CN101516879A - 具有催眠作用的取代的咪唑并吡啶化合物的制备及用途 - Google Patents
具有催眠作用的取代的咪唑并吡啶化合物的制备及用途 Download PDFInfo
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
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| CN101516879A true CN101516879A (zh) | 2009-08-26 |
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| JP (1) | JP5528105B2 (enExample) |
| CN (1) | CN101516879A (enExample) |
| AU (1) | AU2007256893A1 (enExample) |
| BR (1) | BRPI0711491A2 (enExample) |
| CA (1) | CA2654445A1 (enExample) |
| WO (1) | WO2007143468A2 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104447555A (zh) * | 2009-10-26 | 2015-03-25 | 大塚制药株式会社 | 苯并氮杂*化合物 |
| CN107982375A (zh) * | 2017-12-04 | 2018-05-04 | 黑龙江参鸽药业有限公司 | 一种风寒双离拐片的制备方法 |
| CN111423456A (zh) * | 2020-04-03 | 2020-07-17 | 南京昊绿生物科技有限公司 | 一种利福昔明-d6的合成工艺 |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0711491A2 (pt) | 2006-06-05 | 2012-07-10 | Auspex Pharmaceuticals Inc | composição, método de tratamento de um mamìfero que sofre uma doença ou de uma condição que envolve um receptor de benzodiazepina e composição farmacêutica" |
| US20090076007A1 (en) * | 2007-09-17 | 2009-03-19 | Protia, Llc | Deuterium-enriched aprepitant |
| US20090076066A1 (en) * | 2007-09-19 | 2009-03-19 | Protia, Llc | Deuterium-enriched zolpidem |
| US20110053968A1 (en) | 2009-06-09 | 2011-03-03 | Auspex Pharmaceuticals, Inc. | Aminopyrimidine inhibitors of tyrosine kinase |
| US20120301463A1 (en) | 2009-09-30 | 2012-11-29 | President And Fellows Of Harvard College | Methods for Modulation of Autophagy Through the Modulation of Autophagy-Enhancing Gene Products |
| WO2011059080A1 (ja) * | 2009-11-16 | 2011-05-19 | 第一三共株式会社 | 同位体置換されたジアミン誘導体 |
| EA201691582A1 (ru) | 2014-02-07 | 2017-01-30 | Оспекс Фармасьютикалз, Инк. | Новые фармацевтические препараты |
| US20210009583A1 (en) * | 2018-03-12 | 2021-01-14 | University Of Notre Dame Du Lac | Deuterated imidazopyridines |
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|---|---|---|---|---|
| FR2492382A1 (fr) * | 1980-10-22 | 1982-04-23 | Synthelabo | Derives d'imidazo (1,2-a) pyridine, leur preparation et leur application en therapeutique |
| JP3696884B2 (ja) | 1994-03-25 | 2005-09-21 | アイソテクニカ、インコーポレーテッド | ジュウテリウム化による薬物の効能の増強 |
| US6221335B1 (en) * | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| EP1005863A1 (en) | 1998-12-04 | 2000-06-07 | Synthelabo | Controlled-release dosage forms comprising a short acting hypnotic or a salt thereof |
| US6440710B1 (en) * | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
| EP1104760B1 (en) * | 1999-12-03 | 2003-03-12 | Pfizer Products Inc. | Sulfamoylheteroaryl pyrazole compounds as anti-inflammatory/analgesic agents |
| EP1134290A3 (en) | 2000-03-14 | 2004-01-02 | Pfizer Products Inc. | Pharmacophore models for the identification of the CYP2D6 inhibitory potency of selective serotonin reuptake inhibitors |
| DE10121638A1 (de) * | 2001-05-03 | 2002-11-14 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von Imidazopyridinen |
| TW200413273A (en) * | 2002-11-15 | 2004-08-01 | Wako Pure Chem Ind Ltd | Heavy hydrogenation method of heterocyclic rings |
| EP1599199A2 (en) * | 2003-01-22 | 2005-11-30 | Pfizer Products Inc. | Methods for treating joint pain or improving sleep using an estrogen agonist/antagonist |
