CN104911068B - A kind of Taxus x media health liquor and preparation method thereof - Google Patents
A kind of Taxus x media health liquor and preparation method thereof Download PDFInfo
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- CN104911068B CN104911068B CN201510388339.8A CN201510388339A CN104911068B CN 104911068 B CN104911068 B CN 104911068B CN 201510388339 A CN201510388339 A CN 201510388339A CN 104911068 B CN104911068 B CN 104911068B
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- taxus
- media
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- health liquor
- wine
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- C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
- C12G3/00—Preparation of other alcoholic beverages
- C12G3/02—Preparation of other alcoholic beverages by fermentation
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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Abstract
The present invention relates to a kind of Taxus x media health liquor and preparation method thereof, the weight proportion of its each component raw material is as follows：Glutinous rice 1,000 1200, rice 150 200, Semen Coicis 50 60, sugarcane top 10 12, mulberry leaf 10 12, corn stigma 10 12, honeysuckle 10 12, pear flower 10 12, distiller's yeast 5 15, water 1,500 1800,10 15 parts of Taxus x media extract.The health liquor of the present invention contains the general flavone (in terms of rutin) of high level, and contains amino acid and trace elements of selenium necessary to a variety of human bodies.Each drink amount is the amount doesn't matter and can drink for a long time, particularly Chang Yinke physical fitness, promotes longevity.Men and women, old and young are drinkable.The health liquor of the present invention has good therapeutic effect to disease of skin such as dermatitis, nettle rash, ichthyosis.
Description
Technical field
The present invention relates to a kind of fruit wine and preparation method thereof, especially a kind of gracefully sub- Taxus x media health liquor and its
Preparation method.
Background technology
Taxus x media (Taxus media), belong to taxaceae Taxus, be a natural hybrid species, its female parent is
Taxus chinensis in northeast (T.cuspidata), its male parent are european yew (T.baccata), and shrub is evergreen all the year round, and main root is failed to understand
Aobvious, lateral root is flourishing, and leaf branch is luxuriant, and germination is strong, resistance to trimming, resists cold, can be grown under a variety of weathers, edaphic condition.The country is certainly
Begin from Canadian introducing and planting within 1996.For Taxus x media compared with traditional Chinese yew, architectural difference is larger, but the former performance
It is more excellent.The taxol extracted in Chinese yew, it is " the currently the only autonomic drug that can contain growth of cancer cells ", is known as
" eucalyptus ", turn into the Medicinal species of most expensive in the world.World today's wild red bean China fir resource is in great shortage, its bark, tree root,
All extractable tool can treat various disease conditions, seed can extract oil, Ye Ke compared with the diterpene-kind compound of high anti-cancer activity in leaf, stem
Qualcomm meridian, hypotensive, and have positive effect to treatment diabetes and cardiovascular and cerebrovascular disease.It is both precious Medicinal species, and
One of ecological shelter forest engineering construction first choice seeds.
Chinese yew is used as medicine long history, in China《Compendium of Materia Medica》、《Dictionary of medicinal plant》、《Northeast medicine plants will》、《Jilin
Chinese herbal medicine》、《Book on Chinese herbal medicine pushes away old》Deng on the books in medical book.Be used as medicine can diuresis, stimulate the menstrual flow.To anti-curing oncoma, cancer, leukaemia,
Diabetes have the effect of special.Soaked currently with branches and leaves of yew, root, skin in white wine, manufactured taxus chinensis wine is very
It is more.But can only be by fat-soluble taxine kind and the part aqueous material in branches and leaves, root, skin by way of soaking in Chinese liquor
Dissolve in wine.Contain taxusin (taxinine) A, H, K, L, sharp leaf soil China fir sterol in branches and leaves of yew, root, skin
(ponasterol) A, ecdysterone (ecdysterone), Sciadopitysin (soi-adopitysin), taxine, taxol,
Makisterone etc..These chemical analysis have the pharmacological action of good cancer-resisting, but toxicity is larger, directly utilize red bean
China fir branches and leaves, skin, root, steep in wine after dissolved in ethanol, then be drunk be it is incorrect and to people know from experience produce damaging effect.2002
Year, the Ministry of Public Health forbids Chinese yew directly as health products and raw-food material using branches and leaves, root, skin being used as medicine.People eats Chinese yew by mistake
Poisoning manifestations be mainly giddy, pupil amplification, Nausea and vomiting, dispersivity stomachache, myasthenia etc., severe patient's appearance is aroused in interest to delay
Slowly there is the change such as pulmonary edema, myocardium bleeding and myocarditis in, heart arrest or death, pathologic finding.Chinese yew is directly soaked to drink
There is no anticancer, anti-cancer efficacy, because the main component of anticancer taxad, anti-cancer is taxol, and taxol is not soluble in water, that is, uses
Special solvent extraction, it is also necessary to add cosolvent.During somebody's cold, fever, it can also capture branches and leaves of yew pot water and drink,
Attempt to cure the disease, this way is wrong.The medical application major embodiment of Chinese yew carries in from bark, root, branches and leaves at present
Taxol is taken to make anticancer class medicine.Directly taking Chinese yew has no obvious medical effect, the food containing Chinese yew, medicine toxicity
It is larger, there may be serious adverse reaction after largely eating for a long time, result even in death.
