CN101353686A - Production method of haemachrome and decolorizing blood plasma albumen powder - Google Patents
Production method of haemachrome and decolorizing blood plasma albumen powder Download PDFInfo
- Publication number
- CN101353686A CN101353686A CNA200810120963XA CN200810120963A CN101353686A CN 101353686 A CN101353686 A CN 101353686A CN A200810120963X A CNA200810120963X A CN A200810120963XA CN 200810120963 A CN200810120963 A CN 200810120963A CN 101353686 A CN101353686 A CN 101353686A
- Authority
- CN
- China
- Prior art keywords
- protoheme
- production method
- decolouring
- globulin powder
- enzymolysis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000843 powder Substances 0.000 title claims abstract description 31
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 14
- 210000002381 plasma Anatomy 0.000 title description 5
- 238000001556 precipitation Methods 0.000 claims abstract description 24
- 210000004369 blood Anatomy 0.000 claims abstract description 18
- 239000008280 blood Substances 0.000 claims abstract description 18
- 238000000034 method Methods 0.000 claims abstract description 18
- 238000001035 drying Methods 0.000 claims abstract description 14
- 238000002425 crystallisation Methods 0.000 claims abstract description 8
- 230000008025 crystallization Effects 0.000 claims abstract description 8
- 239000002994 raw material Substances 0.000 claims abstract description 6
- 102000001554 Hemoglobins Human genes 0.000 claims abstract description 3
- 108010054147 Hemoglobins Proteins 0.000 claims abstract description 3
- 238000003756 stirring Methods 0.000 claims description 33
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 28
- 239000000243 solution Substances 0.000 claims description 18
- 102000006395 Globulins Human genes 0.000 claims description 15
- 108010044091 Globulins Proteins 0.000 claims description 15
- 108091005804 Peptidases Proteins 0.000 claims description 15
- 102000035195 Peptidases Human genes 0.000 claims description 14
- 239000000706 filtrate Substances 0.000 claims description 10
- 239000000047 product Substances 0.000 claims description 10
- 230000001105 regulatory effect Effects 0.000 claims description 10
- 235000013305 food Nutrition 0.000 claims description 9
- 102000004190 Enzymes Human genes 0.000 claims description 8
- 108090000790 Enzymes Proteins 0.000 claims description 8
- 241001465754 Metazoa Species 0.000 claims description 8
- 239000004365 Protease Substances 0.000 claims description 7
- 210000000601 blood cell Anatomy 0.000 claims description 7
- 239000012141 concentrate Substances 0.000 claims description 7
- 239000000796 flavoring agent Substances 0.000 claims description 7
- 235000019634 flavors Nutrition 0.000 claims description 7
- 230000007062 hydrolysis Effects 0.000 claims description 6
- 238000006460 hydrolysis reaction Methods 0.000 claims description 6
- 230000002797 proteolythic effect Effects 0.000 claims description 6
- 244000144972 livestock Species 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- -1 polyoxyethylene Polymers 0.000 claims description 5
- 229920000136 polysorbate Polymers 0.000 claims description 5
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 3
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 3
- 210000002784 stomach Anatomy 0.000 claims description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 230000007935 neutral effect Effects 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 239000012460 protein solution Substances 0.000 claims description 2
- 238000012423 maintenance Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 abstract description 13
- 108090000623 proteins and genes Proteins 0.000 abstract description 13
- 239000006228 supernatant Substances 0.000 abstract description 9
- 102000018146 globin Human genes 0.000 abstract description 8
- 108060003196 globin Proteins 0.000 abstract description 8
- 239000000284 extract Substances 0.000 abstract description 4
- 238000011109 contamination Methods 0.000 abstract description 2
- 239000012535 impurity Substances 0.000 abstract description 2
- 244000144977 poultry Species 0.000 abstract description 2
- 239000002699 waste material Substances 0.000 abstract description 2
- 230000008021 deposition Effects 0.000 abstract 1
- 238000009776 industrial production Methods 0.000 abstract 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 18
- 238000001816 cooling Methods 0.000 description 10
- 238000009413 insulation Methods 0.000 description 9
- 230000000694 effects Effects 0.000 description 7
