CN101484147B - 对于具有水中良好溶解性的活性成分具有受控的活性成分释放性的药物组合物 - Google Patents
对于具有水中良好溶解性的活性成分具有受控的活性成分释放性的药物组合物 Download PDFInfo
- Publication number
- CN101484147B CN101484147B CN200680055284.8A CN200680055284A CN101484147B CN 101484147 B CN101484147 B CN 101484147B CN 200680055284 A CN200680055284 A CN 200680055284A CN 101484147 B CN101484147 B CN 101484147B
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- CN
- China
- Prior art keywords
- weight
- methyl
- acid
- coating
- active component
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Abstract
Description
Claims (11)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1465CH2006 | 2006-08-18 | ||
IN1465/CHE/2006 | 2006-08-18 | ||
PCT/EP2006/066583 WO2008019712A1 (de) | 2006-08-18 | 2006-09-21 | Pharmazeutische zusammensetzung mit kontrollierter wirkstoffabgabe für wirkstoffe mit guter löslichkeit in wasser |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101484147A CN101484147A (zh) | 2009-07-15 |
CN101484147B true CN101484147B (zh) | 2015-07-08 |
Family
ID=37872157
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200680055284.8A Active CN101484147B (zh) | 2006-08-18 | 2006-09-21 | 对于具有水中良好溶解性的活性成分具有受控的活性成分释放性的药物组合物 |
Country Status (14)
Country | Link |
---|---|
US (1) | US8465769B2 (zh) |
EP (1) | EP2051704B1 (zh) |
JP (1) | JP5661281B2 (zh) |
KR (2) | KR20140019038A (zh) |
CN (1) | CN101484147B (zh) |
AT (1) | ATE553754T1 (zh) |
BR (1) | BRPI0621996B8 (zh) |
CA (1) | CA2661561C (zh) |
ES (1) | ES2385498T3 (zh) |
IL (1) | IL195407A (zh) |
MX (1) | MX2009001597A (zh) |
PL (1) | PL2051704T3 (zh) |
SI (1) | SI2051704T1 (zh) |
WO (1) | WO2008019712A1 (zh) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102005007059A1 (de) * | 2005-02-15 | 2006-08-24 | Röhm GmbH & Co. KG | Teilneutralisiertes anionisches (Meth)acrylat-Copolymer |
DE102005032806A1 (de) * | 2005-07-12 | 2007-01-18 | Röhm Gmbh | Verwendung eines teilneutralisierten, anionischen (Meth)acrylat-Copolymers als Überzug für die Herstellung einer Arzneiform mit einer Wirkstofffreisetzung bei erniedrigten pH-Werten |
DE102006035549A1 (de) | 2006-07-27 | 2008-01-31 | Evonik Röhm Gmbh | Arzneiform mit mindestens zweischichtiger Trennschicht |
DE102007009243A1 (de) * | 2007-02-22 | 2008-09-18 | Evonik Röhm Gmbh | Pellets mit einer Wirkstoff-Matrix und einem Polymerüberzug, sowie ein Verfahren zur Herstellung der Pellets |
BRPI0721654B8 (pt) | 2007-05-07 | 2022-07-05 | Evonik Roehm Gmbh | formas de dosagem sólida compreendendo um revestimento entérico com liberação acelerada do fármaco, seu método de fabricação e uso |
KR101500792B1 (ko) * | 2008-01-10 | 2015-03-09 | 에보니크 룀 게엠베하 | 결장에서 증가된 활성 물질 방출을 갖는 코팅된 제약학적 또는 건강기능성 제제 |
CA2711475A1 (en) * | 2008-01-10 | 2009-07-16 | Evonik Roehm Gmbh | Coated pharmaceutical or nutraceutical preparation with accelerated controlled active substance release |
KR101571179B1 (ko) * | 2008-01-10 | 2015-11-23 | 에보니크 룀 게엠베하 | 증가된 맥동성 활성 물질 방출을 갖는 코팅된 제약학적 또는 건강기능성 제제 |
US20100008983A1 (en) * | 2008-06-10 | 2010-01-14 | Muhammad Safadi | Rasagiline soft gelatin capsules |
EP2133072A1 (en) | 2008-06-13 | 2009-12-16 | KRKA, D.D., Novo Mesto | Gastro-resistant pharmaceutical oral compositions comprising duloxetine or its pharmaceutically acceptable derivatives |
