CN101502622B

CN101502622B - External-use medicament composition for treating indigestion as well as preparation method and application thereof

Info

Publication number: CN101502622B
Application number: CN2009103011219A
Authority: CN
Inventors: 陈芳英
Original assignee: Individual
Current assignee: Individual
Priority date: 2009-03-25
Filing date: 2009-03-25
Publication date: 2011-04-20
Anticipated expiration: 2029-03-25
Also published as: CN101502622A

Abstract

The invention belongs to medicine field, in particular to a pharmaceutical composite for treating indigestion by external application, a preparation method and applications thereof. The solved technical problem is using pharmaceutical composite for treating indigestion by external application; the pharmaceutical composite has the following active ingredients according to the parts by weight: 10 to 30 parts of rice-grain sprout, 10 to 30 parts of green malt, 10 to 30 parts of hawthorn, 9 to 25 parts of medicated leaven, 6 to 25 parts of immature bitter orange, 6 to 25 parts of dried orange peel and 15 to 45 parts of mint. The ingredients according to the weight proportion is filtered after decocted with water to obtain filtrate; the obtained filtrate is adjusted to the temperature for bath and is used for bathing the whole body, thus being capable of achieving the effect of treating indigestion, and the added large head atractylodes rhizome, rhizoma atractylodis, codonopsis pilosula, raidx astragali and mulberry leaf can also be used for treating the symptoms of nightly cry of babies and the like.

Description

Dyspeptic pharmaceutical composition of external curing and its production and use

Technical field

The invention belongs to field of medicaments, be specifically related to dyspeptic pharmaceutical composition of external curing and its production and use.

Background technology

Infantile dyspepsia mainly shows as diarrhoea, appetite minimizing, abdominal distention, bowel sound hyperaction, idol vomiting, stomachache, performance such as cry and scream well.Generally selected for use following mode to treat: 1, aid digestion and convergence medicine, as pepsin, polyzyme tablets, lactasinum, tannalbin etc., weight person can use antibiotic therapy in the past.2, Chinese medicine, massage chiropractic therapy have certain curative effect to dyspepsia.3, the suitable fasting of vomiting and diarrhoea severe patient is 12 hours, begins progressively to carry out the transition to normal diet from sucrose solution, rice water then.Serious dehydration person's fluid infusion in time.

Children night crying refers to that the baby laughs as usual and can fall asleep on the daytime, the uneasiness of then crying at nightfall, or regularly cry every night, even all through the night, and a few days at least is at most through the moon, so claim night cry again.Can adopt each 5 gram of Semen Armeniacae Amarum, Radix Scutellariae, Flos Chrysanthemi Indici, being decocted in water for oral dose is used for lung-heat night crying due to fright in infant type and cries night, has the effect of tranquillizing the mind by relieving convulsion in the past; Or adopt the Radix Puerariae levigation, and get 5 gram boiled water every night and brew, call in the Mel drink-service, help children's to sleep peacefully, control night cry; Or adopt five of Ramulus Persicae (it is long to get the sharp chi of branch), and decocting, every day is decoction being taken warmly at twice, and the effect of treatment children night crying is arranged.Above-mentioned Therapeutic Method mostly is the mode of oral medication,

Because the many mouthfeels of medicine are not good, cause the medication in children difficulty, exist compliance not strong, the defective that therapeutic effect is not good.Especially it is more difficult to take medicine less than 6 months baby, if take reluctantly, also exists feed few, the problem of tolerance difference, and may be still unsound because of its gastrointestinal system, produce bigger side effect.

Summary of the invention

Technical problem solved by the invention provides a kind ofly treats dyspeptic pharmaceutical composition in the external mode.

This active ingredient in pharmaceutical is to comprise following components in weight percentage: give birth to Fructus Setariae Germinatus 10-30 part, Fructus Hordei Germinatus 10-30 part, Fructus Crataegi 10-30 part, Massa Medicata Fermentata 9-25 part, Fructus Aurantii Immaturus 6-25 part, Pericarpium Citri Reticulatae 6-25 part, Herba Menthae 15-45 part.Adopt the component of this ratio range to boil the filterable filtrate in back by decocting, transfer to the temperature that adapts to bathing, with its bathing whole body, can reach the dyspeptic effect of treatment, the inventor adopts this pharmaceutical composition mainly to treat infantile dyspepsia in the mode of external bathing, avoided the child take medicine the difficulty problem, curative effect is obvious.Situations such as the excessive milk (children's's spitting milk) that causes for infantile dyspepsia, halitosis, loss of appetite (anorexia), abdominal distention, stomachache, diarrhoea, bowel sound hyperaction, constipation improve significantly, and effective percentage reaches more than 95%.

