CN101511384A - 采用GM-CSF和α干扰素制成的并装载热处理的且杀死的癌细胞的树突状细胞 - Google Patents
采用GM-CSF和α干扰素制成的并装载热处理的且杀死的癌细胞的树突状细胞 Download PDFInfo
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- CN101511384A CN101511384A CNA200780032430XA CN200780032430A CN101511384A CN 101511384 A CN101511384 A CN 101511384A CN A200780032430X A CNA200780032430X A CN A200780032430XA CN 200780032430 A CN200780032430 A CN 200780032430A CN 101511384 A CN101511384 A CN 101511384A
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/00119—Melanoma antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/19—Dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/24—Antigen-presenting cells [APC]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/876—Skin, melanoma
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/24—Interferons [IFN]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/25—Tumour necrosing factors [TNF]
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81791606P | 2006-06-30 | 2006-06-30 | |
| US60/817,916 | 2006-06-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101511384A true CN101511384A (zh) | 2009-08-19 |
Family
ID=38895372
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA200780032430XA Pending CN101511384A (zh) | 2006-06-30 | 2007-06-29 | 采用GM-CSF和α干扰素制成的并装载热处理的且杀死的癌细胞的树突状细胞 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20080031900A1 (enExample) |
| EP (2) | EP2630968A1 (enExample) |
| JP (3) | JP2009542714A (enExample) |
| KR (1) | KR20090033375A (enExample) |
| CN (1) | CN101511384A (enExample) |
| AU (1) | AU2007269245B2 (enExample) |
| CA (1) | CA2691346A1 (enExample) |
| WO (1) | WO2008005859A2 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109310709A (zh) * | 2015-12-30 | 2019-02-05 | 细胞基因公司 | T淋巴细胞生产方法和由此产生的t淋巴细胞 |
| CN112646778A (zh) * | 2012-12-28 | 2021-04-13 | 阿姆弗拉公司 | 免疫原性裂解物制备方法、获得的裂解物、负载有该裂解物的树突状细胞以及药物组合物 |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2728772A1 (en) * | 2008-06-06 | 2009-12-10 | Baylor Research Institute | Anti-cd8 antibodies block priming of cytotoxic effectors and lead to generation of regulatory cd8+t cells |
| WO2009155332A1 (en) | 2008-06-17 | 2009-12-23 | Cedars-Sinai Medical Center | Use of toll-like receptor ligands as adjuvants to vaccination therapy for brain tumors |
| EP2547360A4 (en) * | 2010-03-15 | 2013-11-20 | Univ Pennsylvania | SYSTEM AND METHOD FOR THE PRODUCTION AND STORAGE OF ACTIVATED TIRES OF DENDRITIC CELLS |
| KR20140054140A (ko) * | 2011-07-27 | 2014-05-08 | 베일러 리서치 인스티튜트 | 췌장암에 대한 수지상 세포(dc) - 백신 치료요법 |
| CN105999249A (zh) * | 2011-10-20 | 2016-10-12 | 新干细胞肿瘤学有限责任公司 | 具有γ干扰素的抗原呈递癌症疫苗 |
| PL2591798T3 (pl) | 2011-11-09 | 2015-04-30 | Werner Lubitz | Szczepionka do zastosowania w immunoterapii nowotworów |
| EP2787005A1 (en) * | 2013-04-02 | 2014-10-08 | Activartis Biotech GmbH | Targeted cancer immune therapy |
| JP6967963B2 (ja) * | 2014-07-17 | 2021-11-17 | ブライアン ジェイ ツェルニキCZERNIECKI, Brian, J. | 複数用量注射準備済樹状細胞ワクチンの製造ならびにher2およびher3を遮断するための併用療法 |
| US20170191034A1 (en) * | 2014-09-04 | 2017-07-06 | Agency For Science Technology And Research | A method to up-regulate cancer stem cell markers for the generation of antigen specific cytotoxic effector t cells |
| WO2016064899A1 (en) * | 2014-10-21 | 2016-04-28 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for antibody and antibody-loaded dendritic cell mediated therapy |
| US20180066229A1 (en) * | 2015-03-17 | 2018-03-08 | Shinshu University | Method for preparing dendritic cells via non-adhesive culture using ifn |
| EP3195878A1 (en) | 2016-01-22 | 2017-07-26 | Werner Lubitz | Bacterial ghosts for the treatment of cancer |
| CA3029902A1 (en) | 2016-07-07 | 2018-01-11 | The Board Of Trustees Of The Leland Stanford Junior University | Antibody adjuvant conjugates |
| CN108567977B (zh) * | 2017-03-13 | 2022-04-12 | 复旦大学 | 一种免疫增强剂、免疫治疗药物组合物及其制备与用途 |
| KR20190057938A (ko) | 2017-11-21 | 2019-05-29 | 이근량 | 버스닥트의 다점 온도감지 및 광학적 경보시스템 |
| US12329807B2 (en) * | 2018-01-18 | 2025-06-17 | Meganano Biotech, Inc. | Dead antigen stimulated immature heterogenous dendritic cells as therapeutics for diseases |
