CN101426553A - Toothpaste - Google Patents

Abstract

A toothpaste composition comprising an abrasive calcium compound, a fluoride salt, alkali metal silicate and a salt selected from the class comprising alkali metal citrates.

Description

Toothpaste

Technical field

The present invention relates to a kind of dentifrice composition, more especially a kind of have the good fluoride and the toothpaste of physical stability.

Background and prior art

Dentifrice includes the abrasive material that helps cleaning teeth usually.One class abrasive material commonly used comprises the insoluble compound of calcium, magnesium or aluminum, for example aluminium oxide, calcium carbonate, dicalcium phosphate dehydrate.In these, the toothpaste that contains based on the abrasive material of calcium compounds is to be called chalk based toothpaste.Chalk based toothpaste generally is opaque.Another kind of abrasive material commonly used in the toothpaste production is a Silicon stone.When the abrasive silicas of careful selection is used to prepare dentifrice, can make gel type toothpaste with transparent or semitransparent outward appearance.Multiple other abrasive materials have added toothpaste routinely so that the benefit of multiple mouth care to be provided.Fluoride dental cream obtains immense success aspect the anti-dental caries benefit providing usually.

Observe, the chemical stability of fluoride is not very good in the chalk based toothpaste.GB999857 (nineteen sixty-five) has described a kind of toothpaste, comprise the alkali metal fluoride of insoluble basically calcium or magnesium salt abrasive, therapeutic dose and the Silicon stone (preferably alkali silicate) of enough water-soluble form, so that the toothpaste with improved fluoride availability to be provided.

The inventor finds at the broad research process that the chalk based toothpaste with enhanced fluoride stability is provided at it, when alkali silicate provides the improvement of fluoride stability in these toothpaste, there is the other problems that relates to the product stability of following such prescription discovery.The inventor finds that these toothpaste have manifested syneresis under special storage is higher temperatures, and syneresis is such phenomenon, and wherein flavoring agent, water and other water-soluble components separate mutually from main semisolid or paste.The inventor works hard and solves this problem and obtain the solution that relates to embedding selectivity salt, and it guarantees that these toothpaste provide essential fluoride stability to have the phase stability of expectation in the storage life that prolongs simultaneously.Dentifrice composition of the present invention has shown the enhanced physical stability in the storage life that prolongs, and liquid phase is without any separation.When storing under different temperatures, dentifrice composition has shown that the fluoride stability of expectation improved product integrity and stability simultaneously.In low temperature, ambient temperature and pyritous extending shelf life, compositions has also shown the visual attraction of height.

WO02030381 (Block Drug Co) has described the anhydrous composition of the dentin surface that reduces Dentinal hypersensitivity and remineralization exposure, contain the desensitizer that is selected from alkali metal salt, wherein alkali metal is strontium or potassium and anion is bicarbonate radical, citrate, chloride ion, nitrate anion or acetate, water-soluble Ca salt and be selected from the incompatible composition of water-soluble silicate, water-soluble phosphate and soluble fluoride salt.This publication has been described anhydrous composition, and it does not comprise Chalk as abrasive material, does not therefore have instruction to stablize the solution of the problem of the fluoride aspect appearance in this class toothpaste.

Therefore, although as the described multiple salt of above prior art has been used for oral care composition, comprise toothpaste, but do not have prior art to be disclosed in stablize fluoride in the chalk based toothpaste preparation to keep the solution of the problem of appearance aspect its physical stability in extending shelf life simultaneously.

Therefore, an object of the present invention is to provide and shown than prior art compositions and compare the toothpaste that has strengthened fluoride stability.

Another object of the present invention has provided and has shown and strengthened fluoride stability keeps the physical integrity of expectation simultaneously in the storage life that prolongs toothpaste.

Summary of the invention

According to an aspect of the present invention, provide the dentifrice composition that comprises abrasive calcium compound, fluoride salt, alkali silicate and be selected from the salt of the kind that comprises alkali-metal citrate.

Particularly preferably be, fluoride salt is a sodium monofluorophosphate.Further particularly preferably being described salt is potassium citrate.

