CN101468166A - Pharmaceutical composition for treating rhagadia manus and pedalis, and preparation method thereof - Google Patents
Pharmaceutical composition for treating rhagadia manus and pedalis, and preparation method thereof Download PDFInfo
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- CN101468166A CN101468166A CNA200710151188XA CN200710151188A CN101468166A CN 101468166 A CN101468166 A CN 101468166A CN A200710151188X A CNA200710151188X A CN A200710151188XA CN 200710151188 A CN200710151188 A CN 200710151188A CN 101468166 A CN101468166 A CN 101468166A
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Abstract
The present invention discloses a pharmaceutical composition which is used for treating rhagades of hand and foot and a preparing method thereof. The pharmaceutical composition is composed of bletilla striata, astragalus, alkanna tinctoria, frank inscense, myrrh, liquorice, coptis, sophora root and sessile stemona root. The pharmaceutical composition is prepared through extracting with an appropriate dissolvent and adding with an appropriate amount of preservative substance. The active component of the product has the advantages of quick keratin dissolution, keratinized tissue elimination, inflammation elimination, bacterium repression, partial metabolism quickening, skin lubrication, rhagades concrescence, rhagades regeneration prevention, skin caducity delay, partial microcirculation improvement and skin moisturizing.
Description
Technical field
The present invention relates to a kind of drug regimen for the treatment of rhagadia manus et pedis and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Rhagadia manus et pedis is a kind of by multiple reason hand-foot skin drying that causes and the disease of splitting.Commonly encountered diseases is because of as working out of doors cold season, or often contact lysis fat or water absorption material, or often using alkaline soap etc. to make xerosis cutis, thickening, follow the string and toughness, the sebum sweat secretion reduces especially in the winter time, meet mechanical friction or traction, primary disease just takes place easily.Be common in adult and old people.Long-term physical labourer of working out of doors, or often contact the workman of work posts such as machine oil at work to hand-foot skin drying autumn and winter, coarsely thickens, easily takes place the crack.Primary disease is sent out in finger tip well, is referred to positions such as toe joint face, palm, heel, the sufficient sole of the foot outside.Primary disease is sent out the position of or frequent friction thick in the skin angleplied laminate well, it is many along the dermatoglyph directions to chap, as refers to the face of bending, and finger tip, refers to positions such as toe joint face, palm, heel, the sufficient sole of the foot outside, crisscross, the utmost point is like wood grain, and with the passing of time breach increases expansion, has concurrently hemorrhage, stretch in the wrong limited, stride pain. can be divided into three degree according to the crack depth degree: once only reaching epidermis, cutaneous manifestations is that drying has be full of cracks, symptom such as no hemorrhage, pain.Two degree xerosis cutiss, high dermis is goed deep into by epidermis in the crack, mild pain can be arranged, but do not cause bleeding; Three degree xerosis cutiss, corium and subcutaneous tissue are goed deep into by epidermis in the crack, often cause bleeding and tenderness or causalgia, are commonly encountered diseases in a kind of winter.At present, the method for the treatment of rhagadia manus et pedis both at home and abroad is more, as western medicine, and medicine commonly used chap frost, sulphuric acid unguentum acidi salicylici etc., but the western medicine relapse rate is higher; Treatment by Chinese herbs commonly used, a kind of medicine and its therapeutic effect of preparation method for the treatment of rhagadia manus et pedis is better though a kind of liniment for the treatment of rhagadia manus et pedis described in CN1872121 as Ye Zhijun and preparation method and dried treasured are apt to describe in CN1876118, but the former uses Oleum Sesami as extracting medium, its taste does not loose for a long time, and the latter uses Mel, the phenomenon that has pollution clothes in patient's use takes place, and these all are that patient's use makes troubles.
Summary of the invention
The inventor is through research repeatedly, and the checking repeatedly by clinical trial, thereby has obtained having the external used medicine of better healing rhagadia manus et pedis to finish the present invention finally.
The object of the invention just provides a kind of a kind of Chinese medicine composition of more effectively treating rhagadia manus et pedis.
Another object of the present invention has provided the preparation method of this Chinese medicine composition.
