CN101511785A - 取代的苄基胺化合物 - Google Patents

取代的苄基胺化合物 Download PDF

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Publication number
CN101511785A
CN101511785A CNA2007800324649A CN200780032464A CN101511785A CN 101511785 A CN101511785 A CN 101511785A CN A2007800324649 A CNA2007800324649 A CN A2007800324649A CN 200780032464 A CN200780032464 A CN 200780032464A CN 101511785 A CN101511785 A CN 101511785A
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Prior art keywords
alkyl
phenyl
piperazin
methyl
phenoxy
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Chinese (zh)
Inventor
B·阿利森
M·P·库尔蒂斯
C·A·格赖斯
J·M·凯思
M·A·勒塔维克
J·M·B·米勒
E·M·斯托金
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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Publication of CN101511785A publication Critical patent/CN101511785A/zh
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    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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CNA2007800324649A 2006-06-29 2007-06-21 取代的苄基胺化合物 Pending CN101511785A (zh)

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US80616906P 2006-06-29 2006-06-29
US60/806,169 2006-06-29

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CN101511785A true CN101511785A (zh) 2009-08-19

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US (2) US7479493B2 (https=)
EP (1) EP2049473A2 (https=)
JP (1) JP2009544579A (https=)
CN (1) CN101511785A (https=)
AU (1) AU2007265242A1 (https=)
CA (1) CA2656089A1 (https=)
WO (1) WO2008002820A2 (https=)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN111848577A (zh) * 2014-09-16 2020-10-30 克罗诺斯治疗有限公司 可用于治疗与中枢神经系统有关的疾病或病症的n-(杂)芳基-取代的杂环衍生物

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Publication number Priority date Publication date Assignee Title
SI1668014T1 (sl) * 2003-09-17 2009-06-30 Janssen Pharmaceutica Nv Kondenzirane heterociklične spojine kot modulatorji serotoninskih receptorjev
US7598255B2 (en) * 2005-08-04 2009-10-06 Janssen Pharmaceutica Nv Pyrimidine compounds as serotonin receptor modulators
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
WO2009119528A1 (ja) * 2008-03-24 2009-10-01 武田薬品工業株式会社 複素環化合物
WO2009143404A1 (en) * 2008-05-23 2009-11-26 Wyeth Piperazine metabotropic glutamate receptor 5 (mglur5) negative allosteric modulators for anxiety/depression
AR074466A1 (es) 2008-12-05 2011-01-19 Sanofi Aventis Piperidina espiro pirrolidinona y piperidinona sustituidas y su uso terapeutico en enfermedades mediadas por la modulacion de los receptores h3.
AR074467A1 (es) 2008-12-05 2011-01-19 Sanofi Aventis Tetrahidropiran espiro pirrolidinonas y piperidinonas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas en el tratamiento y/o prevencion de enfermedades del snc ,tales como alzheimer y parkinson, entre otras.
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US8652527B1 (en) 2013-03-13 2014-02-18 Upsher-Smith Laboratories, Inc Extended-release topiramate capsules
US9101545B2 (en) 2013-03-15 2015-08-11 Upsher-Smith Laboratories, Inc. Extended-release topiramate capsules
JP2021534215A (ja) * 2018-08-24 2021-12-09 ゼニオプロ ゲーエムベーハー 病的症状の治療における使用のための芳香族分子

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0008958A (pt) * 1999-02-23 2001-11-27 Pfizer Prod Inc Inibidores de reabsorção de monoamina para otratamento de distúrbios do snc
AP2002002481A0 (en) 1999-10-13 2002-06-30 Pfizer Prod Inc Biaryl ether derivatives useful as monoamine reuptake inhibitors.
GB0007884D0 (en) 2000-03-31 2000-05-17 Pfizer Ltd Diphenyl ether compounds useful in therapy
AP2001002265A0 (en) * 2000-08-31 2001-09-30 Pfizer Phenoxybenzylamine derivatives as SSRIs.
US20020107244A1 (en) * 2001-02-02 2002-08-08 Howard Harry R. Combination treatment for depression
GB0324159D0 (en) 2003-10-15 2003-11-19 Glaxo Group Ltd Novel compounds
EP1831173B1 (en) * 2004-12-17 2011-01-26 Janssen Pharmaceutica NV Tetrahydroisoquinoline compounds for treatment of cns disorders
CA2612495A1 (en) * 2005-06-17 2006-12-28 Janssen Pharmaceutica N.V. Hexahydro-pyrrolo-isoquinoline compounds for the treatment of cns disorders
WO2006138714A2 (en) * 2005-06-17 2006-12-28 Janssen Pharmaceutica N.V. Naphthyridine compounds

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111848577A (zh) * 2014-09-16 2020-10-30 克罗诺斯治疗有限公司 可用于治疗与中枢神经系统有关的疾病或病症的n-(杂)芳基-取代的杂环衍生物
CN111848577B (zh) * 2014-09-16 2023-09-01 克罗诺斯治疗有限公司 可用于治疗与中枢神经系统有关的疾病或病症的n-(杂)芳基-取代的杂环衍生物

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