CN101342170A - Application of Xinjiang radix macrotomiae for treating flat wart, common wart and fig wart - Google Patents
Application of Xinjiang radix macrotomiae for treating flat wart, common wart and fig wart Download PDFInfo
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- CN101342170A CN101342170A CNA2007101372393A CN200710137239A CN101342170A CN 101342170 A CN101342170 A CN 101342170A CN A2007101372393 A CNA2007101372393 A CN A2007101372393A CN 200710137239 A CN200710137239 A CN 200710137239A CN 101342170 A CN101342170 A CN 101342170A
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Abstract
The invention discloses paste, emulsifiable paste and liquid medicine used for treating verrucous diseases including verruca plana, verruca vulgaris, condyloma acuminata, verruca plantaris, verruca filiformis, verruca digitalis and periungual wart, etc. Fat-soluble naphthoquinone alkannin, the effective component of radix macrotomiae, is adopted as the core of the invention. The fat-soluble naphthoquinone alkannin has an effect on anti-HPV. The main components of prescription by mass percent are as follows: 0.05 to 1.2 percent of the naphthoquinone alkannin, 0.2 to 0.8 percent of allantoin, 0.1 to 2 percent of Vitamin E, emulsifier and humectant, and the like, which constitute the paste, the emulsifiable paste and the liquid medicine. A test proves that the invention can treat the various verrucous diseases, including the verruca plana, the verruca vulgaris, the condyloma acuminata, the verruca plantaris, the verruca filiformis, the verruca digitalis and the periungual wart, and the like, and a curative effect is over 86 percent, so the invention is good medicine for treating the various verrucous diseases without any adverse reaction. The medicine with the high content of the naphthoquinone alkannin treats the condyloma acuminata best and has an effect on diminishing the inflammation of a hurt on an afflicted part, thus sterilizing the hurt and stimulating the healing of the hurt without leaving a scar.
Description
Technical field:
The present invention relates to a kind of medicament under the technical field of Chinese medicines, belong to the external-applied ointment, emulsifiable paste, medicinal liquid, washing liquid of wart class diseases such as treatment verruca plana, verruca vulgaris, condyloma acuminatum, plantar wart, verruca filiformis, verruca digitalis, periungual wart etc.
Background technology:
Flat Verrucosis is a kind of viral dermatosis, and the traditional Chinese medical science claims " verruca plana ", and its pathogen is the same with verruca vulgaris, is to infect the skin vegetations that causes by human papilloma virus HPV3 and HPV5.Verruca plana is sent out in teenager well, claims flat wart again.Be mainly in face, the back of the hand and forearm etc. and locate, show as normal color of the leather or light brown, about 2～4mm diameter or the big slightly flat pimple of circle, ellipse or polygon, smooth surface, boundary is obvious.General no conscious sympton or idol have little itching.Verruca plana is that viral infection causes, and has certain infectiousness, sometimes owing to scratch virus inoculation in proximate skin, is the wire that distributes along scratch and arranges, and the autoinoculation expansion increases by scratching.But the mutual transmission capacity in the crowd is more weak, and daily contact can not infect.If but the skin of oneself has the damaged skin lesion cut place that touches the patient again, can be infectious.Primary disease is not propagated by sexual behaviour, need not isolate yet.
Condyloma acuminatum (Condyloma acuminata) CA claims sharp Gui condyloma latum, genital wart (pudendum wart), genital wart again.Because the extension of sexually transmitted disease (STD) constantly enlarges, this disease is acknowledged as sexually transmitted disease (STD), also is one of modal sexually transmitted disease (STD) of modern society in recent years.The pathogen of primary disease is human papillomavirus (HPV).Belong to DNA viruses.On the stratified squamous epithelium of human body skin and mucosa HPV only-host, as yet in In vitro culture success.The virion diameter is 50～55nm.This is very little, and general optical microscope can not be seen, only just can see by ultramicroscope.The type of human papillomavirus is a lot, Protocols in Molecular Biology research and development in recent years is rapid, confirm that human papillomavirus has the antigenic type more than 130 kinds, be that more than 130 similar and don't virus (hypotype) is together arranged in this family, wherein have at least 10 types relevant with condyloma acuminatum (as 6,11,16,18 and 33 types, the most common 6,11 types), and the 11st, 16,18 types then are the most popular virokines of external research at present cervical cancer, carcinoma vulvae even carcinoma of penis, and its long-term infection is relevant with the generation of women's cervical cancer.Condyloma acuminatum and verruca vulgaris, verruca plana, verruca filiformis, palmoplantar verruca etc. are all infection human papillomavirus (HPV) and cause.But dissimilar HPV can cause different warts.Mainly cause palmoplantar verruca as the I type, the II type mainly causes verruca vulgaris, and the III type mainly causes verruca plana, and condyloma acuminatum is caused by VI type, XI type viral infection.HPV especially easily existence propagation in the environment of warm moist is so the amphoteric external genitalia of men and women is the most susceptible position.But the virus autoinoculation, the infringement that therefore betides positions such as anus often comes across the contact both sides face.
