CN101333203A - Method for extracting dihydroquercetin form larch - Google Patents
Method for extracting dihydroquercetin form larch Download PDFInfo
- Publication number
- CN101333203A CN101333203A CNA2007100724357A CN200710072435A CN101333203A CN 101333203 A CN101333203 A CN 101333203A CN A2007100724357 A CNA2007100724357 A CN A2007100724357A CN 200710072435 A CN200710072435 A CN 200710072435A CN 101333203 A CN101333203 A CN 101333203A
- Authority
- CN
- China
- Prior art keywords
- tamarack
- dihydro quercetin
- extraction
- quercetin
- dihydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Disclosed is a method for extracting dihydro quercetin from larch. The invention is an improved production method. Due to different production materials and extraction processes, the dihydro quercetin products in U.S. and European markets are very expensive, at a price of 200-1000 euros per gram. Such a high market price economically limits the wide range of practicability of dihydro quercetin products. During the pretreatment of raw materials, 50 kilograms of larch wood chips and 500-800 liters of 50% ethanol solution are added into a reactor to get fully stirred and mixed; then the mixture is extracted and filtered for the second extraction; the filtrates are combined and adsorbed; the organic solvents are collected and dried by a vacuum evaporator through organic phase vacuum distillation; according to a weight proportion of 10:1, the residues are dissolved with hot water, decolorized with activated carbon and then crystallized at a temperature of 3-5 DEG C to precipitate the dihydro quercetin product which is then crushed after vacuum drying to finished product. The invention is used to extract dihydro quercetin from larch.
Description
Technical field:
The present invention relates to the improvement of the method for extraction dihydro Quercetin in a kind of tamarack.
Background technology:
Dihydro Quercetin (taxifolin) belongs to Vitamin P complex (bioflavonoids) vitamer P.Also claim taxifolin, Taxifolin, taxifolin.[dihydroquercetin; 2-(3,4-dihydroxypheny1)-2,3-dihydro-3,5,7-trihydroxy-4H-denzopyran-4-one], molecular formula: C
15H
12O
7, molecular mass: 304.3.
The dihydro Quercetin is the Nobelist, and biologist Sheng Jieerji finds, tamarack extract dihydro Quercetin, fine particle crystallization or unformed sprills are white in color, faint yellow, free from extraneous odour, no special taste is natural antioxidant, has multiple biological activity.Along with continually developing of new variety, the dihydro Quercetin has been applied to fields such as medicine, food, makeup, industry, agricultural plant growth adjusting.
As seen the application of dihydro Quercetin is very extensive, but because the difference of raw materials for production, extraction process is very expensive in American-European market dihydro Quercetin product price, 200-1000 Euro of every gram.Such market value has limited its practicality widely economically.As to select tamarack for use be extraction feed, adopts this technology to extract, and will reduce its production cost significantly, about 0.5 Euro of every gram.
Summary of the invention:
It is extraction feed that the present invention selects tamarack for use, and swirling effect and the heat effect of utilizing reactor pressure, temperature to produce are quickened dihydro Quercetin diffusion dissolution.
Above-mentioned purpose realizes by following technical scheme:
The method of extraction dihydro Quercetin in a kind of tamarack, it is characterized in that: raw materials pretreatment, getting tamarack wood chip and ethanolic soln joins in the reactor and fully mixes, both add-ons are 50 kilograms of tamarack wood chips, 500～800 liters of 50% ethanolic solns, extract, carrying out the second time after the filtration extracts, merging filtrate, organic solution is collected in absorption, extremely do with vacuum-evaporator underpressure distillation organic phase, used hot water dissolving's residue in 10: 1 by weight, and used activated carbon decolorizing, crystallization under 3-5 ℃ of temperature, separate out dihydro Quercetin product, again through vacuum-drying, pulverize and be finished product.
