CN101460100A - In-situ measurement of phyisical parameters - Google Patents
In-situ measurement of phyisical parameters Download PDFInfo
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- CN101460100A CN101460100A CNA2007800209142A CN200780020914A CN101460100A CN 101460100 A CN101460100 A CN 101460100A CN A2007800209142 A CNA2007800209142 A CN A2007800209142A CN 200780020914 A CN200780020914 A CN 200780020914A CN 101460100 A CN101460100 A CN 101460100A
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Abstract
A data logger device for in-situ measurement of one or more physical parameters comprising a power source; one or more sensors for measuring the one or more physical parameters; a data store for storing representations of at least some of the measured values of the one or more physical parameters; control logic arranged to write the representations of at least some of the measured values to the data store and arranged to read data from the data store during data transmission; an antenna; and a transmitter coupled to the antenna and configured to transmit the stored data by passive transmission.
Description
Technical field
The present invention relates to a kind of one or more physical parameter is carried out data logger (data logger) device that original position (in-situ) measures, a kind of one or more physical parameter carried out the system of in site measurement, a kind of system that is used for determining women's ovulation period, and a kind of system that temperature is carried out in site measurement.
Background technology
The data record apparatus that is used to measure and store physical parameter is used widely in engineering and scientific domain.This device makes it possible in position that is difficult to arrive or the situation at hazardous environment, promptly in manual measurement possibility inconvenience or very time taking situation, automatically physical parameter is carried out in-situ monitoring in long time-histories.
A this digital data recording system of having developed is the MiniMitter system (http://www.minimitter.com) that is used to write down temperature.Yet the cost of overall plan is quite high, and data logger itself is quite heavy and too huge for many application.
Specifically, for many medical conditions, must carry out periodic measurement to various physiological parameters, these parameters comprise body fluid pressure and temperature conductivity and thermograde.Can for example be measured physiological parameter by doctor or nurse " artificially ", perhaps can monitor it by (common costliness) armarium, the patient must keep being connected with armarium during carrying out the desired period of described measurement.
Need in home environment, measure people's (for example diabetics) of special physiological parameters, situation even even more serious for those.Under the situation of the support equipment that does not possess clinic or hospital, the patient forgets possibly and carries out required measurement, perhaps the patient may find sometimes this and inconvenient, and the patient may at first just can not bear the expense of medical equipment.
Therefore need provide a kind of cheapness and write down the in-situ measurement device of physiological parameter automatically.This device can alleviate healthcare givers's burden, reduce and omit the probability of measuring, and because device is retained in required place, measuring position with original position, therefore this device will reduce number of times misery or that intrusive mood is measured that the patient must stand potentially.In addition, can measure leaving under patient's the situation (for example between sleep period or during the busy daily arrangement) alone.
For special physiological parameters or long term medical situation, implantable device helps to measure these parameters most.The medical treatment device that expectation is implanted has long as far as possible life-span and as far as possible little volume in patient's body.In many devices, this is subjected to the restriction weighed between battery life and battery size, and just to battery being recharged or changing battery and device must be removed and insert again.This has brought pressure and discomfort improperly for the patient.
Specifically, the women sometimes will wish to measure termly its body temperature, so that the time point that they may ovulate in determining in every month.This " natural method " is attractive for the women of many hope pregnancies, and also may be had special religious women as contraceptive device.In order to obtain the most reliable result, need during the most time of ovulatory cycle, regularly measure temperature.
European patent application has been described a kind of uterus implant that is used for periodically writing down temperature data for No. 0195207, and this temperature data should require and be wirelessly sent to receptor so that it is analyzed and shows.This has solved the major issue that is used for basal body temperature (BBT) method of nature family planning in use, because neither need the user to wake up, even does not also need the user to remember every day and will measure temperature.Unfortunately, owing to need change or recharge, therefore must periodically this device be taken out and insert once more the battery in installing.Though be introduced in the body cavity that is easy to pass in and out, this taking-up and the process of inserting once more are very inconvenient, and have great related medical risk.
Alternatively, the user can use following implanting device, and this implanting device is not stored in the DATA REASONING result in the implanting device, but measurement result is directly sent to reader.In this case, can power to implant, for example described in the european patent application the 0476730th by reader.This is common for passive radio frequency identification (RF-ID) pick off.Yet this matching requirements is when implanting device is measured, and implant will be positioned near the RF-ID reader.
In using the digital data recording system of rechargeable battery, battery life is restricted, because be reduced to before battery can't keep the level of the reasonable electric weight that makes data logger work at battery performance, battery only has the recharging period of specific times.For wishing that the life-span is the implant data recorder of 10 years magnitudes, the desired times that will be used to change the minor operation of implant keeps minimum especially to be a problem.
European patent application has proposed a kind of passive system No. 0746040, and this european patent application has been described a kind of passive balise (transponder) that comprises integrated sensor.This responder can be operated and be used for receiving request signal from scanner, and identity information and physical characteristics information are sent to scanner.Yet this system does not provide data recording function, therefore when needs are measured, scanner need be connected to responder.
Summary of the invention
According to a first aspect of the invention, provide a kind of data record apparatus that is used for one or more physical parameter is carried out in site measurement, it comprises: power supply; One or more pick off, this one or more pick off is used to measure described one or more physical parameter; Data storage, this data storage are used for storing the expression of at least some measured values of the measured value of described one or more physical parameter; Control logic, this control logic are configured to the described expression of at least some measured values in the described measured value is write described data storage, and read data during being provided in the data transmission from described data storage; Antenna; And transmitter, this transmitter is coupled to described antenna and is configured to and sends the data that transmission is stored by passive.
Preferably, power supply is a rechargeable power supply, and at least a portion that transmitter is configured to the electromagnetic power that will receive at the antenna place is supplied to rechargeable power supply, thereby rechargeable power supply is recharged.
Described data record apparatus may further include the selector logic, and described transmitter is configured to: if described selector logic is selected and will be recharged described rechargeable power supply, then at least a portion of the described electromagnetic power that will receive at described antenna place is supplied to described rechargeable power supply.Described selector logic is configured to: be lower than predeterminated level if the voltage of described both ends of power drops to, then select described rechargeable power supply is recharged.
At least some expression in the described expression of described measured value can be physical parameter last measured value with the back one measured value poor.
Preferably, described control logic is configured at least some expression in the described expression of measured value together with having indicated the timestamp that carries out the corresponding time of measuring to write described data storage.Preferably, each pick off is configured to measure described one or more physical parameter with preset frequency.
Preferably, described control logic has first pattern of work and second pattern of work, in first pattern of described work, described control logic can be operated with the expression with measured value and be write in the described data storage, and in second pattern of described work, described control logic can not be operated the expression that is used for measured value and be write described data storage, the power that described control logic consumes in described first pattern is greater than the power that consumes in described second pattern, and described control logic enters second pattern of described work when being configured in meeting the following conditions one or more:
(a) after writing described data storage, passed through time of predetermined length;
(b) when the variation of described measured value between measurement result of a selected physical parameter in described one or more physical parameter is greater than or less than scheduled volume;
(c) the described measured value when a selected physical parameter in described one or more physical parameter is when being greater than or less than value of predetermined value.
Preferably, described control logic enters described first pattern after being formed at the time that enters the predetermined length after described second pattern.Preferably, described data logger further comprises comparison circuit, this comparison circuit is configured for the variation of described measured value between measurement result of determining a selected physical parameter in described one or more physical parameter and when is greater than or less than scheduled volume, and this comparison circuit is configured to: determine in response to described, make described control logic enter described first pattern, and the expression of at least some measured values in the described measured value is write in the described data storage.
Preferably, described data logger further comprises with lower device, this device is used for one group of measured value of the selected physical parameter of described one or more physical parameter is averaged, and the expression that makes described control logic will organize the described meansigma methods of measured value writes in the described data storage.
Described physical parameter can be the orientation of temperature, pressure, pH value, light intensity, acoustic pressure, motion, spectral quality, data logger or one or more kinds in inclination angle and the vibration.
Preferably, the described data storage of described data logger is configured to storing additional data.Described additional data comprises personal information and/or medical information.
At least some physical parameters in described one or more physical parameter can be physiological parameters, and described data record apparatus is incorporated into in one in the lower member:
(a) be suitable for being implanted to the intravital assembly of animal body or people;
(b) be suitable for the bonding paster on skin, dressed; And
(c) clothes or other wearable items;
(d) containment vessel.
A pick off in described one or more pick off can be first temperature sensor.A pick off in described one or more pick off can be second temperature sensor, and described first temperature sensor is configured to measure the temperature of human body or animal body, and described second temperature sensor is configured to measure the ambient temperature of described human body or animal body.
A pick off in described one or more pick off can be accelerometer or other device that is used to measure the motion of the motion of described data record apparatus or health, wherein is used to measure the described accelerometer of motion or other devices attached on the described data record apparatus or health.
Preferably, described control logic is configured to: when only the variation of the previous measured value of selected second physical parameter in described one or more physical parameter was less than predetermined value, just the expression with the measured value of selected first physical parameter in described one or more physical parameter write in the described data storage.
