CN101380433A - Combination with antialcoholism action and preparation method thereof - Google Patents
Combination with antialcoholism action and preparation method thereof Download PDFInfo
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- CN101380433A CN101380433A CNA2008103050863A CN200810305086A CN101380433A CN 101380433 A CN101380433 A CN 101380433A CN A2008103050863 A CNA2008103050863 A CN A2008103050863A CN 200810305086 A CN200810305086 A CN 200810305086A CN 101380433 A CN101380433 A CN 101380433A
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Abstract
The invention discloses a composite which has the effect of anti-inebriation and a preparation method thereof, belonging to the filed of medicine, health-care food and ordinary food. The technical problem to be solved by the invention is to provide the composite which has the effect of anti-inebriation and can increase drinking amount. The composite comprises the following active components by weight proportion: 50-150 parts of flower of kudzuvine, 50-150 parts of radix puerariae, 50-100 parts of chrysanthemum, 10-50 parts of hawthorn, 50-100 parts of malt, and also can comprises 100 parts of Semen Hoveniae, 100 parts of agaric, and 100 parts of alisma orientale. The composite mainly alleviate a hangover, has the efficacy of liver-protection, promoting digestion, strengthening the stomach, clearing damp and promoting dieresis, is suitable for taking before drinking, in drinking, and excess drinking, can significantly increase drinking amount and alleviate discomfort of the stomach after excess drinking.
Description
Technical field
The present invention relates to have the composition and method of making the same of antialcoholism action, belong to medicine, health food and bread and cheese field
Background technology
Show that according to interrelated data there is that the people dies from alcoholism more than 110,000 an every year in China, has at least 60 kinds of diseases directly related with ethanol.Studies show that at present, domestic and international existing beverage for dispelling alcoholic intoxication mostly is simple excited type, enters body and produces adrenocorticomimetic stress effect, " thereby neutralization " ethanol (mainly being ethanol) is to the effect of drawing up of human central nervous system, and the expert points out should not advocate this class excited type product of use.
At present, the following product that mainly contains that has antialcoholism action or conduct " companion drinks " use:
Hai Wangjin cup: main component is a Concha Ostreae extract, as glycogen, aminoacid, various vitamin and mineral.From saying that in fact extra large Wang Jin cup belongs to nutriment, there is not direct liver-protecting and alcoholism-relieving effect on the pharmacology angle, need take for a long time.Suitable old crowd.
The Sobering up extraction oral liquid: main component is Radix Glycyrrhizae, the Radix Paeoniae Alba, Radix Codonopsis, Fructus Crataegi, Pericarpium Citri Reticulatae, plays invigorating the stomach and promoting digestion, invigorating middle warmer is invigorated blood circulation, and can promote ethanol digestion.Suitable dyspeptic crowd.
Do unit: composition is a yeast extract, has taken liver protection effect for a long time, belongs to nutriment, does not have direct hepatoprotective and antialcoholism action.Suitable old crowd.
'Xiaochuankangle ' capsule: main component is the Radix Astragali, Radix Panacis Quinquefolii, chitosan, yeast rich in selenium powder, Fructus Hippophae, helps digestion and enhancing immunity, need take for a long time, does not have direct antialcoholism action from the pharmacology angle, has taken liver protection effect for a long time.Suitable hypoimmunity, fatiguability person take.
HUOXIANG ZHENGQI YE: main component is a Herba Pogostemonis, is used for vomiting and diarrhoea, and use among the people has antialcoholism action, and antialcoholism action is arranged behind insobriety.
Summary of the invention
Technical problem solved by the invention provides a kind of antialcoholism action that has, and can increase the compositions of drinking amount, its active component is made up of following components in weight percentage: 50～150 parts of Flos puerariae lobataes, 50～150 parts of Radix Puerariaes, 50～100 parts of Flos Chrysanthemis, 10～50 parts of Fructus Crataegis, 50～100 parts in Fructus Hordei Germinatus.Said composition to be to relieve the effect of alcohol, have concurrently protect the liver, the merit of promoting digestion and invigorating the stomach and diuresis eliminating dampness by diuresis, be suitable for drinking preceding, take when drinking and during insobriety.On the basis of said components, according to actual needs, can also add 50～150 parts of Semen Hoveniae (Fructus Hoveniae)s, 50～150 parts of Polyporus, 50～150 parts of Rhizoma Alismatis etc. have relieve the effect of alcohol, the medicine performance synergism of effect such as promoting diuresis to eliminate damp pathogen.