My company for many years, find from the research of Chinese medicine Xinjiang Radix Arnebiae with producing, the fat-soluble naphthoquinones shikonin of the effective ingredient that from the Radix Arnebiae of Xinjiang, extracts, very strong antiviral, antitumor action are arranged, we further further investigate, test with naphthoquinones shikonin verruca plana, verruca vulgaris, condyloma acuminatum etc. are tested on this basis, find that naphthoquinones shikonin has better curative effect to above-mentioned disease.
Summary of the invention:
The Xinjiang Radix Arnebiae is a Boraginaceae Radix Arnebiae platymiscium, belongs to ancient plant population, is perennial herb, can root turion is numerous plants seminal propagation.Medicinal part is underground aubergine root.It has the function of heat-clearing and toxic substances removing, antibiotic, antiinflammatory, sterilization, antiviral, laxation relieving constipation.Can prevent and treat diseases such as measles, jaundice, purple abdominal mass, haematemesis, hematuria, dysentery, stranguria with turbid discharge, sore, painting, eczema, burn and scald, constipation with heat retention, also have effects such as resisiting influenza virus, hepatitis virus resisting, antitumor.Extensively used in pharmaceuticals industry.Fat-soluble " naphthoquinones shikonin " that extracts in the Radix Arnebiae (Radix Lithospermi) takes on a red color, aubergine, the medicine active ingredient " naphthoquinones shikonin " that it mainly contains Radix Arnebiae (Radix Lithospermi) is respectively: deoxyshikonin, β, β '-dimethyl allene acyl A Kaning, acetylshikonin, β-acetoxyl group isovaleryl A Kaning, shikonin, beta-hydroxy isovaleryl A Kaning etc.They are the active ingredient of Radix Arnebiae medicine, are again natural plant pigments.The content of naphthoquinones shikonin in Radix Arnebiae (Radix Lithospermi) is about 3%.
The present invention is according to pharmacological action of above-mentioned Chinese medicine Radix Arnebiae (Radix Lithospermi) and our years of researches and tests and find that particularly the Radix Arnebiae extract naphthoquinones shikonin also has growth, the healing of acceleration of wound mouth, antiinflammatory, the sterilization, anticorrosion that promotes the granulation cell. effects such as antiallergic, antiviral, antioxidation.
We have antiviral, antineoplastic characteristic at naphthoquinones shikonin, and verruca plana, verruca vulgaris, condyloma acuminatum are all and infect that human papillomavirus (HPV) causes; Further investigation, test have been carried out, we find that naphthoquinones shikonin has good therapeutic effect to above-mentioned disease, this explanation naphthoquinones shikonin has the effect of anti-human papillomavirus (HPV), can treat wart class diseases such as verruca plana, verruca vulgaris, condyloma acuminatum, plantar wart, verruca filiformis, verruca digitalis, periungual wart.
The present invention's " the Xinjiang Radix Arnebiae is used for the treatment of the application of verruca plana, verruca vulgaris, condyloma acuminatum ": be with organic solvents such as ethanol, normal hexane from Radix Arnebiae (Radix Lithospermi)s such as Xinjiang Radix Arnebiae, gromwell root, Yunnan Radix Arnebiae (Radix Lithospermi), extract, concentrate, the medicine active ingredient fat-soluble " naphthoquinones shikonin " of purification, the refining Radix Arnebiae (Radix Lithospermi) of obtaining is as the core of the present invention " anti-human papillomavirus (HPV) ".Main component by mass percentage in this prescription: naphthoquinones shikonin 0.05%-1.2%, allantoin 0.2-0.8%, vitamin E 0.1-2%; A kind of external-applied ointment, emulsifiable paste, medicinal liquid, the washing liquid that also have oil such as vaseline, squalane, Cera Flava, microwax, emulsifying agent, wetting agent, ester, fat, wax to form.
