CN101485446B - Preparation method of garlic oil cyclodextrin or cyclodextrin derivate inclusion compound - Google Patents
Preparation method of garlic oil cyclodextrin or cyclodextrin derivate inclusion compound Download PDFInfo
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- CN101485446B CN101485446B CN2009100094972A CN200910009497A CN101485446B CN 101485446 B CN101485446 B CN 101485446B CN 2009100094972 A CN2009100094972 A CN 2009100094972A CN 200910009497 A CN200910009497 A CN 200910009497A CN 101485446 B CN101485446 B CN 101485446B
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- cyclodextrin
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Abstract
The invention relates to a garlic oil cyclodextrin or cyclodextrin derivative inclusion compound, and a preparation method thereof. Garlic oil is an organic sulfide extracted from garlic and has the functions of resisting bacteria, diminishing inflammation, improving organism immunity, preventing and treating cardiovascular system diseases, and the like. Garlic oil has aroma and hot taste similar to fresh garlic, is integral in flavor, pure natural, safe and healthy, and is widely applied to salty food additives, health-care food, edible blend oil and the like, but as the garlic oil is unstable in properties, strong in volatility and acrimony and difficult to dissolve in water, the application of the garlic oil to food is greatly limited. The preparation method applies cyclodextrin and cyclodextrin derivatives to the inclusion of garlic oil so as to prepare the garlic oil cyclodextrin or cyclodextrin derivative inclusion compound, solves the problems that the garlic oil is low in water solubility, strong in acrimony and the like, and enables the garlic oil to be directly applied to food and health care products.
Description
Technical field
The invention belongs to field of food, relate to garlic oil cyclodextrine or cyclodextrin derivant clathrate and preparation method, or be applied to food, nutrition, health products trade.
Background technology
Garlic is the bulb of Liliaceae allium garlic (Allium sativum L.), garlic oil be the class from garlic, extracted and water immiscible have volatile organic sulfur compound, effect with anti-inflammation, can improve body's immunity, prevention and treatment disease of cardiovascular system and cancer-resisting can be widely used in industries such as food chemical and medicine industry health care.Allicin is the main active ingredient of garlic oil, and allicin is a diallyl trisulfide, and structural formula is CH
2=CHCH
2-S-S-S-CH
2CH=CH
2
Discover that garlic oil has the health-care effect of multiple mystery: 1. protect the cardiovascular system effect for reducing blood fat of unifying: garlic oil can improve microcirculation; increase the peripheral blood flow; the activity that suppresses clotting factor; tangible study of anti-atherogenic effect is arranged, and the atherosclerosis of aorta that hypercholesterolemia is caused has the better protect effect.Nowadays become international health fashion with the garlic oil lipopenicillinase, because it is an integration of drinking and medicinal herbs, so meet the international new opinion of " the lifelong dietotherapy of reducing blood lipid needs ".2. prevent function of tumor: garlic oil can suppress and disturb the oncogenic process of number of chemical carcinogenic substance such as BaP etc., tissue canceration the startup stage just blocked the mutagenic processes that carcinogenic substance produces normal cell.Galic essential oil can participate in normal division of cytogenetics matter DNA and repair process, can prevent the generation of lung cancer, liver cancer, cancer of the esophagus.Diallyl sulphur in the garlic oil is the very important anticancer factor, forms by preventing carcinogenic substance, disturbs carcinogenic activation, strengthens detoxifying properties, avoids the conversion of normal cell to cancer cell, further stops the formation of tumour cell.3. thrombolysis is more thorough: garlic oil can shorten the clotting time, and medical science points out this function also can prevent thrombosis, is the most strong composition of pre-preventing thrombosis.4. garlic is described as " natural antibiotics ", and garlic oil has sterilization or bacteriostatic activity to multiple pathogenic fungus, and is especially effective to various skin disease and beriberi.5. immunization: allicin can induce human lymphocyte to transform, and can increase the T lymphocyte transformation, increases macrophage and lymphocytic functional activity, and immunologic function is strengthened.In addition, garlic oil also has effects such as anti-ageing, hypoglycemic, radioresistance, anti-platelet aggregation, protection biomembrane.
Garlic oil character instability, what be subject to pH, light, temperature, oxygen influences generation oxidation deterioration and garlic oil high volatility, tanginess, itself is insoluble in water garlic oil, has volatility and strong and stimulating, unstable chemcial property has greatly limited its application aspect food.Therefore adopt cyclodextrin encapsulated after, can reduce the excitant of garlic oil, improve bad smell, improve the water-soluble and stable of garlic oil, improve the storage rate of garlic oil greatly.