In the present composition active component, Flos puerariae lobatae: sweet in the mouth is cool in nature, and the function spleen that relieves the effect of alcohol cures mainly the heating excessive thirst of getting sick from drinking too much wine, anorexia, vomiting acid regurgitation." herbal classic is met the source ": " can alcoholic intoxication.", " not Lu ": " wine disappears ", " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control dizziness, high fever ... relieving acute alcoholism and recuperating the spleen, wine dysentery, diet is not thought, and chest and diaphragm is glutted, sends out oh, vomits sour expectorant, and alcoholism injures one's stomach ... ".Flos puerariae lobatae is monarch drug in we.Radix Puerariae: the sweet in the mouth suffering is cool in nature, and the function expelling pathogenic factors from muscles for reducing heat promotes the production of body fluid, rash, and yang invigorating antidiarrheal helps wine to distribute with its expelling pathogenic factors from muscles for reducing heat in we, promotes the production of body fluid to quench the thirst." prescriptions worth thousand gold ": " controlling drunk awake ", Radix Puerariae can improve metabolic unusual that ethanol causes.Flos puerariae lobatae and Radix Puerariae are the most representative medicines that relieves the effect of alcohol of Chinese medicine, and it is usefulness with the Flos puerariae lobatae mutual reinforcement between often that Radix Puerariae is used to relieve the effect of alcohol, with the merit that helps Flos puerariae lobatae to relieve the effect of alcohol.Flos Chrysanthemi: the sweet-bitter flavor cold nature, return liver, lung meridian.Have dispelling wind and heat pathogens, suppressing the hyperactive liver makes eye bright, heat-clearing and toxic substances removing, hypotensive effect." detailed outline is picked up any lost article from the road ": " specially going into sun divides.Control all dizziness due to wind, alcoholic intoxication is treated swollen ", " medicine mirror " year its " ... separate drunkard's stupor, legibility, Radix puerariae is fried in shallow oil soup altogether." " book on Chinese herbal medicine justice ": " ..., solely Flos Chrysanthemi is then taken the photograph and is received declines, can the suppressing the hyperactive liver fire, put out endogenous wind, but the perverse and unreasonable manner of wood gas." being used for said composition, its meaning has three, and suppressing the hyperactive liver, heat-clearing and toxic substances removing to be reducing the injury of wine to liver, the increased blood pressure of blood pressure lowering to prevent to cause because of drinking, tool antialcoholism action own and Flos puerariae lobatae mutual reinforcement between are with the merit that helps Flos puerariae lobatae to relieve the effect of alcohol.Fructus Crataegi: sour in the mouth, sweet slightly warm in nature, function promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.Fructus Hordei Germinatus: sweet in the mouth is flat, function promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite.Fructus Crataegi, Fructus Hordei Germinatus two medicines share, and promoting digestion and invigorating the stomach is to reduce the injury of wine to stomach, and circulation of qi promoting helps distributing of wine.Semen Hoveniae (Fructus Hoveniae): sweet in the mouth is acid flat, and the energy heat clearing away is quenched the thirst, relieve the effect of alcohol, and relieving restlessness, preventing or arresting vomiting is contrary, sharp defecation." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " ... the energy alcoholic intoxication ", Compendium of Material Medica: preventing or arresting vomiting is told.Supplement to the Herbal: " quench the thirst and be tired of, moistening five ZANG-organs, sharp defecation ... " " Chinese regimen complete works ": " control the calentura excessive thirst, drunk and alcoholism ... " Semen Hoveniae (Fructus Hoveniae) water extract and Flos puerariae lobatae unite use and can obviously strengthen the antialcoholism action of Flos puerariae lobatae.Polyporus, Rhizoma Alismatis: promoting diuresis to eliminate damp pathogen, being used for this compositions mainly is to assist ethanol is excreted fast.