The content of the naphthoquinones shikonin among the present invention's " the Xinjiang Radix Arnebiae is used for the treatment of the application of verruca plana, verruca vulgaris, condyloma acuminatum " is to find through test, when content just has therapeutical effect, therapeutic effect to strengthen with the increase of naphthoquinones shikonin content to verruca plana, verruca vulgaris, condyloma acuminatum etc. 0.05% the time; When content is increased to 1% when above, therapeutic effect does not then have obvious enhancing; When content 1.2% the time, skin is easy to become purple and Lan Se in the use.Therefore the naphthoquinones shikonin content among the present invention is fixed in the scope of 0.05%-1.2%.
The present invention's " the Xinjiang Radix Arnebiae is used for the treatment of the application of verruca plana, verruca vulgaris, condyloma acuminatum " can treat wart class diseases such as verruca plana, verruca vulgaris, condyloma acuminatum, plantar wart, verruca filiformis, verruca digitalis, periungual wart etc. through evidence.And having has anti-inflammation and sterilization, promotes wound healing, the effect of preventing from scar the affected part wound.
The specific embodiment:
Allantoin among following each embodiment extracts from the Radix Arnebiae of Xinjiang and obtains.
Embodiment 1
Xinjiang Radix Arnebiae extract for treating verruca plana, verruca vulgaris, condyloma acuminatum medical ointment prescription 1 (by mass percentage)
Naphthoquinones shikonin 0.08%, allantoin 0.5%, vitamin E 1.1%, vaseline 25%, squalane 15%, iso-octyl palmitate 15%, GTCC18%, Cera Flava 15%, microwax 10%, wetting agent 0.3%.
Preparation method: above-mentioned various oil, ester, fat, wax stock are stirred sterilization in 30 minutes by ℃ mixing of the accurate weighing post-heating to 95 of prescription, add the naphthoquinones shikonin intimate mixing in the time of 85 ℃, carry out moulding, freezing, molding after filtering, the ointment body that will be " light rose " the special-purpose container inner packing of packing into gets product well.
Using method: at first the wart body is punctured with sterile pin; Can allow naphthoquinones shikonin fully contact the wart inside and outside like this and reach the effect of thoroughly killing human papillomavirus (HPV).Can screw out the precession ointment then and smear the skin affected part.
Embodiment 2
Xinjiang Radix Arnebiae extract for treating verruca plana, verruca vulgaris, condyloma acuminatum medical ointment prescription 2 (by mass percentage)
Naphthoquinones shikonin 0.1%, allantoin 0.5%, vitamin E 1.1%, vaseline 25%, squalane 15%, iso-octyl palmitate 15%, GTCC18%, Cera Flava 15%, microwax 10%, wetting agent 0.3%.
Preparation method: above-mentioned various oil, ester, fat, wax stock are stirred sterilization in 30 minutes by ℃ mixing of the accurate weighing post-heating to 95 of prescription, add the naphthoquinones shikonin intimate mixing in the time of 85 ℃, carry out moulding, freezing, molding after filtering, the ointment body that will be " light rose " the special-purpose container inner packing of packing into gets product well.
Using method: at first the wart body is punctured with sterile pin; Can allow naphthoquinones shikonin fully contact the wart inside and outside like this and reach the effect of thoroughly killing human papillomavirus (HPV).Can screw out the precession ointment then and smear the skin affected part.
Use proof embodiment 2 more quite a lot of through test and actual clinical, but therapeutic effect is not very obvious than the therapeutical effect of 1 pair of verruca plana of embodiment, verruca vulgaris, condyloma acuminatum.
Embodiment 3
Xinjiang Radix Arnebiae extract for treating verruca plana, verruca vulgaris, pointed condyloma (soft) paste formulation 3 (by mass percentage)
Naphthoquinones shikonin 0.3%, allantoin 0.5%, vitamin E 1%, vaseline 35%, squalane 20%, iso-octyl palmitate 16%, GTCC22%, Cera Flava 5%, wetting agent 0.2%.
Preparation method: above-mentioned various oil, ester, fat, wax stock are stirred sterilization in 30 minutes by ℃ mixing of the accurate weighing post-heating to 95 of prescription, in the time of 85 ℃, add the naphthoquinones shikonin intimate mixing, cool off after filtering, will be " light rose " ointment canned in bottle or the flexible pipe inner packing get product well.
Using method: at first the wart body is punctured with sterile pin; Can allow naphthoquinones shikonin fully contact the wart inside and outside like this and reach the effect of thoroughly killing human papillomavirus (HPV).Ointment can be smeared the skin affected part then.
Embodiment 4
Xinjiang Radix Arnebiae extract for treating verruca plana, verruca vulgaris, pointed condyloma (soft) paste formulation 4 (by mass percentage)
Naphthoquinones shikonin 0.6%, allantoin 0.5%, vitamin E 1%, vaseline 36.7%, squalane 20%, iso-octyl palmitate 16%, GTCC 20%, Cera Flava 5%, wetting agent 0.2%.