The method of extraction dihydro Quercetin in a kind of tamarack, it is characterized in that: described being extracted as soaked 1 hour, stirred betwixt twice, each 10 minutes, begin to be warmed to 65-75 ℃ then, constant temperature kept 1 hour, restir twice betwixt, and each 10 minutes, the off-response still.
The method of extraction dihydro Quercetin in a kind of tamarack, it is characterized in that: described absorption is under temperature 30-40 ℃ condition, adsorbs twice with methyl tertiary butyl ether and filtrate by 1: 10, the time is 1 hour.
The method of extraction dihydro Quercetin in a kind of tamarack, it is characterized in that: described raw materials pretreatment is to select tamarack rhizome part, raw material saw section, wood chip is processed in peeling.
This technical scheme has following beneficial effect:
1. the dihydro Quercetin of present method preparation is natural antioxidant, can eliminate the free radical of human body, and anti-ageing, radioprotective, antiviral suppresses cell and produces pathology, aging generation, the evolution that reaches various diseases of block cell.Free radical is degenerated disease ground roots such as initiation is old and feeble, cardiovascular, tumour.Carcinogens such as physics and chemistry make and produce free radical in the body, combine in the lipid cytolemma around, cause lipid peroxidation.The DNA that makes cell is damaged and is carcinogenic.The necessary enzyme system protein kinase C but dihydro Quercetin anticancer is grown has blocked the sick cell increment, simultaneously anticancer DNA synthetic activation factor.Also powerful to mdr cell, improve coronary artery blood flow, strengthen convergent force, the irritability of cardiac muscle, treatment ischemic heart disease, stenocardia, arrhythmia, myocardial infarction etc.
2. the dihydro Quercetin of the inventive method preparation has anti-inflammatory effect, and the mechanism of preventing and treating inflammation has been to suppress the lipoxidase (LOX) in prostaglandin(PG) (PG) biosynthetic process.Rheumatism, septic intimitis, acute pneumonia, chronic bronchitis, bronchial asthma there is therapeutic efficiency.
The dihydro Quercetin of the inventive method preparation can pre-anti-virus and toxin to the infringement of liver, acute, chronic hepatitis, liver cirrhosis, fatty liver and the toxic liver injury that causes because of GalN and CC14 etc. are all had therapeutic efficiency.Increasing of liver mda (MDA, liver lipid peroxidation thing) content due to the CC14 there is the obvious suppression effect.Can alleviate the consumption of liver injury to glutathione (GSH).Can protect the integrity of liver cell mechanism, prevent that the lyoenzymes such as transaminase in the liver cell from raising because of spill activity from cell.Protect the effect that liver mechanism is its strong anti-oxidation and Green Tea Extract.
4. nonspecific immunity function and the humoral immune function that the dihydro Quercetin of the inventive method preparation can enhancing body.Increase T cell percentage, thymus index, the special Rose formation of spleen cell (SRFC), (SRFC) that energy antagonism ring unicorn acid amides causes reduces, when lower concentration, promote lymphocyte transformation, suppress lymphocyte transformation during high density, thereby improve the immunologic function of human body.It can remove anaphylactogen in the person and improve the resistibility of health to anaphylactogen.
5. diabetes are because of islet secretion Regular Insulin imbalance causing blood sugar increasing, hyperglycemia causes the polyvalent alcohol metabolism unusual hyperfunction diabetic complication that causes of going the same way again, aldose reductase is a key enzyme in how pure pathways metabolism, and it makes multiple aldehyde reduction, causes diabetic complication.The dihydro Quercetin of the inventive method preparation can promote the recovery of beta Cell of islet, and lowering blood glucose and serum cholesterol improve sugar tolerance, and the green blood sugar effect of antagonism kidney parathyrine suppresses aldose reductase, therefore can treat diabetes and complication thereof.It can also improve the male sex, female reproduction ability, promotes the sexual gland function, kidney invigorating and YANG supporting.
