CN101371909A - Medicine for treating carcinoma of stomach and preparation method thereof - Google Patents
Medicine for treating carcinoma of stomach and preparation method thereof Download PDFInfo
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- CN101371909A CN101371909A CNA2008101672886A CN200810167288A CN101371909A CN 101371909 A CN101371909 A CN 101371909A CN A2008101672886 A CNA2008101672886 A CN A2008101672886A CN 200810167288 A CN200810167288 A CN 200810167288A CN 101371909 A CN101371909 A CN 101371909A
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Abstract
The invention relates to a medicament for treating gastric cancer, and the medicament is composed of swordlike atractylodes rhizome, twotooth achyranthes root, alum, trogopterus dung, eucommia bark, pine nut, cold food flour and liquor. The invention further relates to a preparation method of the medicament for treating gastric cancer. The medicament has the advantages of scientific and reasonable formula, good efficacy, less toxicity or side effects, and the like.
Description
[technical field]
The present invention relates to a kind of medicine.Particularly, relating to a kind of is the medicine and preparation method thereof of the treatment gastric cancer of feedstock production with the Chinese herbal medicine.
[background technology]
Gastric cancer is one of modal malignant tumor, with its primary symptom difference, can belong to disease categories such as " dysphagic ", " regurgitation ", " gathering ", " trusted subordinate's painful abdominal mass " in Chinese medicine.Its sickness rate occupies first of the malignant tumor of digestive tract, but tangible regional difference is arranged, and other and rate can differ 7～10 times in district occurred frequently and low sending out between the district.China belongs to the gastric cancer district occurred frequently on the whole, and it also has tangible regional difference, is the gastric cancer district occurred frequently as NORTHWEST CHINA, northeast, Jiangsu, region following the line of the sea, Zhejiang, and particularly Hexi Corridor, Gansu Province, Jiaodong Peninsula and Jiangsu, Zhejiang incidence gastric cancer rate are the highest.And middle south-southwest especially the Guangxi sickness rate is low.China's gastric cancer mortality is approximately 15.41/10 ten thousand, and world's gastric cancer mortality is approximately 23.86/10 ten thousand, and the world population markization mortality rate of gastric cancer is the highest with Japan, and the U.S. is minimum, and China Shanghai is only second to Japan, in the middle of Beijing occupy.Gastric cancer can betide any age, rises with advancing age but total trend is sickness rate.Occur in that the person accounts for 20% below 40 years old; Occur in that the person accounts for 70% between 40～60 years old.Adolescence gets a cancer of the stomach, and its grade malignancy is often more outstanding with respect to person in middle and old age.Should pay much attention to.China's incidence gastric cancer rate is higher, and its mortality rate accounts for position first of the various malignant tumor, and average sicken age is lower again, therefore says that gastric cancer is the commonly encountered diseases of serious harm China people ' s health.
Yet owing to the reason of bringing out gastric cancer is a lot, ill mechanism complexity is so the healing difficulty is also very big.At present the method for state's internal therapy gastric cancer mainly is divided into two kinds, a kind of be operation and put, the chemotherapy auxiliary treatment, but this method is very big to the lethality of human normal tissue cell and immunologic function, has seriously destroyed the normal function of human body; Another kind method is exactly therapy of combining Chinese and Western medicine, current wide-spread be to adopt Ganoderma spore powder, though gastric cancer is had inhibitory action, but, should be used for seeing through clinical practice, effect is not too obvious, also have some as precious balosam capsule, Fushengkang capsule, but these will often cost an arm and a leg, side effect is very big, and its pharmaceutical compositions is easy to be captured by the antibody protein of cancerous cell outside cancerous cell, really can enter the intravital pharmaceutical compositions of cancerous cell seldom, thereby the effect of anticancer is not obvious.Therefore, also need a kind of treatment short treating period at present, toxic and side effects is low, the medicine of economical and practical treatment gastric cancer.For this reason, the applicant has passed through a large amount of experimental studies, has made the present invention finally.
[summary of the invention]
[problem that invention will solve]
The purpose of this invention is to provide that a kind of short treating period, good effect, toxic and side effects are few, the medicine of taking convenience, economical and practical treatment gastric cancer.
