CN101433647A - Plaster for treating femoral head necrosis and preparation method thereof - Google Patents

Abstract

The invention discloses a plaster for treating caput femoris necrosis, which belongs to the field of traditional Chinese medicine. The plaster comprises more than ten natural Chinese herbal medicines such as muskiness, ginger, radix sileris, eucommia bark, teasel root, native copper, sapanwood, rhizoma drynariae, Caulis Trachelospermi, lopseed, rhizoma cibotii, frankincense, myrrh, Panax notoginseng, safflower, dragon blood, radix polygoni multiflori preparata and Fructus Liquidambaris, and efficacies of various medicines generate synergic action through the scientific and reasonable compatibility to achieve the aim of effectively treating the caput femoris necrosis. The plaster has strict and scientific prescription, symptomatic medicine selection, and elaborate and comprehensive medicine use, fully utilizes effective ingredients of the medicines, ensures that the medicines directly reach pathological change parts, and achieves the ideal effect of treating both root causes and symptoms; the plaster has broad medicine sources, a simple process, easy processing and manufacture and low cost; after the pasting, the medicines saturate towards afflicted parts with the help of body temperature and is extremely easily absorbed by skin, so the plaster has the advantages of good treatment effect, short treatment course, quick effect, exact and reliable treatment effect, small toxic side effect and no contraindication, and the total effective rate reaches more than 99.6 percent. The invention also discloses a method for preparing the plaster for treating the caput femoris necrosis.

Description

Plaster of treatment femur head necrosis and preparation method thereof

Technical field

The present invention relates to a kind of plaster for the treatment of femur head necrosis and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Femur head necrosis is the difficult disease that world's orthopaedics is generally acknowledged, its serious harm human beings'health gently then makes the people disable, and is heavy then the people is paralysed, and forfeiture is worked and self care ability.The cause of disease that generally believes femur head necrosis mainly contains: wound, hormone, excessive drinking or osteoporosis etc.Main clinic symptoms is pain and hip joint movable function obstacle.For this disease, mainly take conservative treatment, late period then to adopt artificial replacement's art early stage.Though have the external used medicine of some treatment femur head necrosiss to occur at present, exist shortcomings such as prescription is numerous and diverse, cost is high, the course of treatment is long, side effect is big, curative effect is undesirable in various degree.

Summary of the invention

The objective of the invention is at above-mentioned deficiency, the plaster of a kind of prescription uniqueness, cost treatment femur head necrosis low, safe and reliable, evident in efficacy is provided.

Plaster of the present invention is mainly selected ten multi-flavor natural Chinese medicinal herb such as Moschus, Rhizoma Zingiberis Recens, Radix Saposhnikoviae, the Cortex Eucommiae, Radix Dipsaci, Pyritum, Lignum Sappan, Rhizoma Drynariae, Caulis Trachelospermi, Herba speranskiae tuberculatae, Rhizoma Cibotii, Olibanum, Myrrha, Radix Notoginseng, Flos Carthami, Sanguis Draxonis, Radix Polygoni Multiflori Preparata, Fructus Liquidambaris for use, through scientific and reasonable compatibility, make the effect of each medicine produce synergism, thereby reach the purpose of effective treatment femur head necrosis.

The objective of the invention is to be achieved through the following technical solutions.

The plaster of this treatment femur head necrosis, by following raw medicaments in portion by weight:

4-6 parts in Moschus, 10-20 parts in Rhizoma Zingiberis Recens, 25-35 parts of Radix Saposhnikoviaes, 40-60 parts of the Cortexs Eucommiae, 20-30 parts of Radix Dipsacis, 25-35 parts of Pyritums, 25-35 parts of Lignum Sappans, 20-30 parts of Rhizoma Drynariae, 20-30 parts of Caulis Trachelospermis, 30-50 parts of Herba speranskiae tuberculataes, 20-30 parts of Rhizoma Cibotii, 15-25 parts of Olibanums, 15-25 parts of Myrrhas, 25-35 parts of Radix Notoginseng, 15-25 parts on Flos Carthami, 4-6 parts of Sanguis Draxonis, 30-50 parts of Radix Polygoni Multiflori Preparata, 25-35 parts of Fructus Liquidambaris.

