CN101443020A - RNAi介导的脾酪氨酸激酶相关炎性病症的抑制 - Google Patents

RNAi介导的脾酪氨酸激酶相关炎性病症的抑制 Download PDF

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Publication number
CN101443020A
CN101443020A CNA2007800131881A CN200780013188A CN101443020A CN 101443020 A CN101443020 A CN 101443020A CN A2007800131881 A CNA2007800131881 A CN A2007800131881A CN 200780013188 A CN200780013188 A CN 200780013188A CN 101443020 A CN101443020 A CN 101443020A
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China
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nucleotide
seq
rna interfering
mrna
syk
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Pending
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CNA2007800131881A
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English (en)
Chinese (zh)
Inventor
约翰·M·雅尼
乔恩·E·查特顿
丹尼尔·A·葛玛奇
史蒂文·T·米勒
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Alcon Research LLC
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Alcon Research LLC
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications

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  • Chemical & Material Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
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  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Pulmonology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNA2007800131881A 2006-04-13 2007-04-13 RNAi介导的脾酪氨酸激酶相关炎性病症的抑制 Pending CN101443020A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79184706P 2006-04-13 2006-04-13
US60/791,847 2006-04-13

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN2010105249510A Division CN101972483A (zh) 2006-04-13 2007-04-13 RNAi介导的脾酪氨酸激酶相关炎性病症的抑制

Publications (1)

Publication Number Publication Date
CN101443020A true CN101443020A (zh) 2009-05-27

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CNA2007800131881A Pending CN101443020A (zh) 2006-04-13 2007-04-13 RNAi介导的脾酪氨酸激酶相关炎性病症的抑制
CN2010105249510A Pending CN101972483A (zh) 2006-04-13 2007-04-13 RNAi介导的脾酪氨酸激酶相关炎性病症的抑制

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CN2010105249510A Pending CN101972483A (zh) 2006-04-13 2007-04-13 RNAi介导的脾酪氨酸激酶相关炎性病症的抑制

Country Status (13)

Country Link
US (4) US8048863B2 (https=)
EP (3) EP2004240A4 (https=)
JP (1) JP2009533475A (https=)
KR (1) KR20080110900A (https=)
CN (2) CN101443020A (https=)
AR (1) AR060448A1 (https=)
AU (2) AU2007238027B2 (https=)
BR (1) BRPI0709506A2 (https=)
CA (1) CA2649138C (https=)
MX (2) MX2008013068A (https=)
TW (2) TW200808360A (https=)
WO (1) WO2007121347A2 (https=)
ZA (1) ZA200808744B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2010117178A (ru) * 2007-10-01 2011-11-10 Алькон Рисерч, Лтд. (Us) Опосредованная самокомплементарными aav доставка молекул, интерферирующих рнк для лечения или профилактики глазных заболеваний
ES2470644T3 (es) * 2008-05-26 2014-06-24 Universitt Zrich Nanopart�culas de protamina/ARN para inmunoestimulaci�n
JP6013736B2 (ja) * 2008-12-22 2016-10-25 オトノミ—，インク． 耳の障害の処置のための耳感覚細胞モジュレータ組成物の制御放出及びその方法
EP2865758A1 (en) * 2013-10-22 2015-04-29 Sylentis, S.A.U. siRNA and their use in methods and compositions for inhibiting the expression of the ORAI1 gene
CN104805085A (zh) * 2014-01-29 2015-07-29 江苏命码生物科技有限公司 串联表达的siRNA及其在治疗慢性淋巴细胞白血病中的应用
CA2971830A1 (en) * 2014-12-29 2016-07-07 Bonac Corporation Composition containing nucleic acid molecule stably
US10888391B2 (en) 2015-05-29 2021-01-12 Ablacon Inc Optical force sensing assembly for an elongated medical device
MX2018005146A (es) * 2015-10-30 2018-08-23 Bonac Corp Composicion que contiene de manera estable molecula de acido nucleico de un solo filamento que suprime la expresion de gen tgf-b1.
BR102018001541B1 (pt) 2018-01-24 2021-05-11 Universidade Federal Do Rio Grande Do Sul composição farmacêutica nanométrica na forma de lipossomas ou nanoemulsão que contém sequências específicas de rna de interferência

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005007623A2 (en) * 2003-07-03 2005-01-27 The Trustees Of The University Of Pennsylvania Inhibition of syk kinase expression
WO2005049838A3 (en) * 2003-11-14 2005-10-06 Univ Yale Syk-targeted nucleic acid interference