In addition, a kind of taxus chinensis rare fruit wine disclosed in Chinese patent application 96113169.1, is that taxus fruit is straight
Connect made from being immersed in white wine.This mode, also can only be by the part aqueous in taxus fruit or part alcohol-soluble thing
Matter is dissolved in wine, and can not make full use of other nutritional ingredients in fruit.Meanwhile white wine alcohol content made of this mode
Also it is high, it is not suitable for using as health care wine.A kind of gracefully sub- red bean disclosed in Chinese patent application 200410054388.X
China fir health liquor and its manufacture craft, it is formulated using taxus fruit, is also had seed in fruit, bitter after processing, is influenceed
Into the taste of wine.Different additionally, due to technique, contained composition is also different in wine, and its technique will be through steaming, its volatility
Composition such as safflower oil etc. is extractable out, but other many nonvolatile effective ingredients are lost, simultaneously because temperature is high when steaming,
Some compositions such as composition such as 10 1 D A B, sequoyitol is met high temperature and destroyed.Therefore its technique is unreasonable.In addition, its technique be by
Glutinous rice, taxus fruit, acorn nut fruit cook and charge and attack into cake, crush, then admix safflower and steamed, and add after distiller's yeast and beat
Into cake, then fermented, take fermented glutinous rice that wine is made into through distillation, and add spices.The complex process, flow are very long.Japanese yew fruit
Steam fermentation of taking away again after multipass in fact, many nutritions in taxus fruit have made a price reduction destruction loss.In addition, the wine is real
Border is a kind of distilled spirit, and Main Ingredients and Appearance is ethanol, and the nutrition in the taxus fruit contained in wine is few, it is impossible to fully
Utilize the nutrition in taxus fruit.The research of the medical active of taxaceae is focused mostly on now with paclitaxel structure class
As bearing taxanes active anticancer in terms of, but to other active components, the research such as flavones, polysaccharide is less.It is and yellow
Ketone has extensive pharmacological action with polysaccharide, is such as used as immunomodulator, can activating macrophage, T lymphocytes, LAK cells
Etc. panimmunity cell, promote cell factor generation, complement activation；Also antitumor, antiviral, anti-infective, anti-digestibility bursts
The various active such as ulcer, anti-oxidant, hypoglycemic, reducing blood lipid, and toxicity is relatively low.
The content of the invention
The shortcomings that present invention is directed to above-mentioned prior art, there is provided a kind of not have toxicity, and can will have in Chinese yew to human body
The health liquor that fully retains of composition of benefit, utilize a large amount of aromatic hydrocarbon of Chinese yew leaf branch release and biological ketone, blue and white plain and micro-
Secondary element etc., effective volatile component (i.e. efficiency factor) that activity is extremely strong, biological utilisation value is high is formed in human body, these
Efficiency factor enters blood circulation, plays its biological effect, such as improves sleep, hypotensive, protection angiocarpy, anti-aging, enhancing
Immunity of organisms, cancer-preventing health, and produce heteroglycan by fermenting and reach the multiple functional Taxus x media of nutrition and health care
Health liquor and preparation method thereof.In particular, through detection in this health liquor containing high level general flavone (with
Rutin meter), and Anticancer Element Selenium-trace elements of selenium generally acknowledged containing amino acid necessary to a variety of human bodies and in the industry.