And make by following preparation method:

(1) Moschus, Rhizoma Zingiberis Recens, Radix Saposhnikoviae, the Cortex Eucommiae, Radix Dipsaci, Pyritum, Lignum Sappan, Rhizoma Drynariae, Caulis Trachelospermi, Herba speranskiae tuberculatae, Rhizoma Cibotii, Olibanum, Myrrha, Radix Notoginseng, Flos Carthami, Sanguis Draxonis, Radix Polygoni Multiflori Preparata and the Fructus Liquidambaris with described weight portion mixes the back pulverizing, crosses 100 mesh sieves and gets mixed powder;

(2) mixed powder is added the yellow wine of 150-250 weight portions, stir pasty state medicated powder, in the hermetically sealed can of packing into;

(3) with hermetically sealed can under 3-5 ℃ of conditions of temperature, deposit 100-200 hours after, promptly.

Above-mentioned each crude drug also all has better curative effect in the following weight parts scope:

4.5-5.5 parts in Moschus, 12-18 parts in Rhizoma Zingiberis Recens, 27-33 parts of Radix Saposhnikoviaes, 45-55 parts of the Cortexs Eucommiae, 22-28 parts of Radix Dipsacis, 27-33 parts of Pyritums, 27-33 parts of Lignum Sappans, 22-28 parts of Rhizoma Drynariae, 22-28 parts of Caulis Trachelospermis, 35-45 parts of Herba speranskiae tuberculataes, 22-28 parts of Rhizoma Cibotii, 17-23 parts of Olibanums, 17-23 parts of Myrrhas, 27-33 parts of Radix Notoginseng, 17-23 parts on Flos Carthami, 4.5-5.5 parts of Sanguis Draxonis, 35-45 parts of Radix Polygoni Multiflori Preparata, 27-33 parts of Fructus Liquidambaris.

Above-mentioned each crude drug preferably be:

5 parts in Moschus, 15 parts in Rhizoma Zingiberis Recens, 30 parts of Radix Saposhnikoviaes, 50 parts of the Cortexs Eucommiae, 25 parts of Radix Dipsacis, 30 parts of Pyritums, 30 parts of Lignum Sappans, 25 parts of Rhizoma Drynariae, 25 parts of Caulis Trachelospermis, 40 parts of Herba speranskiae tuberculataes, 25 parts of Rhizoma Cibotii, 20 parts of Olibanums, 20 parts of Myrrhas, 30 parts of Radix Notoginseng, 20 parts on Flos Carthami, 5 parts of Sanguis Draxonis, 40 parts of Radix Polygoni Multiflori Preparata, 30 parts of Fructus Liquidambaris.

In the plaster of treatment femur head necrosis of the present invention:

Monarch drug: Moschus, Flos Carthami, Sanguis Draxonis are with the main effect that plays blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain.

Ministerial drug; The Radix Notoginseng removing stasis to stop bleeding, detumescence is fixed logical; The Pyritum eliminating stasis to stop pain; Lignum Sappan blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain; Rhizoma Drynariae invigorate blood circulation continuous muscle, the kidney invigorating bone strengthening; Caulis Trachelospermi removing heat from blood detumescence collateral dredging; Herba speranskiae tuberculatae detoxifcation pain relieving, expelling wind and removing dampness; Fructus Liquidambaris is active to dispel the wind; Olibanum, Myrrha promoting blood circulation and stopping pain, detumescence and promoting granulation.

Adjuvant drug: the Cortex Eucommiae, Radix Dipsaci, Rhizoma Cibotii invigorating the liver and kidney, bone and muscle strengthening, the continuous muscle of curing the wound; Radix Polygoni Multiflori Preparata enrich and benefit essence and blood, the kidney invigorating bone strengthening, Radix Saposhnikoviae, Rhizoma Zingiberis Recens expelling pathogenic wind from the body surface.

Messenger drug: Rhizoma Zingiberis Recens detoxifcation.

