CN101489471B - 利用检测微血管血液含量早期增大来识别异常组织的装置 - Google Patents

利用检测微血管血液含量早期增大来识别异常组织的装置 Download PDF

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Publication number
CN101489471B
CN101489471B CN200780026888.4A CN200780026888A CN101489471B CN 101489471 B CN101489471 B CN 101489471B CN 200780026888 A CN200780026888 A CN 200780026888A CN 101489471 B CN101489471 B CN 101489471B
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CN
China
Prior art keywords
light
collection
tissue
fiber
lens
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200780026888.4A
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English (en)
Chinese (zh)
Other versions
CN101489471A (zh
Inventor
V·贝克曼
金泳来
刘洋
H·洛伊
M·塞戈尔
V·图尔兹提斯奇
R·瓦里
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NORTHWEST UNIVERSITY
NorthShore University HealthSystem
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NORTHWEST UNIVERSITY
NorthShore University HealthSystem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/604,659 external-priority patent/US20070129615A1/en
Priority claimed from US11/604,653 external-priority patent/US20070179368A1/en
Application filed by NORTHWEST UNIVERSITY, NorthShore University HealthSystem filed Critical NORTHWEST UNIVERSITY
Publication of CN101489471A publication Critical patent/CN101489471A/zh
Application granted granted Critical
Publication of CN101489471B publication Critical patent/CN101489471B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00064Constructional details of the endoscope body
    • A61B1/00071Insertion part of the endoscope body
    • A61B1/0008Insertion part of the endoscope body characterised by distal tip features
    • A61B1/00096Optical elements
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163Optical arrangements
    • A61B1/00165Optical arrangements with light-conductive means, e.g. fibre optics
    • A61B1/00167Details of optical fibre bundles, e.g. shape or fibre distribution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/31Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the rectum, e.g. proctoscopes, sigmoidoscopes, colonoscopes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/026Measuring blood flow
    • A61B5/0265Measuring blood flow using electromagnetic means, e.g. electromagnetic flowmeter
    • A61B5/027Measuring blood flow using electromagnetic means, e.g. electromagnetic flowmeter using catheters

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Endoscopes (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN200780026888.4A 2006-05-19 2007-05-21 利用检测微血管血液含量早期增大来识别异常组织的装置 Expired - Fee Related CN101489471B (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US80195406P 2006-05-19 2006-05-19
US80194706P 2006-05-19 2006-05-19
US60/801,954 2006-05-19
US60/801,947 2006-05-19
US11/604,659 US20070129615A1 (en) 2005-10-27 2006-11-27 Apparatus for recognizing abnormal tissue using the detection of early increase in microvascular blood content
US11/604,659 2006-11-27
US11/604,653 US20070179368A1 (en) 2005-10-27 2006-11-27 Method of recognizing abnormal tissue using the detection of early increase in microvascular blood content
US11/604,653 2006-11-27
PCT/US2007/012359 WO2007136880A2 (en) 2006-05-19 2007-05-21 Method & apparatus for recognizing abnormal tissue using the detection of early increase in microvascular blood content

Publications (2)

Publication Number Publication Date
CN101489471A CN101489471A (zh) 2009-07-22
CN101489471B true CN101489471B (zh) 2014-08-27

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN200780026888.4A Expired - Fee Related CN101489471B (zh) 2006-05-19 2007-05-21 利用检测微血管血液含量早期增大来识别异常组织的装置

Country Status (6)

Country Link
EP (1) EP2020910B1 (enExample)
JP (2) JP5616058B2 (enExample)
CN (1) CN101489471B (enExample)
AU (1) AU2007254086B2 (enExample)
CA (1) CA2653040A1 (enExample)
WO (1) WO2007136880A2 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9314164B2 (en) 2005-10-27 2016-04-19 Northwestern University Method of using the detection of early increase in microvascular blood content to distinguish between adenomatous and hyperplastic polyps
US20090203977A1 (en) * 2005-10-27 2009-08-13 Vadim Backman Method of screening for cancer using parameters obtained by the detection of early increase in microvascular blood content
US9885834B2 (en) 2009-01-08 2018-02-06 Northwestern University Probe apparatus for measuring depth-limited properties with low-coherence enhanced backscattering
JP5478639B2 (ja) * 2009-01-08 2014-04-23 アメリカン バイオオプティクス エルエルシー 装置
JP2012237595A (ja) * 2011-05-10 2012-12-06 Sumitomo Electric Ind Ltd 光トモグラフィ装置
JP5623348B2 (ja) * 2011-07-06 2014-11-12 富士フイルム株式会社 内視鏡システム、内視鏡システムのプロセッサ装置、及び内視鏡システムの作動方法
US10064554B2 (en) 2011-12-14 2018-09-04 The Trustees Of The University Of Pennsylvania Fiber optic flow and oxygenation monitoring using diffuse correlation and reflectance
JP6028015B2 (ja) * 2012-03-07 2016-11-16 オリンパス株式会社 測定プローブ
CN104168812B (zh) * 2012-03-07 2016-08-24 奥林巴斯株式会社 光学测量装置以及光纤束的关联方法
JP6173325B2 (ja) 2012-09-13 2017-08-02 オリンパス株式会社 測定プローブおよび生体光学測定システム
JP6358573B2 (ja) * 2014-05-15 2018-07-18 国立大学法人浜松医科大学 乳房計測装置の作動方法及び乳房計測装置
JP6371613B2 (ja) * 2014-07-09 2018-08-08 オリンパス株式会社 画像処理装置、画像処理方法、及び画像処理プログラム
DE112015005176T5 (de) * 2014-12-12 2017-08-24 Olympus Corporation Messsonde und bio-optisches Messsystem
JP2017018483A (ja) * 2015-07-14 2017-01-26 オリンパス株式会社 医療用プローブ
CA3102138A1 (en) 2018-06-08 2019-12-12 East Carolina University Determining peripheral oxygen saturation (spo2) and hemoglobin concentration using multi-spectral laser imaging (msli) methods and systems
EP3945986A1 (en) 2019-03-26 2022-02-09 East Carolina University Near-infrared fluorescence imaging for blood flow and perfusion visualization and related systems and computer program products
US11882994B2 (en) 2020-07-24 2024-01-30 Gyrus Acmi, Inc. Systems and methods for image reconstruction and endoscopic tracking