Take a broad view of full side,, have the merit of hepatoprotective, promoting digestion and invigorating the stomach and promoting diuresis to eliminate damp pathogen concurrently to relieve the effect of alcohol, be suitable for drinking preceding, take the stomach discomfort sense after significantly increasing drinking amount and alleviating excessive consumption of alcohol when drinking and during insobriety.
The specific embodiment
The present invention has the compositions of antialcoholism action, it is characterized in that, its active component is made up of following components in weight percentage: 50～150 parts of Flos puerariae lobataes, 50～150 parts of Radix Puerariaes, 50～100 parts of Flos Chrysanthemis, 10～50 parts of Fructus Crataegis, 50～100 parts in Fructus Hordei Germinatus.
Further preferred, its active component is made up of following components in weight percentage:
125 parts of Flos puerariae lobataes, 100 parts of Radix Puerariaes, 100 parts of Flos Chrysanthemis, 25 parts of Fructus Crataegis, 75 parts in Fructus Hordei Germinatus.
According to actual medication needs, can also add Semen Hoveniae (Fructus Hoveniae), Polyporus, Rhizoma Alismatis etc. have relieve the effect of alcohol, the medicine of effect such as promoting diuresis to eliminate damp pathogen.Wherein, its weight proportion is: 50～150 parts of Semen Hoveniae (Fructus Hoveniae)s, 50～150 parts of Polyporus, 50～150 parts of Rhizoma Alismatis.100 parts of preferred Semen Hoveniae (Fructus Hoveniae)s, 100 parts of Polyporus, 100 parts of Rhizoma Alismatis.
The present composition is to be active component with Flos puerariae lobatae, Radix Puerariae, Flos Chrysanthemi, Fructus Crataegi, Fructus Hordei Germinatus, can also add Semen Hoveniae (Fructus Hoveniae), Polyporus, Rhizoma Alismatis isoreactivity composition according to actual needs, the preparation that the food additive of adding acceptable accessories or bread and cheese is prepared from.
Particularly, can be prepared as regular dosage forms such as tablet, capsule, granule, oral liquid.Both can be used as medicinal application, and also can be used as health food and bread and cheese and use.Tablet can be with drinking behind the water dissolution during use.Dosage forms such as capsule, granule, oral liquid are then used according to conventional instructions of taking.
The preparation method of the present composition comprises the steps:
A, take by weighing active component according to weight proportion;
B, the described component of step a is decocted with water, filter, collect filtrate and promptly get the present composition.
The filtrate of all right step b gained concentrates the back and adds ethanol, and adjusting ethanol content is 30～60%, leaves standstill filtering and impurity removing; Collect filtrate and promptly get the present composition.
Can also be again with the filtrate recycling ethanol of precipitate with ethanol, filtration gained, drying is pulverized, and the food additive preparation that adds acceptable accessories or bread and cheese promptly gets the present composition.
Again foregoing of the present invention is described in further detail by the following examples, but this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following example, do not breaking away under the above-mentioned technological thought situation of the present invention, various replacements or change according to ordinary skill knowledge and customary means are made all should comprise within the scope of the invention.
Embodiment 1
A, take by weighing raw material: Flos puerariae lobatae 125g, Radix Puerariae 100g, Flos Chrysanthemi 100g, Fructus Crataegi 25g, Fructus Hordei Germinatus 75g, Semen Hoveniae (Fructus Hoveniae) 100g, Polyporus 100g, Rhizoma Alismatis 100g;
B, with above-mentioned raw materials, add purified water and decoct twice, add 10 times in water for the first time, decocted 60 minutes; For the second time add 7.5 times in water, decocted 40 minutes; Collecting decoction, being concentrated into relative density is 1.08～1.12 (80 ℃), adds ethanol, it is 50% that accent contains alcoholic degree, stirs, and places 12 hours; Get supernatant, filter, filtrate recycling ethanol and to be concentrated into relative density be 1.22～1.25 (75 ℃); Drying is pulverized; Add lactose, stevioside, citric acid, sodium bicarbonate, granulate, drying adds Polyethylene Glycol, Mentholum, Fructus Citri sinensis powdered flavor, mixing, and tabletting, that is, every 5g is equivalent to crude drug 2g, can be with drinking behind the water dissolution during use.
