CN101343143A - Neutral boron silex glass for mold-formed bottle for storing and freezing biotic product, and method of manufacturing the same - Google Patents
Neutral boron silex glass for mold-formed bottle for storing and freezing biotic product, and method of manufacturing the same Download PDFInfo
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- CN101343143A CN101343143A CNA2008100458404A CN200810045840A CN101343143A CN 101343143 A CN101343143 A CN 101343143A CN A2008100458404 A CNA2008100458404 A CN A2008100458404A CN 200810045840 A CN200810045840 A CN 200810045840A CN 101343143 A CN101343143 A CN 101343143A
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Abstract
The invention discloses a neutral boron silicate glass of a mold-formed bottle storing freezing biological products as well as a production method thereof, which are characterized in that the glass is prepared by the following materials: quartz sand: aluminum hydroxide: borax: calcined soda: sodium nitrate: zinc oxide: calcite: fluorite: barium carbonate: compound clarifier =50-70: 3-6: 20-40: 1-2.5: 2-3.5: 0.5-1: 0.2-0.5: 0.2-1.0: 1.5-3.5: 0.3-1. The product includes constituents, in weight percentage: 72 to 73 percent of SiO2, 3.6 to 3.8 percent of Al2O3, 12 to 12.8 percent of B2O3, 0.7 to 1.0 percent of ZnO, 2.0 to 2.2 percent of BaO, 0.7 to 1.0 percent of CaO, and 6 to 7 percent of R2O, and the physicochemical properties of the glass include: no breakage under refrigeration at a temperature of -45+-2DEG C for twenty four hours, and no breakage when being positioned in water with a temperature of between 20 and 25DEG C after being positioned in a condition with a temperature of 121DEG C+-1DEG C for preserving heat for 60+-1min. The glass has advantages of excellent appearance quality, chemical stability, water resistance, freezing resistance, thermal shock resistance, acid and alkali resistance and strong corrosion resistance capacity, and can fully meet the packaging requirements of biological and blood products for refrigeration and autoclaving of medium and high grade drugs.
Description
Technical field
The present invention relates to a kind of glass and production method thereof, especially a kind of neutral borosilicate glass and production method thereof of storing the frozen biological products mold-formed bottle.
Background technology
As everyone knows, neutral borosilicate glass chemical property is stable, be difficult for and thing generation chemical reactions such as medicine, acid, alkali, can guarantee that store medication never degenerates, thereby it is included in the drug packaging preferred material by state food drug surveilance office, especially it is listed in the compulsory execution standard of some high-grade medicine of packing and biological refrigerated products.And neutral borosilicate glass infusion bottle YBB00022005-2 and neutral borosilicate glass molding injection bottle YBB00062005-2 standard have been formulated; because neutral borosilicate glass production technique and preparation of raw material complexity; production unit and manufacturing condition require harsh; overseas enterprise is to the monopolization of this technology in addition; the biological products that use on the present domestic market; injection; the packing bottle material of transfusion goods does not all reach the material requirement of neutral borosilicate glass; although developing a small amount of technical indicator in experimental study, the domestic people of having reaches neutral borosilicate glass requirement; but because in batching; production technique; each component content and anti-freezing in the finished product; there is more problem in aspects such as the heat-resisting sudden turn of events; be difficult to produce in batches; the neutral borosilicate glass large-scale production of the molded medicine bottle of present domestic saving frozen biological products still is in space state, required high-grade medicine and the main dependence on import of frozen biological products storage bottling.
Summary of the invention
The objective of the invention is to overcome the deficiencies in the prior art, provide a kind of physicochemical property stable, acid and alkali-resistance corrodes, cold-resistantly freeze, the heat-resisting sudden turn of events, be used to store the neutral borosilicate glass and the production method thereof of frozen biological products mold-formed bottle, purpose of the present invention realizes by following technical proposals: the present invention by following raw materials according component and weight ratio through prepare, found, moulding forms, preparation of raw material is; Quartz sand: aluminium hydroxide: borax: soda ash: SODIUMNITRATE: zinc oxide: calcite: fluorite: barium carbonate: compound clarifier=50～70: 3～6: 20～40: 1～2.5: 2～3.5: 0.5～1: 0.2～0.5: 0.2～1.0: 1.5～3.5: 0.3～1, said compound clarifier is to be a kind of NEW TYPE OF COMPOSITE finings based on cerium oxide.