The inventor further optimizes component in actual applications, adjusts its proportion relation make a living 12 parts of Fructus Setariae Germinatuss, 12 parts of Fructus Hordei Germinatus, 15 parts of Fructus Crataegis, 9 parts of Massa Medicata Fermentata, 8 parts of Fructus Aurantii Immaturuss, 8 parts of Pericarpium Citri Reticulataes, 15 parts of Herba Menthaes, and effective percentage reaches 99%, cure rate 80%.

In order to treat children night crying on this basis, the inventor is being contained living Fructus Setariae Germinatus, Fructus Hordei Germinatus, Fructus Crataegi, Massa Medicata Fermentata, Fructus Aurantii Immaturus, Pericarpium Citri Reticulatae, added the Rhizoma Atractylodis Macrocephalae on the basis of the pharmaceutical composition of Herba Menthae, Rhizoma Atractylodis, Radix Codonopsis, the Radix Astragali, Folium Mori, Flos Chrysanthemi, Ramulus Cinnamomi, Herba Portulacae, Folium Artemisiae Argyi, Radix Puerariae, Poria, its weight proportion relation is: give birth to Fructus Setariae Germinatus 10-30 part, Fructus Hordei Germinatus 10-30 part, Fructus Crataegi 10-30 part, Massa Medicata Fermentata 9-25 part, Fructus Aurantii Immaturus 6-25 part, Pericarpium Citri Reticulatae 6-25 part, Herba Menthae 15-45 part, Rhizoma Atractylodis Macrocephalae 10-30 part, Rhizoma Atractylodis 10-30 part, Radix Codonopsis 10-30 part, Radix Astragali 10-30 part, Folium Mori 15-45 part, Flos Chrysanthemi 15-45 part, Ramulus Cinnamomi 10-30 part, Herba Portulacae 10-30 part, Folium Artemisiae Argyi 10-30 part, Radix Puerariae 10-30 part, Poria 10-30 part.Adopt the pharmaceutical composition of this proportion relation not only to can be applicable to treat dyspepsia (especially infantile dyspepsia), the infant of suffering from diseases such as children night crying is also had clear and definite therapeutic effect.

In order to guarantee stable curative effect, the proportion relation of further optimizing component is as follows: give birth to 12 parts of Fructus Setariae Germinatuss, 12 parts of Fructus Hordei Germinatus, 15 parts of Fructus Crataegis, 10 parts of Massa Medicata Fermentata, 8 parts of Fructus Aurantii Immaturuss, 8 parts of Pericarpium Citri Reticulataes, 15 parts of Herba Menthaes, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 12 parts of Rhizoma Atractylodis, 10 parts of Radix Codonopsis, 10 parts of the Radixs Astragali, 15 parts on Folium Mori, 15 parts of Flos Chrysanthemis, 10 parts of Ramulus Cinnamomi, 12 parts of Herba Portulacaes, 15 parts of Folium Artemisiae Argyis, 10 parts of Radix Puerariaes, 10 parts in Poria.

Concrete when using pharmaceutical composition of the present invention, be the raw material that takes by weighing the said ratio relation according to corresponding indication, decoct with water, adopt to decoct the filterable filtrate in back and be used for bathing.Effective ingredient more strippings faster when decocting for the benefit of can suitably be pulverized raw material before decoction.Decocting time boiled the back reheat 15-30 minute, preferably adjusted temperature to 30-40 ℃ when using the filtrate bathing, avoided scalding.Decoction process owing to Folium Artemisiae Argyi, Herba Menthae contain volatile ingredient, adopts the mode under the back to decoct usually, decocts approximately to get final product in 5 minutes.