Preferably, described control logic is configured to: only when the variation of measured value between measurement result during greater than scheduled volume, just the expression with the measured value of a selected physical parameter in described one or more physical parameter writes in the described data storage.
Described expression can be the timestamp of having indicated the time when measuring described the variation.
According to a second aspect of the invention, provide a kind of system that one or more physical parameter is carried out in site measurement, this system comprises: any described data record apparatus in the claim as described above; And data reader device, this data reader device comprises receptor, this receptor is configured to by passive transmission at least some data from the data that described data record apparatus reception is stored.
Preferably, described data logger is configured to: when the energy that is received from described data reader by described receptor surpasses predeterminated level, send at least some data in the data that described data logger stores.
Preferably, described data logger is configured in response to from the appropriate command of described data reader and send at least some data in the data that described data logger stores.Preferably, described order has indicated described data logger will send which data in the data of being stored.
Preferably, each pick off is configured to predetermined frequency described one or more physical parameter be measured, and described data reader can be operated and is used for sending the signal that is used to set this frequency to described data logger.
Preferably, the described data storage of described data logger is configured to storing additional data.Described additional data can comprise personal information and/or medical information.Preferably, described data logger is configured to: in case receive appropriate command from described data reader, just send at least some additional datas in the described additional data.
Preferably, in response to receiving appropriate command from described data reader, described data logger is configured to: (a) utilize the data that send together with described order to rewrite at least some data in the described additional data, perhaps (b) will write together with the data that described order sends in the described data storage as further additional data.
Preferably, described data reader can be operated and be used for sending authentication code to described data logger.Can determine at least a portion authentication code in the described authentication code according to the identification code of described data logger.Can determine at least a portion authentication code in the described authentication code according to the identification code of described data reader.Alternatively, described data logger keeps (hold) one group of effective authentication code, and described data logger is configured to: only when described data logger received effective authentication code, just at least some data in the data that described data logger is stored sent to described data reader.
Preferably, described data logger is configured to described data reader is carried out authentication public key, perhaps vice versa, and described data logger is configured to: only when described data logger received significant response, just at least some data in the data that described data logger is stored sent to described data reader.
Preferably, described data reader device comprises the device that is used for entering data into described reader.Preferably, at least some data storages in the described data reader device data that are configured to receive at described data reader device place.
Described data reader device can be operated at least some data that are used for the data that will receive from described data logger by wired or wireless communication and be sent to one or more kinds Internet Server, personal computer (comprising laptop computer, desk computer, PDA, smart phone or handheld computer), storage device or any other data processing equipment.
Preferably, described data reader device is configured to handle according to the corresponding measured value of described second temperature sensor each measured value of described first temperature sensor, so that the human body that described first temperature sensor is configured to measure or the core temperature of animal body are estimated.
Preferably, described data reader device is configured to: at least some measured values of the described measured value of described first temperature sensor that will record in the time of will surpassing predetermined value in the variation of the described measured value of the described accelerometer that is used for motion is measured or other devices are ignored.
Preferably, described data reader device is configured to: at least some measured values of the described measured value of described first temperature sensor that will record in the time of will surpassing predetermined value at the described measured value of the described accelerometer that is used for motion is measured or other devices are ignored.
According to a third aspect of the invention we, a kind of system that is used for definite women's ovulation period is provided, this system comprises: the data record apparatus, this data record apparatus comprises first temperature sensor of first temperature that is used to measure the women, be used for one or more first temperature measurement result is stored as the data storage of first physiological data set, be configured to expression with described first temperature measurement result and be stored in control logic in the described data storage, be configured to send the transmitter of at least some data in the data of being stored; Data reader, this data reader comprise the receptor that is configured to receive from described data record apparatus at least some data the data of being stored; And data processor, this data processor has can operate the input equipment that is used to receive at least one other physiological data set; Wherein, described data processor is configured to: will combine from described first temperature data and described at least one other physiological data set of described data reader device, to form the indication to ovulation period.
Preferably, described data record apparatus is incorporated into in one in the lower member:
(a) be suitable for being implanted to the intravital assembly of animal body or people;
(b) be suitable for the bonding paster on skin, dressed; And
(c) clothes or other wearable items;
(d) containment vessel.
Described at least one other physiological data set can comprise cervical mucus qualitative data, hormone horizontal data and indicate at least a in the data on menstruation date last time at least.
Preferably, described data processor can be operated and be used for by means of the ovulation prediction algorithm described first temperature data and described at least one other physiological data set being combined, and wherein said ovulation prediction algorithm is configured to different statistical weights distributed to each of these data centralizations.Described statistical weight can be based on indicated ovulation period of these data sets and the previous degree of association between the actual ovulation period.
Preferably, described data processor or described data reader can be operated and be used to point out the user to provide additional physiological data set in described input equipment place of described data processor.
Preferably, described data reader device comprises shell, and described data processor is incorporated in the described shell of described data reader device.Preferably, described data reader device is a handheld apparatus.
Preferably, described data reader device comprises and is used to store the described memory of data that receives from described data record apparatus.Preferably, described data reader device comprises the display that is used to show the described data that receive from described data record apparatus.Preferably, described data reader device is configured to make at least some data from the described data that described data logger receives to use by the wired or wireless communication with described data processor.
Preferably, described data record apparatus further comprises and is used for accelerometer or other devices that women's motion is measured, and the expression that described control logic further is configured to the motion measurement result is stored in the described data storage, described data processor can operate that to be used for to be that at least some temperature measurement result in the temperature measurement result that records of true time are ignored when a condition of following condition, and these conditions are:
(a) described motion measurement result's variation has surpassed predetermined value;
(b) described motion measurement result has surpassed predetermined value.
Preferably, described data record apparatus further comprises and is used for accelerometer or other devices that women's motion is measured, and described control logic further is configured to: a condition in following condition is a true time, at least some expression in the described expression of described first temperature measurement result are not stored in the described data storage, these conditions are:
(a) previous motion measurement result's variation has surpassed predetermined value;
(b) at least one previous motion measurement result has surpassed predetermined value.
Preferably, at least one other physiological data set that receives in described input equipment place of described data processor are exercise datas of women, and described data processor can operate that to be used for a condition in following condition be that at least some first temperature measurement result in first temperature measurement result that records of true time are ignored, and these conditions are:
(a) variation of the measurement result of being represented by described exercise data has surpassed predetermined value;
(b) measurement result of being represented by described exercise data has surpassed predetermined value.
Preferably, described data record apparatus further comprises second temperature sensor, and the expression that described control logic further is configured to described second temperature measurement result is stored in the described data storage.Preferably, described second temperature sensor is configured to measure women's ambient temperature, and described data reader device is configured to handle according to the corresponding measurement result of described second temperature sensor each measurement result of described first temperature sensor, to estimate women's core temperature.
Preferably, described data processor can be operated and is used for whether having reached first of basal body temperature and determining according to make relevant this women from the data of described data logger and/or described at least one other physiological data set, if and described first result who determines negates, then described data processor is configured to come basal body temperature is estimated that according at least one parameter in the following parameter these parameters are:
(a) any one measurement of bldy temperature result's rate of change among these measurement of bldy temperatures result;
(b) rate of change of any one measurement of bldy temperature result's rate of change among these measurement of bldy temperatures result;
(c) represent the data of the previous variation of temperature when women's temperature levels off to basal body temperature in the past.
Preferably, described data logger is configured to by wired or wireless transmission at least some data in the data of its storage be sent to described data reader.
According to a forth aspect of the invention, provide a kind of assembly that comprises the data record apparatus, this data record apparatus comprises: first temperature sensor, and it is used to measure first temperature; Data storage, it is used to store one or more first temperature measurement result; Control logic, it is configured to the expression of first temperature measurement result is stored in the described data storage; And transmitter, it is configured to send at least some data in the data of being stored.Described assembly further comprises first and second portion.Described data record apparatus is placed between described first and the described second portion, wherein, described first temperature sensor is adjacent with described first, and has the thermal conductivity higher than described second portion with at least one zone of the immediate described first of described first temperature sensor.
Preferably, described first with described data logger facing surfaces can the coated with adhesive layer, so that can be attached to described assembly on the object or human or animal's health on, thereby make described first temperature sensor approach described object or health most.
Optionally, described assembly further comprises strap configurations or long band structure, described strap configurations or long band structure are configured to dispose around the part of the part of object or human body or animal body, and be configured to make in use described assembly to remain on the described object or on described human body or the animal body, so that described first temperature sensor approaches described object or health most.
Preferably, described first has opening, and this opening is positioned such that described first temperature sensor of described data record apparatus comes out.
Preferably, described first has opening, can insert or remove described data record apparatus by this opening.
Optionally, the described first of described assembly and described second portion are disposable.
Preferably, described data record apparatus further comprises power supply, and described first temperature sensor is close to described power supply and is installed.