Above-mentioned monarch, minister, help, make each drug synergism, have functions such as blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain, the kidney invigorating bone strengthening, expelling wind and removing dampness, detumescence and promoting granulation, promotion microcirculation, promote osteogenesis, can receive ideal therapeutic effect in a short time.

Another object of the present invention provides the preparation method of the plaster of this treatment femur head necrosis.

Above-mentioned each crude drug is made the preparation method of plaster of the present invention, comprise the steps:

(1) Moschus, Rhizoma Zingiberis Recens, Radix Saposhnikoviae, the Cortex Eucommiae, Radix Dipsaci, Pyritum, Lignum Sappan, Rhizoma Drynariae, Caulis Trachelospermi, Herba speranskiae tuberculatae, Rhizoma Cibotii, Olibanum, Myrrha, Radix Notoginseng, Flos Carthami, Sanguis Draxonis, Radix Polygoni Multiflori Preparata and the Fructus Liquidambaris with described weight portion mixes the back pulverizing, crosses 100 mesh sieves and gets mixed powder;

(2) mixed powder is added the yellow wine of 150-250 weight portions, stir pasty state medicated powder, in the hermetically sealed can of packing into;

(3) with hermetically sealed can under 3-5 ℃ of conditions of temperature, deposit 100-200 hours after, promptly.

The consumption of each crude drug in the plaster of the present invention can be done suitably to adjust, to make the series of products that adapt to different syndromes according to the difference of disease.General by every subsides 20 grams, packing respectively.

Using method:

The first lumbar vertebra that is attached to the patient is to the fifth lumbar vertebra place, and pasted 8 hours every day 1, and 32 days is a course of treatment.

Plaster of the present invention, prescription is rigorous, science, select medicine to suit the medicine to the illness invariably, and medication is meticulous comprehensive, makes full use of the active ingredient of medicine, makes the medicine diseased region that goes directly, and reaches the ideal effect for the treatment of both the principal and secondary aspects of a disease; The medicine source is extensive, technology is simple, processing and manufacturing is easy, cheap; Paste with the back medicine under the help of body temperature, help soaking into and very easily by skin absorbs to ill position, so good effect, short treating period, instant effect, determined curative effect is reliable, and toxic and side effects is little, no contraindication.

The inventor through for many years, nearly thousand routine clinical practices prove that total effective rate reaches more than 99.6%.

The specific embodiment

Below by embodiment the present invention is further described.But the present invention is not limited to embodiment, and those of ordinary skills do some modification, all in protection domain of the present invention.

Embodiment 1-5: the preparation of the plaster of treatment femur head necrosis of the present invention

(the unit: gram) see Table 1 of the consumption of each crude drug among each embodiment.

Preparation method (with embodiment 3 is example, and other embodiment is except that raw material consumption difference, and preparation method is substantially the same manner as Example 3):

(1) 50 gram Moschus, 150 gram Rhizoma Zingiberis Recenss, 300 gram Radix Saposhnikoviaes, the 500 gram Cortexs Eucommiae, 250 gram Radix Dipsacis, 300 gram Pyritums, 300 gram Lignum Sappans, 250 gram Rhizoma Drynariae, 250 gram Caulis Trachelospermis, 400 gram Herba speranskiae tuberculataes, 250 gram Rhizoma Cibotii, 200 gram Olibanums, 200 gram Myrrhas, 300 gram Radix Notoginseng, 200 gram Flos Carthamis, 50 gram Sanguis Draxonis, 400 are restrained the Radix Polygoni Multiflori and 300 gram Fructus Liquidambaris, mix the back and pulverize, cross 100 mesh sieves and get mixed powder.

(2) mixed powder is added the yellow wine of 2000 grams, with mortar or electronic mortar stir pasty state medicated powder, in the hermetically sealed can of packing into.

(3) with hermetically sealed can under 5 ℃ of conditions, deposit 150 hours after, by every big packed 8 pouches, every pouch 20 grams, after the packing sterilization, " health plaster " finished product.

Raw materials used among each embodiment, all select commercially available medical material for use, each raw material all should meet the specification requirement of a regulation of Pharmacopoeia of the People's Republic of China version in 2005.

