CN101480468A - Immunity-improving, fatigue-resisting and antivirus compound recipe as well as preparation method and application - Google Patents
Immunity-improving, fatigue-resisting and antivirus compound recipe as well as preparation method and application Download PDFInfo
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- CN101480468A CN101480468A CNA2008100193742A CN200810019374A CN101480468A CN 101480468 A CN101480468 A CN 101480468A CN A2008100193742 A CNA2008100193742 A CN A2008100193742A CN 200810019374 A CN200810019374 A CN 200810019374A CN 101480468 A CN101480468 A CN 101480468A
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Abstract
The invention provides a compound for improving immune and resisting fatigue and virus. The compound is prepared by adding vitamin C and vitamin E to natural plant essences extracted from honeysuckle, chrysanthemum, liquorice, polygonatum, sea backthern, sealwort, Chinese yam, tuckahoe, Chinese anise and the like. The invention also provides a preparation method of the effective compound and the application to the preparation of food, food additive, health-care food and medicaments having the efficacy of improving immune, resisting fatigue and virus, and the like.
Description
Technical field:
The invention belongs to food, health food, medicine development field, relate to a kind of raising immunity, resisting fatigue, antivirus compound recipe and preparation method and application, be specifically related to the compound recipe formed by Flos Lonicerae, Flos Chrysanthemi, Radix Glycyrrhizae, Rhizoma Polygonati Odorati, Fructus Hippophae, Rhizoma Polygonati, Rhizoma Dioscoreae, Poria, Fructus Anisi Stellati, vitamin C, the effective spice of vitamin E, also related to the preparation method of this compound recipe and had application in the food, health food, medicine of effects such as improving immunity, resisting fatigue, antiviral in preparation.
Background technology:
Modern immunologist's sincere advice: immunity is human body " amulet ".According to immune scientist's research of the U.S., human 99% disease derives from immune system and goes wrong.If lacked immune system, people's life at most also can only be kept 24-48 hours, and any dust all may be fatal.Immunity is exactly the ability that the human immune system resists the invasion and attack of all pathogen, virus, mushroom, Excreta and toxin etc. that tellurian biology can touch and defeats all diseases.Modern internationally famous immunologist discovers that the human immune system is creating human life's four big miracles: the first, resist the intrusion of " exopathogen " (all pathogen) automatically; The second, the health status of automatically comprehensive close inspection whole machine body; The 3rd, safeguard homoiostasis automatically; The 4th, strengthen the self-healing ability of health itself automatically.Therefore, immunity is " amulet " of human body for a certainty, maintaining healthy, and raising immunity is key, is basic.
Summary of the invention:
Technical problem to be solved by this invention is that a kind of compound recipe with effects such as improving immunity, resisting fatigue, antiviral will be provided, this compound recipe is by the natural plants elite of extracting in the raw materials such as Flos Lonicerae, Flos Chrysanthemi, Radix Glycyrrhizae, Rhizoma Polygonati Odorati, Fructus Hippophae, Rhizoma Polygonati, Rhizoma Dioscoreae, Poria, Fructus Anisi Stellati, and adding vitamin C, vitamin E are formed.
The present invention also provides the preparation method of this compound recipe, and in the purposes that improves immunity, resisting fatigue, anti-virus aspect.
The present invention is by said components is made up according to certain consumption, through pulverizing or the solvent extraction, concentrate a series of modern extraction process flow processs such as drying, extract effective component wherein, the application that is used for preparing food, food additive, health food and medicine.
The amount ranges of the used medical material of extract provided by the present invention is designated as (1000 preparation unit) with weight: Flos Lonicerae 50～200g, Flos Chrysanthemi 100～400g, Radix Glycyrrhizae 10～80g, Rhizoma Polygonati Odorati 1～30g, Fructus Hippophae 1～60g, Rhizoma Polygonati 1～60g, Rhizoma Dioscoreae 1～30g, Poria 1～30g, Fructus Anisi Stellati 1～10g, vitamin C 1～10g, vitamin E 0.1～10g; Preferable amount (1000 preparation unit) is: Flos Lonicerae 100～180g, Flos Chrysanthemi 150～250g, Radix Glycyrrhizae 40～60g, Rhizoma Polygonati Odorati 10～20g, Fructus Hippophae 30～50g, Rhizoma Polygonati 30～50g, Rhizoma Dioscoreae 10～20g, Poria 10～20g, Fructus Anisi Stellati 4～8g, vitamin C 4～8g, vitamin E 0.1～1g.