In order to achieve the above object, the technical scheme of its technical problem of present invention solution use is：A kind of gracefully sub- red bean
China fir health liquor, the weight proportion of its each component raw material are as follows：
Glutinous rice 1000-1200, rice 150-200, Semen Coicis 50-60, sugarcane top 10-12, mulberry leaf 10-12, corn stigma 10-
12nd, honeysuckle 10-12, pear flower 10-12, distiller's yeast 5-15, water 1500-1800, Taxus x media extract 10-15 parts.
In above-mentioned formula, glutinous rice is ecological agriculture green cereal, and Taxus x media extract is extracted using following methods
Obtain, water is high-quality spring, and remaining several added material can play capable of clearing heat and reducing internal heat, nourishing Yin and moistening lung and other effects.This several raw material
Proportioning fermentation, can reach we determined that raising immunity of organism force health-care purpose, this formula and the wine of technique productions do not have
There is any side effect.
The preparation method of this above-mentioned Taxus x media health liquor, comprises the following steps：
(1) Taxus x media activity extract, is obtained：After Taxus x media branches and leaves co-grinding, powder of getting it filled is fitted
Measure, 30-38 DEG C is soaked 1 hour in addition petroleum ether, repeats the step 3 time, separates petroleum ether and solid powder；It will obtain
Petroleum ether extract be evaporated, powder carries out pillar layer separation, using silica and octadecylsilane chemically bonded silica to fill out
Agent is filled, the dilute acetic acid solution using pH value as 5.5-6.5 is mobile phase A, with ethanol: petroleum ether: chloroform=15: 1: 1 mixing is molten
Agent is Mobile phase B, and gradient elution, column temperature is 20-30 DEG C, flow velocity 1.5-2.0ml/min, Detection wavelength 220nm, uses HPLC
Analysis, extract required Taxus x media active component；
The condition of gradient elution is
| Time/minute | Mobile phase/B% (ml) | Mobile phase/A% (ml) |
| 0 | 90-95 | 5-10 |
| 5 | 80-85 | 15-20 |
| 20 | 72-75 | 25-28 |
| 35 | 65-70 | 30-35 |
| 50 | 80-85 | 15-20 |
(2), add water to cook the above-mentioned recipe ingredient in addition to Taxus x media extract, distiller's yeast, after cooling, admix
Distiller's yeast, it is put into container and is sealed by fermentation；
(3) after, being sealed by fermentation 3-4 days, Taxus x media extract is added, stirs evenly, ferment；
(4), continue again at 0-30 DEG C after being sealed by fermentation -1 month 20 days, add food grade citric acid, tune pH value is
6.5-6.8 continue to ferment；
(5), it is further continued for after normal temperature is sealed by fermentation -1 month 20 days, adds food grade citric acid, tune pH value is 7.0-
7.3, continue to ferment；
(6), after 15-20 days, Wine blending liquid pH value is neutrality, squeezes to obtain wine liquid, then produce by refined filtration.
Brief description of the drawings：
Fig. 1 represents the high-efficient liquid phase chromatogram for the taxus chinensis wine that embodiment 1 obtains；
Fig. 2 represents the high-efficient liquid phase chromatogram for the taxus chinensis wine that embodiment 2 obtains.
As shown by data after testing, using above-mentioned formula and technique, Taxus x media extract (without steaming), glutinous rice,
Distiller's yeast is fermented, and the composition beneficial to human body is farthest remained in obtained health liquor, and has dispelled toxic component,
It is safe to the human body harmless.And the general flavone (in terms of rutin) in this health liquor containing high level, and contain a variety of human body institutes
Necessary amino acid and Anticancer Element Selenium-trace elements of selenium generally acknowledged in the industry.
Embodiment
The solution of the present invention is further described below by embodiment：
Embodiment 1：A kind of Taxus x media health liquor, the weight proportion of its each component raw material are as follows：
Glutinous rice 1000, rice 160, Semen Coicis 50, sugarcane top 10, mulberry leaf 12, corn stigma 12, honeysuckle 12, pear flower 10-12,
Distiller's yeast 10, water 1800,12 parts of Taxus x media extract.