The inventor uses aforementioned pharmaceutical compositions and adopted living Fructus Setariae Germinatus, Fructus Hordei Germinatus, Fructus Crataegi, Massa Medicata Fermentata, Fructus Aurantii Immaturus, Pericarpium Citri Reticulatae, Herba Menthae compatibility application of treatment dyspepsia from 2004, if infant has the symptom of crying night, then add raw materials such as the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis, Radix Codonopsis, the Radix Astragali, Folium Mori, Flos Chrysanthemi, Ramulus Cinnamomi, Herba Portulacae, Folium Artemisiae Argyi, Radix Puerariae, Poria.Clinical case exceedes 20,000 examples, and effective percentage reaches more than 99%, and obvious effective rate reaches more than 95%, and cure rate reaches more than 80%, does not have improvement less than indivedual infant symptoms of about 1% approximately.

Annotate: recovery from illness is meant clinical symptom disappearance, recovers normal.Produce effects is meant the most of disappearance of a bed symptom or sx, improvement.Be meant that effectively symptom makes moderate progress.The invalid symptom that is meant does not have improvement.

The specific embodiment

Below by specific description of embodiments of the present invention the explanation but do not limit the present invention.

Prior art is: generally adopt the mode of oral drugs to treat diseases such as infantile dyspepsia, children night crying.

Pharmaceutical composition provided by the invention is used for the treatment of above-mentioned disease in the mode of external bathing.

Embodiment one:

The inventor is when practical application treatment dyspepsia, raw material can be used in following weight range adjustment: give birth to Fructus Setariae Germinatus 10-30 part, Fructus Hordei Germinatus 10-30 part, Fructus Crataegi 10-30 part, Massa Medicata Fermentata 9-25 part, Fructus Aurantii Immaturus 6-25 part, Pericarpium Citri Reticulatae 6-25 part, Herba Menthae 15-45 part, treatment dyspepsia effective percentage reaches 95%.But effect optimum when giving birth to 15 parts of treatments of 12 parts of Fructus Setariae Germinatuss, 12 parts of Fructus Hordei Germinatus, 15 parts of Fructus Crataegis, 9 parts of Massa Medicata Fermentata, 8 parts of Fructus Aurantii Immaturuss, 8 parts of Pericarpium Citri Reticulataes, Herba Menthae, effective percentage reaches 99%, so cure rate 80% inventor's pharmaceutical compositions of using this best proportion relation when the later stage more.

Embodiment two:

The inventor is when practical application treatment children night crying, raw material can be used in following weight range adjustment: give birth to Fructus Setariae Germinatus 10-30 part, Fructus Hordei Germinatus 10-30 part, Fructus Crataegi 10-30 part, Massa Medicata Fermentata 9-25 part, Fructus Aurantii Immaturus 6-25 part, Pericarpium Citri Reticulatae 6-25 part, Herba Menthae 15-45 part, Rhizoma Atractylodis Macrocephalae 10-30 part, Rhizoma Atractylodis 10-30 part, Radix Codonopsis 10-30 part, Radix Astragali 10-30 part, Folium Mori 15-45 part, Flos Chrysanthemi 15-45 part, Ramulus Cinnamomi 10-30 part, Herba Portulacae 10-30 part, Folium Artemisiae Argyi 10-30 part, Radix Puerariae 10-30 part, Poria 10-30 part, during the treatment children night crying, effective percentage reaches 92%.But effect optimum when giving birth to 10 parts of treatments of 12 parts of Fructus Setariae Germinatuss, 12 parts of Fructus Hordei Germinatus, 15 parts of Fructus Crataegis, 10 parts of Massa Medicata Fermentata, 8 parts of Fructus Aurantii Immaturuss, 8 parts of Pericarpium Citri Reticulataes, 15 parts of Herba Menthaes, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 12 parts of Rhizoma Atractylodis, 10 parts of Radix Codonopsis, 10 parts of the Radixs Astragali, 15 parts on Folium Mori, 15 parts of Flos Chrysanthemis, 10 parts of Ramulus Cinnamomi, 12 parts of Herba Portulacaes, 15 parts of Folium Artemisiae Argyis, 10 parts of Radix Puerariaes, Poria, effective percentage reaches 99%, so cure rate 80% inventor's pharmaceutical compositions of using this best proportion relation when the later stage more.