Preparation method: above-mentioned various oil, ester, fat, wax stock are stirred sterilization in 30 minutes by ℃ mixing of the accurate weighing post-heating to 95 of prescription, in the time of 85 ℃, add the naphthoquinones shikonin intimate mixing, cool off after filtering, will be " light rose " ointment canned in bottle or the flexible pipe inner packing get product well.。
Using method: at first the wart body is punctured with sterile pin; Can allow naphthoquinones shikonin fully contact the wart inside and outside like this and reach the effect of thoroughly killing human papillomavirus (HPV).Ointment can be smeared the skin affected part then.
The therapeutic effect that use to prove embodiment 3 and 4 pairs of verruca plana of embodiment, verruca vulgaris, condyloma acuminatum through test and actual clinical is all very obvious; Embodiment 4 is more quite a lot of than the therapeutical effect of embodiment 3; 4 pairs of condyloma acuminatum cases of embodiment therapeutic effect is obvious.
Embodiment 5
Xinjiang Radix Arnebiae extract for treating verruca plana, verruca vulgaris, condyloma acuminatum liquid formula 5 (by mass percentage)
Naphthoquinones shikonin 0.4%, allantoin 0.5%, vitamin E 1%, transparent vaseline 25%, squalane 25%, iso-octyl palmitate 20%, GTCC 22%, Cera Flava 2%, microwax 4%, wetting agent 0.2%.
Preparation method: above-mentioned various oil, ester, fat, wax stock ℃ are mixed by the accurate weighing post-heating to 95 of prescription stir sterilization in 30 minutes, in the time of 85 ℃, add the naphthoquinones shikonin intimate mixing, be the sticky medicinal liquid of " light rose " after being cooled to room temperature after filtering.Can cannedly get product well to the bottle inner packing that has ball or little brush.
Using method: at first the wart body is punctured with sterile pin; Can allow naphthoquinones shikonin fully contact the wart inside and outside like this and reach the effect of thoroughly killing human papillomavirus (HPV).Available then medicinal liquid smears the skin affected part.
Embodiment 5 is the thick liquid shape, and drug effect is identical with above-mentioned example, just smears the difference of mode.
Embodiment 6
Xinjiang Radix Arnebiae extract for treating verruca plana, verruca vulgaris, condyloma acuminatum medicinal liquid (water) prescription 6 (by mass percentage)
Naphthoquinones shikonin 0.5%, allantoin 0.5%, vitamin E 1%, squalane 3%, wetting agent 0.2%, bulking agent 9%, distilled water 86%.
Preparation method: after respectively above-mentioned various (oil, ester, bulking agents), (distilled water) raw material being pressed the accurate weighing of prescription, be heated to 75 ℃ respectively and mix stirring sterilization in 30 minutes, after in the time of 65 ℃, adding naphthoquinones shikonin intimate mixing, filtration, add the water preparation medicinal liquid that the distilled water intimate mixing is cooled to be behind the room temperature " light rose " again.Can cannedly get product well to the bottle inner packing that has ball or little brush.
Using method: a, at first the wart body is punctured with sterile pin; Can allow naphthoquinones shikonin fully contact the wart inside and outside like this and get to the effect of killing human papillomavirus (HPV).Available then medicinal liquid smears the skin affected part.
B, this medicinal liquid is added 30% water be made into washing liquid, can clean the skin affected part, also can reach the effect of treatment.
Embodiment 6 is the water preparation medicinal liquid, and drug effect is identical with above-mentioned example, just the difference of occupation mode.
Embodiment 7
Xinjiang Radix Arnebiae extract for treating verruca plana, verruca vulgaris, condyloma acuminatum cream formulation 7 (by mass percentage)
Naphthoquinones shikonin 0.5%, allantoin 0.5%, vitamin E 1%, transparent vaseline 8%, squalane 10%, %, Cera Flava 2%, emulsifying agent 5%, wetting agent 0.2%, distilled water 76%.
Preparation method: respectively with above-mentioned various (oil, ester, fat, wax, naphthoquinones shikonin, emulsifying agents) and (distilled water, wetting agent) raw material by the accurate weighing of prescription after, be heated to 85 ℃ respectively and mix stir sterilization in 30 minutes, biphase mixing emulsifying in the time of 85 ℃, be the emulsifiable paste of " light redness " after being cooled to room temperature profit.Can be canned in bottle or the flexible pipe inner packing get product well.