6. food owing to situations such as hydrolysis, oxidations, has not only reduced the quality of food in storage process, can also make food have toxic action.For addressing this problem, foodstuffs industry has been through having attempted different types of antioxidant for many years, and chemosynthesis is natural.Clearly,, select natural antioxidant, become the object of people's first-selection along with making constant progress of science.The dihydro Quercetin of the inventive method preparation has tangible biological activity and strong anti-oxidation in Vitamin P complex, effectively hinder the oxidation of free radical lipid.Make the shelf life storage that contains the grease composition prolong 3-4 doubly.Reaching the purpose of long-period freshness preserving food, is green sanitas and preservation agent.Liquor, beer, brandy, fruit wine are added the dihydro Quercetin; wine is soft silk floss; increase tasty and refreshing sensation; can improve the quality of wine; especially remove uncomfortable feeling such as the headache that causes after drunk, gastrointestinal upset; play and prevent crapulent effect from liver is had the protection therapeutic action.
7. the dihydro Quercetin of the inventive method preparation is used for makeup, and skin is had health-care effect, makes skin gelatine gastral cavity, the comprehensive normalizing of elastin, the skin cells of repairing, regenerate.Eliminate acne and useless fellow macula, the protection skin elasticity smoothes away wrinkles, and human senility aged speed slows down.
8. the dihydro Quercetin of the inventive method preparation is antioxidant, stablizer, the knock-compound in the industry.Be fuel, oil, lacquer class prolongation and the stablizer of storage time.Be engine raw material and jet (rocket) raw material, the stablizer of hydrocarbon material, knock-compound.
9. the dihydro Quercetin that utilizes the inventive method to prepare is made, and the diseases prevention of pure natural high-efficiency plant, volume increase plant medical agent are because of its nontoxicity, no sensitization.Noresidue in plant materials and the soil, natural biology process 3-5 days.Be used for crops such as vegetables, fruit, grain.Owing to improved the plant-growth activity, output can increase 10%-30%, and the sickness rate 2-5 that has reduced bacterium, fungi has doubly improved the quality of seed and fruit, strengthens the cold-resistant and drought tolerance of plant, has shortened the ripening stage of farm crop.
10. the dihydro Quercetin of the inventive method preparation can be safeguarded human tissue organs such as cell, diaphragm, strong vessel wall and capillary vessel, and the effect of blood vessel osmotic pressure is regulated in step-down, antibiotic.Microcirculation improvement, suppress because of malnutrition to the caused pathology of eyes.Regulating blood fat prevents the effect of low-density lipoprotein (LDL) oxidation, and the aortic endothelial cell adenosine deaminase is had restraining effect, can prevent and treat atherosclerosis.
11. the technology that from tamarack, extracts the dihydro Quercetin provided by the invention, production process is at low temperature 65-75 ℃, its process is saved the energy, production process is not destroyed its natural structure, ensured that its biological activity is not destroyed, shortened the production cycle, simplified separating technology, improved separation efficiency, the productive rate height.When reducing cost, be fit to suitability for industrialized production.
12. that the present invention adopts is natural, the northern big or small Xingan of the resourceful China geographic tamarack in mound is a raw material.Its raw materials cost is cheap, and the production cycle is little.Product goes out the rate height, the biological activity height.The byproduct wood chip can be processed into charcoal, gac and density board.Rosin can be processed into rosin, turps and natural gum etc.Utilize raw material fully, do not caused waste.
13. Vitamin P complex is different because of its structure and source, dissolution characteristics difference is also very big, has water-solublely, has fat-soluble again.Can select suitable solvent to extract according to its polarity and water miscible size, it is extraction feed that the present invention selects tamarack for use, swirling effect and the heat effect of utilizing reactor pressure, temperature to produce are quickened dihydro Quercetin diffusion dissolution, and cavity effect and heat effect have been accelerated the disturbance of flavonoid molecule.Thereby can improve the rate of mass transfer and the effect of leaching process on the whole, play the effect of assisted extraction flavonoid.The present invention adopts this technology, have extraction time short, extraction yield is high, cost is low, save energy input, pollute little characteristics, easy realization of industrialization.Adopt the organic solution amount few, ensure quality product, the high 90%-98% of monomer purity.