The preparation method of this above-mentioned Taxus x media health liquor, comprises the following steps：
(1) Taxus x media activity extract, is obtained：After Taxus x media branches and leaves co-grinding, powder of getting it filled is fitted
Measure, 35 DEG C are soaked 1 hour in addition petroleum ether, repeat the step 3 time, separate petroleum ether and solid powder art；By what is obtained
Petroleum ether extract is evaporated, and powder carries out pillar layer separation, the use of silica and octadecylsilane chemically bonded silica is filling
Agent, using the dilute acetic acid solution that pH value is 6.0 as mobile phase A, using ethanol: petroleum ether: chloroform=15: 1: 1 mixed solvent is stream
Dynamic phase B, gradient elution, column temperature are 25 DEG C, flow velocity 1.5ml/min, Detection wavelength 220nm, are analyzed with HPLC, extract institute
Need Taxus x media active component；
The condition of gradient elution is
| Time/minute | Mobile phase/B% (ml) | Mobile phase/A% (ml) |
| 0 | 95 | 5 |
| 5 | 80 | 20 |
| 20 | 75 | 25 |
| 35 | 65 | 35 |
| 50 | 80 | 20 |
(2), add water to cook the above-mentioned recipe ingredient in addition to Taxus x media extract, distiller's yeast, after cooling, admix
Distiller's yeast, it is put into container and is sealed by fermentation；
(3) after, normal temperature is sealed by fermentation 3 days, Taxus x media extract is added, stirs evenly, ferment；
(4), it is further continued at 4 DEG C, after being sealed by fermentation 20 days, adds food grade citric acid, tune pH value is 6.5-6.8, after
Supervention ferment；
(5), it is further continued at normal temperatures, after being sealed by fermentation 20 days, adds food grade citric acid, tune pH value is 7.0-7.3, after
Supervention ferment；
(6), after 20 days, Wine blending liquid pH value is neutrality, squeezes to obtain wine liquid, then produce by refined filtration.
Embodiment 2：A kind of Taxus x media health liquor, the weight proportion of its each component raw material are as follows：
Glutinous rice 1200, rice 200, Semen Coicis 60, sugarcane top 12, mulberry leaf 10, corn stigma 12, honeysuckle 12, pear flower 12, distiller's yeast
15th, 15 parts of water 1500, Taxus x media extract.
The preparation method of this above-mentioned Taxus x media health liquor, comprises the following steps：
(1) Taxus x media activity extract, is obtained：After Taxus x media branches and leaves co-grinding, powder of getting it filled is fitted
Measure, 30 DEG C are soaked 1 hour in addition petroleum ether, repeat the step 3 time, separate petroleum ether and solid powder art；By what is obtained
Petroleum ether extract is evaporated, and powder carries out pillar layer separation, the use of silica and octadecylsilane chemically bonded silica is filling
Agent, using the dilute acetic acid solution that pH value is 6.0 as mobile phase A, using ethanol: petroleum ether: chloroform=15: 1: 1 mixed solvent is stream
Dynamic phase B, gradient elution, column temperature are 25 DEG C, flow velocity 1.5ml/min, Detection wavelength 220nm, are analyzed with HPLC, extract institute
Need Taxus x media active component；
The condition of gradient elution is
| Time/minute | Mobile phase/B% (ml) | Mobile phase/A% (ml) |
| 0 | 90 | 10 |
| 5 | 85 | 15 |
| 20 | 72 | 28 |
| 35 | 70 | 30 |
| 50 | 80 | 20 |
(2), add water to cook the above-mentioned recipe ingredient in addition to Taxus x media extract, distiller's yeast, after cooling, admix
Distiller's yeast, it is put into container and is sealed by fermentation；
(3) after, normal temperature is sealed by fermentation 3 days, Taxus x media extract is added, stirs evenly, ferment；
(4), it is further continued for after being sealed by fermentation 1 month at 25 DEG C, adds food grade citric acid, tune pH value is 6.5-6.8, after
Supervention ferment；
(5), it is further continued at normal temperatures, after being sealed by fermentation 1 month, adds food grade citric acid, tune pH value is 7.0-7.3,
Continue to ferment；
(6), after 20 days, Wine blending liquid pH value is neutrality, squeezes to obtain wine liquid, then produce by refined filtration.