Preferably, described data record apparatus further comprises second temperature sensor that is used to measure second temperature.Preferably, described second temperature ambient temperature that is described assembly.Preferably, described second portion has opening, and this opening is positioned such that described second temperature sensor of described data record apparatus comes out.
Description of drawings
To the present invention be described by example now.
Fig. 1 is the data logger schematic representation of apparatus.
Fig. 2 does not have the circuit that source data sends principle for illustration.
Fig. 3 illustration according to the relation between data logger, data reader and the data processor of one embodiment of the present invention.
Fig. 4 represents to be incorporated into the data logger in the bonding paster.
Fig. 5 represents data logger and disposable bonding paster.
Fig. 6 shows the figure of the BBT that (i) estimated by the prototype data logger according to one embodiment of the present invention; (ii) the morning 6:30 utilize the figure of twice measurement of bldy temperature result's that Braun Thermoscan carries out average.
Fig. 7 is the circuit diagram according to the prototype data logger of one embodiment of the present invention.
The specific embodiment
Fig. 1 is the sketch map according to data record apparatus 100 of the present invention.In the data record apparatus of Fig. 1,112 pairs of signals from one or more pick off 106 of control logic are sampled, and the result is stored in the data storage 110.In a preferred embodiment, control logic comprises modulus (A-D) transducer, and this analog-digital converter analog signal conversion of autobiography sensor 106,108 in the future is that digital value is to be stored in the data storage 110.Control logic 112 further comprises intervalometer, makes it possible to gap periods storage sensor value clocklike.At least a portion that is used in the control logic carry out sensing or be used to store the temperature that senses is by power supply 102 power supplies.
Data among the present invention send preferably carries out according to principle shown in Figure 2.Alternatively, can adopt known any existing passive sending method in the prior art (especially relevant technology) with the passive mode rfid system.
Can think that transceiver 116 comprises transmitter and receptor.Refer to and to carry out any element or the element group that data send by any way at this " transmitter "." receptor " is meant any element or the element group that receives electric power and/or data from the electromagnetic field with this receptor coupling (preferably by the antenna coupling).An element of circuit can be regarded as is to be that the part of transmitter is again the part of receptor.
In passive transmitting system, can be along a direction transferring electric power, and along another direction transmission data.Fig. 2 is the circuit of illustration by the passive transmission principle of multiple passive mode rfid system employing.Typically, produce radiofrequency signal at reader 204 places by the generator 208 that reader coil 205 is driven.Responder 202 receives electric power by the electromagnetic coupled between reader coil 206 and the transponder coil 205 from reader 204.Carry out rectification by induced oscillating voltage in 212 pairs of circuit 216 of diode, so that between terminal 214, provide the voltage of usefulness.This voltage can be used for circuit is driven.
Specifically, the electric power that receives at responder can be used for transmitter circuit is driven.Transmitter circuit among Fig. 2 when switch 210 closures, makes capacitor 207 short circuits by switch 210 expressions.By open and close switch 210, the resonant frequency of LCR circuit 216 can be switched between two values.This so determined the electric power that draws by the oscillating field that circuit 216 produces from coil 206.Think that the most intuitively coil 205 and coil 206 have formed transformator: the resonant frequency of circuit 216 is switched made the load on the coil 205 is switched.This load variations can detect at the reader place by means of testing circuit 209, and testing circuit 209 can be ammeter (ammeter).Therefore, by between two resonant conditions of circuit 216, switching simply, numerical data can be sent to reader 204 from responder 202 by means of switch 210.Typically, the frequency that only has a resonant frequency to be in the resonant frequency of circuit 216 or approach to produce by generator 208.This makes the load at coil 205 places produce strong variations.
Preferably, power supply 102 is rechargeable.Because transceiver 116 can be operated the oscillating electromagnetic fields that is used for from antenna 114 and obtain electric power, so transceiver can be given rechargeable power supply with this supply of electric power.In addition, because transceiver has the seedbed and do not send, so transceiver need be from the incident electromagnetic field of reader device so that send to reader with data.Reader can be provided for electric power being offered the field of data logger and making it possible to by by data logger this being handled the independent field that (manipulation) do not have the source data transmission.Therefore data logger can be provided with second antenna and further be provided with transceiver circuit.Preferably, these two fields are identical.
The selector logic can be provided, whether power supply be recharged so that select.The selector logic can be so that can recharge power supply when being lower than predeterminated level when the voltage of both ends of power drops to.Can during fabrication this predeterminated level be stored in the selector logic.Alternatively, the selector logic can be so that can recharge power supply when having passed through at least the scheduled time from recharging for the last time.Can recharge selection by the electric current that under the indicated specified conditions of selector logic, is switched on or switched off by element (for example transistor).
In a preferred implementation, transceiver receives its electric power from the oscillating electromagnetic fields that reader device produced.In Fig. 3 illustration according to the digital data recording system of one embodiment of the present invention.Reader device 307 can be hand-held, therefore can easily be placed by the user, so that between reader device and data record apparatus 301 effective coupling is set.Reader can comprise screen 303, so that data that can observation post receive or provide the visual menu interface for the user.Reader can be battery-powered, perhaps can physically be connected to second device such as the processor device 309 that is used to handle the data that receive.Can wirelessly or by wire communication data be sent to data processor from reader.Alternatively, data processor can form the part of data reader.
Reader can comprise one or more input, and for example keyboard 305, and the user can carry out mutual with reader whereby or enter data in the reader.Data processor can comprise one or more input 311, thereby makes it possible to the more data collection is input in the data processor, perhaps makes it possible to carry out alternately with the function of data processor/reader.Shown in the frame of broken lines among Fig. 3, data reader and data processor can form the part of same device or independent device.
Data logger may further include receiver logic, is used for explaining one or more order that receives and be encoded into the electromagnetic field that is provided by reader at transceiver.Can pass through to switch the frequency or the amplitude of electromagnetic field, or data be sent to data logger by any other transmission technology well known in the prior art.The electric power that receiver logic is preferably also drawn from electromagnetic field by transceiver is powered.
Reader can send to data logger with one or more order.These orders can comprise the sampling interval that is used for setting sensor 106 order, be used for the order and the configuration order of log-on data transmission, for example calibrate constant, ID sign indicating number, replacement (reset) order and any control logic that is embodied as firmware upgraded.
Alternatively, during fabrication calibration factor, sampling interval and recorder ID are fixed.
In one embodiment, in case the electric power that receives at the transceiver place surpasses predeterminated level, transceiver just begins to send the data of storage.Alternatively, when when reader receives signal, transceiver begins to send.Reader will comprise that preferably the identifier of identification code sends to data logger.If this identification code is complementary with the sign indicating number that is stored in the data logger, then data logger only sends to reader with the data of storage.Data logger can (a) be stored and corresponding one or more identification code of one or more data reader, and perhaps (b) can require data reader to send the unique code of data logger.Identification code can be stored in the data storage 110.Data logger does not preferably send its sign indicating number, therefore in situation (b), requires reader to have the priori of this yard.This helps to protect the data that are stored in the data logger to avoid unauthorized or undesirable observation.Alternatively, can use known cipher protocol for example " put question to-reply (challenge-response) " agreement or other agreements well known in the prior art to strengthen safety.
Except the sampling sensor signal, data logger can be with data storage in data storage 110.These data can comprise above-mentioned one or more identification code and/or with subscriber-related data, for example personally identifiable information or medical information.This is used under the situation of physiological parameter of record patient particularly useful for patient and data logger the user: medical information can be for general patient's identity information or from the result of previous medical test or observed and recorded.These other data also can be sent to reader.
Can require reader that different identifiers is provided, so that receive different data types.For example, the first identifier trigger data recorder can be required, and the second identifier trigger data recorder can be required so that send user/patient information so that send the physiological parameter data of being stored.
In one embodiment, at least one in the pick off is temperature sensor.Temperature sensor is preferably critesistor.Alternatively, temperature sensor can be silicon-based devices, for example the voltage source of " and the proportional " of absolute temperature.In order to increase sensitivity, signal can amplify (boost) by the Signal Regulation element such as electric bridge, wave filter and amplifier.
For size and the electric power that makes data logger requires to minimize, as far as possible the data logger circuit is manufactured single microchip.
Under the situation of the data record apparatus that is used to measure one or more physiological parameter, can be set to (under the corium) implant or wearable paster by this device.If as implant, the data logger shell preferably has inertia and coated, so that help to prevent host's immune repulsion.
The example of the physical parameter that can be measured by data logger is temperature, pressure, pH value, light intensity, vibration, acoustic pressure, orientation (orientation) or motion.The example of the physiological parameter that can be measured by data logger is body temperature, blood pH, blood glucose, pulse rates, blood pressure.Can measure these parameters by any method well known in the prior art.
Data record apparatus according to the present invention can be configured to body temperature is measured, thereby makes it possible to determine automatically basal body temperature.This makes it possible to estimate from ovulatory cycle to the ovulation period of ovulatory cycle next time by the rising of searching basis in many day when the quietest () body temperature.This is irrelevant with the short term variations of user's skin temperature in fact, and user's skin temperature can be used as the result that level of activation, ambient temperature etc. change and changes apace in each all day.