Embodiment 2
A, take by weighing raw material: Flos puerariae lobatae 50g, Radix Puerariae 150g, Flos Chrysanthemi 100g, Fructus Crataegi 50g, Fructus Hordei Germinatus 100g, Semen Hoveniae (Fructus Hoveniae) 150g, Polyporus 150g, Rhizoma Alismatis 150g;
B, with above-mentioned raw materials, add purified water and decoct twice, add 10 times in water for the first time, decocted 80 minutes; For the second time add 7.5 times in water, decocted 30 minutes; Collecting decoction, being concentrated into relative density is 1.08～1.12 (80 ℃), adds ethanol, it is 60% that accent contains alcoholic degree, stirs, and places 10 hours; Get supernatant, filter, filtrate recycling ethanol and to be concentrated into relative density be 1.22～1.25 (75 ℃); Drying is pulverized; Add lactose, sodium bicarbonate, granulate, drying, promptly encapsulated.
Embodiment 3
A, take by weighing raw material: Flos puerariae lobatae 150g, Radix Puerariae 50g, Flos Chrysanthemi 50g, Fructus Crataegi 10g, Fructus Hordei Germinatus 50g, Semen Hoveniae (Fructus Hoveniae) 50g, Polyporus 50g, Rhizoma Alismatis 50g;
B, with above-mentioned raw materials, add purified water and decoct twice, add 10 times in water for the first time, decocted 80 minutes; For the second time add 7.5 times in water, decocted 30 minutes; Collecting decoction, being concentrated into relative density is 1.08～1.12 (80 ℃), adds ethanol, it is 30% that accent contains alcoholic degree, stirs, and places 10 hours; Get supernatant, filter, add Fructus Citri Limoniae essence, add water to 10000ml, packing promptly.
Embodiment 4
A, take by weighing raw material: Flos puerariae lobatae 70g, Radix Puerariae 100g, Flos Chrysanthemi 100g, Fructus Crataegi 50g, Fructus Hordei Germinatus 10g, Semen Hoveniae (Fructus Hoveniae) 100g, Polyporus 150g, Rhizoma Alismatis 150g;
B, with above-mentioned raw materials, add purified water and decoct twice, add 10 times in water for the first time, decocted 80 minutes; For the second time add 7.5 times in water, decocted 30 minutes; Collecting decoction, being concentrated into relative density is 1.08～1.12 (80 ℃), adds ethanol, it is 30% that accent contains alcoholic degree, stirs, and places 10 hours; Get supernatant, filter, add Fructus Citri Limoniae essence, add water to 10000ml, packing promptly.
Embodiment 5
A, take by weighing raw material: Flos puerariae lobatae 150g, Radix Puerariae 100g, Flos Chrysanthemi 100g, Fructus Crataegi 50g, Fructus Hordei Germinatus 10g, Semen Hoveniae (Fructus Hoveniae) 100g, Polyporus 150g, Rhizoma Alismatis 50g;
B, with above-mentioned raw materials, add purified water and decoct twice, add 10 times in water for the first time, decocted 80 minutes; For the second time add 7.5 times in water, decocted 30 minutes; Collecting decoction, being concentrated into relative density is 1.08～1.12 (80 ℃), adds ethanol, it is 60% that accent contains alcoholic degree, stirs, and places 10 hours; Get supernatant, filter, add Fructus Citri Limoniae essence, add water to 10000ml, packing promptly.
Embodiment 6
A, take by weighing raw material: Flos puerariae lobatae 125g, Radix Puerariae 100g, Flos Chrysanthemi 100g, Fructus Crataegi 25g, Fructus Hordei Germinatus 75g;
B, with above-mentioned raw materials, add purified water and decoct twice, add 10 times in water for the first time, decocted 60 minutes; For the second time add 7.5 times in water, decocted 40 minutes; Collecting decoction, being concentrated into relative density is 1.08～1.12 (80 ℃), adds ethanol, it is 50% that accent contains alcoholic degree, stirs, and places 12 hours; Get supernatant, filter, filtrate recycling ethanol and to be concentrated into relative density be 1.22～1.25 (75 ℃); Drying is pulverized; Add an amount of lactose, stevioside, citric acid, sodium bicarbonate, granulate drying, add Polyethylene Glycol, Mentholum, Fructus Citri sinensis powdered flavor, mixing, tabletting (finished product claims solid beverage) is promptly, every 5g is equivalent to crude drug 2g, can be with drinking behind the water dissolution during use.