The physical and chemical index of health liquor obtained by detection embodiment 1,2, with reference to GB2757-2012 Spirits and its preparation
Wine, GB27588-2011 alcoholic drink mixed with fruit juice are detected, and testing result is as follows：
Physical and chemical index meets GB2757-2012 Spirits and its assembled alcoholic drinks, the regulation of GB27588-2011 alcoholic drink mixed with fruit juice.
Meanwhile trace selenium content in the health liquor of the present invention is determined, use RF-540 (molecular fluorescence)
Instrument, detection are 19 DEG C according to GB 5009.93-2010, detection environment, relative humidity 70%.As a result it is as follows：
It it is well known that selenium-supply can effectively prevent Keshan disease, Kaschin-Beck disease, coronary heart disease etc., can decline liver cancer incidence
35%, can inhibition of hepatitis b virus the functions such as immunity are propagated and improved in crowd.
General flavone (in terms of rutin) content of the health liquor of embodiment 1,2 is detected, using Cary100Bio spectrophotometers,
Detection is according to the ultraviolet and absorbable spectrographic technique general rules of JY/T 022-1996 are used, and detection environment is 18 DEG C, relative humidity
60%.As a result it is as follows：
From above-mentioned testing result as can be seen that containing abundant general flavone in the health liquor of the present invention, and using rutin as
The Flavonoid substances of representative have anti-inflammatory, keep blood vessel normally act on, be antiviral, suppress the effect of aldose reductase, belong to people
Body institute necessary material, often drink this product can physical fitness, promote longevity.Men and women, old and young are drinkable.
The amino acid content of the health liquor of embodiment 1,2 is detected, using LC-20AT high performance liquid chromatographs, detects foundation
Using GB/T 16631-2008 high performance liquid chromatography general rules, detection environment is 18 DEG C, relative humidity 78%.As a result it is as follows：
It can be seen that the several amino acids containing abundant content in health liquor of the invention, these aminoacid ingredients can be mended effectively
Fill human body necessary amino acid daily.
In addition health liquor of the invention finds the present invention by the long-term observation taken to rat and healthy population is taken
Health liquor it is safe and effective, have no toxic side effect.Do not occur rats death and people take after produce the phenomenon of any discomfort.And
Found through clinical experimental study, health liquor of the invention has therapeutic effect to disease of skin such as dermatitis, nettle rash, ichthyosis.
The test effect of 1~2 pair of dermatitis of embodiment
Upper table data illustrate that the product of the present invention for drinking embodiment 1~2 has preferable effect, wherein embodiment to dermatitis
1 effect is best.
The test effect of 1~2 pair of nettle rash of embodiment
Upper table data illustrate that the product of the present invention for drinking embodiment 1~2 has preferable effect to nettle rash, wherein implementing
The effect of example 2 is best.
The test effect of 1~2 pair of ichthyosis of embodiment
Upper table data illustrate that the product of the present invention for drinking embodiment 1~2 has preferable effect to ichthyosis, wherein implementing
The effect of example 2 is best.
The immunizing health function of the invention of further investigating health liquor.Respectively by people of 300 age distributions 18-60 year
Group mean is randomly divided into two groups, and one group of daily rule takes health liquor of the invention 1-2 times, each 50-100mL.One group of conduct
Control group, the health liquor of the present invention is not taken.Normal work and rest diet daily.Two groups of crowds keep roughly the same work and rest diet
Rule.Within 2014.11.01-2015.1.31 three months periods, counting the disease of two groups of crowds respectively, a situation arises.Statistics
As a result it is as follows：Two groups of crowds are survived in three months probations, wherein take in the group of people of the health liquor of the present invention,
There are the light symptoms 9 such as flu, fever, no malignant tumour and other major diseases occur.In second group of crowd, feel
The symptom 28 such as emit, have a fever, wherein 7 are converted into pneumonia hospitalization, coronary heart disease, heart disease, cranial vascular disease occur and be in hospital
Treat case 8.It can be seen that health liquor of the invention has the effect of immunizing health really.