14. methyl tertiary butyl ether is as the reextraction agent, ethanol is water-soluble, and the solubleness of methyl tertiary butyl ether in water is low, and water is dissolved in methyl tertiary butyl ether hardly, helps the monomeric extraction of dihydro Quercetin, removes the compound of other compositions.Utilize activated carbon decolorizing and absorption impurity, can make highly purified dihydro Quercetin product.
Description of drawings:
Accompanying drawing 1 is the schema of technology of the present invention.
The specific embodiment of the present invention:
Embodiment 1:
The method of extraction dihydro Quercetin in the tamarack: select tamarack rhizome part, raw material saw section, wood chip is processed in peeling, takes by weighing the tamarack wood chip of 50 grams, places reactor.50% ethanolic soln of measuring 500～800ml with graduated cylinder joins in the reactor and fully mixes with the tamarack wood chip, soaks 1 hour, stirs betwixt twice, each 10 minutes, begin to be warmed to 65-75 ℃ then, constant temperature kept 1 hour, restir twice betwixt, each 10 minutes.Off-response still, mixture present slightly oily turbid solution of yellowish brown, filter, and collect filtrate, and raw material is carried out second extraction, remove wood chip, through extracted twice, and merging filtrate.Under temperature 30-40 ℃ condition, with methyl tertiary butyl ether filtrate was adsorbed twice by 1: 10, collect organic mixing solutions.Cabinet is arranged to doing with the vaporizer underpressure distillation.Extremely do with vacuum-evaporator underpressure distillation organic phase.Isolated organic solution, the aqueous solution are preserved standby.Use hot water dissolving's residue by 10: 1, use activated carbon decolorizing.Dihydro Quercetin product is separated out in crystallization under 3-5 ℃ of temperature.Be finished product through vacuum-drying, pulverizing again.
Embodiment 2:
In the process of extracting the dihydro Quercetin, be subjected to the influence of several factors.Wherein, tamarack wood chip quality is main influence factor with ratio, cooking time, filtrate sorbent material consumption, adsorption time, absorption number of times and the pH value of ethanolic soln.Through the quality of the product of repeatedly testing and obtaining, and then determined to extract in the tamarack best process flow of dihydro Quercetin.Carry out under reactor constant temperature 65-75 ℃.
1. change the solid-liquid ratio, the constant experimental result that compares of other conditions:
| Solid-to-liquid ratio | Cooking time | The sorbent material consumption | Adsorption time | The absorption number of times | PH value | Percentage extraction % |
| 1/8 | 60 minutes | 1/10 | 1 hour | 2 | 5 | 1.30 |
| 1/10 | 60 minutes | 1/10 | 1 hour | 2 | 5 | 2.20 |
| 1/12 | 60 minutes | 1/10 | 1 hour | 2 | 5 | 2.50 |
| 1/14 | 60 minutes | 1/10 | 1 hour | 2 | 5 | 2.60 |
From chart as can be seen, solid-to-liquid ratio is big more, and the extraction yield of dihydro Quercetin is high more.The just continuous increase of solid-to-liquid ratio, behind certain value, promptly 1/12 extraction yield will can obviously not increase, and therefore select 1/12 solid-to-liquid ratio for best.
2. change cooking time, the constant experimental result that compares of other conditions:
| Cooking time | Solid-to-liquid ratio | The sorbent material consumption | Adsorption time | The absorption number of times | PH value | Percentage extraction % |
| 30 minutes | 1/12 | 1/10 | 1 hour | 2 | 5 | 1.50 |
| 45 minutes | 1/12 | 1/10 | 1 hour | 2 | 5 | 2.00 |
| 60 minutes | 1/12 | 1/10 | 1 hour | 2 | 5 | 2.60 |
| 90 minutes | 1/12 | 1/10 | 1 hour | 2 | 5 | 2.62 |
From chart as can be seen, the prolongation of cooking time, the extraction yield of dihydro Quercetin is high more, is 60 minutes behind certain value, and extraction yield will can obviously not increase, and therefore select 60 minutes for best.
