CN101485734A - Chinese medicinal composition for resisting ageing and preparation method thereof - Google Patents

Abstract

The invention relates to a traditional Chinese medicine composition for resisting consenescence. The traditional Chinese medicine composition is prepared from sanchi flower, gingkgo, medicinal indianmulberry root, semen sesami nigrum, radix polygoni multiflori preparata, mother chrysanthemum, safflower, radix salviae miltiorrhizae, schisandra, szechwan lovage rhizome, radix astragali, epimedium, russian boschnai aki herb, herba portulacae, fructus cnidii, geranium and/or a pharmaceutically accepted carrier. The invention also relates to a method for preparing the traditional Chinese medicine composition. The traditional Chinese medicine composition can promote microcirculation of a human body, regulate equilibrium between yin and yang of the human body, activate functions of heart and lungs, liver and kidney, intestines and stomach of the human body, and can be used for preventing and treating consenescence and complicating diseases of the human body.

Description

A kind of antidotal Chinese medicine composition and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine composition, specifically, relate to a kind of antidotal Chinese medicine composition and preparation method thereof.

Background technology

Human when absorbing oxygen, consumption of calorie or decomposition glucose, can produce free radical (also being active oxygen or free radical).But free radical can wait for an opportunity to seek binding molecule and cause damage constantly; Perhaps be converted into toxin and be penetrated into cell interior, even arrive the position and the breaking-up at DNA place.Analyse in depth and find that the similar process that the aging of human body and ferrum get rusty is oxidated result.The body metabolism process produces the activist of a kind of being called " free radical ", is a kind of senescence-factor, and it acts on the skin peptide and causes " rust staining ", acts on internal organs and forms similar " body rust ".At an early age under normal physiological conditions, people's physical ability is removed unnecessary free radical, but with age, reasons such as life stress, psychentonia, smoking and drinking, air pollution, electromagnetic radiation, melancholy, insomnia cause metabolism disorder, cause oxygen-derived free radicals surplus in the body, hereditary material DNA in the continuous attack cells of unnecessary free radical makes the suffered oxidative damage of DNA long-pending more heavy more.Free radical surplus in the human body, following disease can appear in the oxidation resistance deficiency: wrinkle, mottle, Dermatochalasia, eye pouch, the colour of skin are dark and gloomy, insomnia, tired, dizzy nervous, constipation, blood-fat and blood sugar rising, arthritis, flu, apoplexy, senile dementia, endocrine disturbance, visual deterioration, sexual disorder, climacteric in advance, hypoimmunity, cancer etc.Endogenous disease and free radical more than 70% are closely bound up.

Traditional Chinese medical science causes of senescence comprise suffer from a deficiency of the kidney cause decline, weakness of the spleen and stomach cause decline, qi stagnation blood stasis causes several theories such as decline." element is asked " emphasizes whether old and feeble, old and feeble speed, is decided by the power of kidney qi.Well-known doctor Li Gao then attaches great importance to the effect of taste in aging, points out " one of stomach disease of FU-organ, then 12 through the neither foot of vigour also ... all have this disease, though his disease of not becoming different has been decreased its natural life-span ".

These theories have all embodied self-organization theory.Chinese medicine thinks that human body is a self-organizing system, and when unbalanced state occurring, human body has and automatically restores to normal ability, i.e. self organization ability.After entering the geratic period, this self organization ability weakens, and causes the susceptibility of various diseases is strengthened.The self organization ability that the generation development of various diseases has further destroyed human body has again quickened aging.

The traditional Chinese medical science is to be familiar with old and feeble process and essence from the angle of self-organization theory all the time, by the meridian dredging, transfers internal organs, and the toxin expelling element is built up one's health, qi and blood invigorating, and the replenishing essence marrow consolidates unit and reaches purpose anti-aging in advance, slow down aging.

Summary of the invention

The purpose of this invention is to provide a kind of antidotal Chinese medicine composition.

The present invention also aims to provide a kind of preparation method of this Chinese medicine composition.