According to another aspect of the present invention, provide preparation to comprise abrasive calcium compound, fluoride salt, alkali silicate and be selected from the method for dentifrice composition of the salt of the kind that comprises alkali-metal citrate, this method comprises:

(i) in water and other optional members such as wetting agent, mix this salt to make solution;

(ii) in this solution, add abrasive calcium compound and mixing to make the mixture of homogeneous;

(iii) add and mixed alkali metal silicate, then in this mixture, add fluoride salt to make toothpaste.

Detailed Description Of The Invention

The invention provides the chalk based toothpaste compositions that in extending shelf life, has enhanced fluoride stability and enhanced physical stability.Dentifrice composition of the present invention comprises abrasive calcium compound, fluoride salt, alkali silicate and is selected from the salt of the kind that comprises alkali-metal citrate.

Abrasive calcium compound is to be selected from levigated natural whiting (FGNC), sedimentary calcium carbonate (PCC) or dicalcium phosphate dihydrate (DCPD).In these calcium compounds, FGNC and PCC are preferred.Not only FGNC is the more cheap and more extensive abrasive material that obtains, and the improvement of fluoride stability and phase stability is better in the FGNC based toothpastes according to observations in the toothpaste.The amount scope of abrasive calcium compound is the 20-70% of composition weight, is more preferably 25-50%.

Fluoride salt is present in the dentifrice composition of the present invention.The fluoride salt that is fit to is sodium fluoride, sodium monofluorophosphate or potassium fluoride, preferably sodium monofluorophosphate (SMFP).The 0.3%-1.5% that the preferred amount scope of fluoride salt is a toothpaste weight.

Alkali silicate is present in the dentifrice composition of the present invention.Alkali metal can be sodium or potassium, preferably sodium.Therefore, sodium silicate is the most preferred alkali silicate that is present in the toothpaste of the present invention.Sodium silicate generally can be used as the 10%-40% aqueous solution and obtains, and the most common is 30% solution.Sodium silicate can be used as neutral sodium silicate or alkaline sodium silicate obtains.Neutral sodium silicate preferably in the dentifrice composition of the present invention.Can obtain to have multiple Na ₂O:SiO ₂The sodium of ratio.Has Na ₂O:SiO ₂Proportion is that the sodium silicate of 3.0-3.8 is preferred, and higher preferable range is 3.25-3.5.Alkali silicate amount scope is 0.1-5.0%, based on the dry weight basis with respect to composition weight.Therefore, 30% sodium silicate solution is the weight range adding compositions with 0.3-16.0%.

Salt is selected from the kind that comprises alkali-metal citrate, for example, salt can be single, two or the citrate of trisodium or potassium.In these salt, potassium citrate is preferred.Observe, any of these salt when mixing toothpaste of the present invention, provides the toothpaste of fabulous physical stability.In addition, when being 6-50 ℃ when storing down high time expand to March at extreme temperature conditions, mix these salt very surface of good character such as smooth and ribbon upright (ribbonstand-up) also are provided.

Toothpaste of the present invention preferably comprises flavoring agent.Flavoring agent can be Herba Menthae, Herba Menthae Rotundifoliae, menthol or its combination.Observe the poor stability of this flavoring agent in the chalk based toothpaste of fluoride in the past.Find that surprisingly compositions of the present invention not only provides the fluoride stability that is additional to outside the toothpaste physical stability when storing, and flavoring agent is stable and power of influence is also better than the similar toothpaste of prior art.The amount scope of flavoring agent is the 0.5-2% of composition weight.

Toothpaste also contains other conventional ingredients, for example wetting agent.Preferred humectants is Sorbitol, Polyethylene Glycol, xylitol or glycerol.Based on dry weight basis, wetting agent amount scope is the 5-40% of composition weight.Toothpaste contains water.Preferred water yield scope is the 10-50% of composition weight.

Dentifrice composition of the present invention preferably has fluoride stability so that fluoride concentration is at least 80% of initial fluoride concentration after height to 50 ℃ stores 3 months, and toothpaste does not show visible syneresis.

Compositions of the present invention can also contain other compositions such as sweeting agent, antimicrobial, binding agent, thickening agent, buffer agent, gloss enhancer, coloring agent and antiseptic.

The present invention is illustrated by means of following non-limiting example now.