Summary of the invention
The purpose of this invention is to provide inclusion compound of a kind of garlic oil cyclodextrine and preparation method thereof, this method is utilized cyclodextrin encapsulated effect, garlic oil is carried out inclusion, improve it to light, to the stability of heat, reduce the excitant of garlic oil, improve the bad smell of garlic oil, improve the solubility of the garlic oil that is insoluble in water simultaneously to a certain extent.
Technical scheme of the present invention:
The present invention is the inclusion compound of a kind of garlic oil and cyclodextrin, and the architectural feature of inclusion compound is that in the cavity of cyclodextrin, form with the cyclodextrin is that host molecule, garlic oil are the inclusion compound of guest molecule to garlic oil by inclusion.
As the cyclodextrin of host molecule is in alpha-cyclodextrin, beta-schardinger dextrin-, gamma-cyclodextrin, hydroxypropyl cyclodextrin, the grape basic ring dextrin any, and wherein beta-schardinger dextrin-and hydroxypropyl cyclodextrin are cheap and easy to get, is the lapping of the host molecule of first-selection.
The present invention realizes by following technical method: with garlic oil and cyclodextrin, and by coprecipitation, solid reaction process, the cyclodextrin inclusion compound of generation garlic oil.Described co-precipitation preparation method is, accurately take by weighing a certain amount of cyclodextrin and under 60 ℃ of waters bath with thermostatic control, be dissolved in the distilled water of certain volume and it is dissolved fully, be cooled to 40 ℃ after, (airtight) slowly added garlic oil-ethanolic solution (1: 1 under stirring, v/v), container is airtight, after the stirred for several hour, place down for 4 ℃ and spend the night, suction filtration obtains precipitation, precipitation is washed with an amount of distilled water, and 40 ℃ of following vacuum drying 24h can get inclusion compound.
Described solid reaction process is, take by weighing a certain amount of cyclodextrin, place mortar, add low amounts of water, grind well, take by weighing a certain amount of garlic oil again, be added in the mortar, obtain paste after fully grinding, wash to remove unreacted garlic oil in the inclusion compound with ethanol or acetone and other organic solvent, remove the inclusion compound that unreacted cyclodextrin gets chemical pure garlic oil cyclodextrine with Warm Wash again, place then more than 40 ℃ of dry 4h of vacuum desiccator, obtain the cyclodextrin inclusion compound of garlic oil.
Technique effect of the present invention
By cyclodextrin and derivative thereof garlic oil is carried out inclusion, garlic oil is embedded in the tubular structure of cyclodextrin, become the inclusion compound of garlic oil cyclodextrine, thereby improved the water-soluble and stable of garlic oil, this active component of garlic oil is directly applied in food, the health products with the form of inclusion compound, solved shortcomings such as water-soluble low, the poor stability of garlic oil, excitant be strong.
The specific embodiment
Garlic oil cyclodextrine and derivative clathrate thereof contain garlic oil and cyclodextrin and derivative thereof, and the weight ratio of cyclodextrin and derivative thereof and garlic oil is 6-600: 1.
Garlic oil is meant the oily liquids that obtains by solvent lixiviation process, steam distillation, supercritical fluid extraction from garlic.Cyclodextrin and derivative thereof comprise alpha-cyclodextrin, beta-schardinger dextrin-, gamma-cyclodextrin, HP-, hydroxyethyl-, dihydroxypropyl-beta-schardinger dextrin-, glucose ring dextrin, maltose cyclodextrin, maltotriose cyclodextrin.
Garlic oil cyclodextrine and derivative clathrate preparation method thereof are as follows: be dissolved in the cyclodextrin or derivatives thereof in the water of certain volume or the ethanol and it is dissolved fully, according to cyclodextrin and derivative and garlic oil weight ratio 6-600: 1, under stirring, slowly added garlic oil-ethanolic solution (1: 1, v/v), container is airtight, after the stirred for several hour, place down for 4 ℃ and spend the night, suction filtration obtains precipitation, precipitation washes with water, and 40 ℃ of following dry 24h promptly get solid garlic oil cyclodextrine and derivative clathrate thereof.