Another object of the present invention provides a kind of preparation method of medicine of described treatment gastric cancer.
[technical scheme]
The present invention seeks to be achieved through the following technical solutions.
A kind of medicine for the treatment of gastric cancer is characterized in that it is the medicine that the following weight proportion raw material is made:
20-40 parts of grey Zhu, 20-40 parts of Radix Achyranthis Bidentataes, 20-40 parts of Alumens, 5-25 parts of Oletum Trogopteroris, 20-40 parts of the Cortexs Eucommiae, 20-40 parts of Semen pini koraiensis, 5-25 parts in cold food face, 20-40 parts of Chinese liquor.
Preferably, the weight proportion of above-mentioned each raw material is:
25-35 parts of grey Zhu, 25-35 parts of Radix Achyranthis Bidentataes, 25-35 parts of Alumens, 10-20 parts of Oletum Trogopteroris, 25-35 parts of the Cortexs Eucommiae, 25-35 parts of Semen pini koraiensis, 10-20 parts in cold food face, 25-35 parts of Chinese liquor.
More preferably, the weight proportion of above-mentioned each raw material is:
30 parts of grey Zhu, 30 parts of Radix Achyranthis Bidentataes, 30 parts of Alumens, 15 parts of Oletum Trogopteroris, 30 parts of the Cortexs Eucommiae, 30 parts of Semen pini koraiensis, 15 parts in cold food face, 30 parts of Chinese liquor.
The medical material that the present invention uses has following characteristic:
Grey Zhu: surperficial taupe brown, wrinkle, lateral flexure stricture of vagina and retained root palpus are arranged, it is cylindrical to be irregular beaded or nodositas.Gas perfume (or spice) is special, and it is little sweet, hot, bitter to distinguish the flavor of.Its effect with cure mainly: drying damp and strengthening spleen, expelling wind and cold makes eye bright.Be used for distension and fullness in the abdomen, removing water retention by purgation is swollen, rheumatic arthralgia, anemofrigid cold etc.
Radix Achyranthis Bidentatae: surperficial lark or light brown, be elongated cylindrical, crooked slightly, slightly distortion is arranged and trickle vertical wrinkle, grow crosswise hole skin and sparse radicula trace.Feeble QI, it is little sweet and pained slightly to distinguish the flavor of.Its effect with cure mainly: invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation draws the row that snows.Be used for soreness of waist and knee joint, muscles and bones is unable, dizziness due to hyperactivity of liver-YANG etc.
Alumen: popular name Alumen, sour-puckery flavor cold in nature is returned lung, liver, spleen, stomach, large intestine channel has stronger astriction.Can grind and be used as medicine.Effect with cure mainly: the detoxifcation parasite killing, dampness removing to stop itchin, the hemostasis antidiarrheal, heat clearing away expectorant etc.
Oletum Trogopterori: the feces that is Mammalia, flying squirrel section animal trogopterus xanthipes Milne-Edwards (cold number bird), flying squirrel or other nearly edge animals.This product is sweet in flavor and warm in property, and is nontoxic, goes into Liver Channel, has the mediation blood vessels, the effect of eliminating stasis to stop pain; It is gynecological's key medicine.Effect with cure mainly: cure mainly stasis, amenorrhea, stomachache; Diseases such as breast side of body twinge tumbling and swelling and snake bite and insect sting.
The Cortex Eucommiae: deciduous tree is yellowish-brown, tool lamellar marrow.Get its bark, the rough skin of outside of pruning, drying both can be used as medicine.The sweet in the mouth temperature, nontoxic.Effect with cure mainly: invigorating the liver and kidney, bone and muscle strengthening, antiabortive; Control the spinal column ache, foot and knee flaccidity, dribbling urination, frequent fetal movement, diseases such as hypertension.