Because body temperature changes usually lentamente, therefore can make a plurality of improvement to the data recording process.First improvement is in data logger sensing data to be compressed.Last measurement temperature is the good candidate of " entropy coding " with the data flow of the difference of current measurement temperature or is used for the feasible good candidate of comparing required minimized any other means of memorizer of the more frequent value of occurrence number with the value of less appearance.This makes it possible to the measurement result of the bigger quantity of storage in data logger.
By using the proper compression scheme, for example Fibonacci (Fibonacci) coding can separate individual data point.Sense data from circular buffer simply, and only in memorizer, introduce error in latter two measurement result, this error can easily abandon.
The data that write down with Fixed Time Interval may not require to keep a record (for example timestamp) when measurement data (or one group of data).For example, full if memorizer becomes, then can replace old value, and timestamp has guaranteed to know each sensor values is when to record with new value.
Second be improved to when temperature with respect to the variation of last measured value logging timestamp only during more than scheduled volume (for example 0.01 degree).Can measure according to preset frequency, perhaps can be basically the variations in temperature of monitoring sensor continuously.Can be with temperature value or temperature difference with the timestamp record, the person or can be not yet with temperature value or temperature difference with the timestamp record.As mentioned above, poor by writing time, data are easy to be compressed.
The common quick and small fluctuation of sensor values (for example being used for the fluctuation of the temperature measurement result of definite ovulation period) is unimportant.In these cases, can use very simple analog-digital converter or sampling hold circuit that temperature value is compared, so that determine the poor of a last value and currency.Can make main analog-digital converter remain on resting state, greater than scheduled volume, and timestamp and/or temperature value will be stored in the data logger up to this difference.Can utilize minimum dormancy time further to strengthen this scheme, often waken up during the temperature fluctuation period greatly and fast to avoid main analog-digital converter.These schemes help to save memorizer and the electric power in the data logger.
The 3rd is improved to these value seeking times average.This time average has the effect that abandons the information relevant with the rapid fluctuations of sensor values (being to remove high frequency " noise " in essence).This can realize by using sliding window: for example circular buffer can keep back 16 measurement results of recording with 14 bit resolutions, and the meansigma methods of 16 measurement result is stored in the memorizer.These 14 measurement results and be one 18 number, but the least significant bit in the supposition analog-digital converter (least significant bits) is a Gaussian noise distribution, then being improved to signal: the noise that produces sqrt (16)=4: only use preceding 16 of this 18 figure place just can produce 16 place values according to 14 measurement results.Also can use other bit length and buffer size.
Further improving is maximum measurement result and the minimum measurement result that does not comprise in asking average computation in the buffer.This helps to make that the influence of outlying (outlying) measurement result minimizes.Also can get rid of some measurement results (for example only using 12 measurement results in 16 centres in the measurement result) selectively so that further reduce the short-term effect of outlying measurement result.
Carry out natural contraception by the specific sign that monitoring occurs during menstrual cycle.Observed modal sign is that menstrual bleeding, cervical mucus change and body temperature changes.
Calendar rhythm method is the method for the most ancient and most widely used understanding fertility.Drawing the calendar chart makes the women can estimate time started and persistent period that ovum may be fertilized by sperm.Calculate educating the phase (fertile period) according to three hypothesis: 1) ovulation appears in the 14th day (adding or deduct two days) before next can begin the phase of educating; 2) the sperm survival is 2-3 days; 3) survival of ovum or ovum is 24 hours.
Basal body temperature (BBT) method is a kind of method that generally adopts, this method in the morning (preferably identical time of the every morning) at first measure oral temperature and these temperature be plotted in the chart.When for three days on end temperature occurring and be higher than any given day in previous 7 days, generally show and ovulate.Make unpredictable in this way ovulation, but can take place to identify ovulation after the ovulation in a single day.Sterile (infertile) time that is used to discern the women when begin aspect this method the most useful.
In the women of great majority ovulation, even in the irregular women of ovulatory cycle, the cervical mucus variation has the distinctiveness pattern.In order to assess cervical mucus, the women obtains some mucus from its vaginal orifice.When checking its mucus, the women need determine to feel that mucus is wet or dried.For example whether the bright women of phlegmatic temperament scale of stickiness, elasticity and humidity is in ovulatory cycle.Common " is the last time slided a day before wet " mucus day or was ovulated the same day.When mucus has the raw albumen characteristic, can educate and occur period.Use vaginal lubricant or lavation meeting to cause these characteristics to be difficult to identification more.
Various diagram methods can individually or combine use.A kind of common technique is to allow the women write down its mucous variation and write down its basal body temperature.Some women also notices and writes down ovulation pain, and that this ovulation pain may comprise is heavy, abdominal distention, rectum pain or uncomfortable and lower abdominal pain or uncomfortable these sensations.Pain may appear at before the ovulation, between the onset of ovulation or after the ovulation.
Data logger described herein can automatically be carried out temperature monitoring, and the women needs constantly for example other subjective parameters of its mucus variation of record.By being input to these additional subjective parameters in (aforesaid) reader device or being input in the data processor (temperature data is sent to this data processor), but and only just be used in its time spent (though not requiring that it is available), can combine with temperature data and time/date data selectively, so that the ovulation date to future is estimated, and the future date that the expection of subjective parameters changes estimated that prompting is the women monitor them when most probable needs.
The importance of these additional subjective parameters is that temperature raises after ovulation, other parameters then changed before ovulation.Can educate window (fertilewindow) if attempt only to discern by temperature, then because the ovulation rear section in this cycle has obtained good qualification (usually about 10 before the menstruation was to 12 days), thereby uncertain window is than broad, and ovulation rear section that should the cycle changes little in length from one-period to another cycle.Therefore thermograph can identify this period.Yet the ovulation forward part in this cycle has length variable from one-period to another cycle.By adding the data relevant, added very objective second parameter, and can improve estimation ovulation period with the menstruation first day.
By adding for example relevant information, can more accurately determine to educate the time started of window with the cervical mucus quality.Yet,, particularly after having sexual intercourse the previous day, be difficult to obtain reliably the quality of cervical mucus for some women.Bestly be: only when other physiological datas are provided, just use these physiological datas, and when these physiological datas were not provided, system depended on temperature measurement result and calculates opportunity the time started that can educate window.Similarly, if observe for example other parameters of saliva quality, distending pain of the breast (breast tenderness), ovulation pain and hormone measurement result and so on, also can add these.
The data record apparatus that is used to monitor body temperature can adopt the form of implant, this implant to be injected in women's body or insert when minor operation.Preferably, data logger is inserted into abdominal part or upper arm inboard, thereby the temperature that data logger is write down accurately reflects real core temperature.Alternatively, data logger can be incorporated in paster, the wearable belt or clothes (for example underwear).This way of realization has below been described.
Fig. 6 illustration serviceability temperature data logger benefit that basal body temperature is estimated.First figure among Fig. 6 is basal body temperature every day, and this, basal body temperature was to go out by the data estimation according to prototype data logger nocturnal periodicity ground record when the user sleeps of one embodiment of the present invention every day.The temperature measurement result that obtains during the large amount of exercise stage is left in the basket, and the residuals temperatures data from data logger are handled, so that remove outlying temperature measurement result.Then remaining temperature measurement result is asked on average, so that the shortage term fluctuation that estimation records temperature.
Second figure is the basal body temperature in the date identical with first figure that utilizes routine techniques to estimate: the user utilizes ear temperature meter (aural thermometer) (Blang's thermoscope, Braun ThermoScope) to carry out twice measurement when just wake up for six thirty in the morning.The prototype data logger clearly detects the ovulation date (by the indication of the arrow among the figure), yet uses conventional method to be very difficult to detect the ovulation date.The usage data record device also make the user needn't every morning get up to measure its temperature very early and with thermograph in notepad.
Fig. 7 illustration be used to gather the circuit diagram of the prototype data logger of data shown in Figure 6.
By being arranged to regularly, make the electric power that obtains from the electromagnetic field that reader produced regularly recharge to power supply from data logger sense data (so that predicting ovulation).Therefore, the power supply of device can be less relatively.The small size of device and during data send, carry out wireless recharging the two combines and makes device to be embodied as implant by actual, alternatively, make device be incorporated in the little bonding paster, the mode that this little bonding paster can be identical with the rubber plaster of routine or adhesive bandage (band-aid) is attached on the skin separatedly.
In one embodiment, data logger comprises integrated circuit and antenna, this integrated circuit comprise control logic, regularly, measurement, power control, temperature sense and radio communication, this integrated circuit is attached to the lithium polymer battery that is used for store power.Because data logger is measured body temperature, so the temperature range that device is subjected to is very narrow, and by using the R-C time constant, can realize the simulation timing of extremely lower powered sample frequency with acceptable accuracy.Also can periodically measure supply of electric power over time, therefore can during writing down, calibrate the frequency of measuring.Data logger typically carries out record with preset frequency (for example every ten minutes) to temperature, and with thermograph in memorizer.