In order to realize purpose of the present invention, the invention provides a kind of antidotal Chinese medicine composition, be to make by effective ingredient and/or pharmaceutically acceptable carrier, described effective ingredient is made by weight by following raw materials according:

1, prescription:

Flower of Radix Notoginseng 2-15 part Semen Ginkgo 10-50 part Radix Morindae Officinalis 10-25 part

Semen Sesami Nigrum 10-25 part Radix Polygoni Multiflori Preparata 10-30 part Flos Chrysanthemi 5-15 part

Flos Carthami 5-20 part Radix Salviae Miltiorrhizae 5-30 part Fructus Schisandrae Chinensis 5-20 part

Rhizoma Chuanxiong 2-28 part Radix Astragali 5-30 part Herba Epimedii 5-30 part

Herba Boschniakiae Rossicae 10-30 part Herba Portulacae 10-30 part Fructus Cnidii 10-30 part

Herba Erodii 10-30 part

Effective ingredient is preferably made by weight by following raw materials according:

20 parts of 40 parts of Radix Morindae Officinaliss of 12 portions of Semen Ginkgoes of flower of Radix Notoginseng

12 parts of 20 parts of Flos Chrysanthemis of 15 parts of Radix Polygoni Multiflori Preparata of Semen Sesami Nigrum

18 parts of 25 parts of Fructus Schisandrae Chinensis of 18 parts of Radix Salviae Miltiorrhizaes of Flos Carthami

25 parts of 20 parts of Herba Epimedii of 20 parts of Radixs Astragali of Rhizoma Chuanxiong

25 parts of 20 parts of Fructus Cnidiis of 20 portions of Herba Portulacaes of Herba Boschniakiae Rossicae

25 parts of Herba Erodiis

The present invention also provides a kind of preparation method of this Chinese medicine composition, comprises the steps:

2, preparation technology

(1) flower of Radix Notoginseng, Semen Ginkgo, Radix Morindae Officinalis, Semen Sesami Nigrum,, Radix Polygoni Multiflori Preparata, Flos Chrysanthemi, Flos Carthami, Radix Salviae Miltiorrhizae, Fructus Schisandrae Chinensis, Rhizoma Chuanxiong, the Radix Astragali, Herba Epimedii, Herba Boschniakiae Rossicae, Herba Portulacae, Fructus Cnidii, Herba Erodii water decoct secondary, each 1 hour, filter, merging filtrate concentrates, get thick paste (d=1.15-1.20,60 ℃);

(2) with the thick paste drying and crushing, and/or pharmaceutically acceptable carrier system granule, capsule.

Pharmaceutical composition of the present invention can with receivable carrier pharmaceutically, for example: filler such as starch, microcrystalline Cellulose etc.; Binding agent such as vitamin derivative, starch etc.; Mode by granule, capsule oral administration is used.

Chinese medicine composition of the present invention has the promotion microcirculation in human body, mediator's yin-yang, human activin cardiopulmonary, Liver and kidney, each function of gastrointestinal.Be used for prevention and treatment human senility and complication.

The specific embodiment:

Following examples are used to illustrate the present invention, but are not used for limiting the scope of the invention.

Embodiment 1 Chinese medicinal composition granules of the present invention

1, prescription:

20 parts of 40 parts of Radix Morindae Officinaliss of 12 portions of Semen Ginkgoes of flower of Radix Notoginseng

12 parts of 20 parts of Flos Chrysanthemis of 15 parts of Radix Polygoni Multiflori Preparata of Semen Sesami Nigrum

18 parts of 25 parts of Fructus Schisandrae Chinensis of 18 parts of Radix Salviae Miltiorrhizaes of Flos Carthami

25 parts of 20 parts of Herba Epimedii of 20 parts of Radixs Astragali of Rhizoma Chuanxiong

25 parts of 20 parts of Fructus Cnidiis of 20 portions of Herba Portulacaes of Herba Boschniakiae Rossicae

25 parts of Herba Erodiis

2, preparation technology:

(1) flower of Radix Notoginseng, Semen Ginkgo, Radix Morindae Officinalis, Semen Sesami Nigrum,, Radix Polygoni Multiflori Preparata, Flos Chrysanthemi, Flos Carthami, Radix Salviae Miltiorrhizae, Fructus Schisandrae Chinensis, Rhizoma Chuanxiong, the Radix Astragali, Herba Epimedii, Herba Boschniakiae Rossicae, Herba Portulacae, Fructus Cnidii, Herba Erodii water decoct secondary, each 1 hour, filter, merging filtrate concentrates, get thick paste (d=1.15-1.20,60 ℃);

(2) with the thick paste drying and crushing, add lactose 800, dextrin 200, mixing, with 70% ethanol wet granulation promptly.

