CN101314026B - 一种用于家禽的鸭浆膜炎疫苗口服液增效剂及其制备方法 - Google Patents
一种用于家禽的鸭浆膜炎疫苗口服液增效剂及其制备方法 Download PDFInfo
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Abstract
本发明涉及一种家禽用药物组合物及其制备方法。所述的用于鸭浆膜炎疫苗口服液增效剂，是由下列重量份的原料制成：茵陈10-15份、天麻2-5份、五味子15-20份、独一味10-20份、山楂20-25份、苍术10-15份、龙胆草10-15份、蛇胆2-5份、牛胆10-20份、芦荟40-60份、冰糖25-40份、利福平10份、多粘菌素15份。本发明所述的口服液增效剂可以直接投喂日常饲料中，也可直接饮水给药，能够有效提高机体免疫力、抗病能力，抗应激、降低患鸭浆膜炎率和提高鸭浆膜炎疫苗防治效果。
Description
【技术领域】
本发明涉及一种家禽用药物组合物及其制备方法。
【背景技术】
鸭浆膜炎是因家禽感染里默氏杆菌而发生的一种急性败血性传染病，目前世界上至少有21个血清型，且彼此之间无交叉免疫作用，流行于我国的以1、2、6、10型为主，其中1型最常见，该病目前是家禽业最常见、也是危害最大的病，如果治疗不及时往往引发大批量死亡。以前该病主要发生于5周龄以内的小鸭，目前随着毒力的增强，基本上任何日龄的鸭子都易感，病鸭是主要传染源，主要经呼吸道和消化道传播，也可经创伤之创面感染，死亡率可达50-90％。
对于防治鸭浆膜炎，除了极积改善养殖环境外，就是接种防鸭浆膜炎疫苗。关于疫苗接种，目前尚无十分有效的免疫防制措施，现常用的疫苗是大肠杆菌、默里氏杆菌两联苗，接种是需分二次注射而效果十分有限而且不稳定，给防治鸭浆膜炎带来很大的不确定性。
【发明内容】
本发明的目的是提供一种能提高家禽机体免疫力、抗病能力，降低鸭浆膜炎的感染机率和提高鸭浆膜炎疫苗防治效果的鸭浆膜炎疫苗口服液增效剂及其制备方法。
本发明所述的鸭浆膜炎疫苗口服液增效剂是由下列重量份的原料制成：
茵陈10-15份、天麻2-5份、五味子15-20份、独一味10-20份、山楂20-25份、苍术10-15份、龙胆草10-15份、蛇胆2-5份、牛胆10-20份、芦荟40-60份、冰糖25-40份、利福平5-10份、多粘菌素5-15份。
优选为：
茵陈15份、天麻5份、五味子20份、独一味15份、山楂20份、苍术15份、龙胆草15份、蛇胆5份、牛胆20份、芦荟60份、冰糖25份、利福平10份、多粘菌素15份。
本发明所述鸭浆膜炎疫苗口服液增效剂的制备方法，包括以下步骤：
(1)按所述重量比称取各原料，备用；
(2)将除利福平和多粘菌素之外的原料加水煎煮两次，每次加水量以没过原料面为宜，合并两次煎液，过滤得滤液，浓缩成比重为1.35的浸膏，加85-95％食用冰醋酸进行浸提，回收冰醋酸并浓缩，在45-50℃下干燥，制得干浸膏；
(3)将干浸膏粉碎成粉，加入利福平和多粘菌素，拌匀后再加入85-95％食用冰醋酸，搅匀即可。
本发明选择上述原料组合使得各成分功效产生协同作用，从而能够提高家禽机体免疫力、抗病能力，降低猪患鸭浆膜炎的机率和提高鸭浆膜炎疫苗防治效果。
其中选用茵陈是因为其清湿热、退黄疸，选用天麻是因为其平肝息风、止痉，选用五味子是因为其收敛固涩、益气生津、补肾宁心，选用独一味是因为其活血止血、祛风止痛、干黄水，选用山楂是因为其消食健胃、行气散瘀，选用苍术是因为其燥湿健脾、祛风散寒、明目，选用龙胆草是因为其泻肝胆实活、除下焦湿热，选用蛇胆是因为其解毒、化痰止咳、清湿热、凉血解毒、消肿利喉、湿热毒斑、保肝利胆、清理内毒素，选用牛胆是因为其清热解毒、风寒感冒、清肝明目、去湿利喉、解热泻火、排毒、消肿、利胆通肠、清热生津，选用芦荟是因为其抗病毒、抗细菌、清热败毒，清肝热、抗菌杀菌，提高抗病能力、阻止病毒侵入宿主细胞、抑制其DNA及RNA的合成、抑制病毒生长繁殖而起到抗病毒的效果、解毒、提高机体免疫力，选用冰糖是因为其抗应激、提高机体免疫力、抗病能力、促进血液循环、并可以改善口感。
本发明所述的口服液增效剂可以直接投喂日常饲料中，也可直接饮水给药，能够有效提高机体免疫力、抗病能力，抗应激、降底患鸭浆膜炎机率和提高鸭浆膜炎疫苗防治效果。
【具体实施方式】
实施例一：本发明口服液增效剂1制备
(1)称取茵陈10克、天麻2克、五味子15克、独一味10克、山楂20克、苍术10克、龙胆草10克、蛇胆2克、牛胆10克、芦荟40克、冰糖25克。
(2)将原料加水煎煮两次，第一次加水8倍量，煎煮2小时，第二次加水6倍量，煎煮1小时，合并两次煎液，过滤得滤液，浓缩成比重为1.35的浸膏，加85-95％食用冰醋酸进行浸提，回收冰醋酸并浓缩，在45-50℃下干燥，制得干浸膏14.86克；
(3)将干浸膏粉碎成粉，加入5克利福平和5克多粘菌素，搅拌均匀；
(4)加85-95％食用冰醋酸约至2000ml，搅匀即可。
