CN101407472B - L-carnitine dodecyl sulphonate, and preparation method and use thereof - Google Patents
L-carnitine dodecyl sulphonate, and preparation method and use thereof Download PDFInfo
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- CN101407472B CN101407472B CN200810228940.0A CN200810228940A CN101407472B CN 101407472 B CN101407472 B CN 101407472B CN 200810228940 A CN200810228940 A CN 200810228940A CN 101407472 B CN101407472 B CN 101407472B
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- carnitine
- alkyl sulfonate
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- dodecyl
- dodecyl alkyl
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Abstract
The invention discloses L-carnitine dodecyl alkyl sulfonate, a preparation method and the application thereof. The L-carnitine dodecyl alkyl sulfonate has double efficacy of moisturizing beauty and cleanliness, and is a preferred main material of detergent, compound soap, dish washing detergent and non-phosphate detergent. The preparation method is: L-carnitine hydrochloride is dissolved in ethanol, heated up to 20-60 DEG C, and dodecyl alkyl sulfonate is added; stirring and reacting last for 2-8 hours; L-carnitine dodecyl alkyl sulfonate is obtained after temperature reduction and crystallization, filtering, concentration and crystallization of mother liquor. Combination containing L-carnitine dodecyl alkyl sulfonate is applicable to cosmetics, skin care, oral care, face cream, facial mask, perfumed soap, hand-washing liquid, bath product, hairdressing and hair care, bathing supplies, and fruit and vegetable tableware cleaning products.
Description
Technical field
The present invention relates to a kind of dodecane sulfonate class tensio-active agent, particularly relate to a kind of L-carnitine dodecyl sulphonate and preparation method thereof and purposes, belong to the technology of preparing of tensio-active agent, be suitable for preparing various washing cosmetic articles for use.
Background technology
Tensio-active agent refers to that a class just can significantly reduce the capillary compound of water when very low concentrations, has wetting or anti-stick, emulsification or breakdown of emulsion, foaming or froth breaking and solubilising, dispersion, washing, series of physical chemical action and the corresponding practical application such as anticorrosion, antistatic.Tensio-active agent also is widely used in pharmaceutical industries: in medicament, many insoluble drugs such as some stearopten cellulose of solubleness, steroid hormone utilize the solublization of tensio-active agent can form clear solution and increase concentration; Can be used as sterilant and sterilizing agent uses, the strong interaction that its sterilization and disinfection ascribe they and bacterium living beings membrane protein to makes it sex change or loses function, these sterilizing agents have larger solubleness in water, according to working concentration, can be used for pre-surgical skin disinfection, wound or mucous membrane sterilization, sterilization of instruments and environment disinfected; In the medicament preparation process, it is indispensable emulsifying agent, wetting agent, suspending agent, pore forming material and defoamer etc.At pesticide industry, wettable powder, missible oil and emulsifiable concentrate need that all a certain amount of tensio-active agent is arranged, mostly be organic compound such as wettable powder Central Plains medicine, has hydrophobic nature, only under the condition that tensio-active agent exists, reduce the surface tension of water, powder just might be wetting by water institute, forms aqueous suspensions; And in granula and in for the pulvis that dusts, what have also contains a certain amount of tensio-active agent, its objective is in order to improve medicament at the tack that is subjected to the medicine surface and deposition, improve effective constituent at the release rate and the expanding area that have under the moisture condition, improve diseases prevention, the effect of curing the disease.Sodium lauryl sulphate (SLS) is widely used in toothpaste, soap, body lotion, shampoo, washing powder as whipping agent, and in the makeup, all contains sodium lauryl sulphate in 95% individual skincare product and the household cleaning articles for use.
The existing a lot of reports of the effect of L-carnitine, L-carnitine is a kind of important food enrichment, be widely used in foodstuffs industry, such as infant formula, diet food, in nutrition of athlete's product and the person in middle and old age's nutritional supplement and in the feed processing industry, the curative effect that also has in addition medical aspect, cardiovascular disorder, hepatic diseases, kidney disease, hyperlipidaemia, diabetes, neuromuscular disease etc. all can improve illness by taking L-carnitine and series product thereof, report that L-carnitine can also improve reproductive performance.L-carnitine has the effect of beautifying face, preserving moisture.L-carnitine be one natural, the necessary material of body fat metabolism.Be approved for food, and reached GRAS (GenerallyRecognized As Safe it is generally acknowledged safety) grade.Because the very strong moisture absorption of L-carnitine is applied in cream frost, the smoothing toner, can play obvious humidity-holding effect to skin.