3. change the sorbent material usage ratio, the constant experimental result that compares of other conditions:
| The sorbent material consumption | Solid-to-liquid ratio | Cooking time | Adsorption time | The absorption number of times | PH value | Percentage extraction % |
| 0.5/10 | 1/12 | 60 minutes | 1 hour | 2 | 5 | 2.10 |
| 1/10 | 1/12 | 60 minutes | 1 hour | 2 | 5 | 2.60 |
| 1.5/10 | 1/12 | 60 minutes | 1 hour | 2 | 5 | 2.62 |
| 2/10 | 1/12 | 60 minutes | 1 hour | 2 | 5 | 2.62 |
From chart as can be seen, quantity of sorbent is big more, and the extraction yield of dihydro Quercetin is high more.The just continuous increase of sorbent material consumption, behind certain value, promptly 1/10 extraction yield will can not increase.Therefore select 1/10 sorbent material consumption for best.
4. change adsorption time, the constant experimental result that compares of other conditions:
| Adsorption time | Solid-to-liquid ratio | Cooking time | The sorbent material consumption | The absorption number of times | PH value | Percentage extraction % |
| 30 minutes | 1/12 | 60 minutes | 1/10 | 2 | 5 | 2.00 |
| 45 minutes | 1/12 | 60 minutes | 1/10 | 2 | 5 | 2.40 |
| 60 minutes | 1/12 | 60 minutes | 1/10 | 2 | 5 | 2.60 |
| 90 minutes | 1/12 | 60 minutes | 1/10 | 2 | 5 | 2.60 |
From chart as can be seen, adsorption time is long more.The extraction yield of dihydro Quercetin is high more.Just extract time lengthening behind certain value, extraction yield will can not increase, and therefore select 60 minutes adsorption times for best.
5. change the absorption number of times, the constant experimental result that compares of other conditions:
| The absorption number of times | Solid-to-liquid ratio | Cooking time | The sorbent material consumption | Adsorption time | PH value | Percentage extraction % |
| 1 | 1/12 | 60 minutes | 1/10 | 1 hour | 5 | 2.40 |
| 2 | 1/12 | 60 minutes | 1/10 | 1 hour | 5 | 2.60 |
| 3 | 1/12 | 60 minutes | 1/10 | 1 hour | 5 | 2.60 |
From chart as can be seen, the absorption number of times is many more, and the extraction yield of dihydro Quercetin is high more.Just adsorb number of times and be on the increase, behind certain value, extraction yield will can not increase.Therefore the slective extraction number of times is for 2 times best.
6.PH value:
The acid-basicity of extraction liquid can be regulated with saturated sodium carbonate solution, and selecting pH value is between the 5-6.Significant parameter from the process of tamarack extraction dihydro Quercetin: solid-to-liquid ratio is 1/12, and extraction temperature is 65-75 ℃, and cooking time is 60 minutes, and the ratio of sorbent material is 1/10, and adsorption time is 60 minutes, and number of times is 2 times, and pH value is between the 5-6.
Embodiment 3:
1. the physical and chemical index of product:
Profile is Powdered
Colours white-faint yellow
The smell free from extraneous odour
Mouthfeel does not have special mouthfeel
0.001 milligram/kg of water of solubleness
Moisture≤8
Purity 〉=90%
230 ℃ of fusing points
Mineral substance≤0.3
2. fusing point contrast:
Do contrast by melting point detector.
3. infrared spectra detects:
By infrared spectra detector check product dihydro Quercetin.