Embodiment 2 Chinese medicinal composition capsules agent of the present invention

1, prescription:

20 parts of 40 parts of Radix Morindae Officinaliss of 12 portions of Semen Ginkgoes of flower of Radix Notoginseng

12 parts of 20 parts of Flos Chrysanthemis of 15 parts of Radix Polygoni Multiflori Preparata of Semen Sesami Nigrum

18 parts of 25 parts of Fructus Schisandrae Chinensis of 18 parts of Radix Salviae Miltiorrhizaes of Flos Carthami

25 parts of 20 parts of Herba Epimedii of 20 parts of Radixs Astragali of Rhizoma Chuanxiong

25 parts of 20 parts of Fructus Cnidiis of 20 portions of Herba Portulacaes of Herba Boschniakiae Rossicae

25 parts of Herba Erodiis

2, preparation technology:

(1) flower of Radix Notoginseng, Semen Ginkgo, Radix Morindae Officinalis, Semen Sesami Nigrum,, Radix Polygoni Multiflori Preparata, Flos Chrysanthemi, Flos Carthami, Radix Salviae Miltiorrhizae, Fructus Schisandrae Chinensis, Rhizoma Chuanxiong, the Radix Astragali, Herba Epimedii, Herba Boschniakiae Rossicae, Herba Portulacae, Fructus Cnidii, Herba Erodii water decoct secondary, each 1 hour, filter, merging filtrate concentrates, get thick paste (d=1.15-1.20,60 ℃);

(2) drying and crushing, it is skilful 300 to add dextrin, mixing, in the capsulae vacuus of packing into promptly.

Experimental example

1.1 the animal Kunming mouse, ♂, body weight 18～22g

1.2 medicine and reagent: D-galactose, thiobarbituricacid, benzylamine, glutathione (GSH), dithio-nitrobenzene (DTNB), L-glutamic acid 1,2,3-indantrione monohydrate, GSH-PX, CAT, SOD measure test kit

1.3 instrument WFZ800-D2 type ultraviolet-uisible spectrophotometer, HITACHI650-60 type spectrofluorophotometer, electrophresis apparatus, DYY-III type, 721 spectrophotometers, 910 dual-wavelength lamellar scanning instrument.

2 ways

2.1 the foundation of D-galactose aging model: get 75 of healthy ♂ mices, be divided into normal group, model group, Chinese drug-treated group at random.Chinese drug-treated group (125,250,500mg/kg); Normal group and the isopyknic CMCNa of model group ig; Chinese drug-treated group.Administration is model group and each administration group subcutaneous injection 5%D-galactose 0.25ml/10g simultaneously; The isopyknic normal saline of normal group subcutaneous injection; Continuous 6 weeks, behind the last 1 day filling harmonization of the stomach injection of d-galactose 2h, carry out the learning and memory training experiment, measure the memory achievement next day, put to death then, measure every aging index.

2.2 the mensuration of ability of learning and memory in mice (diving tower method).Animal is put into diving tower case endoadaptation 3min, logical immediately then 36V alternating current.Animal is shocked by electricity, its normal reaction be the rebound platform to hide noxious stimulation, so train 5min.The test of reforming behind the 24h, this promptly remembers and keeps test.The record mice jumps off the incubation period of platform and the errors number in the 5min for the 1st time.

2.3 mouse brain is organized MDA, LF assay.The mice sacrificed by decapitation is got brain immediately, measures the content of organizing malonaldehyde (MDA) with thiobarbituricacid (TBA) method; Content with LF in the fluorescence spectrometry cerebral tissue.

2.4 the mensuration of SOD vigor in mice whole blood GSH-PX, erythrocyte CAT and the brain.The 2nd day eye socket got blood after the administration of mice last, and sacrificed by decapitation is got full brain, presses the test kit explanation respectively and measures GSH-PX, CAT and SOD.

2.5 mouse brain is organized the mensuration of two-story valley histidine content.The mice sacrificed by decapitation, it is an amount of to get full brain immediately, makes 10% homogenate with the trichloroacetic acid of 0.61mol/L, after getting supernatant and washing with petroleum ether-n-butyl alcohol, point sample, electrophoresis, the content of full brain glutamic acid is afterwards measured in the 1,2,3-indantrione monohydrate colour developing with the dual-wavelength lamellar scanning instrument.

Represent 2.6 the statistics way is respectively organized The data x ± s, relatively adopt the t check between group.

3 results

3.1 to the influence of aging model mice body weight and immune organ weight and normal group relatively, aging model mice body weight and thymus and index and spleen index reduce, and Chinese medicine (125,250,500mg/kg) can significantly suppress the reduction of body weight, thymus and index and spleen index.

3.2 the influence to the aging model learning and memory of little mouse is compared with the normal control group, the model group mouse memory obviously fails, and showing as errors number increases, and shortens (all P＜0.01) incubation period.Compare with model group, and Chinese medicine (125,250,500mg/kg) mouse wrong times is obviously reduced, obviously prolong incubation period.

3.3 in the mouse brain LPO, LF, content with normal group relatively, LPO, LF, content increase in the aging model mouse brain tissue, and Chinese medicine (125,250,500mg/kg) can significantly suppress increasing of LPO, LF content.

