CN101395166B - 用于治疗癌症的化合物和方法 - Google Patents

用于治疗癌症的化合物和方法 Download PDF

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Publication number
CN101395166B
CN101395166B CN200780007370.6A CN200780007370A CN101395166B CN 101395166 B CN101395166 B CN 101395166B CN 200780007370 A CN200780007370 A CN 200780007370A CN 101395166 B CN101395166 B CN 101395166B
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CN
China
Prior art keywords
cancer
purposes
compound
carcinoma
therapy
Prior art date
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Expired - Fee Related
Application number
CN200780007370.6A
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English (en)
Chinese (zh)
Other versions
CN101395166A (zh
Inventor
R·A·辛加洛
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Texas A&M University System
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Texas A&M University System
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Publication date
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Publication of CN101395166A publication Critical patent/CN101395166A/zh
Application granted granted Critical
Publication of CN101395166B publication Critical patent/CN101395166B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/285—Arsenic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/66—Arsenic compounds
    • C07F9/70—Organo-arsenic compounds
    • C07F9/72—Aliphatic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/66—Arsenic compounds
    • C07F9/70—Organo-arsenic compounds
    • C07F9/80—Heterocyclic compounds
    • C07F9/82—Arsenic compounds containing one or more pyridine rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN200780007370.6A 2006-01-13 2007-01-16 用于治疗癌症的化合物和方法 Expired - Fee Related CN101395166B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US75921806P 2006-01-13 2006-01-13
US60/759,218 2006-01-13
US76300806P 2006-01-26 2006-01-26
US60/763,008 2006-01-26
PCT/US2007/001127 WO2007082104A2 (en) 2006-01-13 2007-01-16 Compounds and methods for the treatment of cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201410253092.4A Division CN104109177A (zh) 2006-01-13 2007-01-16 用于治疗癌症的化合物和方法

Publications (2)

Publication Number Publication Date
CN101395166A CN101395166A (zh) 2009-03-25
CN101395166B true CN101395166B (zh) 2014-07-09

Family

ID=38158019

Family Applications (2)

Application Number Title Priority Date Filing Date
CN200780007370.6A Expired - Fee Related CN101395166B (zh) 2006-01-13 2007-01-16 用于治疗癌症的化合物和方法
CN201410253092.4A Pending CN104109177A (zh) 2006-01-13 2007-01-16 用于治疗癌症的化合物和方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201410253092.4A Pending CN104109177A (zh) 2006-01-13 2007-01-16 用于治疗癌症的化合物和方法

Country Status (10)

Country Link
US (2) US8222440B2 (https=)
EP (1) EP1979368B1 (https=)
JP (1) JP5202332B2 (https=)
KR (2) KR20130129316A (https=)
CN (2) CN101395166B (https=)
AU (1) AU2007204831B2 (https=)
CA (1) CA2636793C (https=)
HK (1) HK1203512A1 (https=)
IL (3) IL192738A0 (https=)
WO (1) WO2007082104A2 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009075870A1 (en) * 2007-12-12 2009-06-18 Ziopharm Oncology, Inc. Compounds and methods for the treatment of cancer
PT2321012T (pt) 2008-08-20 2019-01-11 Solasia Pharma K K Compostos organoarsénicos e métodos para o tratamento de cancro
CN105899486A (zh) * 2013-12-05 2016-08-24 日本苏爱康制药有限公司 用于治疗癌症的化合物和方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200002243T2 (tr) 1997-11-10 2000-12-21 Memorial Sloan-Kettering Cancer Center Arsenik trioksitin hazırlanması için işlem ve bunların kanser tedavisi için kullanımı.
EP1002537A1 (en) 1998-10-30 2000-05-24 Assistance Publique, Hopitaux De Paris Use of melarsoprol for the manufacture of a medicament for treating B-cell lymphoproliferative diseases, such as multiple myeloma
EP1474128B1 (en) * 2002-01-07 2016-06-01 Board Of Regents, The University Of Texas System S-dimethylarsino-thiosuccinic acid, s-dimethylarsino-2-thiobenzoic acid, s-(dimethylarsino)glutathione as treatments for cancer
TWI411431B (zh) * 2004-07-16 2013-10-11 Texas A & M Univ Sys 有機砷化合物、其用於治療癌症之用途及包含其之醫藥組成物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JAMES R. DANIEL et al..6-THIO-AND-SELENO-D-GALACTOSE ESTERS OF DIMETHYLARSINOUS ACID.《Carbohydrate Research》.1978,第64卷第69-79页. *

Also Published As

Publication number Publication date
AU2007204831B2 (en) 2013-10-03
US20090233894A1 (en) 2009-09-17
US20130143950A1 (en) 2013-06-06
EP1979368A2 (en) 2008-10-15
IL192738A0 (en) 2009-02-11
CN101395166A (zh) 2009-03-25
AU2007204831A1 (en) 2007-07-19
CA2636793A1 (en) 2007-07-19
IL226362A0 (en) 2013-06-27
HK1130804A1 (en) 2010-01-08
KR20130129316A (ko) 2013-11-27
WO2007082104A2 (en) 2007-07-19
US8222440B2 (en) 2012-07-17
EP1979368B1 (en) 2014-12-24
KR101471498B1 (ko) 2014-12-10
CN104109177A (zh) 2014-10-22
WO2007082104A3 (en) 2007-10-18
CA2636793C (en) 2014-07-08
HK1203512A1 (en) 2015-10-30
JP5202332B2 (ja) 2013-06-05
KR20080106897A (ko) 2008-12-09
IL226363A0 (en) 2013-06-27
JP2009527463A (ja) 2009-07-30

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