| WO2019204391A1 (en) * | 2018-04-19 | 2019-10-24 | Robert Caruso | Cryo-inactivated cancer cells for cancer immunotherapy |
| CA3132072A1 (en) * | 2019-03-01 | 2020-09-10 | Gritstone Bio, Inc. | Selection of t cell receptors |
| CA3130794A1 (en) | 2019-03-15 | 2020-09-24 | Bolt Biotherapeutics, Inc. | Immunoconjugates targeting her2 |
| JP2023013211A (ja) * | 2021-07-15 | 2023-01-26 | 大日本印刷株式会社 | 細胞医薬品の提供方法、細胞医薬品用ラベルの作成方法、情報処理方法、プログラム、細胞医薬品、細胞医薬品容器および細胞医薬品提供システム |
| US12433915B2 (en) | 2022-11-23 | 2025-10-07 | Jjr&D, Llc | Cancer cytotoxic exosome formulations and methods for use in treating cancer |
| WO2024256477A1 (en) * | 2023-06-13 | 2024-12-19 | Pdc Line Pharma Sa | Method for preparing plasmacytoid dendritic cells |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE260971T1 (de) * | 1992-04-01 | 2004-03-15 | Univ Rockefeller | Verfahren zur in vitro kultivierung dendritischer vorläuferzellen und deren verwendung zur immunogen herstellung |
| US6821778B1 (en) | 1993-12-01 | 2004-11-23 | The Board Of Trustees Of Leland Stanford Junior University | Methods for using dendritic cells to activate gamma/delta-T cell receptor-positive T cells |
| ATE388237T1 (de) | 1997-04-15 | 2008-03-15 | Dana Farber Cancer Inst Inc | Dendritische zellhybride |
| ATE328607T1 (de) * | 1998-01-16 | 2006-06-15 | Biomira Usa Inc | Von membran-proteoliposomen patient-spezifischen bösartigen weissen blutzellen impstoff |
| CA2321093A1 (en) * | 1998-02-20 | 1999-08-26 | The Rockefeller University | Apoptotic cell-mediated antigen presentation to dendritic cells |
| US7015205B1 (en) * | 1999-10-18 | 2006-03-21 | St. Vincent's Hospital And Medical Center Of New York | Melanoma vaccine and methods of making and using same |
| DE10041515A1 (de) * | 2000-08-24 | 2002-03-14 | Gerold Schuler | Verfahren zur Herstellung gebrauchsfertiger, Antigen-beladener oder -unbeladener, kryokonservierter reifer dendritischer Zellen |
| ATE552011T1 (de) * | 2003-10-15 | 2012-04-15 | Ist Superiore Sanita | Kolorektal-karzinom-antigen |
| US20050214268A1 (en) * | 2004-03-25 | 2005-09-29 | Cavanagh William A Iii | Methods for treating tumors and cancerous tissues |
| US20060045883A1 (en) * | 2004-08-26 | 2006-03-02 | Jeffrey Molldrem | Anti-cancer vaccines |
| WO2006047515A2 (en) * | 2004-10-25 | 2006-05-04 | Baylor Research Institute | Dendritic cells loaded with heat shocked melanoma cell bodies |
-
2007
- 2007-06-29 US US11/771,664 patent/US20080031900A1/en not_active Abandoned
- 2007-06-29 AU AU2007269245A patent/AU2007269245B2/en not_active Ceased
- 2007-06-29 KR KR1020097002075A patent/KR20090033375A/ko not_active Abandoned
- 2007-06-29 WO PCT/US2007/072525 patent/WO2008005859A2/en not_active Ceased
- 2007-06-29 EP EP13159462.4A patent/EP2630968A1/en not_active Withdrawn
- 2007-06-29 EP EP07812497A patent/EP2037957A4/en not_active Withdrawn
- 2007-06-29 JP JP2009518581A patent/JP2009542714A/ja active Pending
- 2007-06-29 CN CNA200780032430XA patent/CN101511384A/zh active Pending
- 2007-06-29 CA CA2691346A patent/CA2691346A1/en not_active Abandoned
-
2013
- 2013-05-28 JP JP2013111446A patent/JP2013177430A/ja active Pending
-
2015
- 2015-10-22 JP JP2015207617A patent/JP6134763B2/ja active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112646778A (zh) * | 2012-12-28 | 2021-04-13 | 阿姆弗拉公司 | 免疫原性裂解物制备方法、获得的裂解物、负载有该裂解物的树突状细胞以及药物组合物 |
| CN109310709A (zh) * | 2015-12-30 | 2019-02-05 | 细胞基因公司 | T淋巴细胞生产方法和由此产生的t淋巴细胞 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20080031900A1 (en) | 2008-02-07 |
| JP2013177430A (ja) | 2013-09-09 |
| CA2691346A1 (en) | 2008-01-10 |
| AU2007269245A1 (en) | 2008-01-10 |
| JP2016041725A (ja) | 2016-03-31 |
| EP2630968A1 (en) | 2013-08-28 |
| EP2037957A2 (en) | 2009-03-25 |
| KR20090033375A (ko) | 2009-04-02 |
| EP2037957A4 (en) | 2010-09-08 |
| JP2009542714A (ja) | 2009-12-03 |
| WO2008005859A3 (en) | 2008-11-20 |
| WO2008005859A2 (en) | 2008-01-10 |
| JP6134763B2 (ja) | 2017-05-24 |
| AU2007269245B2 (en) | 2012-04-12 |
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Application publication date: 20090819 |