Effective spice provided by the present invention is to be prepared from by following method:
(1) Flos Lonicerae, Flos Chrysanthemi, Radix Glycyrrhizae, Fructus Hippophae, Rhizoma Polygonati are added 5～15 times of water gagings～50% ethanol water and extract 2～3 times, filter, concentrate, vacuum drying promptly gets extract;
(2), Rhizoma Polygonati Odorati, Rhizoma Dioscoreae, Poria, Fructus Anisi Stellati directly pulverized be used as medicine, cross 80～200 mesh sieves, standby;
(3), the effective raw material of (1) and (2) gained is mixed, add vitamin C, vitamin E promptly.
This product is rich in multiple nutritional components such as multiple saponins that needed by human body wants, polysaccharide, flavonoid, steroidal class, aminoacid, vitamin, mineral, to equal Yellow Gentian Extracts of each organs and tissues such as the heart of body, liver, spleen, lung, kidneys.Can be by cellular immunization and humoral immunization two-ways regulation body's immunity, health invigorating improves immunity, also has resisting fatigue, antiviral, allaying tiredness, delays effects such as senility of humanbody.
Below further explain the present invention with embodiment, but the present invention is not limited to this.
Specific embodiment:
Embodiment 1: prescription is formed (1000 preparation unit):
Flos Lonicerae 160g Flos Chrysanthemi 200g
Radix Glycyrrhizae 50g Rhizoma Polygonati Odorati 14g
Fructus Hippophae 35g Rhizoma Polygonati 35g
Rhizoma Dioscoreae 14g Poria 14g
Fructus Anisi Stellati 7g, vitamin C 7g
Vitamin E 0.7g
Embodiment 2, preparation method:
Flos Lonicerae, Flos Chrysanthemi, Radix Glycyrrhizae, Fructus Hippophae, Rhizoma Polygonati are added 5～15 times of water gaging-50% ethanol waters extract 2～3 times, filter, concentrate, vacuum drying promptly gets extract; Rhizoma Polygonati Odorati, Rhizoma Dioscoreae, Poria, the direct pulverizing of Fructus Anisi Stellati are used as medicine, cross 80～200 mesh sieves, standby; Effective raw material of gained is mixed, add vitamin C, vitamin E promptly.
Embodiment 3, tablet
Flos Lonicerae, Flos Chrysanthemi, Radix Glycyrrhizae, Fructus Hippophae, Rhizoma Polygonati are added 10 times of water gagings decoctions get 3 times, filter, concentrate, vacuum drying promptly gets extract; Rhizoma Polygonati Odorati, Rhizoma Dioscoreae, Poria, the direct pulverizing of Fructus Anisi Stellati are used as medicine, cross 100 mesh sieves, standby; Effective raw material of gained is mixed, add vitamin C, vitamin E,, add the tablet that edible adjuvant is prepared into different size according to the tablet conventional method.
Embodiment 4, capsule
In a certain amount of Flos Lonicerae, Flos Chrysanthemi, Radix Glycyrrhizae, Fructus Hippophae, Rhizoma Polygonati, add 10 times of amount 30%～50% alcoholic solution and extract 2～3 times, filter, concentrate, be drying to obtain extract; Rhizoma Polygonati Odorati, Poria, Rhizoma Dioscoreae, the direct pulverizing of Fructus Anisi Stellati are used as medicine, cross 80 mesh sieves, standby; Effective raw material of above-mentioned gained is mixed, add appropriate vitamin C, vitamin E, mix homogeneously adds edible adjuvant, granulates, and is prepared into the capsule of different size according to the capsule conventional method.
Effective spice provided by the present invention is except can being prepared into above-mentioned several preparation, conventional formulation forms such as granule, soft capsule, pill, oral liquid, injection can also be prepared into as required, also special preparations such as slow releasing agent, controlled release agent, dispersant, effervescent can be prepared into.