3.4 influence and normal group to SOD vigor in mice whole blood GSH-PX, erythrocyte CAT and the brain compare, the SOD vigor obviously reduces in aging model mice whole blood GSH-PX, erythrocyte CAT and the brain, and Chinese medicine (125,250,500mg/kg) can significantly suppress the reduction of 3 kinds of enzyme activities.

3.5 to the influence of the full brain glutamic acid of mice content and normal group relatively, the full brain glutamic acid of aging model mice content increases, and Chinese medicine (125,250,500mg/kg) can significantly suppress the increase of glutamic acid content.

4 explanations

The subacute aging model of D-galactose is to utilize to give the mice continuous subcutaneous injection heavy dose of D-galactose, causes the animal carbohydrate metabolism disturbance to set up.The D-galactose can produce oxygen-derived free radicals such as superoxide anion under beta-Galactose oxidase catalysis.Oxygen-derived free radicals has high activity, can attack DNA in unsaturated fatty acid, protein, enzyme and the karyon in the membrane phospholipid etc.; Free radical also can make lipid generation peroxidation and form lipid peroxide (LPO), LPO generates MDA after with albumen precipitation under acid condition, MDA is active cross-linking agent, can be rapidly and PHOSPHATIDYL ETHANOLAMINE generate fluorochrome, form flaggy shape lipofuscin (LF) with protein, peptide class, contaminated with lipid then.Inject continuously with the D-galactose, mice can produce the variation of multinomial biochemical indicator, as the rising of cerebral tissue MDA, LF content; The reduction of CAT vigor in GSH-PX, the erythrocyte in SOD, the blood in the brain, these change with old and feeble variation consistent, illustrate that the D-galactose can cause the aging of cell and body.SOD, GSH-PX, the active reflection indirectly of CAT body are removed the ability of oxygen-derived free radicals; And MDA, the LF level height reflection cell order of severity that attacked by free radical indirectly.

Claims (4)

1, a kind of antidotal Chinese medicine composition is to be made by effective ingredient and/or pharmaceutically acceptable carrier, it is characterized in that described effective ingredient is made by weight by following raw materials according:

Flower of Radix Notoginseng 2-15 part Semen Ginkgo 10-50 part Radix Morindae Officinalis 10-25 part

Semen Sesami Nigrum 10-25 part Radix Polygoni Multiflori Preparata 10-30 part Flos Chrysanthemi 5-15 part

Flos Carthami 5-20 part Radix Salviae Miltiorrhizae 5-30 part Fructus Schisandrae Chinensis 5-20 part

Rhizoma Chuanxiong 2-28 part Radix Astragali 5-30 part Herba Epimedii 5-30 part

Herba Boschniakiae Rossicae 10-30 part Herba Portulacae 10-30 part Fructus Cnidii 10-30 part

Herba Erodii 10-30 part

2, Chinese medicine composition as claimed in claim 1 is characterized in that described effective ingredient made by weight by following raw materials according:

20 parts of 40 parts of Radix Morindae Officinaliss of 12 portions of Semen Ginkgoes of flower of Radix Notoginseng

12 parts of 20 parts of Flos Chrysanthemis of 15 parts of Radix Polygoni Multiflori Preparata of Semen Sesami Nigrum

18 parts of 25 parts of Fructus Schisandrae Chinensis of 18 parts of Radix Salviae Miltiorrhizaes of Flos Carthami

25 parts of 20 parts of Herba Epimedii of 20 parts of Radixs Astragali of Rhizoma Chuanxiong

25 parts of 20 parts of Fructus Cnidiis of 20 portions of Herba Portulacaes of Herba Boschniakiae Rossicae

25 parts of Herba Erodiis

3,, it is characterized in that described Chinese medicine composition can be made into granule, capsule as the arbitrary described Chinese medicine composition of claim 1-2.

4, a kind of preparation method as the arbitrary described Chinese medicine composition of claim 1-3 comprises the steps:

(1) flower of Radix Notoginseng, Semen Ginkgo, Radix Morindae Officinalis, Semen Sesami Nigrum,, Radix Polygoni Multiflori Preparata, Flos Chrysanthemi, Flos Carthami, Radix Salviae Miltiorrhizae, Fructus Schisandrae Chinensis, Rhizoma Chuanxiong, the Radix Astragali, Herba Epimedii, Herba Boschniakiae Rossicae, Herba Portulacae, Fructus Cnidii, Herba Erodii water decoct secondary, each 1 hour, filters merging filtrate; Concentrate, get thick paste (d=1.15-1.20,60 ℃);

(2) with the thick paste drying and crushing, and/or pharmaceutically acceptable carrier system granule, capsule.