Table 1

Embodiment number	1	2	3	4	5
						Moschus	40	46	50	55	60
Rhizoma Zingiberis Recens	100	120	150	170	200
						Radix Saposhnikoviae	250	280.	300	330	350
The Cortex Eucommiae	400	455	500	550	600
						Radix Dipsaci	200	230	250	280	300
Pyritum	250	270	300	350	330
						Lignum Sappan	280	250	300	330	350
Rhizoma Drynariae	200	240	250	270	300
						Caulis Trachelospermi	200	230	250	300	270
Herba speranskiae tuberculatae	300	360	400	440	500
						Rhizoma Cibotii	220	200	250	270	300
Olibanum	150	175	200	250	230
						Myrrha	150	185	200	230	250
Radix Notoginseng	280	250	300	320	350
						Flos Carthami	150	170	200	230	250
Sanguis Draxonis	40	45	50	55	60
						Radix Polygoni Multiflori Preparata	360	300	400	500	440
Fructus Liquidambaris	250	270	300	330	350

Test example 1: with the clinical observation on the therapeutic effect of plaster of the present invention " health plaster " treatment femur head necrosis

1, case is selected:

Femur head necrosis patient's 500 examples that the present inventor selects place hospital to accept for medical treatment, male's 391 examples wherein, women's 109 examples, oldest 81 years old, minimum 24 years old, 38.2 years old mean age, 245 examples in 3 months-1 year of the course of disease, 155 examples in 1-5 years, 6 years-10 years 56 examples, 34 examples in 11 years-16 years, 10 examples more than 17 years; 446 examples of Avascular Necrosis Of Femur Head wherein, rheumatism merges 34 examples of femur head necrosis, and osteoarthritis merges 16 examples of femur head necrosis, 4 examples of other bone paranecrosis.Above patient all confirms to make a definite diagnosis through the film making of X line, and clinical cardinal symptom is: pain, tenderness, muscular spasm, hip joint flexing, interior receipts and outward turning deformity.

2, observation index::

Mainly be divided into for 4 phases according to case and the performance of X line:

The I phase: have or do not have the change that unconspicuous femoral head is gone up the heavy burden sections outward, X line (CR sheet) shows as the confusion region that some density have increase slightly, and bone trabecula is fuzzy, disorderly or increase slightly, and nuclear magnetic resonance, NMR shows the hydrops image.

The II phase: the femoral head radian is normal, the joint space is normal, visible one tangible necrotic area, ischemia place, there is bone density to lower the disengaging of subsiding of band, subchondral bone girder or articular cartilage in the bottom in this district, wedge capable or half moon-shaped X line high density area or bright zone (cystis degeneration) are as seen arranged on X line (CR sheet).

The III phase: ischemic region part or obviously subside, articular surface in the edge of ischemic necrosis of bone is fractured, capital shape changes, the joint space narrows down, in the subchondral bone of the heavy burden position of femoral head and acetabular bone, can there be capsule to become, X line (CR sheet) shows as the femoral head radian and changes, and exists high density image and capsule to become the district, and articular surface is damaged.

The IV phase: tangible degeneration, the joint space obviously narrows down, and femoral head seriously subsides, and has bony spur to form, and has a large amount of sequestrums to occur, and X line (CR sheet) has full hipbone arthritis performance.

3, treatment standard:

According to clinical symptoms, following criterion is intended in activity, function of joint and the performance of X line:

(1) recovery from illness: sitting and lying, the no pain of walking of standing; Do not have and walk lamely; Hip joint bends and stretches, comprehensively greater than 260 degree, function is normal for abduction, interior receipts, outward turning, inward turning.

The X line shows: sequestrum absorbs fully, and new bone is filled and ossified or capsule change district fibrosis, and the joint space is clear, and articular surface and acetabular bone are smooth, and the femoral head reparation is good.

(2) produce effects: sitting and lying do not have pain, and the walking back idol of standing has pain or discomfort; The recessive limping slowly do not show; The hip joint mobility reaches 190-260 degree, and function is limited slightly, and life is taken care of oneself substantially.