Be used for determining that the system of ovulation period can comprise having any one form of form described herein and be configured to the data logger that temperature is measured, the data reader with any one form in the form described herein and data processor.Alternatively, data logger can be can carry out passive transmission and with well known in the prior art any temperature data recorder of this data reader compatibility.Data logger sends to data reader by passive transmission with the data of its storage.Data reader and data processor can communicate by any way well known in the prior art.
Reader device can have display and user input capability, thereby makes the user can watch the table or the figure of the data that receive from data logger, and/or makes the user to carry out alternately with the EFR STK system.Reader device can be connected to data processor, and perhaps data processor can form the part of reader device.Only important thing is: system has certain aspect that can handle the data that receive from data logger, thereby the indication to women user's ovulation period is provided.Data processor can only be the personal computer support software that is configured to carry out date processing.
Data reader or data processor comprise at least one input equipment of other physiological datas set of being used for importing women user.Data processor can combine temperature data and other physiological datas set (for example hormone assay of cervical mucus quality, blood or urine etc.), so that indicate ovulation period according to any one principle in above-mentioned ovulation tests principle or the principle well known in the prior art.
Reader device preferably includes the portable mobile wireless reader, when this portable mobile wireless reader when suitably distance is activated, can carry out two-way communication with implant.User interface can comprise a plurality of buttons that are used to import the data such as menstruation natural law and cervical mucus quality, and is used to point out the simple liquid crystal display of measuring or being used to indicate the parameter such as implant and reader battery electric quantity.Equally, if data processor is configured to receive any other physiological data that can be directly inputted in the data processor, then the user can be directly inputted to these physiological datas in the data processor-and if data processor is a personal computer, and then this will provide convenience for the user.Reader itself can estimate ovulation period based on the data (these data can be stored in the reader and/or be stored in the data processor) of precedence record, and reader can be suitable for the Expected Number of Days to ovulation next time of user's range of a signal.For the privacy reason, this device preferably will not show any information relevant with fertility, unless the implant that this device is connected with it was recently got in touch.
Reader device can comprise USB port (or wired or wireless connection of other appropriate formats), thereby makes it possible to be connected to personal computer.This makes it possible to (a) internal cell of reader is recharged, and/or (b) carry out transfer of data with computer in order to carry out data storage, further data are handled, carried out data show, or only handle by the temperature data in the computer execution system.When reader or data processor have found to be not suitable for to expect the data of ovulation model or when needing additional user mutual, it can point out the user to be connected to personal computer.
At this device of computer can be USB " driver " storage device, and has available software and the handbook that is used for this device on this driver, so this device does not need to carry independent software (for example CD).Software can provide the user interface that has more autgmentability, and this user interface can be operated and is used to be connected to the Internet, so that executive software and firmware upgrade.Optionally, can user's data be uploaded, so that analyze by third party such as practitioner by the Internet.
User's training system can serve as in the computer interface aspect of reader when measuring the stronger physiological parameter of subjectivity such as the cervical mucus quality this system of making, this is because training software can be in conjunction with temperature history and other data of user.This has reduced the user to being carried out the dependence of health instruction by the third party, and the health instruction often is considered to invasive or embarrassing.
Along with the user becomes more skilled when measuring these additional parameters, change to be used for the statistical model of ovulation prediction so that make these observed results have higher weight.This makes it possible to progressively reduce to center on the " security window " of ovulation period, during this period should be ascetic to prevent pregnancy.
Data logger described herein can be human body or the animal heat degrees of data recorder that is incorporated in Fig. 4 and the wearable paster 407,503 of binding type shown in Figure 5.Binding agent 411 can be selected from any known skin adhesive, and binding agent 411 preferably has hypoallergenic so that with the risk minimization of 401 negative effects of skin of user.Paster preferably is contained in data logger 403,501 in the bag shaped structure, this bag shaped structure makes it possible to data logger is removed, and (for example when binding agent loses viscosity or user and wants new paster) can be installed in data logger in the new paster in appropriate circumstances.Fig. 5 shows opening 507, can remove and installation data recorder 501 by this opening 507.Alternatively, data logger can be sealed in the paster, if paster and data logger are disposable, then this is easily.
In a preferred implementation, paster is roughly circle, and diameter is approximately 2 centimetres and be skin-color.In order to make body temperature trans and variation of ambient temperature thermal insulation, paster can have adiabatic zone 405 (for example soft foam substrate), and this adiabatic zone 405 extends above the part relative with a side of the close body contact of data logger on the data logger.Paster can have opening 509, and the heat conduction of data logger 409,505 can be outstanding via this opening 509, and forms physics with the health that is attached with paster and contact.This has formed the part of opening 507 in Fig. 5, and data logger can be inserted in the paster by opening 507.
If data logger does not have the heat conduction head, wish usually that then paster (and might be the data logger housing) other position thermal conductivitys above the regional internal ratio paster/housing between body temperature trans and the health itself are better.This can realize in the following manner: be chosen in the material that uses in paster/housing, and/or with paster/housing manufacture make in the zone of this material above temperature sensor thinner.
Can be with above-mentioned paster structure as supplying easily through the disinfectant disposable apparatus.
Alternatively, data logger can be incorporated on belt (for example can center on the belt that arm is dressed) or the clothes, perhaps can data logger be fixed on the appropriate location by long band (strap) or strap configurations.Preferably, the simultaneous temperature pick off that belt is dressed around upper arm is positioned at the arm inboard near axillary fossa.For the minor variations of take temperature accurately, particularly importantly, the same position (measurement point) that data logger is reapposed over user's body when the user puts on belt is again located.Therefore belt can have labelling, correctly data logger is fixed in the belt with assisting users.The long-term wearing feels that the neoprene of comfortable and excellent heat insulating performance is specially suitable band of material.
The several temperature pick off can be fixed in the belt in the form of a ring.This can alleviate the user in the influence of rotating the positioning belt period of the day from 11 p.m. to 1 a.m irrelevantly.Typically, there is temperature contrast in known (for example) near being tied with the arm of belt.Can measure this species diversity, and it is stored in the data logger as specific user's personal information, perhaps more preferably be stored in the data processor, wherein temperature measurement result is sent to this data processor so that handle.This personal information makes to get up with its location association with respect to arm after a while from the temperature measurement result of each pick off in these pick offs, thereby determines the most close " measurement point of which pick off ".May further wish: use the known temperature personal information between these temperature measurement result, to carry out interpolation, so that when changing belt, determine the temperature of measurement point more accurately at every turn.Can carry out these calculating at the data processor place.
In Fig. 3, Fig. 4 and embodiment shown in Figure 5, temperature sensor and antenna are incorporated in the main body of data logger itself.As shown in the figure, in this embodiment, the data logger housing can have the heat-conducting part that is positioned at the temperature sensor top, perhaps can have temperature sensor and body-coupled heat conduction head.Yet temperature sensor can be positioned at the outside of the main body of data logger, and is connected to data logger by wired mode.Similarly, antenna can be positioned at the outside of the main body of data logger, and this may improve data and electric power transfer.Temperature sensor and/or antenna can integrate with paster/belt, and are wired to data logger.
Preferably, data logger itself is encapsulated in the seal casinghousing, so that the parts of protected data recorder are avoided bump, liquid and corrosive influence.In order to make different user to reuse, also be favourable if can in autoclave (autoclave), carry out disinfection to the data recorder to device.Housing preferably has the skin of being made by silicones or other inert materials.The silicones of housing can have variable thickness, thereby has thin silicone layer (may be 0.1 millimeter) in temperature sensor, then has thicker silicone layer (may be 0.5 millimeter) on other zones of housing.Thicker silicone layer helps to make the pick off thermal insulation.Silicones in the temperature sensor can be doped with metallic particles, to improve the heat conductivity of silicones in this zone.
Preferably, but silicones or other protective materials can be injection molding molding (injectionmoldable) but inserted mode system molding (insert moldable), have water proofing property and/or biocompatibility.
As mentioned above, data logger can have the head of being made by high conductivity material (for example metal), part or all of this head highlights via data logger housing/silicones, with the thermal coupling between the temperature sensor that improves data logger and the health of having used temperature sensor.
Under the situation that need estimate core temperature but measure at the external point place of health, can make improvements simple measured skin temperature.If below adiabatic paster, measure skin temperature, and the temperature of measurement insulator outside surface (promptly carrying out secondary measures), can estimate that then skin temperature and core body using warming therapy are poor.The simplest implementation method is that the temperature difference between two pick offs is used an invariant, i.e. T core=T skin+k (T skin-T outside).Complicated more but accurate more method is a situation of considering that ambient temperature is higher than and is lower than skin temperature, and make that this correction is a nonlinear function.Preferably, the data recorder is used this correction, thereby only have resulting core temperature estimated value to be stored in the data logger.Alternatively, two temperature data collection can be stored, and the data processor that can dock the shrinkage temperature data is proofreaied and correct.