Concrete case is as follows:

The children man, 3 months are big, the milk that often overflows during sucking, and diagnosis claims dyspepsia during from one month, symptom continues into the present, bad good sleep in evening after following prescription (living Fructus Setariae Germinatus 12g, Fructus Hordei Germinatus 12g, Fructus Crataegi 15g, Massa Medicata Fermentata 9g, Fructus Aurantii Immaturus 8g, Pericarpium Citri Reticulatae 8g, Herba Menthae 15g, Folium Artemisiae Argyi 15g are raw material) decoction, is adopted decoction liquor bathing three times (once a day), after this change bathing in per two days for three times into once, the infant digestive system is normal, and no longer cry and scream evening, and sleep state is good.

The youngest daughter, 8 months big, often crouch not peaceful night, cry due to fidgets, feverish palms, play and taken off clothing, perspiration on the forehead is many when just sleeping, produce interior-heat for the stagnant the intestines and stomach of hyperphagia after diagnosing, (give birth to Fructus Setariae Germinatus 12g with following prescription, Fructus Hordei Germinatus 12g, Fructus Crataegi 15g, Massa Medicata Fermentata 10g, Fructus Aurantii Immaturus 8g, Pericarpium Citri Reticulatae 8g, Herba Menthae 15g, Rhizoma Atractylodis Macrocephalae 10g, Rhizoma Atractylodis 12g, Radix Codonopsis 10g, Radix Astragali 10g, Folium Mori 15g, Flos Chrysanthemi 15g, Ramulus Cinnamomi 10g, Herba Portulacae 12g, Folium Artemisiae Argyi 15g, Radix Puerariae 10g, Poria 10g) after the decoction, adopt decoction liquor bathing three times (once a day), after this change bathing in per two days for three times into once, the infant gastrointestinal system is regulated normal, guarantee dinner feed insatiety simultaneously, so far, infant does not spend the night and cries.

Children man, 1 years old big, halitosis, particularly morning play halitosis, sour taste in the mouth, through rash disconnected for infantile dyspepsia in gastral cavilty, be the performance that the breast food is stagnated, this stops eating clinical title for a high position.After following prescription (giving birth to Fructus Setariae Germinatus 12g, Fructus Hordei Germinatus 12g, Fructus Crataegi 15g, Massa Medicata Fermentata 10g, Fructus Aurantii Immaturus 8g, Pericarpium Citri Reticulatae 8g, Herba Menthae 15g, Rhizoma Atractylodis Macrocephalae 10g, Rhizoma Atractylodis 12g, Radix Codonopsis 10g, Radix Astragali 10g, Folium Mori 15g, Flos Chrysanthemi 15g, Ramulus Cinnamomi 10g, Herba Portulacae 12g, Folium Artemisiae Argyi 15g, Radix Puerariae 10g, Poria 10g) decoction, adopt decoction liquor bathing three times (once a day), and enjoin and can subtract food or to stop eating one, be beneficial to the recovery of gastrointestinal function.Through this treatment, the intestines and stomach conditioning is normal, no longer halitosis.

The youngest daughter, 7 months big, infant loss of appetite, abdominal distention, bowel sound hyperaction, even can not hear that with stethoscope belly has " rumble " cry yet, after following prescription (giving birth to Fructus Setariae Germinatus 12g, Fructus Hordei Germinatus 12g, Fructus Crataegi 15g, Massa Medicata Fermentata 10g, Fructus Aurantii Immaturus 8g, Pericarpium Citri Reticulatae 8g, Herba Menthae 15g, Rhizoma Atractylodis Macrocephalae 10g, Rhizoma Atractylodis 12g, Radix Codonopsis 10g, Radix Astragali 10g, Folium Mori 15g, Flos Chrysanthemi 15g, Ramulus Cinnamomi 10g, Herba Portulacae 12g, Folium Artemisiae Argyi 15g, Radix Puerariae 10g, Poria 10g) decoction, adopt decoction liquor bathing three times (once a day), it is normal that the intestines and stomach recovers, and appetite is normal.