The X line shows: the sequestrum basic absorption, and the most of filling of new bone is also ossified, and the joint space is clear, and articular surface and acetabular bone are more smooth, and the femoral head reparation is good.

(3) effective: as not have obvious pain during sitting and lying, need hold up and turn and to walk; Walk lamely or slowly walk lamely, need hold up singly and turn; The hip joint mobility reaches 130-190 degree, and funtion part is limited.

The X line shows: sequestrum absorbs to some extent, and new bone growth is slow, the joint space, and articular surface and acetabular bone before have part to take a turn for the better and repair.

(4) invalid: symptom and X line change with the preceding nothing of treatment.

4, Therapeutic Method:

The first lumbar vertebra that embodiment 3 gained " health plaster " are attached to the patient is to the fifth lumbar vertebra place, pastes every day 1, every subsides pasted 8 hours, and 32 days is a course of treatment.

General patient is after first course of treatment, and disease sites is promptly felt generate heat, swell, turn sour, itch, and skin is perspired, and QI-blood circulation is accelerated, and pore diffusion increase excretes the wind-cold damp pathogen etc. of the body of hiding successively with the perspiration pore.Arthralgia, swelling, numb limbs and tense tendons, dysfunction are eased fast, and myalgia alleviates, the red and swollen elimination, and the stiff time in morning obviously shortens.The joint is stretched to bend and is recovered gradually flexibly, the osteoarthrosis improvement of environment, and stiff disappearance is lifted lower limb, is cranked arm, song refers to no longer difficulty, but moderate patient rehabilitation, severe patient's functional disorder is improved gradually.

After second course of treatment, the drug effect of Most patients has goed deep into positions such as skeleton, muscle, kidney waist, rapid permeability decomposes, detumescence is removed harmful pathogenic bacteria in the body, excrete by perspiration defecation, feeling immediately has relaxation again, and disease sites pain is obviously improved, lift lower limb and bend over obviously flexibly, condition of illness obviously alleviates.Joint motion is no longer limited, the basic rehabilitation of tetanic odd-shaped spinal column, and the femur head necrosis position grows new bone.

After third and fourth course of treatment, drug effect directly enters osteoarthrosis, cartilage, ligament, adjusting immunologic function, improve the cartilage microcirculation, the vasa vasorum that mediation is stubborn is promoted the blood oxygen supply of joint and surrounding tissue, activates the unusual hyperosteogeny of " T " cytophagy, the two-ways regulation humoral immunization, soft tissue and sclerotin are repaired automatically, each joint and swelling all the elimination activity freely, the pain complete obiteration.

5, therapeutic outcome:

The patient of I option share head necrosis treats and can cure 4 courses of treatment, the patient of II option share head necrosis, treating 6-8 courses of treatment can cure, and III option share head necrosis patient can cure more than treating 10-12 courses of treatment, IV option share head necrosis patient treats 15-18 courses of treatment and can cure.

In above-mentioned 500 routine patients, reach pre-after date the course of treatment in treatment, and follow up a case by regular visits to through tracking such as the continuous film making in about 2 years, health check-ups, after confirmation reaches the treatment standard, by statistics clinical recovery account for 85.5%, produce effects account for 9.4%, effectively account for 4.7%, total effective rate reaches 99.6%.

From above therapeutic outcome as can be seen; The plaster of treatment femur head necrosis of the present invention has very notable therapeutic effect.

Claims (4)

1, a kind of plaster for the treatment of femur head necrosis is characterized in that by following bulk drugs:

4-6 parts in Moschus, 10-20 parts in Rhizoma Zingiberis Recens, 25-35 parts of Radix Saposhnikoviaes, 40-60 parts of the Cortexs Eucommiae, 20-30 parts of Radix Dipsacis, 25-35 parts of Pyritums, 25-35 parts of Lignum Sappans, 20-30 parts of Rhizoma Drynariae, 20-30 parts of Caulis Trachelospermis, 30-50 parts of Herba speranskiae tuberculataes, 20-30 parts of Rhizoma Cibotii, 15-25 parts of Olibanums, 15-25 parts of Myrrhas, 25-35 parts of Radix Notoginseng, 15-25 parts on Flos Carthami, 4-6 parts of Sanguis Draxonis, 30-50 parts of Radix Polygoni Multiflori Preparata, 25-35 parts of Fructus Liquidambaris;