| US8703099B2 (en) | 2005-02-24 | 2014-04-22 | Dr Pharma Nova, Llc | Registry method and control system for DEA schedule II-V medicines |
| US20080033011A1 (en) | 2005-07-29 | 2008-02-07 | Concert Pharmaceuticals Inc. | Novel benzo[d][1,3]-dioxol derivatives |
| US7750168B2 (en) * | 2006-02-10 | 2010-07-06 | Sigma-Aldrich Co. | Stabilized deuteroborane-tetrahydrofuran complex |
| BRPI0711491A2 (pt) | 2006-06-05 | 2012-07-10 | Auspex Pharmaceuticals Inc | composição, método de tratamento de um mamìfero que sofre uma doença ou de uma condição que envolve um receptor de benzodiazepina e composição farmacêutica" |
| US20080058351A1 (en) | 2006-06-30 | 2008-03-06 | Concert Pharmaceuticals Inc. | Novel heterobicyclic compounds |
| US20080103154A1 (en) | 2006-08-24 | 2008-05-01 | Concert Pharmaceuticals Inc. | 3, 4-dihydro-2(IH)-quinolinone and 2(1H)-quinolinone derivatives |
| US20080318964A1 (en) | 2007-06-19 | 2008-12-25 | Protia, Llc | Deuterium-enriched eszopiclone |
| US20090062312A1 (en) | 2007-08-29 | 2009-03-05 | Protia, Llc | Deuterium-enriched indiplon |
| US20090076066A1 (en) | 2007-09-19 | 2009-03-19 | Protia, Llc | Deuterium-enriched zolpidem |
| EP2454259A1 (en) | 2009-06-23 | 2012-05-23 | Concert Pharmaceuticals Inc. | Deuterium-modified triazolo-pyridazine derivatives as gaba-a receptor modulators |
| WO2011002451A1 (en) | 2009-06-30 | 2011-01-06 | Hewlett-Packard Development Company, L.P. | Optimizing file block communications in a virtual distributed file system |
| WO2011011712A1 (en) | 2009-07-24 | 2011-01-27 | Concert Pharmaceuticals, Inc. | Substituted imidazotriazines |
| WO2011047315A1 (en) | 2009-10-15 | 2011-04-21 | Concert Pharmaceuticals, Inc. | Subsitituted benzimidazoles |
-
2007
- 2007-05-30 BR BRPI0711491-5A patent/BRPI0711491A2/pt not_active IP Right Cessation
- 2007-05-30 WO PCT/US2007/069953 patent/WO2007143468A2/en not_active Ceased
- 2007-05-30 JP JP2009514471A patent/JP5528105B2/ja active Active
- 2007-05-30 US US11/755,634 patent/US7772248B2/en active Active
- 2007-05-30 CN CNA2007800290943A patent/CN101516879A/zh active Pending
- 2007-05-30 CA CA002654445A patent/CA2654445A1/en not_active Abandoned
- 2007-05-30 EP EP07784206A patent/EP2024365A4/en not_active Withdrawn
- 2007-05-30 AU AU2007256893A patent/AU2007256893A1/en not_active Abandoned
-
2009
- 2009-09-01 US US12/552,254 patent/US8101633B2/en active Active
- 2009-09-01 US US12/552,152 patent/US20100121067A1/en not_active Abandoned
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104447555A (zh) * | 2009-10-26 | 2015-03-25 | 大塚制药株式会社 | 苯并氮杂*化合物 |
| CN104829531A (zh) * | 2009-10-26 | 2015-08-12 | 大塚制药株式会社 | 苯并氮杂*化合物 |
| CN107982375A (zh) * | 2017-12-04 | 2018-05-04 | 黑龙江参鸽药业有限公司 | 一种风寒双离拐片的制备方法 |
| CN111423456A (zh) * | 2020-04-03 | 2020-07-17 | 南京昊绿生物科技有限公司 | 一种利福昔明-d6的合成工艺 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2024365A4 (en) | 2010-08-25 |
| US7772248B2 (en) | 2010-08-10 |
| CA2654445A1 (en) | 2007-12-13 |
| JP2009539863A (ja) | 2009-11-19 |
| US8101633B2 (en) | 2012-01-24 |
| WO2007143468A3 (en) | 2008-11-27 |
| WO2007143468A2 (en) | 2007-12-13 |
| AU2007256893A1 (en) | 2007-12-13 |
| EP2024365A2 (en) | 2009-02-18 |
| JP5528105B2 (ja) | 2014-06-25 |
| US20070281965A1 (en) | 2007-12-06 |
| BRPI0711491A2 (pt) | 2012-07-10 |
| US20100121067A1 (en) | 2010-05-13 |
| US20100105720A1 (en) | 2010-04-29 |
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