Semen pini koraiensis: be the kernel of the Pinus armandi Franch-P. Komavovii Lavl. of the species of Pinaceae Pinus, Pinus koraiensis, Pinus massoniana Lamb.Warm in nature, sweet in the mouth are gone into liver, lung, large intestine channel.Effect with cure mainly: have the fluid infusion of nourishing blood, moisten cough-relieving, effects such as laxation relieving constipation.Can treat the xeropulmonary cough, the constipation of old man's intestine-dryness due to consumption of fluid.
The cold food face: the face of three days mills is in the cold food face before and after clear and bright.
Chinese liquor: use the Lao Bai Fenyang wine of Shanxi Fenyang wine group, alcoholic strength is 45%vol.
Above-mentioned medical material can be bought from the market and obtain.
Described medicine is a kind of pill, powder, tablet, syrup or capsular dosage form of being selected from.
Preferably, described medicine is a kind of pill, tablet, syrup or capsular dosage form.
More preferably, described medicine is a kind of pill, tablet or capsular dosage form.
On meaning of the present invention, described pill is meant that adding suitable binding agent or excipient with medical material fine powder or medicinal substances extract makes spherical or similar dosage form, and described pill is the pill that is selected from honeyed pill, water-honeyed pill, the watered pill, concentrated pill, micropill.Described binding agent or excipient are normally used in the art those binding agents or excipient, for example, and Mel, water, liquid glucose, yellow wine, dimmed or starch etc.
On meaning of the present invention, described powder is by the preparation of each component medical material fine powder through fully mixing.
On meaning of the present invention, described tablet is meant with medical material fine powder or medicinal substances extract and mixes the repressed granular preparation that forms in back with proper excipient.Described tablet is to be selected from solubility, suspension ability, effervescency granule.Described excipient is normally used in the art those excipient, for example starch, gelatin etc.Described tablet can also contain appropriate amount or according to the correctives of provisions of the relevant regulations issued by the State amount, aromatic, coloring agent etc.
On meaning of the present invention, described syrup is meant the lane aqueous sucrose solution that contains medicine or medicinal substances extract and aromatic substance.Described syrup can also contain at pharmaceutically acceptable antiseptic, and for example sorbic acid, benzoic acid, P-hydroxybenzoic acid can also contain ethanol, glycerol or other polyhydric alcohol in case of necessity.
On meaning of the present invention, described capsule is meant that medical material fine powder or medicinal substances extract are filled in the capsulae vacuus and the preparation of making behind mixing.Described capsule can be normally used hard capsule, soft capsule, an enteric coated capsule on medicine.Hard capsule is a certain amount of medicine to be added adjuvant make uniform powder or granule, and filling is made in Capsules, or the medicine direct packaging is made in Capsules.Soft capsule is that a certain amount of medicine is sealed in sphere or the oval soft material, and this soft material is gelatin, glycerol etc.Enteric coated capsule is meant hard or soft capsule forms through processing such as pharmaceutical polymerses, and its softgel shell is insoluble to gastric juice, but can disintegrate discharge active component in intestinal juice.
In the present invention, the preparation method of described pill, powder, tablet, syrup or capsule formulation is the method for knowing the people that adopt usually in the art.
In addition, the invention still further relates to the preparation method of the medicine of described treatment gastric cancer, it is characterized in that this method comprises the steps:
(1) takes by weighing in 20-40 parts of grey Zhu of weight portion, 20-40 parts of Radix Achyranthis Bidentataes, 5-25 parts of Oletum Trogopteroris, 20-40 parts of the Cortexs Eucommiae, 20-40 parts of Semen pini koraiensis, 5-25 parts in cold food face;
(2) take by weighing in 20-40 parts of grind into powders of weight portion Alumen, join in the above-mentioned medical material;
(3) these Chinese medicine waters 100-500 part was soaked 30-60 minute then, decocted 10-30 minute again, obtained traditional Chinese medicine liquid like this;
Preferably, described Chinese medicine water 200-400 part was soaked 30-50 minute, decocted 10-20 minute again.
(4) take by weighing in 20-40 parts of weight portion Chinese liquor and join in the above-mentioned traditional Chinese medicine liquid, fully mix, obtain described medicine.