4. to the liquid chromatographic detection of product:
Reference standards dihydro Quercetin 0.1 gram is put into 120 ℃ of oven dry of loft drier.Be dissolved in then in the middle of 10 milliliters the acetone soln.
In the acetone soln with 300 milliliters of 700 milliliter 2% acetum addings, stir evenly.
19 milliliters of acetums with 2% are dosed in the metering beaker of one liter of capacity, and adding distil water to a liter stirs evenly.
The positive nitrophenolss of 10 milligrams of sample dihydro Quercetins and 10 grams are added in 10 milliliters the acetone soln, stir evenly.
2 milliliters solution are injected in the liquid chromatography instrument of ultraviolet detector, carry out stratographic analysis:
Row annotates 64mm * 2.0mm
Sorbent material separation of C 180
Wavelength analysis 290nm
Phase place acetone soln (circulation in 3: 7) in 2% acetic acid flows
100 milligrams/minute of moving phase bit rates
Chromatogram timing 10 minutes
The analysis of peak area available electron totalizing instrument is determined in the chromatogram.
Measure the peak area of dihydro Quercetin.
The dihydro quercetin content equals:
(B2×A1×10/B1×A2×10)×100％
The peak area of A1 dihydro Quercetin in the chromatography experiment sample.
The peak area of A2 dihydro Quercetin in standard model solution.
The quality of B1 test sample, unit: gram
The quality of B2 standard substance dihydro Quercetin, unit: gram
| Sequence number | Time | Highly | The zone | The end | Opposed end | Title |
| 1 | 598.32 | 0.00 | 0.176 | 0.00 | 0.00 | |
| 2 | 806.58 | 8.65 | 145.69 | 0.51 | 0.65 | |
| 3 | 1000.11 | 0.00 | 0.212 | 0.00 | 0.00 | |
| 4 | 1401.41 | 9.13 | 223.10 | 96.20 | 95.20 | The dihydro Quercetin |
| 5 | 1765.63 | 0.21 | 7.36 | 0.00 | 0.00 | |
| 6 | 1799.28 | 0.03 | 1.00 | 0.00 | 0.00 | |
| 7 | 1965.82 | 0.00 | 0.109 | 0.00 | 0.00 | |
| 8 | 2312.78 | 0.01 | 0.658 | 0.00 | 0.00 | |
| 9 | 2359.85 | 0.00 | 0.168 | 0.18 | 0.00 | |
| 10 | 2468.82 | 0.00 | 0.166 | 0.21 | 0.21 | |
| 11 | 2835.12 | 0.01 | 0.178 | 0.00 | 0.00 | |
| 12 | 3175.65 | 0.00 | 0.121 | 0.00 | 0.00 |
The content of dihydro Quercetin is not less than 90%.
Claims (4)
1. the method for extraction dihydro Quercetin in the tamarack, it is characterized in that: raw materials pretreatment, getting tamarack wood chip and ethanolic soln joins in the reactor and fully mixes, both add-ons are 50 kilograms of tamarack wood chips, 500～800 liters of 50% ethanolic solns, extract, carrying out the second time after the filtration extracts, merging filtrate, organic solution is collected in absorption, extremely do with vacuum-evaporator underpressure distillation organic phase, used hot water dissolving's residue in 10: 1 by weight, and used activated carbon decolorizing, crystallization under 3-5 ℃ of temperature, separate out dihydro Quercetin product, again through vacuum-drying, pulverize and be finished product.
2. the method for extraction dihydro Quercetin in the tamarack according to claim 1, it is characterized in that: described being extracted as soaked 1 hour, stir betwixt twice, each 10 minutes, begin to be warmed to 65-75 ℃ then, constant temperature kept 1 hour, and restir is twice betwixt, each 10 minutes, the off-response still.
3. the method for extraction dihydro Quercetin in the tamarack according to claim 1 and 2, it is characterized in that: described absorption is under temperature 30-40 ℃ condition, adsorbs twice with methyl tertiary butyl ether and filtrate by 1: 10, the time is 1 hour.