Its concrete production method follows these steps to carry out:
1, selects materials: select purity, granularity, all satisfactory each raw material for standby of foreign matter content according to the desired raw material kind;
2, batch mixing: accurately take by weighing satisfactory each raw material, and each raw material thorough mixing is even, its uniformity coefficient＞98%;
3, found, clarify: with the raw material behind the mixing input to key position, easily the position of deteriorating is in two horse shoe flame kilns of Corhart Zac-block matter, defeated material takes each two minutes thin layer formula reinforced, each bed of material that adds is controlled in the 50mm, founds clarification under 1610 ℃ of conditions;
4, discharging and moulding: found the good glass metal of clarification through being provided with full separation autocontrol temperature system the material road and after stirring, to connecting material basin, insert moulding in the shaping mould of selecting as required by material road flash mouth again.
The weight percentage that stores the neutral borosilicate glass each component of frozen biological products mold-formed bottle by aforesaid method being used to of making is: SiO
272-73 Al
2O
33.6-3.8B
2O
312-12.8 ZnO0.7-1.0 BaO2.0-2.2 CaO0.7-1.0R
2O6-7.
Wherein R is a basic metal, and its physicochemical property is-45 ± 2 ℃ of freezing 24 hours crack-frees, and it inserts 20-25 ℃ of water crack-free after placing 121 ℃ ± 1 ℃ insulation 60 ± 1min.
The present invention is selected best composition prescription and reasonable, the easiest production technique, the every finger art of the neutral borosilicate glass index of producing has has all met or exceeded YBB00022005-2 and YBB00062005-2 standard, it is in-45 ± 2 ℃ of freezing 24 hours crack-frees, 121 ℃ ± 1 ℃ insulation 60 ± 1min venting back is taken out and is dropped into crack-free in the 20-25 ℃ of water immediately in pressure kettle, and each component concentration of the present invention is SiO after testing
272-73 Al
2O
33.6-3.8 B
2O
312-12.8 ZnO0.7-1.0BaO2.0-2.2 CaO0.7-1.0 R
2O6-7, the present invention has excellent visual appearance, excellent chemical stability, water tolerance, freezing-resistance, heat-resisting acute degeneration, antiacid, alkali and anti-erosional competency are strong, not only can satisfy the requirement of medium-to-high grade drug packing material fully, and can satisfy and need refrigeration and autoclaved biology, PACKAGE FOR BLOOD PRODUCTS requirement.Product of the present invention is mainly used in the splendid attire of biotechnological formulation, Blood Preparations, vaccine, special medicine, to improving China's pharmaceutical prod class, satisfy the great demand of numerous domestic scientific research, pharmacy corporation, promote China's drug packing material industry fast development, promote China's pharmaceutical industries to adapt to international practices, all will play an important role.
From above-mentioned situation as can be known, the objective of the invention is to realize.
Embodiment
Embodiment 1: get the raw materials ready by following material component and weight, through prepare, found, moulding forms, preparation of raw material is quartz sand 50kg aluminium hydroxide 4kg borax 35kg soda ash 1.5kg SODIUMNITRATE 2kg zinc oxide 0.5kg calcite 0.2kg fluorite 0.3kg barium carbonate 1.5kg compound clarifier 0.3kg.
Its concrete production method follows these steps to carry out:
1, selects materials: select purity, granularity, all satisfactory each raw material for standby of foreign matter content according to above-mentioned desired raw material kind; The SiO of quartz sand specifically
2〉=99%, aluminium hydroxide purity is more than 63.5%, and borax purity is more than 95%, and soda ash purity is more than 98%, and SODIUMNITRATE purity is more than 98%, and zinc oxide purity is more than 98%, calcite Ca0 〉=54%, Fe
2O
3≤ 0.05%, fluorite CaF
2〉=80%, Fe
2O
3≤ 0.2%, moisture content≤12%, barium carbonate purity is more than 97%, and each raw material granularity is the 20-200 order, and wherein the 20-160 order accounts for more than 80%, and 200 orders are following less than 50%.