The Pseudobulbus Bletillae (Rhizoma Bletillae) in the drug regimen of the present invention, Compendium of Material Medica is carried: " astringing QI oozes expectorant, hemostasis, and the medicine of eliminating carbuncle is also.This medicine matter is extremely sticky, property utmost point astringent therapy, the packing breakage, carbuncle can disappear, the routed holder, dead flesh can go, pus and blood can be clean, have holder early tissue regeneration promoting magical effect also." modern study shows that the Pseudobulbus Bletillae (Rhizoma Bletillae) contains a large amount of lymphatic temperamentes, and multiple polysaccharide is wherein arranged, and also contains volatile oil, starch, the clotting time of shortening arranged and suppress the fibrinolytic effect, and good protection ulcer surface, anti-effect such as chap are arranged.The Radix Astragali, Shennong's Herbal is classified it as top grade, calls its " main carbuncle loses skin ulcer for a long time, the evacuation of pus pain relieving ", and " Japan hanako materia medica " said it and " helped the gas strengthening bone and muscle, put on flesh, enrich blood ".Effect with toxin expelling evacuation of pus, holder skin ulcer promoting regeneration of the tissue and arresting bleeding, pharmacological evaluation shows, also can strengthen capillary resistance, blood vessel dilating, improve cutaneous circulation and nutrition supply, and downright bad histiocyte is rejuvenated, the Radix Astragali can be by recovering the local fibroblastic form and function of ulcer, increase the fibroblast content of various cell growth factor on every side, play a role by increasing fibroblast superficial growth factor acceptor quantity or sensitivity.Radix Arnebiae (Radix Lithospermi), removing heat from blood, invigorate blood circulation, heat-clearing and toxic substances removing.Can quicken epithelial growth and treatment burn and scald, suppress capillary permeability.Wherein the effective ingredient Acetyl-shikonin Acetylshikonin has antibiotic, antiinflammatory action, and staphylococcus aureus and various skin fungus are had inhibitory action, and the topical application Acetyl-shikonin Acetylshikonin can promote wound healing.Olibanum, Myrrha, the externally used detumescence granulation promoting.Radix Glycyrrhizae, glycyrrhizic acid wherein and derivant thereof have the nourishing skin, suppress the effect of inflammatory reaction; Glycyrrhizin have antiulcer, antiinflammatory pharmacological action.Many external curings of Radix Glycyrrhizae contact dermatitis, allergic dermatitis, eczema, chapped skin etc.This Six-element medical instrument has detumescence, granulation promoting to promote the effect of chapping and healing.Rhizoma Coptidis has the effect of heat clearing and damp drying, eliminating fire and detoxication, and external has inhibitory action to various bacteria.Radix Sophorae Flavescentis contains matrine, Radix Sophorae Flavescentis alcohol, heat clearing and damp drying is arranged, germ-resistant function.The Radix Stemonae contains sessilistemonine, and the function of deodorization and sterilization is arranged.This three flavors medicine heat clearing and damp drying, sterilizing.
Preferably, the preparation method of medicine activity component of the present invention is as follows: the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Astragali, Radix Glycyrrhizae, Rhizoma Coptidis, Radix Sophorae Flavescentis, the Radix Stemonae, Radix Arnebiae (Radix Lithospermi) are boiled 3 times each 2h with the decocting of 10 times of medicine total amounts, filter, merging filtrate discards filtering residue, and filtrate is concentrated into 20 times of medicine total amounts; Olibanum, Myrrha are with 50 times of 80% glycerol heating for dissolving, and elimination impurity with above-mentioned filtrate mixing, adds an amount of antiseptic, filter, and obtain clear liquor, carry out fill, and packing gets final product.Clinical observation on the therapeutic effect
1, the patient that chaps of 100 brothers of picked at random adopts the own control mode to carry out clinical observation on the therapeutic effect.
2, Therapeutic Method: patient's left foot adopts this medicinal liquid to treat, and right crus of diaphragm adopts the medical ventolin treatment.Every day clean hands and to smear the position after, get this product or vaseline is an amount of, be massaged into this product or vaseline with hands and absorbed fully and get final product.Two weeks were a course of treatment.The observation cycle is a week.
3, result: the cure rate of chapping of treatment group reaches 93%, and effective percentage reaches 100%, and the cure rate of chapping of matched group is 20%, and effective percentage reaches 85%, the results are shown in Table 1.
Table 1 clinical observation on the therapeutic effect table
Case load | Obvious effective rate | Cure rate % | Inefficiency | Effective percentage % | |
The medicinal liquid group | 100 | 7 | 93 | 0 | 100 |
The vaseline group | 100 | 65 | 20 | 15 | 85 |
4, conclusion: confirm that by this clinical trial the medicinal liquid that the present invention developed has clinical cure rate cream, is convenient to the characteristics that the patient uses.
The specific embodiment
Embodiment 1
Get Pseudobulbus Bletillae (Rhizoma Bletillae) 10g, Radix Astragali 10g, Radix Arnebiae (Radix Lithospermi) 15g, Radix Glycyrrhizae 20g, Rhizoma Coptidis, 10g, Radix Sophorae Flavescentis 10g, Radix Stemonae 10g boils 3 times with the decocting of 10 times of medicine total amounts, and each 2h filters, and merging filtrate discards filtering residue, and filtrate is concentrated into 20 times of medicine total amounts; Olibanum 2g, Myrrha 2g, with 50 times of 80% glycerol heating for dissolving, elimination impurity with above-mentioned filtrate mixing, adds an amount of antiseptic, filters, and obtains clear liquor, carries out fill, and packing gets final product.