The youngest daughter, 3 months big, occurs the symptom of crying and screaming evening after coming Sichuan from Shenzhen soon, begins to cry and scream about 11: 2 o'clock of every night, how to fool all not all rightly, must must spend this time period and could fall asleep.By analysis, that baby exists is insufficiency of the spleen, intrinsic heat and terrified, after the inventor adopts following prescription (giving birth to Fructus Setariae Germinatus 12g, Fructus Hordei Germinatus 12g, Fructus Crataegi 15g, Massa Medicata Fermentata 10g, Fructus Aurantii Immaturus 8g, Pericarpium Citri Reticulatae 8g, Herba Menthae 15g, Rhizoma Atractylodis Macrocephalae 10g, Rhizoma Atractylodis 12g, Radix Codonopsis 10g, Radix Astragali 10g, Folium Mori 15g, Flos Chrysanthemi 15g, Ramulus Cinnamomi 10g, Herba Portulacae 12g, Folium Artemisiae Argyi 15g, Radix Puerariae 10g, Poria 10g) to decoct, adopt decoction liquor bathing three times (once a day), improving situation, no longer make a lot of noise evening, and it is very fragrant to sleep.

Children man, two months are big, and crying jag always before the sleep in the recent period wails with regard to gratuitous the beginning in when eating up milk before sleeping and will sleep, and goes back the hand plane pedal, can't fool sleepingly, breast-feeds and also do not eat, and cries that having tired out sleeps then cries, all will turn from side to side every day more than one hour.Through the disconnected born weakness of the spleen and stomach of this children's of rash, insufficiency of the spleenly cause that night is not peaceful, after the inventor adopts following prescription (giving birth to Fructus Setariae Germinatus 12g, Fructus Hordei Germinatus 12g, Fructus Crataegi 15g, Massa Medicata Fermentata 10g, Fructus Aurantii Immaturus 8g, Pericarpium Citri Reticulatae 8g, Herba Menthae 15g, Rhizoma Atractylodis Macrocephalae 10g, Rhizoma Atractylodis 12g, Radix Codonopsis 10g, Radix Astragali 10g, Folium Mori 15g, Flos Chrysanthemi 15g, Ramulus Cinnamomi 10g, Herba Portulacae 12g, Folium Artemisiae Argyi 15g, Radix Puerariae 10g, Poria 10g) to decoct, adopt decoction liquor bathing three times (once a day), the improving situation of crying night, bathing is once enjoyed a very sound sleep basically evening behind the two weeks.

The youngest daughter, two years old big, and the symptom of crying night is arranged, and sleeps when situation is serious and just cried oneself to wake up once in 15 minutes.Soon just break out crying after just sleeping.After the inventor adopts following prescription (giving birth to Fructus Setariae Germinatus 12g, Fructus Hordei Germinatus 12g, Fructus Crataegi 15g, Massa Medicata Fermentata 10g, Fructus Aurantii Immaturus 8g, Pericarpium Citri Reticulatae 8g, Herba Menthae 15g, Rhizoma Atractylodis Macrocephalae 10g, Rhizoma Atractylodis 12g, Radix Codonopsis 10g, Radix Astragali 10g, Folium Mori 15g, Flos Chrysanthemi 15g, Ramulus Cinnamomi 10g, Herba Portulacae 12g, Folium Artemisiae Argyi 15g, Radix Puerariae 10g, Poria 10g) to decoct, adopt decoction liquor bathing three times (once a day), the improving situation of crying night, wash weekly once then, washed continuously four times, child's sleep quality in evening is very good.

The children man, 10 months big, went to a doctor preceding 2 months in, the situation of being hard and dry often appears, about three or four days conveniently once, the head of a family has eaten the medicine of a lot of Mel and other treatment child constipation to child, but lose effect, the inventor adopts following prescription (to give birth to Fructus Setariae Germinatus 12g, Fructus Hordei Germinatus 12g, Fructus Crataegi 15g, Massa Medicata Fermentata 10g, Fructus Aurantii Immaturus 8g, Pericarpium Citri Reticulatae 8g, Herba Menthae 15g, Rhizoma Atractylodis Macrocephalae 10g, Rhizoma Atractylodis 12g, Radix Codonopsis 10g, Radix Astragali 10g, Folium Mori 15g, Flos Chrysanthemi 15g, Ramulus Cinnamomi 10g, Herba Portulacae 12g, Folium Artemisiae Argyi 15g, Radix Puerariae 10g, Poria 10g) after the decoction, adopt decoction liquor bathing four times (once a day), the constipation transference cure, recovery from illness.