2, batch mixing: accurately take by weighing satisfactory each raw material, and it is even that each raw material is merged thorough mixing; Its uniformity coefficient is not less than 98%.
3, found, clarify: the raw material behind the mixing is inputed in advanced two horse shoe flame heat exchange type kilns found, for avoiding and reducing the glass defect of bringing because of refractory quality, key position at kiln has adopted the extra best best Corhart Zac-block, for reducing the kiln heat leakage, whole kiln has been adopted multi-layer heat preserving, cause kiln temperature to be not less than 1610 ℃, guarantee the high temperature melting of compound, for preventing reinforced in heaps and the powder volatilization, guarantee the stable of admixtion quality, the automatically-monitored thermometric of multiple spot has been adopted at each position of kiln, guarantees that fully melting technology is stable, and defeated material takes regularly the thin layer formula reinforced, each two minutes, add the bed of material and be controlled at below the 50mm, under 1610 ℃ of conditions, melt, clarification, be glass clarifying and the cleaning after guaranteeing to found, it is the glass fining agent of important composition that the present invention has added with cerium oxide, and said glass fining agent can be YS-B1 type or YS-B2 type or any finings of YS-C type, and present embodiment is selected YS-B2 type finings for use.
4, discharging and moulding: found the good glass metal of clarification and be provided with the autocontrol temperature system of full separation and after stirring through supply channel, by the flash mouth to the basin that connects material, insert moulding in the shaping mould of selecting as required again, mould adopts parison mo(u)ld, Cheng Mo and mouthful mould of full surfacing, promote the manufacturing accuracy of mould, guaranteed all even good smooth finish of wall thickness of product.
Embodiment 2: get the raw materials ready by following material component and weight, through prepare, found, moulding forms preparation of raw material quartz sand 70kg aluminium hydroxide 6kg borax 20kg soda ash 2.5kg SODIUMNITRATE 3kg zinc oxide 1kg calcite 0.5kg fluorite 0.2kg barium carbonate 3.5kg compound clarifier 1kg.
Making method is with embodiment 1.
Embodiment 3: get the raw materials ready by following material component and weight, through prepare, found, moulding forms, preparation of raw material is quartz sand 60kg aluminium hydroxide 3kg borax 40kg soda ash 1kg SODIUMNITRATE 3.5kg zinc oxide 0.8kg calcite 0.4kg fluorite 1kg barium carbonate 3kg compound clarifier 0.6kg.
Making method is with embodiment 1.
Claims (3)
1, a kind of neutral borosilicate glass of storing the frozen biological products mold-formed bottle, it is characterized in that: the weight percentage of each component is SiO
27 2-73 Al
2O
33.6-3.8B
2O
312-12.8 ZnO 0.7-1.0 BaO 2.0-2.2 CaO 0.7-1.0R
2O 6-7
Wherein R is a basic metal, and its physicochemical property is-45 ± 2 ℃ of freezing 24 hours crack-frees, and it inserts 20-25 ℃ of water crack-free after placing 121 ℃ ± 1 ℃ insulation 60 ± 1min.
2, a kind of production method of storing the neutral borosilicate glass of frozen biological products mold-formed bottle, it is characterized in that by following raw materials according formulated, quartz sand: aluminium hydroxide: borax: soda ash: SODIUMNITRATE: zinc oxide: calcite: fluorite: barium carbonate: compound clarifier=50～70: 3～6: 20～40: 1～2.5: 2～3.5: 0.5～1: 0.2～0.5: 0.2～1.0: 1.5～3.5: 0.3～1.