US8282957B2 (en) * | 2008-06-26 | 2012-10-09 | Mcneil-Ppc, Inc. | Coated particles containing pharmaceutically active agents |
EP2359814A1 (en) * | 2010-02-11 | 2011-08-24 | Laboratorios Liconsa, S.A. | Pharmaceutical mini-tablets for sustained release of flecainide acetate |
WO2012162492A1 (en) * | 2011-05-24 | 2012-11-29 | Teva Pharmaceutical Industries Ltd. | Compressed core comprising organic acids for a pharmaceutical composition |
JP2015537029A (ja) | 2012-11-14 | 2015-12-24 | ダブリュー・アール・グレース・アンド・カンパニー−コーンW R Grace & Co−Conn | 生物学的に活性な物質及び不規則性無機酸化物を含有する組成物 |
US20140271851A1 (en) | 2013-03-14 | 2014-09-18 | Redhill Biopharma Ltd. | Antiemetic extended release solid dosage forms |
JP6461186B2 (ja) | 2014-03-11 | 2019-01-30 | レッド ヒル バイオファーマ リミテッドRedHill Biopharma Ltd. | 悪心、嘔吐または下痢の症状を処置するためのオンダンセトロン徐放固形製剤 |
US9580896B2 (en) | 2014-07-05 | 2017-02-28 | John David Hopkins | Apparatus and method for prolonged active agent in aqueous systems |
US10799138B2 (en) | 2018-04-05 | 2020-10-13 | University Of Maryland, Baltimore | Method of administering sotalol IV/switch |
EP3801462A4 (en) | 2018-05-24 | 2022-03-16 | Celanese EVA Performance Polymers LLC | IMPLANTABLE DEVICE FOR EXTENDED RELEASE OF A MACROMOLECULAR DRUG COMPOUND |
KR20210013089A (ko) | 2018-05-24 | 2021-02-03 | 셀라니즈 이브이에이 퍼포먼스 폴리머스 엘엘씨 | 거대 분자 약물 화합물의 지속적인 방출을 위한 이식가능 장치 |
US10512620B1 (en) | 2018-08-14 | 2019-12-24 | AltaThera Pharmaceuticals, LLC | Method of initiating and escalating sotalol hydrochloride dosing |
US11344518B2 (en) | 2018-08-14 | 2022-05-31 | AltaThera Pharmaceuticals LLC | Method of converting atrial fibrillation to normal sinus rhythm and loading oral sotalol in a shortened time frame |
US11610660B1 (en) | 2021-08-20 | 2023-03-21 | AltaThera Pharmaceuticals LLC | Antiarrhythmic drug dosing methods, medical devices, and systems |
US11696902B2 (en) | 2018-08-14 | 2023-07-11 | AltaThera Pharmaceuticals, LLC | Method of initiating and escalating sotalol hydrochloride dosing |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1052788A (zh) * | 1989-12-28 | 1991-07-10 | 田辺制药株式会社 | 控制释放药物的制剂及其生产方法 |
EP1157690A1 (en) * | 2000-05-26 | 2001-11-28 | Pharma Pass LLC | Sustained release pharmaceutical composition |
CN1446083A (zh) * | 1998-10-02 | 2003-10-01 | 罗姆两合公司 | 具有活性物质可控性释放的涂覆药物剂型 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE55745B1 (en) * | 1983-04-06 | 1991-01-02 | Elan Corp Plc | Sustained absorption pharmaceutical composition |
US5945124A (en) * | 1995-07-05 | 1999-08-31 | Byk Gulden Chemische Fabrik Gmbh | Oral pharmaceutical composition with delayed release of active ingredient for pantoprazole |
CA2355829A1 (en) * | 1999-01-07 | 2000-07-13 | Louise Templeton | Multiparticulate oral dosage forms |
DE10260919A1 (de) * | 2002-12-20 | 2004-07-01 | Röhm GmbH & Co. KG | Verfahren zur Herstellung von überzogenen Arzneiformen und Nahrungsergänzungsmitteln mit Konzentrationsgradienten im Überzug |
US20060183767A1 (en) * | 2003-01-06 | 2006-08-17 | Eugene Mandrea | Methods of stimulating immune response in certain individuals |
DE102004035938A1 (de) * | 2004-07-23 | 2006-02-16 | Röhm GmbH & Co. KG | Verfahren zur Herstellung von überzogenen Arzneiformen mit stabilem Wirkstofffreigabeprofil |