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6320184B1 (en) * 1998-07-09 2001-11-20 Avl List Gmbh Optoelectric measuring device for monitoring combustion processes
US6571118B1 (en) * 1998-05-04 2003-05-27 Board Of Regents, The University Of Texas System Combined fluorescence and reflectance spectroscopy
US6922583B1 (en) * 1997-10-10 2005-07-26 Massachusetts Institute Of Technology Method for measuring tissue morphology

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6198532B1 (en) * 1991-02-22 2001-03-06 Applied Spectral Imaging Ltd. Spectral bio-imaging of the eye
US6485413B1 (en) * 1991-04-29 2002-11-26 The General Hospital Corporation Methods and apparatus for forward-directed optical scanning instruments
US5799656A (en) * 1996-10-21 1998-09-01 The Research Foundation Of City College Of New York Optical imaging of breast tissues to enable the detection therein of calcification regions suggestive of cancer
ATE391451T1 (de) * 1998-01-26 2008-04-15 Massachusetts Inst Technology Endoskop zur erfassung von fluoreszenzbilder
EP1112022A4 (en) * 1998-09-11 2004-08-04 Spectrx Inc MULTI-MODAL OPTICAL TISSUE DIAGNOSIS DEVICE
US6353226B1 (en) * 1998-11-23 2002-03-05 Abbott Laboratories Non-invasive sensor capable of determining optical parameters in a sample having multiple layers
US6404497B1 (en) * 1999-01-25 2002-06-11 Massachusetts Institute Of Technology Polarized light scattering spectroscopy of tissue
US20040147843A1 (en) * 1999-11-05 2004-07-29 Shabbir Bambot System and method for determining tissue characteristics
JP2000325295A (ja) * 1999-05-21 2000-11-28 Fuji Photo Film Co Ltd 蛍光診断情報出力方法および装置
JP4067696B2 (ja) * 1999-05-21 2008-03-26 富士フイルム株式会社 蛍光強度比較出力方法および蛍光診断情報出力装置
WO2001008552A1 (en) * 1999-08-03 2001-02-08 Biophysica, Llc Spectroscopic systems and methods for detecting tissue properties
JP2003510112A (ja) * 1999-09-23 2003-03-18 ジー.ナドウ リチャード 直交偏光スペクトルイメージングの医学的応用
US6639674B2 (en) * 2000-03-28 2003-10-28 Board Of Regents, The University Of Texas System Methods and apparatus for polarized reflectance spectroscopy
US6697652B2 (en) * 2001-01-19 2004-02-24 Massachusetts Institute Of Technology Fluorescence, reflectance and light scattering spectroscopy for measuring tissue
JP3762646B2 (ja) * 2001-02-01 2006-04-05 オリンパス株式会社 蛍光観察装置
US7217266B2 (en) * 2001-05-30 2007-05-15 Anderson R Rox Apparatus and method for laser treatment with spectroscopic feedback
US7404929B2 (en) * 2002-01-18 2008-07-29 Newton Laboratories, Inc. Spectroscopic diagnostic methods and system based on scattering of polarized light
US8849379B2 (en) * 2002-04-22 2014-09-30 Geelux Holdings, Ltd. Apparatus and method for measuring biologic parameters
US7390298B2 (en) * 2003-01-06 2008-06-24 City Of Hope Expandable surgical retractor for internal body spaces approached with minimally invasive incisions or through existing orifices
EP1610671B1 (en) * 2003-03-18 2013-08-21 The General Hospital Corporation Polarized light devices and methods
US20060155178A1 (en) * 2004-03-26 2006-07-13 Vadim Backman Multi-dimensional elastic light scattering

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6922583B1 (en) * 1997-10-10 2005-07-26 Massachusetts Institute Of Technology Method for measuring tissue morphology
US6571118B1 (en) * 1998-05-04 2003-05-27 Board Of Regents, The University Of Texas System Combined fluorescence and reflectance spectroscopy
US6320184B1 (en) * 1998-07-09 2001-11-20 Avl List Gmbh Optoelectric measuring device for monitoring combustion processes

Also Published As

Publication number Publication date
AU2007254086B2 (en) 2013-03-21
EP2020910A4 (en) 2014-01-08
EP2020910B1 (en) 2019-07-10
CN101489471A (zh) 2009-07-22
JP2013048914A (ja) 2013-03-14
EP2020910A2 (en) 2009-02-11
AU2007254086A1 (en) 2007-11-29
JP2009537285A (ja) 2009-10-29
WO2007136880A3 (en) 2008-04-24
CA2653040A1 (en) 2007-11-29
JP5616058B2 (ja) 2014-10-29
JP5670982B2 (ja) 2015-02-18
WO2007136880A2 (en) 2007-11-29

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Granted publication date: 20140827

Termination date: 20200521