CN101385791B

CN101385791B - Leukoderma treating medicine

Info

Publication number: CN101385791B
Application number: CN2008103051974A
Authority: CN
Inventors: 严跃华
Original assignee: Individual
Current assignee: Individual
Priority date: 2008-10-27
Filing date: 2008-10-27
Publication date: 2012-07-04
Anticipated expiration: 2028-10-27
Also published as: CN101385791A

Abstract

The invention discloses a drug for treating vitiligo. The drug is made from raw materials of traditional Chinese medicines including psoralea fruit, forrest silkvine stem, auriculate swallowwort root, knotweed, glossy ganoderma and dark plum fruit. The formula of the drug is widely applied to patients with various vitiligo based on the theory of the Chinese traditional medical science for treating the vitiligo by being combined with clinical practices and adopting an external treatment method for treating internal diseases, and clinical applications prove that the drug has quick effect, no toxic and side effect, and can solve fundamental problems of the vitiligo in the whole body and a part.

Description

A kind of medicine of treating leucoderma disease

Technical field

The present invention relates to field of traditional Chinese medicine pharmacy, particularly relate to a kind of Chinese medicine medicine of treating leucoderma disease.

Background technology

Vitiligo (vitiligo) is a kind of pigmented dermatosis of common pilosity, and this disease is with local or general property depigmentation, and the formation white macula is a characteristic; Generation is all arranged all over the world, and India's sickness rate is the highest, and China has 1,200 ten thousand people morbidity approximately; Primary disease can involve all races; Men and women's no marked difference of falling ill, the vitiligo sickness rate rises year by year in recent years, causes people's common concern.Traditional treatment such as steroid hormone and ultraviolet radiation PUVA.And 8-oxygen psoralen; Chinese medicines etc. all have certain curative effect, are a kind of Therapeutic Method of just carrying out in the 50-80 age from body surface skin grafting dermepenthesis treatment vitiligo; PUVA irradiation (black light lamp treatment) effective percentage of going again after the normal skin transplantation of patient self is just healed to the white macula position can reach 90%; Though these methods can make part patient's white macula that pigment regeneration partly takes place, irregular colour is even, and tangible limitation is arranged.

Known vitiligo is by tyrosine tryrosinase system disorders, the plain generation of causes black can not, long wave ultraviolet can suppress sulfydryl and melatonin (MELATONIN) in the epidermis; Activity of tyrosinase, thus recover or quicken melanic generation, shift and make lesions recover pigment; Along with the development of immunology research, find that patients with vitiligo exists some immunologic function disorder phenomenons in recent years, it is hyperfunction lowly to reach humoral immunization like some cellular immunization; The local improvement in various degree in treatment back this patient of treatment simultaneously, notes regulating patient's immunologic function; So as to improving curative effect, also be one of problem of comprehensive study therapy of vitiligo and prevention from now on.

Summary of the invention

Technical problem to be solved by this invention provides a kind of determined curative effect, has no side effect, can solve the medicine of the treatment leucoderma disease of vitiligo whole body and local root problem.

In order to solve the problems of the technologies described above; The present invention adopts following technical scheme: according to listed as parts by weight, it is made up of raw material of Chinese medicine Fructus Psoraleae 5-100 part, Heiguteng exract 10-150 part, Radix cynanchi wilfordii 15-80 part, Rhizoma Polygoni Paleachi 20-150 part, Ganoderma lucidum seu Japonicum 10-100 part, Fructus Mume 15-80 part.

Best, it is made up of for 15 parts 50 parts of raw material of Chinese medicine Fructus Psoraleaes, 30 parts of Heiguteng exracts, 30 parts of Radix cynanchi wilfordii, 30 parts of Rhizoma Polygoni Paleachi, 15 parts of Ganoderma lucidum seu Japonicumes, Fructus Mume.

The traditional Chinese medical science is thought leucoderma disease by the diseases caused by exogenous pathogenic factor ailment said due to cold or exposure, and is interior by internal injury caused by excess of seven emotions, and five will have some setbacks, mechanism of qi is contrary disorderly, and disharmony between QI and blood or prolonged illness are lost and supported, and decrease smart blood trouble, injure Liver and kidney, so that essence and blood can not change life, and fur loses to support and forms.

The present invention's prescription is according to above-mentioned theory, in conjunction with clinical practice, adopts the method for inner disease outer treat, is widely used in all types of patients with vitiligo, has instant effect through summing up, and is without any side effects, and can solve vitiligo whole body and partial root problem

Fructus Psoraleae: be the dry mature fruit of legumes psoraleae Psoralea corylifolia L., nature and flavor with return through suffering, hardship, temperature is returned kidney, spleen channel; Function with cure mainly: warming the kidney to activate YANG, improving inspiration by invigorating kidney-QI, antidiarrheal is used for impotence and seminal emission; Enuresis frequent micturition, chills and pain of the waist and kness is suffered from a deficiency of the kidney and is done to breathe heavily, and has loose bowels just before dawn; The external curing vitiligo, alopecia areata.