And make by following preparation method:

(1) Moschus, Rhizoma Zingiberis Recens, Radix Saposhnikoviae, the Cortex Eucommiae, Radix Dipsaci, Pyritum, Lignum Sappan, Rhizoma Drynariae, Caulis Trachelospermi, Herba speranskiae tuberculatae, Rhizoma Cibotii, Olibanum, Myrrha, Radix Notoginseng, Flos Carthami, Sanguis Draxonis, Radix Polygoni Multiflori Preparata and the Fructus Liquidambaris with described weight portion mixes the back pulverizing, crosses 100 mesh sieves and gets mixed powder;

(2) mixed powder is added the yellow wine of 150-250 weight portions, stir pasty state medicated powder, in the hermetically sealed can of packing into;

(3) with hermetically sealed can under 3-5 ℃ of conditions of temperature, deposit 100-200 hours after, promptly.

2, the plaster of treatment femur head necrosis according to claim 1 is characterized in that being made by following raw medicaments in portion by weight:

4.5-5.5 parts in Moschus, 12-18 parts in Rhizoma Zingiberis Recens, 27-33 parts of Radix Saposhnikoviaes, 45-55 parts of the Cortexs Eucommiae, 22-28 parts of Radix Dipsacis, 27-33 parts of Pyritums, 27-33 parts of Lignum Sappans, 22-28 parts of Rhizoma Drynariae, 22-28 parts of Caulis Trachelospermis, 35-45 parts of Herba speranskiae tuberculataes, 22-28 parts of Rhizoma Cibotii, 17-23 parts of Olibanums, 17-23 parts of Myrrhas, 27-33 parts of Radix Notoginseng, 17-23 parts on Flos Carthami, 4.5-5.5 parts of Sanguis Draxonis, 35-45 parts of Radix Polygoni Multiflori Preparata, 27-33 parts of Fructus Liquidambaris.

3, the plaster of treatment femur head necrosis according to claim 1 is characterized in that being made by following raw medicaments in portion by weight:

5 parts in Moschus, 15 parts in Rhizoma Zingiberis Recens, 30 parts of Radix Saposhnikoviaes, 50 parts of the Cortexs Eucommiae, 25 parts of Radix Dipsacis, 30 parts of Pyritums, 30 parts of Lignum Sappans, 25 parts of Rhizoma Drynariae, 25 parts of Caulis Trachelospermis, 40 parts of Herba speranskiae tuberculataes, 25 parts of Rhizoma Cibotii, 20 parts of Olibanums, 20 parts of Myrrhas, 30 parts of Radix Notoginseng, 20 parts on Flos Carthami, 5 parts of Sanguis Draxonis, 40 parts of Radix Polygoni Multiflori Preparata, 30 parts of Fructus Liquidambaris.

4, the preparation method of the plaster of treatment femur head necrosis as claimed in claim 1 is characterized in that preparation method comprises the steps:

(1) Moschus, Rhizoma Zingiberis Recens, Radix Saposhnikoviae, the Cortex Eucommiae, Radix Dipsaci, Pyritum, Lignum Sappan, Rhizoma Drynariae, Caulis Trachelospermi, Herba speranskiae tuberculatae, Rhizoma Cibotii, Olibanum, Myrrha, Radix Notoginseng, Flos Carthami, Sanguis Draxonis, Radix Polygoni Multiflori Preparata and the Fructus Liquidambaris with described weight portion mixes the back pulverizing, crosses 100 mesh sieves and gets mixed powder;

(2) mixed powder is added the yellow wine of 150-250 weight portions, stir pasty state medicated powder, in the hermetically sealed can of packing into;

(3) with hermetically sealed can under 3-5 ℃ of conditions of temperature, deposit 100-200 hours after, promptly.