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5360720A (en) 1993-10-08 1994-11-01 Alcon Laboratories, Inc. Method of preparing human conjunctival mast cells for mast cell stabilization assays
US5545626A (en) * 1994-01-19 1996-08-13 The Trustees Of Columbia University In The City Of New York Method of treating glaucoma with oligonucleotides
AU723595B2 (en) * 1995-06-07 2000-08-31 University Of Pennsylvania Methods of inhibiting phagocytosis
WO2005019453A2 (en) * 2001-05-18 2005-03-03 Sirna Therapeutics, Inc. RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID (siNA)
US20050227935A1 (en) * 2001-05-18 2005-10-13 Sirna Therapeutics, Inc. RNA interference mediated inhibition of TNF and TNF receptor gene expression using short interfering nucleic acid (siNA)
ATE437962T1 (de) * 2002-10-01 2009-08-15 Epigenomics Ag Verfahren für die behandlung von proliferativen erkrankungen von brustzellen
WO2006006948A2 (en) 2002-11-14 2006-01-19 Dharmacon, Inc. METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY
EP2305812A3 (en) * 2002-11-14 2012-06-06 Dharmacon, Inc. Fuctional and hyperfunctional sirna
EP1571209B1 (en) * 2002-11-22 2012-06-13 Bio-Think Tank Co., Ltd. Method of detecting target base sequence of rna interference, method of designing polynucleotide base sequence causing rna interference, method of constructing double-stranded polynucleotide, method of regulating gene expression, base sequence processing apparatus, program for running base sequence
WO2004094636A1 (en) * 2003-04-24 2004-11-04 Galapagos Genomics N.V. Effective sirna knock-down constructs
GB0404209D0 (en) 2004-02-25 2004-03-31 Uws Ventures Ltd Materials and methods for treatment of allergic disease
US20060058255A1 (en) * 2004-03-01 2006-03-16 Jianzhu Chen RNAi-based therapeutics for allergic rhinitis and asthma
EP1904649A2 (en) * 2005-07-18 2008-04-02 Epigenomics AG Compositions and methods for cancer diagnostics comprising pan-cancer markers
JP5400388B2 (ja) * 2005-12-15 2014-01-29 ライジェル ファーマシューティカルズ， インコーポレイテッド キナーゼインヒビターおよびその利用
UY31267A1 (es) 2007-08-03 2009-01-05 Alcon Res Ltd Inhibición del pasaje de senalización del tnfa relacionada con arni para el tratamiento de la angiogénesis ocular

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005007623A2 (en) * 2003-07-03 2005-01-27 The Trustees Of The University Of Pennsylvania Inhibition of syk kinase expression
WO2005049838A3 (en) * 2003-11-14 2005-10-06 Univ Yale Syk-targeted nucleic acid interference

Also Published As

Publication number Publication date
TW201336514A (zh) 2013-09-16
AU2007238027B2 (en) 2013-08-15
WO2007121347A3 (en) 2008-12-04
US20140357695A1 (en) 2014-12-04
AU2007238027A1 (en) 2007-10-25
CN101972483A (zh) 2011-02-16
BRPI0709506A2 (pt) 2011-07-19
TW200808360A (en) 2008-02-16
AR060448A1 (es) 2008-06-18
US20160257963A1 (en) 2016-09-08
KR20080110900A (ko) 2008-12-19
EP2662446A3 (en) 2014-04-02
US20090324507A1 (en) 2009-12-31
JP2009533475A (ja) 2009-09-17
US20110288157A1 (en) 2011-11-24
EP2004240A2 (en) 2008-12-24
US8048863B2 (en) 2011-11-01
US8865671B2 (en) 2014-10-21
ZA200808744B (en) 2009-12-30
MX345954B (es) 2017-02-16
EP3156486A2 (en) 2017-04-19
WO2007121347A2 (en) 2007-10-25
CA2649138A1 (en) 2007-10-25
EP2662446A2 (en) 2013-11-13
EP3156486A3 (en) 2017-07-12
EP2004240A4 (en) 2010-12-15
CA2649138C (en) 2018-04-03
US9371529B2 (en) 2016-06-21
MX2008013068A (es) 2008-12-16
AU2013207601B2 (en) 2016-11-17

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Application publication date: 20090527