4. the method for extraction dihydro Quercetin in the tamarack according to claim 1 and 2, it is characterized in that: described raw materials pretreatment is to select tamarack rhizome part, raw material saw section, wood chip is processed in peeling.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100724357A CN101333203A (en) | 2007-06-29 | 2007-06-29 | Method for extracting dihydroquercetin form larch |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100724357A CN101333203A (en) | 2007-06-29 | 2007-06-29 | Method for extracting dihydroquercetin form larch |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101333203A true CN101333203A (en) | 2008-12-31 |
Family
ID=40196116
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007100724357A Pending CN101333203A (en) | 2007-06-29 | 2007-06-29 | Method for extracting dihydroquercetin form larch |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101333203A (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101830881A (en) * | 2010-04-28 | 2010-09-15 | 东北林业大学 | Enzyme-induced method for efficiently extracting toxifolin from larch processing leftover |
| CN101863869A (en) * | 2010-06-03 | 2010-10-20 | 东北林业大学 | Method for extracting dihydroquercetin from larch sheets |
| CN102924420A (en) * | 2012-10-25 | 2013-02-13 | 沈立乾 | Method for extracting dihydroquercetin from root of dahurian larch |
| CN104982940A (en) * | 2015-06-17 | 2015-10-21 | 哈尔滨松根堂生物科技有限公司 | Compound food additive rich in active factors and application thereof |
| CN105237505A (en) * | 2015-10-20 | 2016-01-13 | 北京化工大学 | Method for preparing high-purity taxifolin with saw dust of larix gmelinii in Lesser Khingan mountains as raw material |
| CN105263340A (en) * | 2012-04-10 | 2016-01-20 | 弗拉维特普雷有限公司 | Method of using nutritional compounds dihydroquercetin (taxifolin) and arabinogalactan in combination with dihydroquercetin (taxifolin) to reduce and control cardiometabolic risk factors associated with metabolic syndrome and hypercholesterolemia |
| CN107789346A (en) * | 2017-10-31 | 2018-03-13 | 上海华堇生物技术有限责任公司 | The medicinal usage of texifolin |
| CN109972395A (en) * | 2019-04-09 | 2019-07-05 | 上海喜眠服饰有限公司 | Naked sense sweat absorption fabric, preparation method and naked sense nightwear |
| CN114469926A (en) * | 2022-01-28 | 2022-05-13 | 吉林省健维天然生物科技有限公司 | New application of dihydroquercetin and preparation method of dihydroquercetin hydrogel |
-
2007
- 2007-06-29 CN CNA2007100724357A patent/CN101333203A/en active Pending
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101830881B (en) * | 2010-04-28 | 2012-09-05 | 东北林业大学 | Enzyme-induced method for efficiently extracting toxifolin from larch processing leftover |
| CN101830881A (en) * | 2010-04-28 | 2010-09-15 | 东北林业大学 | Enzyme-induced method for efficiently extracting toxifolin from larch processing leftover |
| CN101863869A (en) * | 2010-06-03 | 2010-10-20 | 东北林业大学 | Method for extracting dihydroquercetin from larch sheets |
| CN105263340A (en) * | 2012-04-10 | 2016-01-20 | 弗拉维特普雷有限公司 | Method of using nutritional compounds dihydroquercetin (taxifolin) and arabinogalactan in combination with dihydroquercetin (taxifolin) to reduce and control cardiometabolic risk factors associated with metabolic syndrome and hypercholesterolemia |
| CN102924420A (en) * | 2012-10-25 | 2013-02-13 | 沈立乾 | Method for extracting dihydroquercetin from root of dahurian larch |
| WO2014063504A1 (en) * | 2012-10-25 | 2014-05-01 | Shen Liqian | Method for extracting dihydroquercetin from the root of larch trees |
| US9206152B2 (en) | 2012-10-25 | 2015-12-08 | Liqian Shen | Method for extracting dihydroquercetin from the root of larch trees |