Garlic oil cyclodextrine and derivative clathrate preparation method thereof among the present invention, also can be that the cyclodextrin or derivatives thereof is placed colloid mill or mortar, adding an amount of water or ethanol grinds, make pastel, according to cyclodextrin and derivative and garlic oil weight ratio 6-600: 1, garlic oil is added in the above-mentioned pastel, obtain paste after fully grinding, wash to remove unreacted garlic oil in the inclusion compound with ethanol or acetone and other organic solvent, remove the inclusion compound that unreacted cyclodextrin gets chemical pure garlic oil cyclodextrine with Warm Wash again, place 40 ℃ of dryings down then, promptly get solid garlic oil cyclodextrine and derivative clathrate thereof.
Above-mentioned drying means can use drying means such as convection drying, vacuum drying, spray-drying, freeze drying.
Claims (1)
1. garlic oil cyclodextrine inclusion compound preparation method, it is characterized in that cyclodextrin is dissolved in an amount of water or ethanol, is 6-600 according to the weight ratio of cyclodextrin and garlic oil:: 1, get a certain amount of garlic oil and be dissolved in an amount of ethanol, under stirring, garlic oil is slowly joined in the cyclodextrin solution, after the stirred for several hour, place down for 4 ℃ and spend the night under the airtight condition, suction filtration obtains precipitation, with the suitable quantity of water washing, 40 ℃ dry down, obtains the solid clathrates of the cyclodextrin of garlic oil.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100094972A CN101485446B (en) | 2009-02-26 | 2009-02-26 | Preparation method of garlic oil cyclodextrin or cyclodextrin derivate inclusion compound |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009100094972A CN101485446B (en) | 2009-02-26 | 2009-02-26 | Preparation method of garlic oil cyclodextrin or cyclodextrin derivate inclusion compound |
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| CN101485446A CN101485446A (en) | 2009-07-22 |
| CN101485446B true CN101485446B (en) | 2010-08-11 |
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| CN2009100094972A Expired - Fee Related CN101485446B (en) | 2009-02-26 | 2009-02-26 | Preparation method of garlic oil cyclodextrin or cyclodextrin derivate inclusion compound |
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| CN102552643B (en) * | 2010-12-21 | 2014-07-09 | 中山市中健药物研究所有限公司 | Combination with blood fat reducing function and application of same |
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| CN106266473A (en) * | 2016-08-11 | 2017-01-04 | 天津大学 | A kind of green Bulbus Allii extract with antihepatocarcinoma effect and Preparation method and use |
| CN107789345B (en) * | 2016-09-07 | 2022-06-28 | 汤臣倍健股份有限公司 | Corrective allicin-cyclodextrin compound and preparation method thereof |
| CN106751279A (en) * | 2016-12-30 | 2017-05-31 | 杜克玲 | A kind of antistatic, the bentonite containing garlic oil/PVA sterilization fresh-keeping films and preparation method thereof |
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| CN106751282A (en) * | 2016-12-30 | 2017-05-31 | 杜克玲 | A kind of bentonite containing garlic oil/PVA sterilization fresh-keeping films and preparation method thereof |
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| CN106751278A (en) * | 2016-12-30 | 2017-05-31 | 杜克玲 | A kind of waterproof, the bentonite containing garlic oil/PVA sterilization fresh-keeping films and preparation method thereof |
| CN108085352A (en) * | 2018-01-24 | 2018-05-29 | 江南大学 | A kind of method of two enzymes method control cyclodextrin inclusion compound sustained release |
| CN110314220A (en) * | 2018-03-28 | 2019-10-11 | 巨野恒丰果蔬有限公司 | A kind of garlic albumen and garlic oil compounding agent and the preparation method and application thereof |
| CN108752647A (en) * | 2018-06-26 | 2018-11-06 | 全椒祥瑞塑胶有限公司 | A kind of plastic additive with bacteriostasis |
| CN113999431B (en) * | 2021-10-29 | 2024-03-15 | 金发科技股份有限公司 | Peroxide inclusion compound and preparation method and application thereof |
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| CN1565430A (en) * | 2003-06-22 | 2005-01-19 | 毛友昌 | Allicin cyclodextrin clathrate compound, formulation and its preparation method |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1565430A (en) * | 2003-06-22 | 2005-01-19 | 毛友昌 | Allicin cyclodextrin clathrate compound, formulation and its preparation method |
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| CN101485446A (en) | 2009-07-22 |
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Inventor after: Wang Jing Inventor after: Wang Chengtao Inventor after: Cao Yanping Inventor after: Sun Baoguo Inventor before: Wang Jing Inventor before: Cao Yanping Inventor before: Sun Baoguo Inventor before: Wang Chengtao |
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