CN101454328A - 新的mch受体拮抗剂 - Google Patents

新的mch受体拮抗剂 Download PDF

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Publication number
CN101454328A
CN101454328A CNA2007800195489A CN200780019548A CN101454328A CN 101454328 A CN101454328 A CN 101454328A CN A2007800195489 A CNA2007800195489 A CN A2007800195489A CN 200780019548 A CN200780019548 A CN 200780019548A CN 101454328 A CN101454328 A CN 101454328A
Authority
CN
China
Prior art keywords
phenyl
thieno
chloro
pyridin
methoxyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2007800195489A
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English (en)
Chinese (zh)
Inventor
M·B·阿诺尔德
Y·道
K·M·伽丁尼尔
D·J·加尔门
S·J·格林
E·J·亨布雷
陆建良
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of CN101454328A publication Critical patent/CN101454328A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNA2007800195489A 2006-06-08 2007-06-08 新的mch受体拮抗剂 Pending CN101454328A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81184106P 2006-06-08 2006-06-08
US60/811,841 2006-06-08

Publications (1)

Publication Number Publication Date
CN101454328A true CN101454328A (zh) 2009-06-10

Family

ID=38651254

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2007800195489A Pending CN101454328A (zh) 2006-06-08 2007-06-08 新的mch受体拮抗剂

Country Status (10)

Country Link
US (2) US8263772B2 (cg-RX-API-DMAC7.html)
EP (1) EP2029609A2 (cg-RX-API-DMAC7.html)
JP (1) JP5198439B2 (cg-RX-API-DMAC7.html)
CN (1) CN101454328A (cg-RX-API-DMAC7.html)
AU (1) AU2007257922A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0712680A2 (cg-RX-API-DMAC7.html)
CA (1) CA2652385A1 (cg-RX-API-DMAC7.html)
EA (1) EA015127B1 (cg-RX-API-DMAC7.html)
MX (1) MX2008015662A (cg-RX-API-DMAC7.html)
WO (1) WO2007146758A2 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114286818A (zh) * 2019-07-02 2022-04-05 诺维逊生物股份有限公司 作为bet抑制剂的杂环化合物