Using method: at first the wart body is punctured with sterile pin; Can allow naphthoquinones shikonin fully contact the effect that wart inside and outside water preparation medicinal liquid is killed human papillomavirus (HPV) like this.Available then emulsifiable paste smears the skin affected part.
Embodiment 6 is an emulsifiable paste, and drug effect is identical with above-mentioned example, just the difference of dosage form.
We have all done clinical trial above-mentioned each example, and result of the test shows that naphthoquinones shikonin has the effect of anti-human papillomavirus (HPV), and each test group all has evident difference with contrast, and therapeutic effect is all very obvious, does not find any untoward reaction; Wart class treatment of diseases effects such as 3,4,5,6,7 pairs of verruca plana of embodiment, verruca vulgaris, condyloma acuminatum, plantar wart, verruca filiformis, verruca digitalis, periungual wart are the good medicine of the various wart class of extraordinary treatment disease more than 86%; The medicine that naphthoquinones shikonin content is high is best to the therapeutic effect of condyloma acuminatum.And having has anti-inflammation and sterilization, promotes wound healing, the effect of preventing from scar the affected part wound.
Claims (4)
1, " the Xinjiang Radix Arnebiae is used for the treatment of the application of verruca plana, verruca vulgaris, condyloma acuminatum " is to use " naphthoquinones shikonin has the effect of anti-human papillomavirus (HPV) " as the core of product, is used for the treatment of a kind of medicine for external use of wart class diseases such as verruca plana, verruca vulgaris, condyloma acuminatum, plantar wart, verruca filiformis, verruca digitalis, periungual wart.It is characterized in that: the prescription main component by mass percentage: naphthoquinones shikonin 0.05%-1.2%, allantoin 0.2-0.8%, vitamin E 0.1-2%.
2, according to claim 1, it is characterized in that: the medicine active ingredient of Radix Arnebiae (Radix Lithospermi)-fat-soluble naphthoquinones shikonin has the effect of anti-human papillomavirus (HPV).
3, according to claim 1, it is characterized in that: be a kind of external-applied ointment that is used for the treatment of wart class diseases such as verruca plana, verruca vulgaris, condyloma acuminatum, plantar wart, verruca filiformis, verruca digitalis, periungual wart, emulsifiable paste, medicinal liquid, washing liquid etc.
4, according to claim 1, it is characterized in that: the medicine active ingredient of Radix Arnebiae (Radix Lithospermi) is fat-soluble naphthoquinones shikonin, fat-soluble naphthoquinones shikonin in the prescription can be deoxyshikonin, β, any or any composition more than 2 kinds of naphthoquinones shikonin such as β '-dimethyl allene acyl A Kaning, acetylshikonin, β-acetoxyl group isovaleryl A Kaning, shikonin, beta-hydroxy isovaleryl A Kaning.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007101372393A CN101342170A (en) | 2007-07-14 | 2007-07-14 | Application of Xinjiang radix macrotomiae for treating flat wart, common wart and fig wart |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2007101372393A CN101342170A (en) | 2007-07-14 | 2007-07-14 | Application of Xinjiang radix macrotomiae for treating flat wart, common wart and fig wart |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012052956A1 (en) * | 2010-10-21 | 2012-04-26 | Huegin Ambros | Methods and compositions for treating pox virus infections with an 1, 4 -naphthoquinone as active agent |
| CN105622374A (en) * | 2016-03-02 | 2016-06-01 | 山东省分析测试中心 | Method for separating and preparing compound with neuraminidase inhibitory activity from radix lithospermi |
| KR101709732B1 (en) * | 2015-10-30 | 2017-02-23 | 한국과학기술연구원 | Composition for healing wound or treating scar comprising deoxyshikonin |
-
2007
- 2007-07-14 CN CNA2007101372393A patent/CN101342170A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012052956A1 (en) * | 2010-10-21 | 2012-04-26 | Huegin Ambros | Methods and compositions for treating pox virus infections with an 1, 4 -naphthoquinone as active agent |
| KR101709732B1 (en) * | 2015-10-30 | 2017-02-23 | 한국과학기술연구원 | Composition for healing wound or treating scar comprising deoxyshikonin |
| CN105622374A (en) * | 2016-03-02 | 2016-06-01 | 山东省分析测试中心 | Method for separating and preparing compound with neuraminidase inhibitory activity from radix lithospermi |
| CN105622374B (en) * | 2016-03-02 | 2018-04-17 | 山东省分析测试中心 | A kind of method that separation prepares the compound with neuraminic acid enzyme inhibition activity from Asian puccoon |
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Open date: 20090114 |