As an alcohol acid, L-carnitine demonstrates the ability of changing skin under lower PH condition, thereby has shortened the cycle of skin metabolism.With separately use or composite with other alcohol acids such as oxyacetic acid, lactic acid of L-carnitine, being applied in the cutin maintenance product will be splendid selection.L-carnitine also has hair tonic, black sends out, the effect of strong tooth, as skin care starting material natural, teleorganic, multifunctional and multipurpose, can be widely used in the individual washing product.The alkylsulfonate of L-carnitine has the function of beauty treatment and cleaning simultaneously.Up to now, the applicant still finds no L-carnitine and dodecane sulfonate and forms double salt as the report of tensio-active agent.
Summary of the invention
Purpose of the present invention has L-carnitine salt--the L-carnitine dodecyl sulphonate of beauty treatment and cleaning function when being to provide new, reaches preparation method and the purposes of L-carnitine dodecyl sulphonate.This L-carnitine dodecyl sulphonate that the present invention provides is applicable to various washing cosmetic articles for use: the first-selected main raw material of washing powder, compound soap, dish washing detergent, free phosphate detergent; Also can be used for shampoo, bath shampoo, cleansing milk, toothpaste etc. and clean the class makeup.
The technical solution that the present invention provides is: the structural formula of this L-carnitine dodecyl sulphonate is:
Wherein R is dodecyl sodium sulfonate root, the basic sulfonate radical of dodecane, the α-anion surfactants such as olefin sulfonic acid root.
Particularly preferred structural formula comprises
L-carnitine dodecyl sulphonate provided by the invention, have the tensio-active agent of cosmetology humidity-holding effect concurrently, have excellent exfoliation, beautifying face, preserving moisture, hair tonic, blackly send out, infiltration, washing, decontamination and emulsifying effect, can be widely used in shampoo, bath shampoo, cleansing milk, toothpaste etc. and clean the class makeup.
The preparation method of this L-carnitine dodecyl sulphonate that the present invention provides is:
L-carnitine hydrochloride is dissolved in the ethanol, and intensification 20-60 ℃ adds sodium laurylsulfonate, and stirring reaction 2-8 hour, the cooling crystallization filtered, and the concentrated crystallization of mother liquor obtains L-carnitine dodecyl sulphonate.
The scope of protection of present invention also should relate to the application of this L-carnitine dodecyl sulphonate; particularly with composition forms as the tensio-active agent with beautifying face, preserving moisture effect, include L-carnitine dodecyl sulphonate as activeconstituents in the wherein said composition.This composition as tensio-active agent is applicable in makeup, skin care, mouth care, cleansing milk, facial mask, perfumed soap, Liquid soap, shower product, hair-dressing and hair care, bath article, the fruits and vegetables tableware class articles for washing.
The application of the claimed L-carnitine dodecyl sulphonate of the present invention also should relate to L-carnitine salt--the composition of L-carnitine dodecyl sulphonate, and optional one or more vehicle of said composition, and other activeconstituents.
Compared with prior art, beneficial effect of the present invention is: this L-carnitine dodecyl sulphonate that provides has the double effects of beautifying face, preserving moisture and cleaning.
Embodiment
The following examples are intended to further specify L-carnitine dodecyl sulphonate that the present invention provides and its production and use:
The preparation of embodiment 1 L-carnitine dodecyl sulphonate
L-carnitine hydrochloride is dissolved in the ethanol, and intensification 20-60 ℃ adds sodium laurylsulfonate, and stirring reaction 2-8 hour, the cooling crystallization filtered, and the concentrated crystallization of mother liquor obtains L-carnitine dodecyl sulphonate.
[α]
D 20＝9.9(1％?H
2O)
HPLC：
Post: APS-2 HYPERSIL (NH
2) (5 μ m) 250 * 4.6mm
Temperature: 30 ℃
Moving phase: KH
2PO
4/ acetonitrile (70/30) (v/v)
pH：4.0H
3PO
4
Detect wavelength: 205nm
Flow velocity: 1.0 ml/min
Carnitine: Rt=5.3 minute
A kind of composition of embodiment 2 preparation cleansing milk:
L-carnitine dodecyl sulphonate 0.1 (Wt%)
Stearyl alcohol 3.0 (Wt%)
White oil 6.0 (Wt%)
Tegin 55G 3.0 (Wt%)
Vitamin-E 2.0 (Wt%)
Sorbyl alcohol 10.0 (Wt%)
Water 75 (Wt%)
Sanitas (such as Tegosept M) 0.1-0.5%
Essence 0.1-0.5%
A kind of composition of embodiment 3 preparation shampoos:
The A phase:
L-carnitine dodecyl sulphonate 30 (Wt%)
Coconut oleoyl diethanolamine 3.00 (Wt%)
Sanitas (such as Tegosept M) 0.1-0.5% (Wt%)
Trolamine 0.20 (Wt%)
The B phase:
AMONYL 380LC 5.00 (Wt%)
Guar gum C-14-S 0.30 (Wt%)
Citric acid 0.1-0.5%
The C phase:
Nonionic silicone emulsion 2-3.0 (Wt%)
Glycerine 1.00 (Wt%)
Ethylenediamine tetraacetic acid (EDTA) 0.20 (Wt%)
Pearlite slurry 4.00 (Wt%)
Essence 0.50 (Wt%)
Sanitas (such as Tegosept M) 0.1-0.5%
Surplus is water.
