CN101401784A - Sodium closantel injection formulation and preparation method thereof - Google Patents
Sodium closantel injection formulation and preparation method thereof Download PDFInfo
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- CN101401784A CN101401784A CNA2008101599861A CN200810159986A CN101401784A CN 101401784 A CN101401784 A CN 101401784A CN A2008101599861 A CNA2008101599861 A CN A2008101599861A CN 200810159986 A CN200810159986 A CN 200810159986A CN 101401784 A CN101401784 A CN 101401784A
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- sodium
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- closantel
- sodium closantel
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Abstract
The invention discloses a closantel sodium injection preparation and a method for preparing the same. The closantel sodium pharmaceutical preparation is characterized in that the formulation proportion thereof comprises 5.0 grams of closantel sodium, 10 milliliters of ethanol, 50 milliliters of propanediol, and 100 milliliters of water for injection. The closantel sodium injection has the advantages of stable property, higher therapeutic effectiveness and convenience for market popularization compared with the prior art.
Description
Technical field
The present invention relates to field of veterinary, relate in particular to injection formulation of a kind of sodium closantel and preparation method thereof.
Background technology
Sodium closantel all has the activity of expeling to cattle, sheep fasciola, haemonchus contortus and some arthropod, to most gastrointestinal tract nematicide expeling rates all above 90%, sodium closantel can effectively be driven away the dog ancylostome, the common strongylid that also can prevent or reduce horse infects, in addition, 1,2,3 phase sheep nose fly larvae all there is 100% killing effect, to 3 phase of bomb fly larva better repelling and killing efficacy is also arranged, sodium closantel is at the intravital plasma protein binding rate of sheep very high (＞99%), thereby the half-life reaches 14.5.But the sodium closantel injection seldom has sale on market, reason is this product technology instability, this product is the propylene glycol sterile water solution of sodium closantel on the standard, pH value is 8.0～10.0, but occur the small part muddiness easily or occur precipitate easily after placement a period of time after doing sterilization like this, influenced it and used popularization.
Summary of the invention
The purpose of this invention is to provide injection formulation of a kind of sodium closantel and preparation method thereof, the technical solution adopted for the present invention to solve the technical problems is:
Formula proportion of the present invention is sodium closantel 5.0g, ethanol 10ml, propylene glycol 50ml, water for injection 100ml.
Preparation method of the present invention is: get ethanol and propylene glycol full dose, mix homogeneously is heated to 50～60 ℃, under agitation slowly add sodium closantel, be stirred to the complete molten back of sodium closantel and continue stirring 5～10 minutes, add the injection water to 80ml, continue to stir 5～10 minutes, with 10% sodium hydroxide solution adjust pH to 11.0～11.2, add to the full amount of water for injection, after-filtration stirs, embedding, 100 ℃ of states continue sterilization in 30 minutes down, lamp inspection, and packing gets final product.
The invention has the beneficial effects as follows: the present invention compared with prior art, the injection stable in properties of prepared sodium closantel, curative effect is higher, is convenient to marketing.
Description of drawings
Fig. 1: embodiment quality stability self-inspection record table
The specific embodiment
The present invention is described in detail below in conjunction with embodiment.
Get ethanol 10ml and propylene glycol 50ml, mix homogeneously is heated to 50～60 ℃, under agitation slowly add sodium closantel 5.0g, be stirred to the complete molten back of sodium closantel and continue stirring 5～10 minutes, add injection water 20ml, continue to stir 5～10 minutes, with 10% sodium hydroxide solution adjust pH to 11.0～11.2, add injection water 80ml, after-filtration stirs, embedding, 100 ℃ of states continue sterilization in 30 minutes down, lamp inspection, and packing gets final product.
Claims (2)
1, injection formulation of a kind of sodium closantel and preparation method thereof, the pharmaceutical preparation formula proportion that it is characterized in that described sodium closantel is sodium closantel 5.0g, ethanol 10ml, propylene glycol 50ml, water for injection 100ml.
2, injection formulation of a kind of sodium closantel according to claim 1 and preparation method thereof, it is characterized in that described preparation method is: ethanol and propylene glycol full dose, mix homogeneously, be heated to 50～60 ℃, under agitation slowly add sodium closantel, be stirred to the complete molten back of sodium closantel and continue stirring 5～10 minutes, add the injection water to 80ml, continue to stir 5～10 minutes, with 10% sodium hydroxide solution adjust pH to 11.0～11.2, add to the full amount of water for injection, after-filtration stirs, embedding, 100 ℃ continue sterilization in 30 minutes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101599861A CN101401784B (en) | 2008-11-14 | 2008-11-14 | Sodium closantel injection formulation and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101599861A CN101401784B (en) | 2008-11-14 | 2008-11-14 | Sodium closantel injection formulation and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101401784A true CN101401784A (en) | 2009-04-08 |
| CN101401784B CN101401784B (en) | 2011-03-23 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008101599861A Expired - Fee Related CN101401784B (en) | 2008-11-14 | 2008-11-14 | Sodium closantel injection formulation and preparation method thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN101401784B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110279657A (en) * | 2019-07-29 | 2019-09-27 | 河南官渡生物工程有限公司 | A kind of sodium closantel injection and preparation method thereof |
-
2008
- 2008-11-14 CN CN2008101599861A patent/CN101401784B/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110279657A (en) * | 2019-07-29 | 2019-09-27 | 河南官渡生物工程有限公司 | A kind of sodium closantel injection and preparation method thereof |
| CN110279657B (en) * | 2019-07-29 | 2021-07-27 | 河南官渡生物工程有限公司 | Closantel sodium injection and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101401784B (en) | 2011-03-23 |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20110323 Termination date: 20111114 |