性
US20090291958A1 (en) Substituted PDE5 inhibitors
JP2009538359A (ja) 置換カルボン酸化合物の製造および利用
JP2010529994A (ja) 置換ピペラジン
JP2010523694A (ja) 高血圧治療のための置換重水素濃縮チオフェン
CN101547696A (zh) 具有α肾上腺素能阻断效应的取代喹唑啉化合物的制备和应用
JP2017503839A (ja) 置換ｎ−アリールピリジノン
JP2009538355A (ja) ジューテリウム化アミノグリシジル化合物
US20070287734A1 (en) Preparation and utility of substituted pyrazole compounds with cannabinoid receptor activity
US20090005431A1 (en) Substituted pyrrolidines
CN101511180A (zh) 取代的羧酸化合物的制备及应用
CN101522027A (zh) 取代的红霉素类似物的制备和用途
HK1134080A (en) Preparation and utility of substituted imidazopyridine compounds with hypnotic effects
HK1134637A (en) Preparation and utility of substituted erythromycin analogs

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1134080

Country of ref document: HK

C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Open date: 20090826

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1134080

Country of ref document: HK