3, according to the said a kind of production method of storing the neutral borosilicate glass of frozen biological products mold-formed bottle of claim 2, it is characterized in that: follow these steps to carry out
(1) selects materials: select purity, granularity, all satisfactory each raw material for standby of foreign matter content according to the desired raw material kind;
(2) batch mixing: accurately take by weighing satisfactory each raw material, and each raw material thorough mixing is even, its uniformity coefficient＞98%;
(3) found, clarify: with the raw material behind the mixing input to key position, easily the position of deteriorating is in two horse shoe flame kilns of Corhart Zac-block matter, defeated material takes each two minutes thin layer formula reinforced, each bed of material that adds is controlled in the 50mm, founds clarification under 1610 ℃ of conditions;
(4) discharging and moulding: found the good glass metal of clarification through being provided with full separation autocontrol temperature system the material road and after stirring, to connecting material basin, insert moulding in the shaping mould of selecting as required by material road flash mouth again.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100458404A CN101343143A (en) | 2008-08-18 | 2008-08-18 | Neutral boron silex glass for mold-formed bottle for storing and freezing biotic product, and method of manufacturing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100458404A CN101343143A (en) | 2008-08-18 | 2008-08-18 | Neutral boron silex glass for mold-formed bottle for storing and freezing biotic product, and method of manufacturing the same |
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| Publication Number | Publication Date |
|---|---|
| CN101343143A true CN101343143A (en) | 2009-01-14 |
Family
ID=40245283
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008100458404A Pending CN101343143A (en) | 2008-08-18 | 2008-08-18 | Neutral boron silex glass for mold-formed bottle for storing and freezing biotic product, and method of manufacturing the same |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103130415A (en) * | 2011-11-23 | 2013-06-05 | 四川天齐矿业有限责任公司 | Medical glass with spodumene |
| CN104926127A (en) * | 2015-06-17 | 2015-09-23 | 芮城县宏光医药包装业有限公司 | First grade water-fast pharmaceutical glass tube and preparation method |
| CN105271743A (en) * | 2015-10-19 | 2016-01-27 | 何书敏 | Formula and production method of pharmaceutical neutral borosilicate glass tube |
| CN110963708A (en) * | 2019-12-21 | 2020-04-07 | 山东省药用玻璃股份有限公司 | Small dose injection is with borosilicate glass injection bottle |
| CN112694254A (en) * | 2021-01-04 | 2021-04-23 | 河北光兴半导体技术有限公司 | Medium borosilicate glass composition, medium borosilicate glass, and preparation method and application thereof |
| CN117088612A (en) * | 2023-10-19 | 2023-11-21 | 山东金晶科技股份有限公司 | Neutral borosilicate glass medical tube and preparation method thereof |
-
2008
- 2008-08-18 CN CNA2008100458404A patent/CN101343143A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103130415A (en) * | 2011-11-23 | 2013-06-05 | 四川天齐矿业有限责任公司 | Medical glass with spodumene |
| CN103130415B (en) * | 2011-11-23 | 2015-06-17 | 成都天齐锂业有限公司 | Medical glass with spodumene |
| CN104926127A (en) * | 2015-06-17 | 2015-09-23 | 芮城县宏光医药包装业有限公司 | First grade water-fast pharmaceutical glass tube and preparation method |
| CN105271743A (en) * | 2015-10-19 | 2016-01-27 | 何书敏 | Formula and production method of pharmaceutical neutral borosilicate glass tube |
| CN110963708A (en) * | 2019-12-21 | 2020-04-07 | 山东省药用玻璃股份有限公司 | Small dose injection is with borosilicate glass injection bottle |
| CN112694254A (en) * | 2021-01-04 | 2021-04-23 | 河北光兴半导体技术有限公司 | Medium borosilicate glass composition, medium borosilicate glass, and preparation method and application thereof |
| CN117088612A (en) * | 2023-10-19 | 2023-11-21 | 山东金晶科技股份有限公司 | Neutral borosilicate glass medical tube and preparation method thereof |
| CN117088612B (en) * | 2023-10-19 | 2024-01-05 | 山东金晶科技股份有限公司 | Neutral borosilicate glass medical tube and preparation method thereof |
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Open date: 20090114 |