- 229940088598 enzyme Drugs 0.000 description 7
- 238000005507 spraying Methods 0.000 description 7
- 238000007710 freezing Methods 0.000 description 4
- 239000003960 organic solvent Substances 0.000 description 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 102000019197 Superoxide Dismutase Human genes 0.000 description 3
- 108010012715 Superoxide dismutase Proteins 0.000 description 3
- 239000013543 active substance Substances 0.000 description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 229940032362 superoxide dismutase Drugs 0.000 description 3
- RNMDNPCBIKJCQP-UHFFFAOYSA-N 5-nonyl-7-oxabicyclo[4.1.0]hepta-1,3,5-trien-2-ol Chemical compound C(CCCCCCCC)C1=C2C(=C(C=C1)O)O2 RNMDNPCBIKJCQP-UHFFFAOYSA-N 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 102000004506 Blood Proteins Human genes 0.000 description 2
- 108010017384 Blood Proteins Proteins 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 238000000975 co-precipitation Methods 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000007750 plasma spraying Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000000108 ultra-filtration Methods 0.000 description 2
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 241000272525 Anas platyrhynchos Species 0.000 description 1
- 241000271566 Aves Species 0.000 description 1
- 239000005996 Blood meal Substances 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 101000925662 Enterobacteria phage PRD1 Endolysin Proteins 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- DPDMMXDBJGCCQC-UHFFFAOYSA-N [Na].[Cl] Chemical compound [Na].[Cl] DPDMMXDBJGCCQC-UHFFFAOYSA-N 0.000 description 1
- 229960000583 acetic acid Drugs 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 235000013527 bean curd Nutrition 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000003749 cleanliness Effects 0.000 description 1
- IRXRGVFLQOSHOH-UHFFFAOYSA-L dipotassium;oxalate Chemical compound [K+].[K+].[O-]C(=O)C([O-])=O IRXRGVFLQOSHOH-UHFFFAOYSA-L 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 150000003278 haem Chemical group 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 235000008935 nutritious Nutrition 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 229940038773 trisodium citrate Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN200810120963XA CN101353686B (en) | 2008-09-09 | 2008-09-09 | Production method of haemachrome and decolorizing blood plasma albumen powder |
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CN200810120963XA CN101353686B (en) | 2008-09-09 | 2008-09-09 | Production method of haemachrome and decolorizing blood plasma albumen powder |
Publications (2)
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CN101353686A true CN101353686A (en) | 2009-01-28 |
CN101353686B CN101353686B (en) | 2011-09-21 |
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CN200810120963XA Expired - Fee Related CN101353686B (en) | 2008-09-09 | 2008-09-09 | Production method of haemachrome and decolorizing blood plasma albumen powder |
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Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102077901A (en) * | 2010-12-14 | 2011-06-01 | 成都宏安生物科技有限公司 | Swine hemoglobin enzymolysis and decoloration method |
CN102125164A (en) * | 2010-10-29 | 2011-07-20 | 成都天屹生物科技有限公司 | Preparation method of pig blood fibrin polypeptide powder |
CN103396418A (en) * | 2013-07-23 | 2013-11-20 | 甘肃农业大学 | Enzymatic preparation method of hemin by using dried yak blood as raw material |
CN104256199A (en) * | 2014-10-16 | 2015-01-07 | 浙江索纳克生物科技有限公司 | Loach feed added with porcine hemoglobin powder |
CN104256198A (en) * | 2014-10-16 | 2015-01-07 | 浙江索纳克生物科技有限公司 | Soft-shelled turtle feed with spray-dried pig blood cells added |
CN105385735A (en) * | 2015-11-25 | 2016-03-09 | 重庆三零三科技有限公司 | Preparation method of chicken blood antimicrobial peptide |
CN106107574A (en) * | 2016-08-11 | 2016-11-16 | 安徽省农业科学院农产品加工研究所 | A kind of preparation method of Sanguis sus domestica source compound microelement supplement |
CN106261817A (en) * | 2016-08-11 | 2017-01-04 | 安徽省农业科学院农产品加工研究所 | A kind of efficient enzymolysis Application way of Sanguis sus domestica |
CN106261816A (en) * | 2016-08-11 | 2017-01-04 | 安徽省农业科学院农产品加工研究所 | A kind of Sanguis sus domestica source iron supplementary intermediate and the preparation method of finished product thereof |
CN106554979A (en) * | 2016-11-18 | 2017-04-05 | 安徽菁硕科技有限公司 | A kind of method of the production haemachrome that combined with acid acetone extraction by enzymatic isolation method |
