CN101361865B - Medicinal preparation - Google Patents
Medicinal preparation Download PDFInfo
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- CN101361865B CN101361865B CN200810068924XA CN200810068924A CN101361865B CN 101361865 B CN101361865 B CN 101361865B CN 200810068924X A CN200810068924X A CN 200810068924XA CN 200810068924 A CN200810068924 A CN 200810068924A CN 101361865 B CN101361865 B CN 101361865B
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- asarum
- volatile oil
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Abstract
The invention discloses a pharmaceutical preparation for curing toothache and a preparation method thereof, pertaining to the medicine for curing toothache. The medical preparation is made from herba verbenae, rhizoma belamcandae, radices tinosporae, berberidis and asarum. The preparation method is that asarum naphtha is extracted by the method of water vapor distillation and the asarum residue after the extraction of the naphtha is mixed with the other four traditional Chinese medicines and extracted by the ethanol of 85percent to 95percent; the extracted concentrated liquid is mixed with the asarum naphtha for subsequent processes, or the extract is concentrated to obtain powdered extract and the asarum naphtha is sprayed on evenly with the powdered extract for subsequent processes; PVA, glycerin and flavoring agent are dissolved in water, the extracted concentrated liquid or the powdered extract is added to the solution to make strip medicines of 3 to 5 mm length which is then cut into segments according to single dosage, or make 3mm thick medicine sheet which is cut into small squares. The medical preparation has the functions of promoting blood flow and removing blood stasis, reducing fever and killing pain and can be used for curing the pain caused by periodontitis, endodontitis, periapicalitis and the like.
Description
Technical field: the present invention relates to treat the medicine of toothache, particularly a kind of pharmaceutical preparation of treating toothache and preparation method thereof.
Background technology: the acute toothache of traditional Chinese medical science indication comprises the pain that periodontitis, pulpitis, periapicalitis etc. cause; Be commonly encountered diseases and frequently-occurring disease; Though induce one to pay attention to unlike inside and outside, woman, pediatric disease that kind; But common saying say " having a toothache is not disease, ache what an awful nuisance " just image expression the misery brought to people of oral disease, directly influenced quality of life of patient.Data shows, " kind surplus the department of stomatology Chinese medicine preparation nearly approximately 30 that records of one one of Chinese pharmacopoeia and national standard is tincture, liniment on dosage form mostly, and like compound recipe Rhizoma et radix valerianae tincture, the compound recipe peaceful liniment of having a toothache of having a toothache, buccal tablet has dental caries buccal tablet and drop pill etc.; Because the restriction on the dosage form exists dosage wayward mostly, use the weakness on the dosage forms such as carrying trouble.
Summary of the invention: the object of the present invention is to provide a kind of pharmaceutical preparation of treating toothache and preparation method thereof, it is that a kind of medicament contg is accurate, has good stability the form of Chinese drug of convenient application treatment acute toothache.
Formation of the present invention: it is made up of Chinese medicine ingredients and adjuvant, and the raw material of wherein processing live part consists of Herba Verbenae 100～150g, Rhizoma Belamcandae 90～120g, Radix Tinosporae 90～120g, Radix Berberidis 90～120g, Herba Asari 30～50g; Adjuvant is: polyvinyl alcohol (PVA) 150～180g, glycerol 12～15mL, Fructus Citri Limoniae essence or flavoring orange essence 0～2%.
With the pulverizing medicinal materials of above-mentioned Chinese medicine ingredients, Herba Asari extracts volatile oil with steam distillation, has extracted medicinal residues and Herba Verbenae, Rhizoma Belamcandae, Radix Tinosporae, Radix Berberidis one behind the volatile oil and has reinstated 85～95% ethanol extraction 3 times; Each 6～8 times of amounts using the alcohol amount as the medical material amount; The each extraction 1 hour filtered, and filtrating merges; Be concentrated into medicinal liquid and medical material than being the small size of 1:2, subsequent use with the volatile oil mix homogeneously; Perhaps filtrating being concentrated into relative density is 1.12～1.18 fluid extract, and lyophilization or spray drying get dry extract, evenly are sprayed on the dry extract Herba Asari volatile oil subsequent use; Be dissolved in the water with polyvinyl alcohol (PVA), glycerol and flavoring agent, add and extract concentrated solution or dry extract, process the strip that diameter is 3～5mm, be cut into segment according to single dose; Or process the diaphragm of thick 3mm, and dice according to single dose, process buccal soluble pill.
Compare with prior art, the present invention is a kind of new-type traditional Chinese preparation, and characteristics are that medicine is dispersed in the moulding material, process the oral cavity buccal soluble pill; Directly be snapped at pain tooth position, through mucosa delivery, dosage is accurate; Rapid-action, no liver first-pass effect, bioavailability is high; It has promoting blood circulation to remove blood stasis, and the function of clearing away heat to alleviate pain is used to treat the pain that periodontitis, pulpitis, periapicalitis cause.