| CN102924420B (en) * | 2012-10-25 | 2013-09-04 | 沈立乾 | Method for extracting dihydroquercetin from root of dahurian larch |
| CN104982940A (en) * | 2015-06-17 | 2015-10-21 | 哈尔滨松根堂生物科技有限公司 | Compound food additive rich in active factors and application thereof |
| CN105237505A (en) * | 2015-10-20 | 2016-01-13 | 北京化工大学 | Method for preparing high-purity taxifolin with saw dust of larix gmelinii in Lesser Khingan mountains as raw material |
| CN107789346A (en) * | 2017-10-31 | 2018-03-13 | 上海华堇生物技术有限责任公司 | The medicinal usage of texifolin |
| CN109972395A (en) * | 2019-04-09 | 2019-07-05 | 上海喜眠服饰有限公司 | Naked sense sweat absorption fabric, preparation method and naked sense nightwear |
| CN114469926A (en) * | 2022-01-28 | 2022-05-13 | 吉林省健维天然生物科技有限公司 | New application of dihydroquercetin and preparation method of dihydroquercetin hydrogel |
| CN114469926B (en) * | 2022-01-28 | 2023-06-27 | 吉林省健维天然生物科技有限公司 | New application of dihydroquercetin and preparation method of dihydroquercetin hydrogel |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101333203A (en) | Method for extracting dihydroquercetin form larch | |
| CN103230473B (en) | Lycium ruthenicum Murr. effective extract, extracting method and extract are applied | |
| CN105998109B (en) | Mango seed polyphenol extract and preparation method thereof | |
| JP4777776B2 (en) | Ginseng preparation using vinegar and method for producing the same | |
| CN111249218B (en) | Saussurea involucrate fermentation stock solution and preparation method and application thereof | |
| KR20050109269A (en) | A ginseng preparation using vinegar and process for thereof | |
| CN114832022B (en) | Preparation of Phellinus linteus fruiting body phenol active substances and application thereof in regulating intestinal flora and uric acid metabolism | |
| CN101229335B (en) | Enzyme method for preparing smilax scobinicaulis total saponin extract | |
| CN101333204B (en) | Method for extracting dihydroquercetin form larch | |
| CN106617047A (en) | Mulberry ferment and production technology thereof | |
| CN108795684A (en) | One kind is enriched blood lipid-loweringing jujube health preserving vinegar and preparation method thereof | |
| KR100872158B1 (en) | The manufacturing process of roasting and fermented red ginseng and mountain ginseng extracts | |
| CN106832045A (en) | A kind of method that gingko episperm extracts pectin and phenolic acid compound simultaneously | |
| CN106138130B (en) | Mango seed flavone extract and preparation method thereof | |
| CN105733902B (en) | A kind of preparation method for the type Liu Yazi pueraria lobata yellow rice wine that relieves the effect of alcohol | |
| CN105713787B (en) | A kind of preparation method of liver-protecting type safflower pueraria lobata yellow rice wine | |
| CN104911068B (en) | A kind of Taxus x media health liquor and preparation method thereof | |
| CN103704633A (en) | Extraction method of carambola polyphenol | |
| JP6627045B2 (en) | Polyphenol derivatives exhibiting stem cell factor receptor activating action | |
| CN113214233A (en) | Method for extracting and purifying mangiferin from mango seeds | |
| CN102613349B (en) | Ginkgo garlic yellow tea composite particle drink | |
| JP6831049B2 (en) | Method for producing a grunge fluorolic acid derivative exhibiting an NF-κB inhibitory effect | |
| CN104946460B (en) | A kind of Taxus x media milk taste Wine and preparation method thereof | |
| KR100512897B1 (en) | Healthy beverages using condensed brewing vinegar and manufacturing method thereof | |
| CN114573430B (en) | Licorice anti-inflammatory substance and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20081231 |