By under various external temperature conditions, calibrating this paster apparatus, can design accurate more corrective system at (recording) core temperature by any routine techniques.Alternatively, in order to be identified for producing the required correction function of core temperature of approximately constant, carry out calibration according to any in the following method from data:
1. use the known temperature gradient of paster both sides, and the response of measuring these two thermometeies.
2. when dressing paster, the user make external temperature sensor be exposed to a temperature range.Importantly: changing applied faster temperature than body temperature can make response to variations in temperature.
3. during using changing fast naturally of comparing with skin temperature that record external temperature, temperature measurement result is analyzed.Preferably, in data logger, carry out this method, and this method can be used for continuously correction function being regulated in response to environmental change.
In one embodiment, following execution calibration calculations in data reader or data processor (reader can be connected to this data processor):
1. data reader sends order to indicate this data logger to enter calibration mode to data logger.
2. startup calibration process, and data logger sends the temperature data from temperature sensor in real time.
3. data reader or the data processor that is connected with data reader calculate correction function.
4. data reader sends to data logger with the parameter of correction function, to use when according to skin temperature transducer value and ambient temperature sensor values core temperature being extrapolated (extrapolate).
Calibration factor can be stored in (if calibration calculations is to carry out, then calibration factor may be stored in the data logger) in the data logger after data reader sends in reader/data processor.The thermal characteristic of data logger housing and/or paster/belt or represent that the derivative of this characteristic can be stored in the data logger or in data reader/processor is for using when recording data and handle.Can determine this thermal characteristic during calibration process, if perhaps data logger housing and/or paster/belt uses the material with known features, then this thermal characteristic is available.Known these characteristics can for example make that data processor can the calculating data recorder and the theoretical temperatures gradient of shell both sides, and this theoretical temperatures gradient can be used for core temperature is extrapolated.
For other sensor types, the relevant physical characteristic of storage will be replaced: for example can store acoustics or the optical propagation characteristic of data logger being incorporated into housing wherein.Above-mentioned calibrating principle is adapted to by the pick off of other types the measurement of other physical parameters be calibrated equally.
Can will have skin temperature transducer and environment temperature sensor two pick offs inputs of two outside temperature sensors of data logger itself (or be used to be positioned at) but data logger be incorporated into aforesaid paster or belt with additional opening or zone, wherein the thermal conductivity of the thermal conductivity ratio external temperature sensor in this opening or zone is better, so that the thermal coupling better of this temperature sensor and external environment condition.
Can utilize be positioned at have different thermal parameters (for example local thermal capacitance and thermal conductivity) the position three or more temperature sensors and make further improvement.For example, if a pick off is positioned at health one side of device, and has low thermal resistance to health, a pick off is positioned at the outside of device, and has low thermal resistance to external environment condition, and a pick off is positioned at the centre of device, and has to the higher thermal resistance of the ratio of any point with than higher local caloic (thermalmass), then can use suitable calibration program that more accurate estimation to core temperature is provided.Calibration program can be set in advance or can be based on experience or adaptive algorithm.
Above-mentioned data logger structure is not limited to be designed to measure the data logger of skin/body temp of animal or human, but is suitable for measuring temperature or any other physical parameter of any body (no matter being plant, animal, machine or rock etc.) usually.
In the data logger for the system that is used for determining women's ovulation period, advantageously from the temperature data and the data combination (employed in this application term " women " refers to jenny and woman) of having indicated women's active state of data logger.Under situation about temperature data and women user's activity association can not be got up, particularly, be difficult to discern the body temperature of having indicated " basal body temperature " to reduce and reduce for being worn on outside data record paster or belt (though for the data logger of implanting, also being a problem).
When the user woke up and move around, the air-flow that is positioned at the skin top that centers on the data record apparatus can make skin temperature reduce.Comparatively speaking, when the user slept, it is adiabatic good that data logger is tending towards, and skin temperature higher (though this normally carries out thermometric Best Times, this is because core temperature and skin temperature are stable).And when the user takes exercise or when fever, skin temperature and core temperature all may raise.Most preferably, take temperature when user's rest changes the temperature conditions change that has nothing to do and the mistake measurement that causes because this helps avoid with basal body temperature.
Advantageously, motion is measured, and these data and the temperature data that records are connected, to determine user's basal body temperature better at the data processor place at data logger or other device places.For example, can be according to determining basal body temperature at the minimum temperature that has continued above recording during 30 minutes not strenuous exercise period.Can originally be in (for example being included in the data logger) at data logger and come the capture movement data by degree of will speed up meter.In this case, as is known in the art, both can write down acceleration/vibration data, and also can use gravity knowledge to come " inclination angle (tilt) " of measurement data record device.During along with user's motion, the inclination angle will change, and therefore can infer motion.Alternatively, can use any other device that motion is detected, for example with the coupled motion detection video camera of data processor, pulse transducer (it has indicated the user when moving/taking exercises indirectly) and the pick off that is positioned at bed/mattress that the motion on the bed (for example the user stands up) is detected.
Preferably, be in the motion of measuring the user certainly at data logger.During strenuous exercise's period, data logger can be arranged to not write down any temperature data.Therefore do not need exercise data itself is recorded in the data logger-but this exercise data be used to determine when and measure and the record temperature when do not measure and write down temperature.Thereby the memorizer of usage data record device effectively.
Alternatively, can all be recorded in motion and temperature in the data logger, and data processor can combine these data sets subsequently, so as to determine temperature data which part may with user's real core temperature close association, which part of data may be not too reliable.Do like this at the data processor place and to make it possible to adopt advanced more method.For example, can use complicated algorithm more, this algorithm makes and is determining when that the non-strenuous exercise that has occurred wherein may having carried out the thermometric relative prolongation of high-quality during the period, can ignore short-term movement (standing up when for example the user sleeps).Preferably, when determining basal body temperature (or its similar parameters), use those temperature measurement result that during the non-strenuous exercise period that prolongs relatively, obtain, and can abandon remaining data.
Below will describe method for optimizing,, can in data processor, will handle with user's movable information (from data logger or externally measured result) from the temperature data of data logger by this method for optimizing.
1. the identification persistent period is at least the user's of predetermined length (for example 30 minutes) the non-strenuous exercise period.
Identification in time with the corresponding temperature measurement result of non-strenuous exercise window.
3. calculate the average of these measurement results, to produce average tranquillization (resting) temperature.
Preferably, the data of (each daytime or night be data once) are handled to each daytime (or night), estimate with the basal body temperature to user every day.Can handle and those measurement results of being limited to temperature data when the user may sleep or obtaining during rest by the temperature data that only special time at 11 (for example in afternoon to point in mornings 6) is recorded.Perhaps, the user can only just dress data logger (for example paster, arm band etc.) when sleep.
Have been found that: the temperature data that records in the time of can sleeping according to the user is determined the reliable estimation to basal body temperature.Yet the user will only can short-term sleep sometimes, and perhaps the temperature data of part sleep period is of poor quality sometimes.In these cases, can be by the body temperature that occurs between user's sleep period be slowly reduced the basal body temperature of extrapolating estimating user, if the minimum body temperature that the user will reach when the user can be slept the sufficiently long time (if or temperature data have enough good quality) is estimated.Can estimate this minimum by technology well known in the prior art according to the slope of temperature-time curve: for example, the rate of change of slope of a curve can be used to predict the minimum that body temperature when occurs.Can by will this incomplete temperature data with the previous sleep period during the temperature-time curve that records compare and improve this estimated result: for example, about reaching its minimum, user's body temperature need knowledge how long can be used for prediction usually:, this minimum when to occur for the given initial temperature and the slope of temperature-time curve.
Can be clear that by above-mentioned discussion according to the input that data logger of the present invention can have any amount, each input can be the input from any kind pick off (for example temperature sensor, accelerometer).After data reader device was carried out poll, data logger sent one or more sensor data set.Any mode of data logger in can be in several ways sends to reader with data, and these modes comprise: only send by those data sets of reader request, send measurement result with the predefined procedure transmit data set and with the order of measuring (or inverted order).
Data logger can have programmable data intra-record slack byte, and this is to set when paster being applied to patient's (for example by means of order from the data reader to the data logger) first at interval.Data logger can come record data according to specified interval then, up to being stopped (or exhaust up to battery electric quantity) by order.In some embodiments, the each timestamp of measuring of data logger storage, the timestamp when perhaps storing each (again) opening entry of data logger.
All embodiments of the above-mentioned data logger that the data logger that uses with the system that is used for determining women's ovulation period is relevant are applicable to the data record apparatus that can have any amount of application and sensor type usually.
Be stored in temperature data in the data logger and represent temperature history along with the health that is attached with data logger of time.For some application, for example for the application of determining women (human or animal) ovulation period, there is no need each the point in time measurement body temperature in a whole day.In this case, be, data logger be incorporated in the belt that this belt is dressed around upper arm but can when the user has a bath or move this belt be removed easily to the user.In these cases, for instance, when (for example) temperature (because pick off no longer with contact skin) drops to when being lower than predeterminated level, perhaps when the button on pressing data recorder/arm band, perhaps when data logger when data reader device receives order, data logger can stop record.