Heiguteng exract: be root or the Herb of Asclepiadaceae plant southwest P. sepium Bunge Periploca forrestii Schlechter, meridian distribution of property and flavor: bitter, cool, slightly poisonous.Function cures mainly: promoting blood circulation to restore menstrual flow, wind-damp dispelling.Control traumatic injury, rheumatism numbness is painful, stomatitis, pharyngolaryngitis, mastitis, menoxenia etc.

Radix cynanchi wilfordii: be the tuber of asclepiadaceae plant cynanchum auriculatum Royle Cynanchum auriculatum Rayle ex Wight.Character: sweet, bitter, flat.Return spleen, stomach, Liver Channel.Effect: promoting digestion and invigorating the stomach, regulating QI to relieve pain, lactogenic.Radix cynanchi wilfordii contains multiple mixing glycosides, and the Radix cynanchi wilfordii glycosides has two-way immunoregulation effect.

Rhizoma Polygoni Paleachi: cool in nature for polygonaceae plant Rhizoma Polygoni Paleachi rhizome, sour in the mouth is nontoxic.Function cures mainly: the blood hemostasis of loosing, therapeutic method to keep the adverse QI flowing downwards pain relieving.

Ganoderma lucidum seu Japonicum: be mostly the Herb of many Cordycepps plant Ganoderma or Ganoderma lucidum (Leyss. Ex Fr.) Karst., nature and flavor are sweet flat, for strengthening by means of tonics, consolidate the precious Chinese herbal medicine of setting upright, have prevent and cure diseases, the effect of life lengthening.

Fructus Mume: be the almost ripe fruit of rosaceae plant deciduous tree prunus mume (sieb.) sieb.et zucc. (Prunus mume), meridian distribution of property and flavor: sour, puckery, flat.Return liver, spleen, lung, large intestine channel.Antidiarrheal dysentery, cough-relieving, relieving colic caused by ascaris promotes the production of body fluid, and hemostasis is astringed the lung, and astringing intestine to stop diarrhea is used for chronic cough of deficiency lung, the chronic dysentery laxation, deficiency-heat is quenched one's thirst, ascariasis of biliary tract vomiting stomachache, ascariasis of biliary tract.

Mainly contain following theory at present for leucoderma disease:

1, theory of autoimmunity: patients with vitiligo is prone to from the body immune disease, like pernicious anemia, and hyperthyroidism, malignant melanoma, alopecia areata etc., these patients' vitiligo sickness rate is apparently higher than general crowd.Serum at patients with vitiligo can detect anti-thyroid antibody, multiple autoantibodys such as anti-gastric parietal cell antibody and antiadrenergic drug antibody.

2, melanocyte self-destruction theory: melanocyte can produce some highly active intermediate products from the process of tyrosine generation melanocyte, gather too much and can destroy melanocyte.

3, neuralization theory: melanocyte comes from deric neural ridge, and isopropyl adrenal gland or teleneuron discharge some neural factor has detrimental effect to melanocyte.The patients with vitiligo autonomic nervous dysfunction that often occurs together, it is unusual to perspire like white macula portion

Clinical data:

The applicant adopts this invention prescription treatment vitiligo to suffer from 273 examples through years of researches and test, wherein, and male's 163 examples, women's 110 examples, minimum 2 years old of age, maximum 68 years old; The course of disease is the shortest 1 month, and is the longest 26 years.Typing: general hair style 45 examples, distribute type 76 examples, topical type 86 examples, segmental pattern 24 examples, acra type 42 examples.By stages: carry out phases 161 example, stablize 102 examples, upward swing 10 examples.Inducement: wound 65 examples, dermatosis 128 examples, emotion 61 examples, endocrine disturbance's 19 examples.The lab testing report: 215 examples are blood, routine urinalysis and liver function result and are normally.

Criterion of therapeutical effect: recovery from illness: local pigment recovers fully; Produce effects: pigment recovers area and surpasses 60%; Effectively: part skin lesion pigment recovers, but does not surpass 60%; Invalid: skin lesion portion does not have obvious change.

The clinical treatment result: 85 examples of fully recovering, produce effects 72 examples, effective 110 examples, invalid 6 examples are treated effective patient, and great majority are seen the pigment island at 1 first quarter moon of treatment.It is remarkable especially that topical type and course of disease short-term are sent out author's curative effect, and 273 examples do not have any untoward reaction in the operating period.101 example check blood, routine urinalysis and the equal no abnormality seens of liver function.

Model case:

Model case 1: Lee, man, 18 years old; The Guangzhou citizen are on October 21st, 1998, because of left side cervical region (being about 8.5cm, wide about 2.5cm); Do not return then shape white macula, once surplus invalid half a year of receiving treatment in local hospital, come my outpatient service to check that on time hemogram and liver function and the mental status are all no abnormal; Only see local white powder, be diagnosed as vitiligo.Through the external prescription, embrocate with 75% alcohol-pickled 15 days parts, every day secondary.Show profit after a treatment in month; Continue after two months, two place skin lesion portions dwindle like Semen Glycines, consolidate two months vitiligo again and disappear entirely, do not have any vestige, and through health check-up comprehensively, all are normal again.