Embodiment 7
A, take by weighing raw material: Flos puerariae lobatae 50g, Radix Puerariae 150g, Flos Chrysanthemi 100g, Fructus Crataegi 50g, Fructus Hordei Germinatus 100g;
B, with above-mentioned raw materials, add purified water and decoct twice, add 10 times in water for the first time, decocted 80 minutes; For the second time add 7.5 times in water, decocted 30 minutes; Collecting decoction, being concentrated into relative density is 1.08～1.12 (80 ℃), adds ethanol, it is 60% that accent contains alcoholic degree, stirs, and places 10 hours; Get supernatant, filter, filtrate recycling ethanol and to be concentrated into relative density be 1.22～1.25 (75 ℃); Drying is pulverized; Add lactose, sodium bicarbonate, granulate, drying, promptly encapsulated.
Embodiment 8
A, take by weighing raw material: Flos puerariae lobatae 150g, Radix Puerariae 50g, Flos Chrysanthemi 50g, Fructus Crataegi 10g, Fructus Hordei Germinatus 50g;
B, with above-mentioned raw materials, add purified water and decoct twice, add 10 times in water for the first time, decocted 80 minutes; For the second time add 7.5 times in water, decocted 30 minutes; Collecting decoction, being concentrated into relative density is 1.08～1.12 (80 ℃), adds ethanol, it is 30% that accent contains alcoholic degree, stirs, and places 10 hours; Get supernatant, filter, add Fructus Citri Limoniae essence, add water to 10000ml, packing promptly.
Embodiment 9
A, take by weighing raw material: Flos puerariae lobatae 150g, Radix Puerariae 100g, Flos Chrysanthemi 100g, Fructus Crataegi 50g, Fructus Hordei Germinatus 10g;
B, with above-mentioned raw materials, add purified water and decoct twice, add 10 times in water for the first time, decocted 80 minutes; For the second time add 7.5 times in water, decocted 30 minutes; Collecting decoction, being concentrated into relative density is 1.08～1.12 (80 ℃), adds ethanol, it is 60% that accent contains alcoholic degree, stirs, and places 10 hours; Get supernatant, filter, add Fructus Citri Limoniae essence, add water to 10000ml, packing promptly.
Illustrate according to the composition material screening experiment: when active component during with 125 parts of Flos puerariae lobataes, 100 parts of Radix Puerariaes, 100 parts of Flos Chrysanthemis, 25 parts of Fructus Crataegis, 75 parts of weight proportions of Fructus Hordei Germinatus, relieving alcoholism and protecting the liver effect the best, be aided with 100 parts of Semen Hoveniae (Fructus Hoveniae)s, 100 parts of Polyporus, 100 parts of Rhizoma Alismatis, combined therapy effect obviously improves.According to clinical experiment explanation, the present composition has tangible antialcoholism action, but hepatoprotective, promoting digestion and invigorating the stomach and promoting diuresis to eliminate damp pathogen, be suitable for drinking preceding, take when drinking and during insobriety.
Taking present composition weight proportion scope through different phase that 156 people are drinking (preceding, the neutralization of drinking of drinking drink after) is 50～150 parts of Flos puerariae lobataes, 50～150 parts of Radix Puerariaes, 50～100 parts of Flos Chrysanthemis, 10～50 parts of Fructus Crataegis, 50～100 parts of tablets of making of Fructus Hordei Germinatus, granule, capsule, powder.142 people reflection is wherein arranged, the stomach discomfort sense after significantly increasing drinking amount and alleviating excessive consumption of alcohol, all the other 14 people are relieved the effect of alcohol and are felt not obvious.
In order to reduce the preparation cost and to be convenient to transportation, preferably said composition is made tablet.
Representative instance:
1, what certain, man, 28 years old now.Usual hobby is drunk Chinese liquor, can drink the Chinese liquor of about 150ml45% (v/v), and this amount has a brick in one's hat: face is rubescent, slight fever, and after 1 hour, stomach has sense of discomfort excessively.Solid beverage 5g through take embodiment 6 gained before wine takes after with water dissolution, after drinking the Chinese liquor of the identical number of degrees same amount of above-mentioned same brand again, the imperceptible signs of getting drunk, drink about 100ml again, and little sense signs of getting drunk: there is slight rubescent heating in face, stomach has sense of discomfort after spending 1 hour, but obviously the degree when not taking the present composition is light.