Below further explain the present invention by functional experiment.
One, mouse spleen lymphocyte transformation experiment
Experimental technique: select 18-22g C57BL/6J mice for use, be divided into blank group, this product I group and this product II after weighing at random and organize totally three groups, experimental group is given the various dose given the test agent, the blank group is given distilled water, be total to 30d once a day, administration finishes the aseptic spleen of getting in back, places to fill an amount of aseptic Hank ' s liquid plate, makes the individual cells suspension.In the complete culture solution of 1mL, with the blue dyeing counting viable count of platform phenol, the adjustment cell concentration is 3*10 with cell suspension
6Individual/mL.Divide two holes to add in 24 well culture plates cell suspension, every hole 1mL, a hole adds 75 μ l ConA liquid, and 5%CO2 is put in contrast in another hole, cultivates 72h in 37 ℃ of incubators.Cultivate and finish preceding 4h, supernatant 0.7mL is inhaled in every hole gently, adds 0.7mL and does not contain calf serum RPMI1640 culture fluid, adds MTT (5mg/mL) 50mL/ hole simultaneously, continues to cultivate 4h.After cultivating end, every hole adds 1mL acid isopropyl alcohol, and purple crystal is dissolved fully.Divide to install in 96 well culture plates, each packing 3-6 hole, hole is measured 570nm absorbance (A as parallel sample with microplate reader
570).Use A
570ConA
+-A
570ConA-represents lymphocytic multiplication capacity.
Experimental result: this product can promote the inductive mouse lymphocyte multiplication capacity of ConA, illustrates that its non-specific cell immunologic function to body has obvious enhancement effect.
Table 1:
Two, old rats antioxidation experiment
Experimental technique: select 20 monthly age male SD rats for use, be divided into aged matched group, this product I group, this product II group at random, other establishes one 3 months old rats for lacking the matched group in age, age, matched group was all given distilled water to aged matched group with less, experimental group is given the given the test agent of various dose, be total to 30d once a day, experiment finishes to put to death animal, gets blood and surveys MDA, SOD, GSH-Ps.
Experimental result: this product can effectively reduce the intravital level of lipid of aged Mus and prevent that the interior antioxidase of body is subjected to the oxidative damage of free yl induction, recovers the activity of antioxidase.
Table 2
Annotate: compare with aged matched group
*P＜0.01,
*P＜0.05.
Three, mice normal pressure anoxia enduring experiment
Experimental technique:
Get the KM mice, male and female half and half are divided into 3 groups at random, i.e. blank group (giving isometric distilled water), extract I, II group.Each group is total to 30d once a day all by gastric infusion, and the administration volume is 20ml/kg.Behind the last administration 45min, mice is placed the airtight wide mouthed bottle of 125ml (built-in sodica calx 20g).Stopping with the mice mouth breathing is the dead mouse sign, the time-to-live of record mice, surpass 60min in 60min.
Table 3
Annotate: compare with the blank group:
*P＜0.01;
*P＜0.05.
The result shows, the time-to-live of this product energy significant prolongation mice normal pressure anoxia enduring.
Four, antifatigue effect
Get male mice and be divided into two groups at random, experimental group is irritated this hair-care articles of stomach 3g/kg, and matched group is given the starch solution of equivalent, and administration dropped into mice in the treadmill after 10 days, and the entry of record mice is to the bottom, and time of unable come-up again is as swimming continuance time.
Table 4:
The result shows: this product can obviously prolong the mice swimming continuance time, has antifatigue effect.
Claims (8)
1, a kind of raising immunity, resisting fatigue, antivirus compound recipe, it is characterized in that it being the natural plants elite of extracting by in the raw materials such as Flos Lonicerae, Flos Chrysanthemi, Radix Glycyrrhizae, Rhizoma Polygonati Odorati, Fructus Hippophae, Rhizoma Polygonati, Rhizoma Dioscoreae, Poria, Fructus Anisi Stellati, adding vitamin C, vitamin E are formed by effective spice.