Embodiment 2
Get Pseudobulbus Bletillae (Rhizoma Bletillae) 5g, Radix Astragali 6g, Radix Arnebiae (Radix Lithospermi) 10g, Radix Glycyrrhizae 14g, Rhizoma Coptidis 6g, Radix Sophorae Flavescentis 6g, Radix Stemonae 6g boils 3 times with the decocting of 10 times of medicine total amounts, and each 2h filters, and merging filtrate discards filtering residue, and filtrate is concentrated into 20 times of medicine total amounts; Olibanum 2g, Myrrha 2g, with 50 times of 80% glycerol heating for dissolving, elimination impurity with above-mentioned filtrate mixing, adds an amount of antiseptic, filters, and obtains clear liquor, carries out fill, and packing gets final product.
Claims (3)
1. treat drug regimen of rhagadia manus et pedis and preparation method thereof for one kind, it is characterized in that, said composition is to be made by following raw material:
1~30 part of 1~20 portion of Radix Arnebiae (Radix Lithospermi) of 1~20 part of Radix Astragali of the Pseudobulbus Bletillae (Rhizoma Bletillae)
1~30 part in 1~5 portion of Radix Glycyrrhizae of 1~5 part of Myrrha of Olibanum
1~20 part of 1~20 part of Radix Stemonae of 1~20 part of Radix Sophorae Flavescentis of Rhizoma Coptidis.
2. a kind of pharmaceutical composition for the treatment of rhagadia manus et pedis according to claim 1 is characterized in that, said composition is to be made by following raw material:
15 parts of 10 portions of Radix Arnebiae (Radix Lithospermi)s of 10 parts of Radixs Astragali of the Pseudobulbus Bletillae (Rhizoma Bletillae)
20 parts in 2 portions of Radix Glycyrrhizaes of 2 parts of Myrrhas of Olibanum
10 parts of 10 parts of Radixs Stemonae of 10 parts of Radix Sophorae Flavescentiss of Rhizoma Coptidis.
3. the preparation method of claim 1 or 2 described medicines may further comprise the steps: the Pseudobulbus Bletillae (Rhizoma Bletillae), the Radix Astragali, Radix Glycyrrhizae, Rhizoma Coptidis, Radix Sophorae Flavescentis, the Radix Stemonae, Radix Arnebiae (Radix Lithospermi) are boiled 3 times each 2h with the decocting of 10 times of medicine total amounts, filter, merging filtrate discards filtering residue, and filtrate is concentrated into 20 times of medicine total amounts; Olibanum, Myrrha are with 50 times of 80% glycerol heating for dissolving, and elimination impurity with above-mentioned filtrate mixing, adds an amount of antiseptic, filter, and obtain clear liquor, carry out fill, and packing gets final product.
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103816282A (en) * | 2013-11-14 | 2014-05-28 | 中国人民解放军海军医学研究所 | Pharmaceutical composition for treating common skin diseases, and preparation method of pharmaceutical composition |
CN103961615A (en) * | 2014-05-23 | 2014-08-06 | 梁亮 | Traditional Chinese medicine composition for treating rhagadia manus and pedalis and preparation thereof |
CN104524206A (en) * | 2014-12-17 | 2015-04-22 | 陈丽艳 | Traditional Chinese medicine composition for treating seasonal keratodermia tgtods palmaris progressiva |
CN104998084A (en) * | 2015-07-15 | 2015-10-28 | 天津科丝美特生物科技有限公司 | Pharmaceutical combination for treating rhagadia manus and pedalis |
CN107157877A (en) * | 2017-05-22 | 2017-09-15 | 漯河医学高等专科学校 | A kind of gel and preparation method for treating hand and foot from chapping |
-
2007
- 2007-12-24 CN CNA200710151188XA patent/CN101468166A/en active Pending
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103816282A (en) * | 2013-11-14 | 2014-05-28 | 中国人民解放军海军医学研究所 | Pharmaceutical composition for treating common skin diseases, and preparation method of pharmaceutical composition |
CN103816282B (en) * | 2013-11-14 | 2017-02-08 | 中国人民解放军海军医学研究所 | Pharmaceutical composition for treating common skin diseases, and preparation method of pharmaceutical composition |
CN103961615A (en) * | 2014-05-23 | 2014-08-06 | 梁亮 | Traditional Chinese medicine composition for treating rhagadia manus and pedalis and preparation thereof |
CN103961615B (en) * | 2014-05-23 | 2017-01-04 | 梁亮 | A kind of Chinese medicine composition treating rhagadia manus et pedis and preparation thereof |
CN104524206A (en) * | 2014-12-17 | 2015-04-22 | 陈丽艳 | Traditional Chinese medicine composition for treating seasonal keratodermia tgtods palmaris progressiva |
CN104998084A (en) * | 2015-07-15 | 2015-10-28 | 天津科丝美特生物科技有限公司 | Pharmaceutical combination for treating rhagadia manus and pedalis |
CN107157877A (en) * | 2017-05-22 | 2017-09-15 | 漯河医学高等专科学校 | A kind of gel and preparation method for treating hand and foot from chapping |
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Open date: 20090701 |