According to the pharmaceutical preparation general rule of Pharmacopoeia of the People's Republic of China defined, said medicine can be made pill, powder, tablet, syrup or capsular dosage form respectively.Medicine of the present invention can according to according to patient's body weight and disease condition with 50-400mg/ people. day administration, these dosage can natural gift be taken for 2-3 time, perhaps according to doctor's suggestion consumption administration.
[beneficial effect]
The present invention has following beneficial effect:
1, scientific formulation is reasonable, and its drug effect is not fully exerted, thereby makes short treating period, good effect, toxic and side effects to oral liquid few.
2, crude drug source is extensive, is very easy to gather or bought, and is economical and practical.
3, process is simple and easy to do can make various dosage forms, taking convenience.
[specific embodiment]
The invention will be further described for the following examples.These embodiment are not restrictive, but illustrative.
Embodiment 1
The syrup preparation
(1) takes by weighing in grey Zhu's 30 grams of weight portion, Radix Achyranthis Bidentatae 30 grams, Oletum Trogopterori 15 grams, the Cortex Eucommiae 30 grams, Semen pini koraiensis 30 grams, cold food face 15 grams, be mixed evenly;
(2) with Alumen 30 gram grind into powders, join in the above-mentioned medical material;
(3) the above-mentioned uniform Chinese crude drug water that is mixed soaked 50 minutes for 200 parts, decocted 15 minutes again, obtained extracts of Chinese herbal medicine after solid-liquid separation;
(4) take by weighing Chinese liquor 30 grams.
(5) in the extracts of Chinese herbal medicine that the Chinese liquor adding step (3) that step (4) is taken by weighing obtains, fully stir, dissolve, add 5 gram sucrose again, obtain syrup of the present invention.
Embodiment 2
The preparation of capsule
(1) takes by weighing grey Zhu's 25 grams, Radix Achyranthis Bidentatae 20 grams, Oletum Trogopterori 10 grams, the Cortex Eucommiae 20 grams, Semen pini koraiensis 30 grams, cold food face 10 grams, be mixed evenly;
(2) with Alumen 25 gram grind into powders, join in the above-mentioned medical material;
(3) the above-mentioned uniform Chinese crude drug water that is mixed soaked 40 minutes for 300 parts, decocted 15 minutes again, obtained extracts of Chinese herbal medicine after solid-liquid separation;
(4) take by weighing Chinese liquor 30 grams.
(5) in the extracts of Chinese herbal medicine that the Chinese liquor adding step (3) that step (4) is taken by weighing obtains, fully stir, dissolve, and then through being evaporated to the dried Chinese medicine medicated powder that obtains;
(6) behind important medicated powder that step (5) is obtained and 5 gram sucrose and the 5 gram starch mixings, reinstall in the polyethylene capsule capsule under obtaining.
Embodiment 3
The preparation of powder
(1) takes by weighing grey Zhu's 35 grams, Radix Achyranthis Bidentatae 25 grams, Alumen 30 grams, Oletum Trogopterori 15 grams, the Cortex Eucommiae 25 grams, Semen pini koraiensis 30 grams, cold food face 15 grams, be mixed evenly;
(2) with Alumen 30 gram grind into powders, join in the above-mentioned medical material;
(3) the above-mentioned uniform Chinese crude drug water that is mixed soaked 45 minutes for 250 parts, decocted 20 minutes again, obtained extracts of Chinese herbal medicine after solid-liquid separation;
(4) take by weighing Chinese liquor 25 grams.
(5) in the extracts of Chinese herbal medicine that the Chinese liquor adding step (3) that step (4) is taken by weighing obtains, fully stir, dissolve, and then through being evaporated to the dried Chinese medicine medicated powder that obtains; Make described powder.
Test example 1
Wang Junnan, 45 years old, married, Five Dragons people from town, Linzhou City, Henan Province.Medical history: frequent epigastrium pain, inappetence, dyspepsia is with pantothenic acid.After take syrup of the present invention, three times on the one, after adhering to taking 3 months, pain obviously alleviates, appetite strengthens, pantothenic acid obviously reduces.
