CN101495450A - 用于治疗疼痛、胃肠道疾病和癌症的异吲哚衍生物 - Google Patents
用于治疗疼痛、胃肠道疾病和癌症的异吲哚衍生物 Download PDFInfo
- Publication number
- CN101495450A CN101495450A CNA2007800284618A CN200780028461A CN101495450A CN 101495450 A CN101495450 A CN 101495450A CN A2007800284618 A CNA2007800284618 A CN A2007800284618A CN 200780028461 A CN200780028461 A CN 200780028461A CN 101495450 A CN101495450 A CN 101495450A
- Authority
- CN
- China
- Prior art keywords
- alkyl
- group
- oxo
- amino
- alkylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80324206P | 2006-05-26 | 2006-05-26 | |
US60/803,242 | 2006-05-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN101495450A true CN101495450A (zh) | 2009-07-29 |
Family
ID=38778884
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA2007800284618A Pending CN101495450A (zh) | 2006-05-26 | 2007-05-24 | 用于治疗疼痛、胃肠道疾病和癌症的异吲哚衍生物 |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP2029535A1 (es) |
JP (1) | JP2009538296A (es) |
CN (1) | CN101495450A (es) |
AR (1) | AR061111A1 (es) |
CL (1) | CL2007001517A1 (es) |
TW (1) | TW200806625A (es) |
UY (1) | UY30363A1 (es) |
WO (1) | WO2007139464A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
WO2010077686A1 (en) * | 2008-12-08 | 2010-07-08 | Sirtris Pharmaceuticals, Inc. | Isoindolinone and related analogs as sirtuin modulators |
EP2632461A4 (en) * | 2010-10-29 | 2014-04-02 | Merck Sharp & Dohme | ISOINDOLINONE COMPOUNDS USEFUL AS PDE INHIBITORS 10 |
US9938269B2 (en) | 2011-06-30 | 2018-04-10 | Abbvie Inc. | Inhibitor compounds of phosphodiesterase type 10A |
US9403802B2 (en) | 2012-03-02 | 2016-08-02 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use therefor |
WO2014077401A1 (ja) | 2012-11-19 | 2014-05-22 | 武田薬品工業株式会社 | 含窒素複素環化合物 |
AU2015250610B2 (en) | 2014-04-23 | 2019-02-07 | Takeda Pharmaceutical Company Limited | Isoindoline-1-one derivatives as cholinergic muscarinic M1 receptor positive alloesteric modulator activity for the treatment of Alzheimers disease |
US10208046B2 (en) | 2014-05-16 | 2019-02-19 | Takeda Pharmaceutical Company Limited | Nitrogen-containing heterocyclic compound |
KR101846475B1 (ko) | 2015-04-27 | 2018-04-09 | 주식회사 녹십자 | TNIK, IKKε 및 TBK1 억제제로서의 화합물 및 이를 포함하는 약학적 조성물 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030045552A1 (en) * | 2000-12-27 | 2003-03-06 | Robarge Michael J. | Isoindole-imide compounds, compositions, and uses thereof |
DE10134482A1 (de) * | 2001-07-16 | 2003-01-30 | Bayer Ag | Substituierte Isoindole und ihre Verwendung |
DE10137163A1 (de) * | 2001-07-30 | 2003-02-13 | Bayer Ag | Substituierte Isoindole und ihre Verwendung |
US7244759B2 (en) * | 2004-07-28 | 2007-07-17 | Celgene Corporation | Isoindoline compounds and methods of making and using the same |
US7405237B2 (en) * | 2004-07-28 | 2008-07-29 | Celgene Corporation | Isoindoline compounds and methods of their use |
-
2007
- 2007-05-21 TW TW096117988A patent/TW200806625A/zh unknown
- 2007-05-23 AR ARP070102233A patent/AR061111A1/es not_active Application Discontinuation
- 2007-05-24 CN CNA2007800284618A patent/CN101495450A/zh active Pending
- 2007-05-24 EP EP07748167A patent/EP2029535A1/en not_active Withdrawn
- 2007-05-24 JP JP2009511980A patent/JP2009538296A/ja active Pending
- 2007-05-24 UY UY30363A patent/UY30363A1/es not_active Application Discontinuation
- 2007-05-24 WO PCT/SE2007/000503 patent/WO2007139464A1/en active Application Filing
- 2007-05-25 CL CL2007001517A patent/CL2007001517A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
WO2007139464A1 (en) | 2007-12-06 |
AR061111A1 (es) | 2008-08-06 |
EP2029535A1 (en) | 2009-03-04 |
CL2007001517A1 (es) | 2008-01-25 |
TW200806625A (en) | 2008-02-01 |
UY30363A1 (es) | 2008-01-02 |
JP2009538296A (ja) | 2009-11-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101495450A (zh) | 用于治疗疼痛、胃肠道疾病和癌症的异吲哚衍生物 | |
CN103608347B (zh) | 咪唑并吡啶化合物 | |
CN1989100A (zh) | 治疗性化合物 | |
CN105814022B (zh) | 作为tnf活性调节剂的稠合的二环杂芳族衍生物 | |
CN1694871B (zh) | 咪唑并吡啶及其制备和使用方法 | |
CN101558040B (zh) | 用作蛋白激酶抑制剂的二氢吡啶衍生物 | |
TW444013B (en) | Quinoline and quinazoline compounds useful in treating benign prostatic hyperplasia | |
JP5868992B2 (ja) | 癌疾患の治療のためのfgfrキナーゼ阻害剤としての置換ベンゾピラジン誘導体 | |
CN103917525B (zh) | Lrrk2激酶活性的抑制剂 | |
CN101098858A (zh) | 吲唑磺酰胺衍生物 | |
CN105001218B (zh) | 用于治疗肺动脉高压的双环杂环衍生物 | |
CN102388055B (zh) | 咪唑并[2,1-b][1,3,4]噻二唑衍生物 | |
CN101001840A (zh) | 治疗用化合物:作为骨架的吡啶 | |
CN106488910A (zh) | Kras g12c的抑制剂 | |
BR122017003188A2 (pt) | composto 1-{2-[4-(2-amino-5-cloro-3-piridinil)fenóxi]-5-pirimidinil}-3-[2-(metilsulfonil)-5-(trifluorometil)fenil]ureia, sal deste, composição farmacêutica compreendendo-os e uso destes para o tratamento de câncer | |
CN102399220A (zh) | 三并环类PI3K和mTOR双重抑制剂 | |
CN104507933A (zh) | 氨基喹唑啉和吡啶并嘧啶衍生物 | |
CN100455580C (zh) | 苯并咪唑衍生物、含有它们的组合物、它们的制备以及它们的用途 | |
CN101537001A (zh) | 作为jak-stat3信号通路抑制剂的化合物的应用 | |
US8034814B2 (en) | Phthalazine derivatives with angiogenesis inhibiting activity | |
TW201321371A (zh) | 做為akt抑制劑之異吲哚啉酮及吡咯并吡啶酮衍生物 | |
CN104837844A (zh) | 作为酪蛋白激酶1 d/e抑制剂的吡唑取代的咪唑并哌嗪 | |
TW200524599A (en) | Substituted tricyclic heterocycles and their uses | |
CN101328151A (zh) | 苯并咪唑衍生物、含有它们的组合物、它们的制备以及它们的用途 | |
US10730878B2 (en) | Fused quinoline compounds as PI3K/mTOR inhibitors |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
WD01 | Invention patent application deemed withdrawn after publication |