TW200626185A (en) * | 2004-12-17 | 2006-08-01 | Bpsi Holdings Inc | Enteric film coating composition containing entericpolymer micronized with detackifier |
US7402325B2 (en) * | 2005-07-28 | 2008-07-22 | Phoenix Biotechnology, Inc. | Supercritical carbon dioxide extract of pharmacologically active components from Nerium oleander |
-
2006
- 2006-09-21 MX MX2009001597A patent/MX2009001597A/es active IP Right Grant
- 2006-09-21 PL PL06793706T patent/PL2051704T3/pl unknown
- 2006-09-21 SI SI200631362T patent/SI2051704T1/sl unknown
- 2006-09-21 JP JP2009524903A patent/JP5661281B2/ja active Active
- 2006-09-21 KR KR1020147002284A patent/KR20140019038A/ko not_active Application Discontinuation
- 2006-09-21 EP EP06793706A patent/EP2051704B1/de active Active
- 2006-09-21 CA CA2661561A patent/CA2661561C/en active Active
- 2006-09-21 KR KR1020097003276A patent/KR101556797B1/ko active IP Right Grant
- 2006-09-21 ES ES06793706T patent/ES2385498T3/es active Active
- 2006-09-21 BR BRPI0621996A patent/BRPI0621996B8/pt active IP Right Grant
- 2006-09-21 CN CN200680055284.8A patent/CN101484147B/zh active Active
- 2006-09-21 WO PCT/EP2006/066583 patent/WO2008019712A1/de active Application Filing
- 2006-09-21 AT AT06793706T patent/ATE553754T1/de active
-
2007
- 2007-04-03 US US11/695,848 patent/US8465769B2/en active Active
-
2008
- 2008-11-20 IL IL195407A patent/IL195407A/en active IP Right Grant
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1052788A (zh) * | 1989-12-28 | 1991-07-10 | 田辺制药株式会社 | 控制释放药物的制剂及其生产方法 |
US5395628A (en) * | 1989-12-28 | 1995-03-07 | Tanabe Seiyaku Co., Ltd. | Controlled release succinic acid microcapsules coated with aqueous acrylics |
CN1446083A (zh) * | 1998-10-02 | 2003-10-01 | 罗姆两合公司 | 具有活性物质可控性释放的涂覆药物剂型 |
EP1157690A1 (en) * | 2000-05-26 | 2001-11-28 | Pharma Pass LLC | Sustained release pharmaceutical composition |
Also Published As
Publication number | Publication date |
---|---|
ATE553754T1 (de) | 2012-05-15 |
PL2051704T3 (pl) | 2012-09-28 |
SI2051704T1 (sl) | 2012-08-31 |
KR20140019038A (ko) | 2014-02-13 |
KR20090042922A (ko) | 2009-05-04 |
JP2010501015A (ja) | 2010-01-14 |
BRPI0621996B1 (pt) | 2020-07-14 |
MX2009001597A (es) | 2009-02-23 |
BRPI0621996A2 (pt) | 2011-12-27 |
CA2661561C (en) | 2013-12-24 |
WO2008019712A1 (de) | 2008-02-21 |
ES2385498T3 (es) | 2012-07-25 |
US20080044470A1 (en) | 2008-02-21 |
CA2661561A1 (en) | 2008-02-21 |
IL195407A (en) | 2013-05-30 |
EP2051704A1 (de) | 2009-04-29 |
KR101556797B1 (ko) | 2015-10-01 |
IL195407A0 (en) | 2009-08-03 |
US8465769B2 (en) | 2013-06-18 |
BRPI0621996B8 (pt) | 2022-07-05 |
EP2051704B1 (de) | 2012-04-18 |
CN101484147A (zh) | 2009-07-15 |
JP5661281B2 (ja) | 2015-01-28 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CP01 | Change in the name or title of a patent holder |
Address after: Darmstadt Patentee after: Roma Chemical Co.,Ltd. Address before: Darmstadt Patentee before: EVONIK ROHM GmbH Address after: Essen, Germany Patentee after: Evonik Operations Ltd. Address before: Essen, Germany Patentee before: EVONIK DEGUSSA GmbH |
|
CP01 | Change in the name or title of a patent holder | ||
TR01 | Transfer of patent right |
Effective date of registration: 20200624 Address after: Essen, Germany Patentee after: EVONIK DEGUSSA GmbH Address before: Darmstadt Patentee before: Roma Chemical Co.,Ltd. |
|
TR01 | Transfer of patent right |