Test example 2
Huang Yannv, 40 years old, married, Yuan Kang people from town, Linzhou City, Henan Province.Medical history: often pantothenic acid, feel sick, vomiting and with black stool.After take granule of the present invention, three times on the one, after adhering to taking 6 months, pantothenic acid, the symptom of feeling sick obviously alleviate, black stool reduces.
Claims (8)
1. medicine for the treatment of gastric cancer is characterized in that it is the medicine that the following weight proportion raw material is made:
20-40 parts of grey Zhu, 20-40 parts of Radix Achyranthis Bidentataes, 20-40 parts of Alumens, 5-25 parts of Oletum Trogopteroris, 20-40 parts of the Cortexs Eucommiae, 20-40 parts of Semen pini koraiensis, 5-25 parts in cold food face, 20-40 parts of Chinese liquor.
2. the medicine of treatment gastric cancer according to claim 1 is characterized in that the weight proportion of each raw material is:
25-35 parts of grey Zhu, 25-35 parts of Radix Achyranthis Bidentataes, 25-35 parts of Alumens, 10-20 parts of Oletum Trogopteroris, 25-35 parts of the Cortexs Eucommiae, 25-35 parts of Semen pini koraiensis, 10-20 parts in cold food face, 25-35 parts of Chinese liquor.
3. the medicine of treatment gastric cancer according to claim 1 is characterized in that the weight proportion of each raw material is:
30 parts of grey Zhu, 30 parts of Radix Achyranthis Bidentataes, 30 parts of Alumens, 15 parts of Oletum Trogopteroris, 30 parts of the Cortexs Eucommiae, 30 parts of Semen pini koraiensis, 15 parts in cold food face, 30 parts of Chinese liquor.
4. according to the medicine of claim 1,2,3 described treatment gastric cancer, it is characterized in that described medicine is a kind of pill, powder, tablet, syrup or capsular dosage form of being selected from.
5. the medicine of treatment gastric cancer according to claim 4 is characterized in that described medicine is a kind of pill, tablet, syrup or capsular dosage form of being selected from.
6. the medicine of treatment gastric cancer according to claim 4 is characterized in that described medicine is a kind of pill, tablet or capsular dosage form of being selected from.
7. the preparation method of the medicine of treatment gastric cancer according to claim 1 is characterized in that this method comprises the steps:
(1) takes by weighing in 20-40 parts of grey Zhu of weight portion, 20-40 parts of Radix Achyranthis Bidentataes, 5-25 parts of Oletum Trogopteroris, 20-40 parts of the Cortexs Eucommiae, 20-40 parts of Semen pini koraiensis, 5-25 parts in cold food face;
(2) take by weighing in 20-40 parts of grind into powders of weight portion Alumen, join in the above-mentioned medical material;
(3) these Chinese medicine waters 100-500 part was soaked 30-60 minute then, decocted 10-30 minute again, obtained traditional Chinese medicine liquid like this;
(4) take by weighing in 20-40 parts of weight portion Chinese liquor and join in the above-mentioned traditional Chinese medicine liquid, fully mix, obtain described medicine.
8. method according to claim 7 is characterized in that: used Chinese medicine water 200-400 part was soaked 30-50 minute, decocted 10-20 minute again.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101672886A CN101371909A (en) | 2008-10-20 | 2008-10-20 | Medicine for treating carcinoma of stomach and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101672886A CN101371909A (en) | 2008-10-20 | 2008-10-20 | Medicine for treating carcinoma of stomach and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN101371909A true CN101371909A (en) | 2009-02-25 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008101672886A Pending CN101371909A (en) | 2008-10-20 | 2008-10-20 | Medicine for treating carcinoma of stomach and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101862360A (en) * | 2010-05-25 | 2010-10-20 | 中国中医科学院中药研究所 | New application of achyranthes for preparing medicines for preventing and/or treating gastric precancerous lesion and gastric cancer |
-
2008
- 2008-10-20 CN CNA2008101672886A patent/CN101371909A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101862360A (en) * | 2010-05-25 | 2010-10-20 | 中国中医科学院中药研究所 | New application of achyranthes for preparing medicines for preventing and/or treating gastric precancerous lesion and gastric cancer |
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Open date: 20090225 |