Embodiment

In following examples, comparing embodiment is to indicate by letter, and embodiments of the invention are to indicate by numeral.Shown in the content of composition be percentage by weight.

Table 1: form

The content of fluoride of the various dentifrice compositions of more than indicating [F] is before storing and the method below using afterwards records.

Measure the method for content of fluoride:

The paste of a part uses the hydrochloric acid of dilution to boil, and any hydrolyzable fluorine-containing complex decomposes with releasing fluoride ion.Use fluoride electrode to measure the fluorion activity.Used fluoride electrode is Orion94-09, and used unijunction reference electrode is Orion90-01.The amount of the fluorion that exists in the paste is to calculate by the contrast calibration trace, and described calibration trace is to use the active measured increase of the fluorion that produces by the fluorion that adds known quantity to make.The linearity of response and this special slope of energy (Nernst slope) of electrode are to measure every day by the drawing standardized method.

At first group of test, the compositions of table 1 is to store 3 months down at 40 ℃.The content of fluoride in ppm [F] and the appearance/physical stability of record toothpaste.The result is summarised in the table 2.

Table 2: the storage stability of table 1 compositions

Therefore, the invention provides the fluoride toothpaste that has the Chalk base of highly fluorinated thing stability and good physical stability with respect to the available toothpaste of prior art in the storage life that prolongs.

Also make the compositions of table 3 and place under various conditions and store the several months.Table 4 is pointed out storage stability, the good fluoride stability of the presentation of results present composition and the good flavoring agent stability of observing.

Table 3: further compositions

Table 4: the storage stability of table 3 compositions

Claims (19)

1, a kind of dentifrice composition comprises abrasive calcium compound, fluoride salt, alkali silicate and is selected from the salt of the kind that comprises alkali-metal citrate.

2, the dentifrice composition of claim 1, wherein this salt is potassium citrate.

3, claim 1 or 2 dentifrice composition, wherein abrasive calcium compound is selected from levigated natural whiting (FGNC), sedimentary calcium carbonate (PCC) or dicalcium phosphate dehydrate (DCPD).

4, the dentifrice composition of claim 3, wherein abrasive calcium compound is FGNC.

5, each described dentifrice composition of above claim, wherein abrasive calcium compound amount scope is the 20-70% of composition weight.

6, each described dentifrice composition of above claim, wherein fluoride salt is sodium monofluorophosphate (SMFP).

7, each described dentifrice composition of above claim, wherein alkali silicate is a sodium silicate.

8, each described dentifrice composition of above claim, wherein sodium silicate is a neutral sodium silicate, has Na ₂O:SiO ₂Proportion is 3.0-3.8.

9, each described dentifrice composition of above claim, wherein alkali silicate amount scope is 0.1-5%, based on the dry weight basis with respect to composition weight.

10, each described dentifrice composition of above claim, the scope that comprises the amount of this salt is the 0.1-2% of composition weight.

11, the arbitrary described dentifrice composition of said composition comprises flavoring agent.

12, the dentifrice composition of claim 11, wherein flavoring agent is Herba Menthae, Herba Menthae Rotundifoliae, menthol or its combination.

13, claim 11 or 12 dentifrice composition, wherein flavoring agent amount scope is the 0.5-2% of composition weight.

14, each described dentifrice composition of above claim comprises wetting agent.

15, the dentifrice composition of claim 14, wherein this wetting agent is selected from Sorbitol, Polyethylene Glycol, xylitol or glycerol.

16, claim 14 or 15 dentifrice composition, wherein wetting agent amount scope is the 5-40% of composition weight, based on dry weight basis.

17, each described dentifrice composition of above claim comprises water, and the scope of its amount is the 10-50% of composition weight

18, each described dentifrice composition of above claim after the storage of height to 50 ℃ 3 months, has the fluoride stability of at least 80% initial fluoride concentration, and does not have visible syneresis.

20, a kind of method for preparing above each described dentifrice composition of claim may further comprise the steps:

(i) in water and optional wetting agent, mix this salt to make solution;

(ii) in this solution, add abrasive calcium compound and mixing to make the mixture of homogeneous;

(iii) add and mixed alkali metal silicate, then in this mixture, add fluoride salt to make toothpaste.