实施例二：本发明口服液增效剂2制备
(1)称取茵陈15克、天麻5克、五味子20克、独一味15克、山楂20克、苍术15克、龙胆草15克、蛇胆5克、牛胆20克、芦荟60克、冰糖25克。
(2)将原料加水煎煮两次，第一次加水8倍量，煎煮2小时，第二次加水6倍量，煎煮1小时，合并两次煎液，过滤得滤液，浓缩成比重为1.35的浸膏，加85-95％食用冰醋酸进行浸提，回收冰醋酸并浓缩，在45-50℃下干燥，制得干浸膏19.35克；
(3)将干浸膏粉碎成粉，加入10克利福平和15克多粘菌素，搅拌均匀；
(4)加85-95％食用冰醋酸约至4000ml，搅匀即可。
实施例三：本发明的安全性
将1000只鸭随机分为二组，1组在每只鸭每天的日常饲料中加入100ml的本发明的口服液增效剂1，2组加入本发明的口服液增效剂2。观察30天。
30天中1000只鸭均无异常，无精神不振或死亡现象，长势良好。说明本发明的口服液安全性能良好。
实施例四：本发明口服液增效剂对鸭对鸭浆膜炎有预防作用
取幼鸭100只，随机均分成四组，每组25只，1组正常喂养，2组在每只的每天饲料中加入100ml(浓度1％)市售痢菌净，3组加入100ml(约浓度1％)本发明的口服液增效剂1，4组加入100ml(约浓度1％)本发明的口服液增效剂2。
饲养2周天后，分别在四组中各加入一只患有鸭浆膜炎的鸭，观察各组幼鸭的生长情况。
结果见表1。结果表明，本发明的口服液增效剂对幼鸭对鸭浆膜炎有明显的预防和治疗作用。
表1本发明的口服液增效剂对鸭的鸭浆膜炎的防治作用
实施例五：本发明口服液增效剂对幼鸭的鸭浆膜炎有预防作用
取幼鸭120头，在小鸭3-5日龄时，对每只幼鸭注射相同的鸭浆膜炎疫苗(皮下接种0.25-0.5ml/只大肠杆菌、默里氏杆菌两联苗)，随机均分成四组，每组30只，1组在每天正常喂养，2组加入100ml(浓度1％)市售痢菌净，3组加入100ml(约浓度1％)本发明的口服液增效剂1，4组加入100ml(约浓度1％)本发明的口服液增效剂2。在小鸭15日龄时，再对每只小鸭注射相同的鸭浆膜炎疫苗(皮下接种0.5-1ml/只大肠杆菌、默里氏杆菌两联苗)。
接种后，分别在四组中各加入2只患有鸭浆膜炎的鸭，观察各组小鸭的生长情况。
结果见表2。结果表明，本发明的口服液增效剂对鸭对鸭浆膜炎有明显的预防和治疗作用。
表2本发明的口服液增效剂对幼鸭的鸭浆膜炎的防治作用
Claims (2)
1.一种用于家禽的鸭浆膜炎疫苗口服液增效剂，其特征在于它是由下列重量份的原料制成：茵陈10-15份、天麻2-5份、五味子15-20份、独一味10-20份、山楂20-25份、苍术10-15份、龙胆草10-15份、蛇胆2-5份、牛胆10-20份、芦荟40-60份、冰糖25-40份、利福平5-10份、多粘菌素5-15份；
其是由如下制备方法制备而成：
(1)按所述重量比称取各原料，备用；
(2)将除利福平和多粘菌素之外的原料加水煎煮两次，每次加水量以没过原料面为宜，合并两次煎液，过滤得滤液，浓缩成比重为1.35的浸膏，加85-95％食用冰醋酸进行浸提，回收冰醋酸并浓缩，在45-50℃下干燥，制得干浸膏；
(3)将干浸膏粉碎成粉，加入利福平和多粘菌素，拌匀后再加入85-95％食用冰醋酸，搅匀即可。
2.如权利要求1所述的口服液增效剂，其特征在于是它由下列重量份的原料制成：茵陈15份、天麻5份、五味子20份、独一味15份、山楂20份、苍术15份、龙胆草15份、蛇胆5份、牛胆20份、芦荟60份、冰糖25份、利福平10份、多粘菌素15份。
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| CN1530023A (zh) * | 2003-03-11 | 2004-09-22 | 刚 宋 | 禽畜饲料绿色添加剂 |
| CN1868309A (zh) * | 2005-05-24 | 2006-11-29 | 河南省金鑫饲料工业有限公司 | 鸭中草药饲料添加剂 |
| CN1872205A (zh) * | 2006-04-17 | 2006-12-06 | 长沙金方堂生物科技有限公司 | 一种治疗畜禽消化道疾病的药物 |
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| CN1530023A (zh) * | 2003-03-11 | 2004-09-22 | 刚 宋 | 禽畜饲料绿色添加剂 |
| CN1868309A (zh) * | 2005-05-24 | 2006-11-29 | 河南省金鑫饲料工业有限公司 | 鸭中草药饲料添加剂 |
| CN1872205A (zh) * | 2006-04-17 | 2006-12-06 | 长沙金方堂生物科技有限公司 | 一种治疗畜禽消化道疾病的药物 |
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