Model case 2: Liu, woman, 42 years old; The cadre of Guiyang river factory; On May 10th, 2003, the irregular white speckle of buccal, the right side (being about 2cm, wide about 3.5cm) and right hand back (being about 3.5cm, wide about 1.5cm), the commentaries on classics of not getting better 2 years of once seeing the doctor for treatment in many ways more; Not having the patient examination health does not upon somebody's introduction have any unusually, is diagnosed as vitiligo.Through the external prescription, to embrocate with 75% alcohol-pickled 15 days parts, every day, secondary was checked after treatment half a year, and two affected parts are the same with the normal colour of skin, and health is good.

The specific embodiment

Embodiment 1: it is subsequent use to take by weighing 50 parts of raw material of Chinese medicine Fructus Psoraleaes, 30 parts of Heiguteng exracts, 30 parts of Radix cynanchi wilfordii, 30 parts of Rhizoma Polygoni Paleachi, 15 parts of Ganoderma lucidum seu Japonicumes, 15 parts of Fructus Mumes; The medical material weighing is assorted; The water cleaned and dried makes up with distilled water decoction three times after pulverizing coarser powder again; Add 6 times of water logging bubbles 30 minutes by total amount for the first time, heated and boiled 2 hours, it is subsequent use to get decoction liquor; For the second time add 4 times of amount distilled water, heated and boiled 1.5 hours, it is subsequent use to get decoction liquor; Doubled amount distilled water for the third time, heated and boiled 45 minutes, decoction liquor; Merge 3 times decoction liquor, left standstill 4-6 hour, filter with 200 mesh sieves, the solution heating evaporation is concentrated into the thick paste shape, adds the adjuvant drying, and the pulverizing sterilization is mixed with the cream frost through special procedure, gel, film liquid, any in the spray liniment.Every day secondary.

Embodiment 2: it is subsequent use to take by weighing raw material of Chinese medicine Fructus Psoraleae 5 gram, Heiguteng exract 10 grams, Radix cynanchi wilfordii 15 grams, Rhizoma Polygoni Paleachi 50 grams, Ganoderma lucidum seu Japonicum 20 grams, Fructus Mume 20 grams; The medical material weighing is assorted; The water cleaned and dried makes up with distilled water decoction three times after pulverizing coarser powder again; Add 6 times of water logging bubbles 30 minutes by total amount for the first time, heated and boiled 2 hours, it is subsequent use to get decoction liquor; For the second time add 4 times of amount distilled water, heated and boiled 1.5 hours, it is subsequent use to get decoction liquor; Doubled amount distilled water for the third time, heated and boiled 45 minutes, decoction liquor; Merge 3 times decoction liquor, left standstill 4-6 hour, filter with 200 mesh sieves, the solution heating evaporation is concentrated into the thick paste shape, adds the adjuvant drying, and the pulverizing sterilization is mixed with the cream frost through special procedure, gel, film liquid, any in the spray liniment.Every day secondary.

Embodiment 3: it is subsequent use to take by weighing raw material of Chinese medicine Fructus Psoraleae 100 gram, Heiguteng exract 150 grams, Radix cynanchi wilfordii 80 grams, Rhizoma Polygoni Paleachi 200 grams, Ganoderma lucidum seu Japonicum 300 grams, Fructus Mume 80 grams; The medical material weighing is assorted; The water cleaned and dried makes up with distilled water decoction three times after pulverizing coarser powder again; Add 6 times of water logging bubbles 30 minutes by total amount for the first time, heated and boiled 2 hours, it is subsequent use to get decoction liquor; For the second time add 4 times of amount distilled water, heated and boiled 1.5 hours, it is subsequent use to get decoction liquor; Doubled amount distilled water for the third time, heated and boiled 45 minutes, decoction liquor; Merge 3 times decoction liquor, left standstill 4-6 hour, filter with 200 mesh sieves, the solution heating evaporation is concentrated into the thick paste shape, adds the adjuvant drying, and the pulverizing sterilization is mixed with the cream frost through special procedure, gel, film liquid, any in the spray liniment.

Claims

1. medicine of treating leucoderma disease; It is characterized in that: according to listed as parts by weight, it is made up of following raw material of Chinese medicine: Fructus Psoraleae 5-100 part, Heiguteng exract 10-150 part, Radix cynanchi wilfordii 15-80 part, Rhizoma Polygoni Paleachi 20-150 part, Ganoderma lucidum seu Japonicum 10-100 part, Fructus Mume 15-80 part.

2. according to the described a kind of medicine of treating leucoderma disease of claim 1; It is characterized in that: according to listed as parts by weight, it is made up of following raw material of Chinese medicine: 50 parts of Fructus Psoraleaes, 30 parts of Heiguteng exracts, 30 parts of Radix cynanchi wilfordii, 30 parts of Rhizoma Polygoni Paleachi, 15 parts of Ganoderma lucidum seu Japonicumes, 15 parts of Fructus Mumes.