CN110183497A (en) * | 2019-07-17 | 2019-08-30 | 甘肃养泰和生物科技有限公司 | A method of purifying hemin from animal blood cell |
CN114592029A (en) * | 2022-03-09 | 2022-06-07 | 山西勰成生物科技有限公司 | Preparation method of fermented enzymatic decolorized hemoglobin |
CN115386000A (en) * | 2022-09-14 | 2022-11-25 | 江苏省农业科学院 | Method for preparing decolorized peptide and heme peptide from poultry blood cell processing byproducts |
CN117886826A (en) * | 2023-12-13 | 2024-04-16 | 甘肃养泰和生物科技有限公司 | Method for extracting methemoglobin by heating and pressurizing |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1188408C (en) * | 2000-12-28 | 2005-02-09 | 内蒙古草原兴发股份有限公司 | Process for extracting heme from animal blood |
CN100390175C (en) * | 2003-04-11 | 2008-05-28 | 王利忠 | Process for extracting and puritying haem |
CN100378103C (en) * | 2006-04-28 | 2008-04-02 | 新疆科丽生物技术有限公司 | Process for extracting protohemin by using surfactant |
CN100581377C (en) * | 2007-11-30 | 2010-01-20 | 华南理工大学 | Apocytochrome porcine hemoglobin hydrolyzates and protoheme peptide preparing method |
-
2008
- 2008-09-09 CN CN200810120963XA patent/CN101353686B/en not_active Expired - Fee Related
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102125164A (en) * | 2010-10-29 | 2011-07-20 | 成都天屹生物科技有限公司 | Preparation method of pig blood fibrin polypeptide powder |
CN102125164B (en) * | 2010-10-29 | 2013-08-28 | 成都天屹生物科技有限公司 | Preparation method of pig blood fibrin polypeptide powder |
CN102077901A (en) * | 2010-12-14 | 2011-06-01 | 成都宏安生物科技有限公司 | Swine hemoglobin enzymolysis and decoloration method |
CN102077901B (en) * | 2010-12-14 | 2013-04-24 | 成都宏安生物科技有限公司 | Swine hemoglobin enzymolysis and decoloration method |
CN103396418A (en) * | 2013-07-23 | 2013-11-20 | 甘肃农业大学 | Enzymatic preparation method of hemin by using dried yak blood as raw material |
CN104256199A (en) * | 2014-10-16 | 2015-01-07 | 浙江索纳克生物科技有限公司 | Loach feed added with porcine hemoglobin powder |
CN104256198A (en) * | 2014-10-16 | 2015-01-07 | 浙江索纳克生物科技有限公司 | Soft-shelled turtle feed with spray-dried pig blood cells added |
CN105385735A (en) * | 2015-11-25 | 2016-03-09 | 重庆三零三科技有限公司 | Preparation method of chicken blood antimicrobial peptide |
CN106107574A (en) * | 2016-08-11 | 2016-11-16 | 安徽省农业科学院农产品加工研究所 | A kind of preparation method of Sanguis sus domestica source compound microelement supplement |
CN106261817A (en) * | 2016-08-11 | 2017-01-04 | 安徽省农业科学院农产品加工研究所 | A kind of efficient enzymolysis Application way of Sanguis sus domestica |
CN106261816A (en) * | 2016-08-11 | 2017-01-04 | 安徽省农业科学院农产品加工研究所 | A kind of Sanguis sus domestica source iron supplementary intermediate and the preparation method of finished product thereof |
CN106554979A (en) * | 2016-11-18 | 2017-04-05 | 安徽菁硕科技有限公司 | A kind of method of the production haemachrome that combined with acid acetone extraction by enzymatic isolation method |
CN110183497A (en) * | 2019-07-17 | 2019-08-30 | 甘肃养泰和生物科技有限公司 | A method of purifying hemin from animal blood cell |
CN114592029A (en) * | 2022-03-09 | 2022-06-07 | 山西勰成生物科技有限公司 | Preparation method of fermented enzymatic decolorized hemoglobin |
CN115386000A (en) * | 2022-09-14 | 2022-11-25 | 江苏省农业科学院 | Method for preparing decolorized peptide and heme peptide from poultry blood cell processing byproducts |
CN117886826A (en) * | 2023-12-13 | 2024-04-16 | 甘肃养泰和生物科技有限公司 | Method for extracting methemoglobin by heating and pressurizing |
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Publication number | Publication date |
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CN101353686B (en) | 2011-09-21 |
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Owner name: FUSHUN DANYANG BIOTECHNOLOGY CO., LTD. Free format text: FORMER OWNER: ZHEJIANG UNIVERSITY Effective date: 20130123 |
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Effective date of registration: 20130123 Address after: 113109 Fushun City, Liaoning province Dongzhou District Pan Xiang Shi Fu Cun Patentee after: Fushun Danyang biological science and Technology Co Ltd Address before: 310027 Hangzhou, Zhejiang Province, Xihu District, Zhejiang Road, No. 38, No. Patentee before: Zhejiang University |
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Address after: 113109 Fushun City, Liaoning province Dongzhou District Pan Xiang Shi Fu Cun Patentee after: Danyang biological Polytron Technologies Inc of Fushun Address before: 113109 Fushun City, Liaoning province Dongzhou District Pan Xiang Shi Fu Cun Patentee before: Fushun Danyang biological science and Technology Co Ltd |
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