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8546405B2 (en) 2008-12-23 2013-10-01 Abbott Laboratories Anti-viral compounds
SG172352A1 (en) 2008-12-23 2011-07-28 Abbott Lab Anti-viral compounds
US8637678B2 (en) 2008-12-24 2014-01-28 Syngenta Limited Methods for the preparation of aryl amides
US9278922B2 (en) * 2009-04-15 2016-03-08 Abbvie Inc. Anti-viral compounds
EA020031B1 (ru) * 2009-06-11 2014-08-29 Эббви Бахамаз Лтд. Противовирусные соединения
US9394279B2 (en) 2009-06-11 2016-07-19 Abbvie Inc. Anti-viral compounds
US8937150B2 (en) 2009-06-11 2015-01-20 Abbvie Inc. Anti-viral compounds
US8716454B2 (en) 2009-06-11 2014-05-06 Abbvie Inc. Solid compositions
NZ605440A (en) 2010-06-10 2014-05-30 Abbvie Bahamas Ltd Solid compositions comprising an hcv inhibitor
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
US9034832B2 (en) 2011-12-29 2015-05-19 Abbvie Inc. Solid compositions
WO2013149940A1 (en) 2012-04-02 2013-10-10 Basf Se Acrylamide compounds for combating invertebrate pests
WO2013167633A1 (en) 2012-05-09 2013-11-14 Basf Se Acrylamide compounds for combating invertebrate pests
US11484534B2 (en) 2013-03-14 2022-11-01 Abbvie Inc. Methods for treating HCV
MX394360B (es) 2013-03-14 2025-03-24 Sumitomo Pharma Oncology Inc Inhibidores de jak2 y alk2 y metodos para su uso.
WO2015103490A1 (en) 2014-01-03 2015-07-09 Abbvie, Inc. Solid antiviral dosage forms
AR102849A1 (es) * 2015-03-09 2017-03-29 Astellas Pharma Inc Compuesto de piridina bicíclica
WO2016205590A1 (en) * 2015-06-18 2016-12-22 Cephalon, Inc. Substituted 4-benzyl and 4-benzoyl piperidine derivatives
KR20180026459A (ko) 2015-06-18 2018-03-12 세파론, 인코포레이티드 1,4-치환된 피페리딘 유도체
AU2019310590A1 (en) 2018-07-26 2021-01-14 Sumitomo Pharma Oncology, Inc. Methods for treating diseases associated with abnormal acvr1 expression and acvr1 inhibitors for use in the same
US11192900B2 (en) 2018-10-30 2021-12-07 Nuvation Bio Inc. Substituted 1,6-dihydropyridinones and 1,2-dihydroisoquinolinones as bet inhibitors
EP4558501A1 (en) * 2022-07-20 2025-05-28 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002003370A (ja) * 1999-09-20 2002-01-09 Takeda Chem Ind Ltd メラニン凝集ホルモン拮抗剤
US20020099073A1 (en) * 2000-07-07 2002-07-25 Andersen Henrik Sune Modulators of protein tyrosine phosphatases (PTPases)
GB0124627D0 (en) * 2001-10-15 2001-12-05 Smithkline Beecham Plc Novel compounds
US20060194871A1 (en) * 2003-04-11 2006-08-31 Barvian Kevin K Heterocyclic mchr1 antagoists
JP2007509158A (ja) * 2003-10-23 2007-04-12 グラクソ　グループ　リミテッド 肥満、糖尿病、うつ病及び不安を治療するためのｍｃｈｒ１アンタゴニストとしての３−（４−アミノフェニル）チエノピリミド−４−オン誘導体
US20050176738A1 (en) * 2003-11-07 2005-08-11 Neurocrine Biosciences, Inc. Melanin-concentrating hormone receptor antagonists and compositions and methods related thereto
RU2358969C2 (ru) * 2004-02-13 2009-06-20 Баниу Фармасьютикал Ко., Лтд. Конденсированное 4-оксопиримидиновое производное
WO2005103039A1 (en) * 2004-04-15 2005-11-03 Neurocrine Biosciences, Inc. 2- (3-aminopyrrolidin-1-yl) pyridines as melanin-concentrating hormone receptor an tagonists
ES2315877T3 (es) 2004-06-18 2009-04-01 Biolipox Ab Indoles utiles en el tratamiento de inflamaciones.
WO2006066174A1 (en) * 2004-12-17 2006-06-22 Eli Lilly And Company Thiazolopyridinone derivates as mch receptor antagonists
WO2007093364A1 (en) * 2006-02-15 2007-08-23 Sanofi-Aventis Azacyclyl-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments
KR20080094699A (ko) * 2006-02-15 2008-10-23 사노피-아벤티스 신규 아미노알콜-치환된 아릴디하이드로이소퀴놀리논, 이의제조 방법 및 이의 약물로서의 용도

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114286818A (zh) * 2019-07-02 2022-04-05 诺维逊生物股份有限公司 作为bet抑制剂的杂环化合物

Also Published As

Publication number Publication date
WO2007146758A3 (en) 2008-02-07
US20090093456A1 (en) 2009-04-09
BRPI0712680A2 (pt) 2012-11-20
JP5198439B2 (ja) 2013-05-15
MX2008015662A (es) 2009-01-12
EA200870517A1 (ru) 2009-04-28
US8263772B2 (en) 2012-09-11
EA015127B1 (ru) 2011-06-30
JP2009539875A (ja) 2009-11-19
US20120302547A1 (en) 2012-11-29
AU2007257922A1 (en) 2007-12-21
EP2029609A2 (en) 2009-03-04
CA2652385A1 (en) 2007-12-21
WO2007146758A2 (en) 2007-12-21

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