A kind of composition of embodiment 4 preparation toothpaste:
N-sodium lauroyl sareosine 5 (Wt%)
L-carnitine dodecyl sulphonate 0.5 (Wt%)
Seaweed gel 0.9 (Wt%)
Proteolytic enzyme (every gram lotion 1500-2000 units) 2 grams
The Purified Water surplus.
Claims (1)
1. the preparation method of a L-carnitine dodecyl sulphonate is characterized in that L-carnitine hydrochloride is dissolved in the ethanol, and intensification 20-60 ℃ adds sodium laurylsulfonate, stirring reaction 2-8 hour, the cooling crystallization filters, and the concentrated crystallization of mother liquor obtains L-carnitine dodecyl sulphonate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810228940.0A CN101407472B (en) | 2008-11-21 | 2008-11-21 | L-carnitine dodecyl sulphonate, and preparation method and use thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810228940.0A CN101407472B (en) | 2008-11-21 | 2008-11-21 | L-carnitine dodecyl sulphonate, and preparation method and use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012104870902A Division CN103006447A (en) | 2008-11-21 | 2008-11-21 | Application of L-carnitine dodecyl alkane sulfonate |
Publications (2)
| Publication Number | Publication Date |
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| CN101407472A CN101407472A (en) | 2009-04-15 |
| CN101407472B true CN101407472B (en) | 2013-04-17 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN200810228940.0A Active CN101407472B (en) | 2008-11-21 | 2008-11-21 | L-carnitine dodecyl sulphonate, and preparation method and use thereof |
Country Status (1)
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104276986B (en) * | 2013-07-12 | 2016-07-06 | 辽宁科硕营养科技有限公司 | The preparation method of L-carnitine taurate |
| CN112250588B (en) * | 2020-11-06 | 2023-03-31 | 哈尔滨工业大学（深圳） | L-carnitine ionic liquid and preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0207437A1 (en) * | 1985-07-05 | 1987-01-07 | BIORESEARCH S.p.A. | New Carnitine salts particularly suitable for oral use |
| CN101297788A (en) * | 2008-06-26 | 2008-11-05 | 杨霖 | Sun-proof cosmetics and preparation thereof |
-
2008
- 2008-11-21 CN CN200810228940.0A patent/CN101407472B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0207437A1 (en) * | 1985-07-05 | 1987-01-07 | BIORESEARCH S.p.A. | New Carnitine salts particularly suitable for oral use |
| CN101297788A (en) * | 2008-06-26 | 2008-11-05 | 杨霖 | Sun-proof cosmetics and preparation thereof |
Non-Patent Citations (1)
| Title |
|---|
| 梁梦兰.表面活性剂在化妆品工业中的应用现状与发展建议.《精细化工增刊》.1998,第15卷第28-36页. * |
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| CN101407472A (en) | 2009-04-15 |
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Owner name: LIAONING KONCEPNUTRA CO., LTD. Free format text: FORMER OWNER: SHENYANG KONCEPNUTRA CO., LTD. Effective date: 20120920 |
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Effective date of registration: 20120920 Address after: 117004 Liaoning city of Benxi province Cladrastis Road Economic Development Zone No. 100 Applicant after: Liaoning Keshuo Nutrition Technology Co., Ltd. Address before: 110172, Liaoning province Shenyang Dongling District Wang Zhen town under the official village Applicant before: Shenyang Keshuo Nutrition Technology Co., Ltd. |
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Address after: 117000 No. 100 Huai Huai Road, Benxi Economic Development Zone, Benxi, Liaoning Patentee after: Liaoning Ke Shuo nutrition Polytron Technologies Inc Address before: 117004 No. 100, Xiang Huai Road, Benxi Economic Development Zone, Liaoning Patentee before: Liaoning Keshuo Nutrition Technology Co., Ltd. |