2, compound recipe according to claim 1 is characterized in that each component amount ranges (1000 preparation unit) is designated as with weight: Flos Lonicerae 50～200g, Flos Chrysanthemi 100～400g, Radix Glycyrrhizae 10～80g, Rhizoma Polygonati Odorati 1～30g, Fructus Hippophae 1～60g, Rhizoma Polygonati 1～60g, Rhizoma Dioscoreae 1～30g, Poria 1～30g, Fructus Anisi Stellati 1～10g, vitamin C 1～10g, vitamin E 0.1～10g.
3, compound recipe according to claim 2 is characterized in that each component preferable amount (1000 preparation unit) is designated as with weight: Flos Lonicerae 100～180g, Flos Chrysanthemi 150～250g, Radix Glycyrrhizae 40～60g, Rhizoma Polygonati Odorati 10～20g, Fructus Hippophae 30～50g, Rhizoma Polygonati 30～50g, Rhizoma Dioscoreae 10～20g, Poria 10～20g, Fructus Anisi Stellati 4～8g, vitamin C 4～8g, vitamin E 0.1～1g.
4, a kind of preparation method that contains any described compound recipe of claim 1-3 is characterized in that:
(1) Flos Lonicerae, Flos Chrysanthemi, Radix Glycyrrhizae, Fructus Hippophae, Rhizoma Polygonati are added 5～15 times of water gagings～50% ethanol water and extract 2～3 times, filter, concentrate, vacuum drying promptly gets extract;
(2), Rhizoma Polygonati Odorati, Rhizoma Dioscoreae, Poria, Fructus Anisi Stellati directly pulverized be used as medicine, cross 80～200 mesh sieves, standby;
(3), the effective raw material of (1) and (2) gained is mixed, add vitamin C, vitamin E promptly.
5, a kind ofly contain the application that the described compound recipe of claim 1 is used for preparing food, food additive, health food, medicine.
6, the application of compound recipe according to claim 5 is characterized in that: the application that is used for preparing food with effects such as improving immunologic function, resisting fatigue, defying age, antiviral, food additive, health food, medicine.
7, a kind of described compound recipe of claim 1 that contains can add proper auxiliary materials and is prepared into any dosage form of acceptable on the pharmaceutics.
8, the dosage form of compound recipe according to claim 7 is characterized in that it can being all acceptable preparations such as tablet, hard capsule, granule, soft capsule, pill, oral liquid, buccal tablet, drop pill.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100193742A CN101480468A (en) | 2008-01-07 | 2008-01-07 | Immunity-improving, fatigue-resisting and antivirus compound recipe as well as preparation method and application |
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|---|---|---|---|
| CNA2008100193742A CN101480468A (en) | 2008-01-07 | 2008-01-07 | Immunity-improving, fatigue-resisting and antivirus compound recipe as well as preparation method and application |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101773548A (en) * | 2010-03-25 | 2010-07-14 | 云南金泰得三七产业股份有限公司 | Pharmaceutical composition for improving immunity |
| CN102771794A (en) * | 2012-07-31 | 2012-11-14 | 新疆伊犁州惠华酒业有限责任公司 | Soft capsule made of seabuckthorn oil and vitamins EC |
| CN107149640A (en) * | 2017-05-12 | 2017-09-12 | 安徽省运酒厂集团有限公司 | It is a kind of can strengthen immunity fen-flavor type white spirit and preparation method thereof |
-
2008
- 2008-01-07 CN CNA2008100193742A patent/CN101480468A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101773548A (en) * | 2010-03-25 | 2010-07-14 | 云南金泰得三七产业股份有限公司 | Pharmaceutical composition for improving immunity |
| CN101773548B (en) * | 2010-03-25 | 2011-12-21 | 云南金泰得三七产业股份有限公司 | Pharmaceutical composition for improving immunity |
| CN102771794A (en) * | 2012-07-31 | 2012-11-14 | 新疆伊犁州惠华酒业有限责任公司 | Soft capsule made of seabuckthorn oil and vitamins EC |
| CN107149640A (en) * | 2017-05-12 | 2017-09-12 | 安徽省运酒厂集团有限公司 | It is a kind of can strengthen immunity fen-flavor type white spirit and preparation method thereof |
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Open date: 20090715 |