Claims

1. the dyspeptic pharmaceutical composition of external curing is characterized in that its active component is made up of following components in weight percentage: give birth to Fructus Setariae Germinatus 10-30 part, Fructus Hordei Germinatus 10-30 part, Fructus Crataegi 10-30 part, Massa Medicata Fermentata 9-25 part, Fructus Aurantii Immaturus 6-25 part, Pericarpium Citri Reticulatae 6-25 part, Herba Menthae 15-45 part.

2. the dyspeptic pharmaceutical composition of external curing according to claim 1 is characterized in that its active component is made up of following components in weight percentage:

Give birth to 12 parts of Fructus Setariae Germinatuss, 12 parts of Fructus Hordei Germinatus, 15 parts of Fructus Crataegis, 10 parts of Massa Medicata Fermentata, 8 parts of Fructus Aurantii Immaturuss, 8 parts of Pericarpium Citri Reticulataes, 15 parts of Herba Menthaes.

3. the dyspeptic pharmaceutical composition of external curing according to claim 1 and 2 is characterized in that it is that component with described weight proportion decocts with water, after decoction liquor filters filtrate gets final product.

4. the dyspeptic pharmaceutical composition of external curing is characterized in that its active component is made up of following components in weight percentage:

Give birth to Fructus Setariae Germinatus 10-30 part, Fructus Hordei Germinatus 10-30 part, Fructus Crataegi 10-30 part, Massa Medicata Fermentata 9-25 part, Fructus Aurantii Immaturus 6-25 part, Pericarpium Citri Reticulatae 6-25 part, Herba Menthae 15-45 part, Rhizoma Atractylodis Macrocephalae 10-30 part, Rhizoma Atractylodis 10-30 part, Radix Codonopsis 10-30 part, Radix Astragali 10-30 part, Folium Mori 15-45 part, Flos Chrysanthemi 15-45 part, Ramulus Cinnamomi 10-30 part, Herba Portulacae 10-30 part, Folium Artemisiae Argyi 10-30 part, Radix Puerariae 10-30 part, Poria 10-30 part.

5. the dyspeptic pharmaceutical composition of external curing according to claim 4 is characterized in that: it is characterized in that its active component is made up of following components in weight percentage:

Give birth to 12 parts of Fructus Setariae Germinatuss, 12 parts of Fructus Hordei Germinatus, 15 parts of Fructus Crataegis, 10 parts of Massa Medicata Fermentata, 8 parts of Fructus Aurantii Immaturuss, 8 parts of Pericarpium Citri Reticulataes, 15 parts of Herba Menthaes, 10 parts of the Rhizoma Atractylodis Macrocephalaes, 12 parts of Rhizoma Atractylodis, 10 parts of Radix Codonopsis, 10 parts of the Radixs Astragali, 15 parts on Folium Mori, 15 parts of Flos Chrysanthemis, 10 parts of Ramulus Cinnamomi, 12 parts of Herba Portulacaes, 15 parts of Folium Artemisiae Argyis, 10 parts of Radix Puerariaes, 10 parts in Poria.

6. according to claim 4 or the dyspeptic pharmaceutical composition of 5 described external curings, it is characterized in that it is that component with described weight proportion decocts with water, after decoction liquor filters filtrate gets final product.

7. claim 1 or the dyspeptic preparation of drug combination method of 4 described external curings is characterized in that it comprises the steps:

A, take by weighing component by weight ratio;

B, decoct with water, filter;

C, filter to such an extent that filtrate gets final product.

8. claim 1 or the 4 described pharmaceutical compositions purposes in the medicine of anorexia that preparation external curing dyspepsia causes, abdominal distention, stomachache, diarrhoea, constipation, children's's spitting milk, halitosis, bowel sound hyperaction.

9. the purposes of the described pharmaceutical composition of claim 4 in the medicine of preparation external curing children night crying.