Carry out comprehensive and continual temperature survey when most important at the body temperature to the patient, (may for disposable) paster be configured in the medical applications is useful.(all having on temperature accuracy and measuring frequency) high-resolution temperature data is in that (for example infection of particular type, hypothermia or heating) is useful when diagnosing to many medical conditions.The comprehensive temperature history of obtaining in the data record apparatus that is stored in patient's wearing helps the doctor to carry out precise diagnosis quickly.
So far, any combination that the applicant discloses each independent feature described herein and two or more this features respectively discloses, disclosed degree makes those skilled in the art according to common sense, based on making as a whole description, can implement these features or combination, and no matter whether this feature or these combination of features have solved any problem disclosed herein, and the scope of claim are not formed restriction.The applicant points out, many aspects of the present invention can be by any this independent feature or these combination of features and formed.In view of previous description, it will be readily apparent to one skilled in the art that and to make various modifications within the scope of the invention.
Claims (69)
1, a kind of data record apparatus that one or more physical parameter is carried out in site measurement, this data record apparatus comprises:
Power supply;
One or more pick off, this one or more pick off is used to measure described one or more physical parameter;
Data storage, this data storage are used for storing the expression of at least some measured values of the measured value of described one or more physical parameter;
Control logic, this control logic are configured to the described expression of at least some measured values in the described measured value is write described data storage, and read data during being provided in the data transmission from described data storage;
Antenna; And
Transmitter, this transmitter are coupled to described antenna and are configured to and send the data that transmission is stored by passive.
2, data record apparatus according to claim 1, wherein, described power supply is a rechargeable power supply, and at least a portion that described transmitter is configured to the electromagnetic power that will receive at described antenna place is supplied to described rechargeable power supply, thereby described rechargeable power supply is recharged.
3, data record apparatus according to claim 2, wherein, described data record apparatus further comprises the selector logic, and described transmitter is configured to: if described selector logic is selected and will be recharged described rechargeable power supply, then at least a portion of the described electromagnetic power that will receive at described antenna place is supplied to described rechargeable power supply.
4, data record apparatus according to claim 3, wherein, described selector logic is configured to: be lower than predeterminated level if the voltage of described both ends of power drops to, then select described rechargeable power supply is recharged.
5, according to any described data record apparatus in the aforementioned claim, wherein, at least some expression in the described expression of described measured value be physical parameter last measured value with the back one measured value poor.
6, according to any described data record apparatus in the aforementioned claim, wherein, described control logic is configured at least some expression in the described expression of measured value together with having indicated the timestamp that carries out the corresponding time of measuring to write described data storage.
7, according to any described data record apparatus in the aforementioned claim, wherein, each pick off is configured to measure described one or more physical parameter with preset frequency.
8, according to any described data record apparatus in the aforementioned claim, wherein, described control logic has first pattern of work and second pattern of work, in first pattern of described work, described control logic can be operated the expression that is used for measured value and be write described data storage, and in second pattern of described work, described control logic can not be operated the expression that is used for measured value and be write described data storage, the power that described control logic consumes in described first pattern is greater than the power that consumes in described second pattern, and described control logic enters second pattern of described work when being configured in meeting the following conditions one or more:
(a) after writing described data storage, passed through time of predetermined length;
(b) when the variation of described measured value between measurement result of a selected physical parameter in described one or more physical parameter is greater than or less than scheduled volume;
(c) the described measured value when a selected physical parameter in described one or more physical parameter is when being greater than or less than value of predetermined value.
9, data record apparatus according to claim 8, wherein, described control logic enters described first pattern after being formed at the time that enters the predetermined length after described second pattern.
10, data record apparatus according to claim 8, wherein, described data logger further comprises comparison circuit, this comparison circuit is configured for the variation of described measured value between measurement result of determining a selected physical parameter in described one or more physical parameter and when is greater than or less than scheduled volume, and this comparison circuit is configured to: determine in response to described, make described control logic enter described first pattern, and the expression of at least some measured values in the described measured value is write in the described data storage.
11, according to any described data record apparatus in the aforementioned claim, described data logger further comprises with lower device, this device is used for one group of measured value of the selected physical parameter of described one or more physical parameter is averaged, and the expression that makes described control logic will organize the described meansigma methods of measured value writes in the described data storage.
12, according to any described data record apparatus in the aforementioned claim, wherein, described physical parameter is the orientation of temperature, pressure, pH value, light intensity, acoustic pressure, motion, spectral quality, data logger or one or more kinds in inclination angle and the vibration.
13, according to any described data record apparatus in the aforementioned claim, wherein, the described data storage of described data logger is configured to storing additional data.
14, data record apparatus according to claim 13, wherein, described additional data comprises personal information and/or medical information.
15, according to any described data record apparatus in the aforementioned claim, wherein, at least some physical parameters in described one or more physical parameter are physiological parameters, and described data record apparatus is incorporated into in one in the lower member:
(a) be suitable for being implanted to the intravital assembly of animal body or people;
(b) be suitable for the bonding paster on skin, dressed; And
(c) clothes or other wearable items;
(d) containment vessel.
16, according to any described data record apparatus in the aforementioned claim, wherein, a pick off in described one or more pick off is first temperature sensor.
17, data record apparatus according to claim 16, wherein, a pick off in described one or more pick off is second temperature sensor, and described first temperature sensor is configured to measure the temperature of human body or animal body, and described second temperature sensor is configured to measure the ambient temperature of described human body or animal body.
18, according to any described data record apparatus in the aforementioned claim, wherein, a pick off in described one or more pick off is accelerometer or other device that is used to measure the motion of the motion of described data record apparatus or health, wherein is used to measure the described accelerometer of motion or other devices attached on the described data record apparatus or health.
19, according to any described data record apparatus in the aforementioned claim, wherein, described control logic is configured to: when only the variation of the previous measured value of selected second physical parameter in described one or more physical parameter was less than predetermined value, just the expression with the measured value of selected first physical parameter in described one or more physical parameter write in the described data storage.
20, according to any described data record apparatus in the aforementioned claim, wherein, described control logic is configured to: when only the variation of the measured value between measurement result was greater than scheduled volume, just the expression with the measured value of a selected physical parameter in described one or more physical parameter write in the described data storage.
21, data record apparatus according to claim 20, wherein, described expression is the timestamp of having indicated the time when measuring described the variation.
22, a kind of system that one or more physical parameter is carried out in site measurement, this system comprises:
Any described data record apparatus in the claim as described above; And
Data reader device, this data reader device comprises receptor, this receptor is configured to by passive transmission at least some data from the data that described data record apparatus reception is stored.
23, system according to claim 22, wherein, described data logger is configured to: when the energy that is received from described data reader by described receptor surpasses predeterminated level, send at least some data in the data that described data logger stores.
24, system according to claim 22, wherein, described data logger is configured in response to from the appropriate command of described data reader and send at least some data in the data that described data logger stores.
25, system according to claim 24, wherein, described order has indicated described data logger will send which data in the data of being stored.
26, according to any described system in the claim 22 to 25, wherein, each pick off is configured to predetermined frequency described one or more physical parameter be measured, and described data reader can be operated and is used for sending the signal that is used to set this frequency to described data logger.
27, according to any described data record apparatus or system in the aforementioned claim, wherein, the described data storage of described data logger is configured to storing additional data.
28, data record apparatus according to claim 27 or system, wherein, described additional data comprises personal information and/or medical information.
29, according to claim 27 or 28 described systems, wherein, described data logger is configured to: in case receive appropriate command from described data reader, just send at least some additional datas in the described additional data.
30, according to any described system in the claim 27 to 29, wherein, in response to receiving appropriate command from described data reader, described data logger is configured to: (a) utilize the data that send together with described order to rewrite at least some data in the described additional data, perhaps (b) will write together with the data that described order sends in the described data storage as further additional data.
31, according to any described system in the claim 22 to 30, wherein, described data reader can be operated and be used for sending authentication code to described data logger.
32, system according to claim 31 wherein, determines at least a portion authentication code in the described authentication code according to the identification code of described data logger.
33, system according to claim 31 wherein, determines at least a portion authentication code in the described authentication code according to the identification code of described data reader.
34, according to any described system in the claim 31 to 33, wherein, described data logger keeps one group of effective authentication code, and described data logger is configured to: only when described data logger received effective authentication code, just at least some data in the data that described data logger is stored sent to described data reader.
35, according to any described system in the claim 22 to 34, wherein, described data logger is configured to described data reader is carried out authentication public key, perhaps vice versa, and described data logger is configured to: only when described data logger received significant response, just at least some data in the data that described data logger is stored sent to described data reader.
36, according to any described system in the claim 22 to 35, wherein, described data reader device comprises the input equipment that is used for entering data into described reader.
37, according to any described system in the claim 22 to 36, wherein, at least some data storages in the data that described data reader device is configured to receive at described data reader device place.