2, Zhang, man, 52 years old now.Do not drink Chinese liquor at ordinary times, during the reception guest, can drink the Chinese liquor of about 52% (v/v) 100ml, but obviously feel to have a brick in one's hat.Solid beverage 5g through taking embodiment 6 gained in the process of drinking takes after with water dissolution, after drinking the Chinese liquor of the identical number of degrees same amount of above-mentioned same brand again, the imperceptible signs of getting drunk, drink about 100ml again, and little sense signs of getting drunk, but drunk degree is obviously slight than the degree of not taking behind the embodiment 6 gained tablets.
3, Liu, woman, 38 years old now.Do not drink Chinese liquor at ordinary times, as long as drink some Chinese liquor, face is hot at short notice, and the head sensation is dizzy heavy.Effective because of hearing that the present composition relieves the effect of alcohol, and having the psychology that has a try in arms, the solid beverage 10g that formerly drinks embodiment 6 gained takes after with water dissolution, has drunk the Chinese liquor of 100ml 45% (v/v), slight face's heating is arranged, and all the other do not have any drunk symptom to occur.
Claims (9)
- [claim 1] has the compositions of antialcoholism action, it is characterized in that, its active component is made up of following components in weight percentage:50～150 parts of Flos puerariae lobataes, 50～150 parts of Radix Puerariaes, 50～100 parts of Flos Chrysanthemis, 10～50 parts of Fructus Crataegis, 50～100 parts in Fructus Hordei Germinatus.
- [claim 2] compositions with antialcoholism action according to claim 1 is characterized in that its active component is made up of following components in weight percentage:125 parts of Flos puerariae lobataes, 100 parts of Radix Puerariaes, 100 parts of Flos Chrysanthemis, 25 parts of Fructus Crataegis, 75 parts in Fructus Hordei Germinatus.
- [claim 3] is according to claim 1 or 2 each described compositionss with antialcoholism action, it is characterized in that, it is to be active component with Flos puerariae lobatae, Radix Puerariae, Flos Chrysanthemi, Fructus Crataegi, Fructus Hordei Germinatus, adds the preparation that the food additive of acceptable accessories or bread and cheese is prepared from.
- [claim 4] compositions with antialcoholism action according to claim 3 is characterized in that described preparation is tablet, capsule, granule or oral liquid.
- [claim 5] is characterized in that according to each described compositions with antialcoholism action of claim 1～4 its active component also contains following components in weight percentage:50～150 parts of Semen Hoveniae (Fructus Hoveniae)s, 50～150 parts of Polyporus, 50～150 parts of Rhizoma Alismatis.
- [claim 6] is characterized in that according to each described compositions with antialcoholism action of claim 1～4 its active component also contains following components in weight percentage:100 parts of Semen Hoveniae (Fructus Hoveniae)s, 100 parts of Polyporus, 100 parts of Rhizoma Alismatis.
- The described preparation of compositions method with antialcoholism action of [claim 7] claim 1 is characterized in that it comprises the steps:A, take by weighing the component of following weight proportion: 50～150 parts of Flos puerariae lobataes, 50～150 parts of Radix Puerariaes, 50～100 parts of Flos Chrysanthemis, 10～50 parts of Fructus Crataegis, 50～100 parts in Fructus Hordei Germinatus;B, the described component of step a is decocted with water, filter, collect filtrate promptly.
- [claim 8] preparation of compositions method with antialcoholism action according to claim 7 is characterized in that also comprising the steps:C, the filtrate of step b gained is concentrated the back add ethanol, adjusting ethanol content is 30～60%, leaves standstill filtering and impurity removing; Collect filtrate promptly.
- [claim 9] preparation of compositions method with antialcoholism action according to claim 8 is characterized in that also comprising the steps:D, with the filtrate recycling ethanol of step c gained, drying is pulverized, and adds the food additive preparation of acceptable accessories or bread and cheese, promptly.
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