Taxus x media health liquor provided by the present invention and preparation method thereof, is fermented by Taxus x media extract
Form, complementary and synergy can be produced to human body, it has the advantages that：1) fabrication processing is simple, product index symbol
Close national standard.2) composition beneficial to human body is farthest remained in wine, and has dispelled toxic component, human body is pacified
Completely without evil.3) general flavone in health liquor containing high level (in terms of rutin), and contain amino necessary to a variety of human bodies
Sour and generally acknowledged in the industry Anticancer Element Selenium-trace elements of selenium.Each drink amount is the amount doesn't matter and can drink for a long time, particularly Chang Yinke
Physical fitness, promote longevity.Men and women, old and young are drinkable.4) health liquor of the invention is to skins such as dermatitis, nettle rash, ichthyosis
Disease has good therapeutic effect.
Claims (1)
1. a kind of Taxus x media health liquor, the weight proportion of its each component raw material are as follows：
Glutinous rice 1000-1200, rice 150-200, Semen Coicis 50-60, sugarcane top 10-12, mulberry leaf 10-12, corn stigma 10-12, gold
Honeysuckle flower 10-12, pear flower 10-12, distiller's yeast 5-15, water 1500-1800, Taxus x media extract 10-15 parts, wherein this is gracefully
The preparation method of sub- health taxad wine, comprises the following steps：
(1) Taxus x media activity extract, is obtained；
(2), add water to cook the above-mentioned recipe ingredient in addition to Taxus x media extract, distiller's yeast, after cooling, admix wine
Song, it is put into container and is sealed by fermentation；
(3) after, being sealed by fermentation 3-4 days, Taxus x media extract is added, stirs evenly, ferment；
(4), continue again at 0-30 DEG C after being sealed by fermentation -1 month 20 days, add food grade citric acid, tune pH value is 6.5-
6.8, continue to ferment；
(5), it is further continued for after normal temperature is sealed by fermentation -1 month 20 days, adds food grade citric acid, tune pH value is 7.0-7.3, after
Supervention ferment；
(6), after 15-20 days, Wine blending liquid pH value is neutrality, squeezes to obtain wine liquid, then produce by refined filtration；
It obtains the concrete operations of Taxus x media extract：
After Taxus x media branches and leaves co-grinding, powder of getting it filled is appropriate, and 30-38 DEG C is soaked 1 hour in addition petroleum ether, is repeated
The step 3 time is carried out, separates petroleum ether and solid powder；Obtained petroleum ether extract is evaporated, powder carries out column chromatography point
From the use of silica and octadecylsilane chemically bonded silica being filler, the dilute acetic acid solution using pH value as 5.5-6.5 is stream
Dynamic phase A, using ethanol: petroleum ether: chloroform=15: 1: 1 mixed solvent is Mobile phase B, gradient elution, column temperature are 20-30 DEG C, stream
Speed is 1.5-2.0ml/min, Detection wavelength 220nm, is analyzed with HPLC, extracts required Taxus x media active component；
The condition of gradient elution is：
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|---|---|---|---|---|
| CN1746285A (en) * | 2004-09-06 | 2006-03-15 | 黄金福 | Chinese yew fruit wine |
| CN103191041A (en) * | 2013-04-18 | 2013-07-10 | 江苏红豆杉药业有限公司 | Chinese yew branch and leaf extractive with anti-oxidative effect as well as extraction method and application of yew branch and leaf extractive |
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| KR20000039284A (en) * | 1998-12-12 | 2000-07-05 | 심규산 | Preparing method of alcoholic liquor |
| CN101875893B (en) * | 2010-06-11 | 2012-07-25 | 杨波 | Taxus fruit wine and preparation method thereof |
| CN103211844B (en) * | 2013-03-26 | 2015-04-15 | 安徽和华生物医药科技有限公司 | Extraction method of taxus active extract |
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| CN1746285A (en) * | 2004-09-06 | 2006-03-15 | 黄金福 | Chinese yew fruit wine |
| CN103191041A (en) * | 2013-04-18 | 2013-07-10 | 江苏红豆杉药业有限公司 | Chinese yew branch and leaf extractive with anti-oxidative effect as well as extraction method and application of yew branch and leaf extractive |
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| 红豆杉资源及开发利用综述;马明东，等;《四川林业科技》;20040331;第25卷(第1期);第21-25页 * |
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