38, according to any described system in the claim 22 to 37, wherein, described data reader device can be operated at least some data that are used for the data that will receive from described data logger by wired or wireless communication and be sent to one or more kinds Internet Server, personal computer (comprising laptop computer, desk computer, PDA, smart phone or handheld computer), storage device or any other data processing equipment.
39, according to any described system in the claim 22 to 38 that is subordinated to claim 17, wherein, described data reader device is configured to handle according to the corresponding measured value of described second temperature sensor each measured value of described first temperature sensor, so that the human body that described first temperature sensor is configured to measure or the core temperature of animal body are estimated.
40, according to being subordinated to claim 18 and further being subordinated to any described system in the claim 22 to 39 of claim 16, wherein, described data reader device is configured to: at least some measured values of the described measured value of described first temperature sensor that will record in the time of will surpassing predetermined value in the variation of the measured value of the described accelerometer that is used for motion is measured or other devices are ignored.
41, according to being subordinated to claim 18 and further being subordinated to any described system in the claim 22 to 39 of claim 16, wherein, described data reader device is configured to: at least some measured values of the described measured value of described first temperature sensor that will record in the time of will surpassing predetermined value at the described measured value of the described accelerometer that is used for motion is measured or other devices are ignored.
42, a kind of system that is used for definite women's ovulation period, this system comprises:
The data record apparatus, this data record apparatus comprises:
First temperature sensor, it is used to measure women's first temperature;
Data storage, it is used for one or more first temperature measurement result is stored as
First physiological data set;
Control logic, it is configured to the expression of described first temperature measurement result is stored in
In the described data storage;
Transmitter, it is configured to send at least some data in the data of being stored;
Data reader, this data reader comprises:
Receptor, it is configured to receive the data of being stored from described data record apparatus
In at least some data; And
Data processor, it has input equipment, and this input equipment can be operated and be used to receive at least one other physiological data set;
Wherein, described data processor is configured to: will combine from described first temperature data and described at least one other physiological data set of described data reader device, to form the indication to ovulation period.
43, according to the described system of claim 42, wherein, described data record apparatus is incorporated into in one in the lower member:
(a) be suitable for being implanted to the intravital assembly of animal body or people;
(b) be suitable for the bonding paster on skin, dressed; And
(c) clothes or other wearable items;
(d) containment vessel.
44, according to claim 42 or 43 described systems, wherein, described at least one other physiological data set comprise cervical mucus qualitative data, hormone horizontal data and have indicated at least a in the data on menstruation date last time at least.
45, according to any described system in the claim 42 to 44, wherein, described data processor can be operated and be used for by means of the ovulation prediction algorithm described first temperature data and described at least one other physiological data set being combined, and wherein said ovulation prediction algorithm is configured to different statistical weights distributed to each of these data centralizations.
46, according to the described system of claim 45, wherein, described statistical weight is based on by indicated ovulation period of these data sets and the previous degree of association between the actual ovulation period.
47, according to any described system in the claim 42 to 46, wherein, described data processor or described data reader can be operated and be used to point out the user to provide additional physiological data set in described input equipment place of described data processor.
48, according to any described system in the claim 42 to 47, wherein, described data reader device comprises shell, and described data processor is incorporated in the described shell of described data reader device.
49, according to any described system in the claim 42 to 48, wherein, described data reader device is a handheld apparatus.
50, according to any described system in the claim 42 to 49, wherein, described data reader device comprises and is used to store the described memory of data that receives from described data record apparatus.
51, according to any described system in the claim 42 to 50, wherein, described data reader device comprises the display that is used to show the described data that receive from described data record apparatus.
52, according to any described system in the claim 42 to 51, wherein, described data reader device is configured to make at least some data from the described data that described data logger receives to use by the wired or wireless communication with described data processor.
53, according to any described system in the claim 42 to 52, wherein, described data record apparatus further comprises accelerometer or other devices that are used for women's motion is measured, and the expression that described control logic further is configured to the motion measurement result is stored in the described data storage, described data processor can operate that to be used for to be that at least some temperature measurement result in the temperature measurement result that records of true time are ignored when a condition of following condition, and these conditions are:
(a) described motion measurement result's variation has surpassed predetermined value;
(b) described motion measurement result has surpassed predetermined value.
54, according to any described system in the claim 42 to 52, wherein, described data record apparatus further comprises and is used for accelerometer or other devices that women's motion is measured, and described control logic further is configured to: a condition in following condition is a true time, at least some expression in the described expression of described first temperature measurement result are not stored in the described data storage, these conditions are:
(a) previous motion measurement result's variation has surpassed predetermined value;
(b) at least one previous motion measurement result has surpassed predetermined value.
55, according to any described system in the claim 42 to 52, wherein, one of concentrating of at least one other physiological data that receives in described input equipment place of described data processor is women's a exercise data, and described data processor can operate that to be used for a condition in following condition be that at least some first temperature measurement result in first temperature measurement result that records of true time are ignored, and these conditions are:
(a) variation of the measurement result of being represented by described exercise data has surpassed predetermined value;
(b) measurement result of being represented by described exercise data has surpassed predetermined value.
56, according to any described system in the claim 42 to 55, wherein, described data record apparatus further comprises second temperature sensor, and the expression that described control logic further is configured to described second temperature measurement result is stored in the described data storage.
57, according to the described system of claim 56, wherein, described second temperature sensor is configured to measure women's ambient temperature, and described data reader device is configured to handle according to the corresponding measurement result of described second temperature sensor each measurement result of described first temperature sensor, to estimate women's core temperature.
58, according to any described system in the claim 42 to 57, wherein, described data processor can be operated and is used for whether having reached first of basal body temperature and determining according to make relevant this women from the data of described data logger and/or described at least one other physiological data set, if and described first result who determines negates, then described data processor is configured to come basal body temperature is estimated that according at least one parameter in the following parameter these parameters are:
(a) any one measurement of bldy temperature result's rate of change among these measurement of bldy temperatures result;
(b) rate of change of any one measurement of bldy temperature result's rate of change among these measurement of bldy temperatures result;
(c) represent the data of the previous variation of temperature when women's temperature levels off to basal body temperature in the past.
59, according to any described system in the claim 42 to 58, wherein, described data logger is configured to by wired or wireless transmission at least some data in the data of its storage be sent to described data reader.
60, a kind of assembly that comprises the data record apparatus,
This data record apparatus comprises:
First temperature sensor, it is used to measure first temperature;
Data storage, it is used to store one or more first temperature measurement result;
Control logic, it is configured to the expression of first temperature measurement result is stored in the described data storage; And
Transmitter, it is configured to send at least some data in the data of being stored;
And described assembly further comprises first and second portion, and described data record apparatus is placed between described first and the described second portion,
Wherein, described first temperature sensor is adjacent with described first, and has the thermal conductivity higher than described second portion with at least one zone of the immediate described first of described first temperature sensor.
61, according to the described assembly of claim 60, wherein, described first and described data logger facing surfaces coated with adhesive layer, so that can be attached to described assembly on the object or human or animal's health on, thereby make described first temperature sensor approach described object or health most.
62, according to the described assembly of claim 60 to 61, wherein, described assembly further comprises strap configurations or long band structure, described strap configurations or long band structure are configured to dispose around the part of the part of object or human body or animal body, and be configured to make in use described assembly to remain on the described object or on described human body or the animal body, so that described first temperature sensor approaches described object or health most.
63, according to any described assembly in the claim 60 to 62, wherein, described first has opening, and this opening is positioned such that described first temperature sensor of described data record apparatus comes out.
64, according to any described assembly in the claim 60 to 63, wherein, described first has opening, can insert or remove described data record apparatus by this opening.
65, according to any described assembly in the claim 60 to 64, wherein, the described first and the described second portion of described assembly are disposable.
66, according to any described assembly in the claim 60 to 65, wherein, described data record apparatus further comprises power supply, and described first temperature sensor is close to described power supply and is installed.
67, according to any described assembly in the claim 60 to 66, wherein, described data record apparatus further comprises second temperature sensor that is used to measure second temperature.
68, according to the described assembly of claim 67, wherein, described second temperature is the ambient temperature of described assembly.
69, according to claim 67 or 68 described assemblies, wherein, described second portion has opening, and this place of opening is positioned such that described second temperature sensor of described data record apparatus comes out.
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WO2008035151A3 (en) | 2008-12-24 |
GB0608829D0 (en) | 2006-06-14 |
EP2020923B1 (en) | 2013-05-01 |
EP2020923B2 (en) | 2019-05-15 |
JP2009535141A (en) | 2009-10-01 |
WO2008035151A2 (en) | 2008-03-27 |
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CN101460100B (en) | 2012-03-21 |
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US20090234200A1 (en) | 2009-09-17 |
US8540644B2 (en) | 2013-09-24 |
BRPI0711559A2 (en) | 2011-11-08 |
PL2020923T5 (en) | 2019-11-29 |
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JP5256191B2 (en) | 2013-08-07 |
MX2008014060A (en) | 2009-03-06 |
ES2414611T5 (en) | 2020-01-31 |
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