The specific embodiment: embodiment 1: Herba Verbenae 100g, Rhizoma Belamcandae 90g, Radix Tinosporae 90g, Radix Berberidis 90g, Herba Asari 30g are pulverized, and Herba Asari extracts volatile oil with steam distillation, has extracted medicinal residues and other four Chinese medicine one behind the volatile oil and has reinstated 85～95% ethanol extraction 3 times; Each 6～8 times of amounts using the alcohol amount as the medical material amount; The each extraction 1 hour filtered, and filtrating merges; Be concentrated into small size, subsequent use with the volatile oil mix homogeneously.Perhaps filtrating being concentrated into relative density is 1.12～1.18 fluid extract, and lyophilization or spray drying get dry extract, and Herba Asari volatile oil evenly is sprayed on the dry extract, and be subsequent use.Be dissolved in the water with PVA150g, glycerol 12ml and flavoring agent Fructus Citri Limoniae essence 1%, add and extract concentrated solution or extract powder, process the strip that diameter is 3～5mm, be cut into segment according to single dose; Or process the diaphragm of thick 3mm, and dice according to single dose, process buccal soluble pill.Method for using is contained between the pain tooth for pill is stung, because the saliva effect is dissolved, oral mucosa absorbs and produces drug effect.
Embodiment 2: Herba Verbenae 150g, Rhizoma Belamcandae 120g, Radix Tinosporae 120g, Radix Berberidis 120g, Herba Asari 50g are pulverized, and Herba Asari extracts volatile oil with steam distillation, has extracted medicinal residues and other four Chinese medicine one behind the volatile oil and has reinstated 85～95% ethanol extraction 3 times; Each 6～8 times of amounts using the alcohol amount as the medical material amount; The each extraction 1 hour filtered, and filtrating merges; Be concentrated into small size, subsequent use with the volatile oil mix homogeneously.Perhaps filtrating being concentrated into relative density is 1.12～1.18 fluid extract, and lyophilization or spray drying get dry extract, and Herba Asari volatile oil evenly is sprayed on the dry extract, and be subsequent use.Be dissolved in the water with PVA180g, glycerol 15ml and flavoring agent flavoring orange essence 2%, add and extract concentrated solution or extract powder, process the strip that diameter is 3～5mm, be cut into segment according to single dose; Or process the diaphragm of thick 3mm, and dice according to single dose, process buccal soluble pill.Method for using is contained between the pain tooth for pill is stung, because the saliva effect is dissolved, oral mucosa absorbs and produces drug effect.
Claims (1)
1. pharmaceutical preparation, it is characterized in that: it is made up of Chinese medicine ingredients and adjuvant, and the raw material of wherein processing live part consists of Herba Verbenae 100～150g, Rhizoma Belamcandae 90～120g, Radix Tinosporae 90～120g, Radix Berberidis 90～120g, Herba Asari 30～50g; Adjuvant is: polyvinyl alcohol (PVA) 150～180g, glycerol 12～15mL, flavoring agent Fructus Citri Limoniae essence or flavoring orange essence 0～2%, and with the pulverizing medicinal materials of above-mentioned Chinese medicine ingredients, Herba Asari extracts volatile oil with steam distillation; Extract medicinal residues and Herba Verbenae, Rhizoma Belamcandae, Radix Tinosporae, Radix Berberidis one behind the volatile oil and reinstated 85～95% ethanol extraction 3 times; Each 6～8 times of amounts using the alcohol amount as the medical material amount were extracted 1 hour at every turn, filtered; Filtrating merges; Be concentrated into medicinal liquid and medical material ratio and be 1: 2 small size, subsequent use with the volatile oil mix homogeneously, perhaps filtrating being concentrated into relative density is 1.12～1.18 fluid extract; Lyophilization or spray drying get dry extract, evenly are sprayed on the dry extract Herba Asari volatile oil subsequent use; Be dissolved in the water with polyvinyl alcohol (PVA), glycerol and flavoring agent, add and extract concentrated solution or dry extract, process the strip that diameter is 3～5mm, be cut into segment according to single dose; Or process the diaphragm of thick 3mm, and dice according to single dose, process buccal soluble pill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810068924XA CN101361865B (en) | 2008-09-24 | 2008-09-24 | Medicinal preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810068924XA CN101361865B (en) | 2008-09-24 | 2008-09-24 | Medicinal preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101361865A CN101361865A (en) | 2009-02-11 |
| CN101361865B true CN101361865B (en) | 2012-08-08 |
Family
ID=40388593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200810068924XA Expired - Fee Related CN101361865B (en) | 2008-09-24 | 2008-09-24 | Medicinal preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101361865B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101647904B (en) * | 2009-09-02 | 2011-02-02 | 李荣亮 | Medicine composition for treating periapicalitis |
| CN102258484B (en) * | 2010-05-26 | 2017-11-03 | 董玲 | A kind of lyophilized excipient containing Chinese medicine volatile ingredient |
| CN102895455B (en) * | 2012-11-09 | 2013-09-11 | 曹红娟 | Drug for treating periodontitis |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1106283A (en) * | 1994-09-11 | 1995-08-09 | 张敬梓 | Toothache cigarette |
| CN1178092A (en) * | 1996-06-01 | 1998-04-08 | 余内逊 | Touring pillow cup with multifunctions of medicinal magnet health-care refreshing and hypnotizing |
-
2008
- 2008-09-24 CN CN200810068924XA patent/CN101361865B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1106283A (en) * | 1994-09-11 | 1995-08-09 | 张敬梓 | Toothache cigarette |
| CN1178092A (en) * | 1996-06-01 | 1998-04-08 | 余内逊 | Touring pillow cup with multifunctions of medicinal magnet health-care refreshing and hypnotizing |
Non-Patent Citations (1)
| Title |
|---|
| 贵州省中医研究所.龋齿，方三.《贵州中草药验方选》.贵州人民出版社,1974,第238页. * |
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| Publication number | Publication date |
|---|---|
| CN101361865A (en) | 2009-02-11 |
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