CN101313751A - Health food for auxiliary improvement of memory - Google Patents
Health food for auxiliary improvement of memory Download PDFInfo
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- CN101313751A CN101313751A CNA200810028968XA CN200810028968A CN101313751A CN 101313751 A CN101313751 A CN 101313751A CN A200810028968X A CNA200810028968X A CN A200810028968XA CN 200810028968 A CN200810028968 A CN 200810028968A CN 101313751 A CN101313751 A CN 101313751A
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- taurine
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Abstract
The invention discloses healthcare food used for helping to improve the memory. The active ingredients by weight percentage of the healthcare food are: 15 to 85 percent of taurine, 13 to 80 percent of nutrient zinc and 0.01 to 10 percent of nutrient selenium. Among the active ingredients of the healthcare food, the taurine has the function of promoting the cerebral development; the nutrient selenium can improve the learning ability; and the nutrient zinc is a cerebrum nutriment. The functions of the three raw materials are combined according to a certain rule, and the three raw materials are prepared into the healthcare food according to a certain proportion, and give full play to respective functions during the process of improving the memory so as to achieve the aim of effectively improving the memory. As proved by animal function experimental researches and clinic human feeding trials, the healthcare food has the function of obviously helping to improve the memory.
Description
Technical field
The present invention relates to a kind of health food that is used for auxiliary improvement of memory, relate in particular to a kind of health food that is used for auxiliary improvement of memory with trace element and amino acid starting material preparation.
Background technology
Along with the development of society, people grow with each passing day to the dependence of information technology, except meeting causes the infringement of body posture, may also can bring antimigraine, be losing one's memory, restless and obstacle that notice can not be concentrated.Extensive use along with office automation and computer, people use computer more and more for a long time, the increase that social pressures, operating pressure and family are trifling, the ability to bear of excessively overdrawing brain, failure of memory almost is a universal phenomenon, therefore, entire society exists strengthening brain function, replenish brain nutrition, improving the requirement of remembering.
Decrease of memory mainly shows: the decrease of memory that age growth causes; The decrease of memory that the hobby tobacco and wine cause; Life, the big initiation psychological problems of operating pressure cause decrease of memory; Take in subalimentation and cause decrease of memory.People's brain is the maincenter that produces thinking and consciousness, and metabolism is very vigorous, and the normal operation of cerebral function needs the participation of multiple nutrients material, and in addition, when carrying out mental activity, brain cell needs a large amount of oxygen.If the oxygen supply deficiency will influence the function and thinking of brain.Therefore, improving memory generally is to take following approach to be effective: the essential material that replenishes the normal operation of brain; Increase the utilization of brain cell to oxygen; Replenish the material that can promote that the brain metabolism product is discharged.
The domestic health food that is used for auxiliary improvement of memory mainly is unsaturated fatty acids, protein and amino acids, mineral matter and microelement kind, vitamins, Chinese herbal medicine class at present.Utilize the very strong trace element of physiologically active, amino acid scientific composition, be refined into auxiliary improvement of memory and the health food that has no side effect is not seen at home as yet.
Summary of the invention
The object of the present invention is to provide a kind of health food that is used for auxiliary improvement of memory and has no side effect.
Solution of the present invention is based on the understanding of auxiliary improvement of memory power and principle, and to the trace element and the understanding of amino acid active effect, with reference to modern medicine and pharmacological research achievement, comform to filter out in multiple trace element and the amino acid and have the raw material that improves the memory activity, scientific composition makes its performance promote brain development; Improve learning ability; Replenish the effect of brain nutrient.
Active component and the weight content thereof of forming health food of the present invention are:
Taurine 15～85%
Nutrition zinc 13～80%
Nutrition selenium 0.01～10%.
The preferred weight content of forming the active component of health food of the present invention is:
Taurine 30～70%
Nutrition zinc 25～65%
Nutrition selenium 1～5%.
In the above-mentioned active component, described taurine is meant taurine or the artificial synthetic taurine that extracts from biology; Described nutrition zinc is meant employed zinc citrate, zinc acetate, zinc carbonate, zinc chloride, zinc gluconate, zinc lactate, zinc sulfate or zinc oxide in drug additive, food additives and health food nutrient; Described nutrition selenium is meant employed selenide of carragheen, selenocysteine, cereuisiae fermentum rich in selenoaminoacid, sodium selenate, sodium selenite or selenomethionine in drug additive, food additives and health food nutrient.
The above-mentioned health food that is used for auxiliary improvement of memory by common process, can be made said multiple formulation on the pharmacy, as capsule, tablet, powder, electuary, paste or granule.
An important feature of the present invention is the mechanism of action that taurine promotes brain development.Taurine is a kind of beta-amino acids that is transformed by cystine; can prevent or improve the effect that causes obstacle and promotion learning and memory of D-galactolipin; its mechanism of action may be to increase with superoxides disproportionation (SOD) activity, removes free radical effectively, and anti peroxidation of lipid, anti-damage are relevant.There are some researches show; no matter the learning memory disorder that to be taurine induce the D-galactolipin be formed with prevention effect; still to setting up D-galactolipin learning memory disorder learning and memory abilities in aging mice facilitation is arranged, show that all taurine can improve the obstacle learning and memory abilities in aging mice.Taurine has the effect that promotes that rat brain is grown, the rat that taurine lacks, and brain and intelligence development are adversely affected, and show as brain weight, brain function does not reach normal level.Taurine has protective effect to nerve cell, can promote propagation, differentiation and the inhibition cell ageing of nerve cell to improve ability of learning and memory.
Another important feature of the present invention is the mechanism of action that nutrition selenium improves learning ability.Selenium can effectively improve memory, and the content of blood lead and brain lead directly influences the learning ability of animal used as test, and plumbous have the characteristics of irreversibility to the influence of intelligence development, can cause academic record to fall behind, and takes selenium and can suppress plumbous absorption, influences the apoptosis of cranial nerve cell.Confirm by pharmacological evaluation: the selenizing stuck glue has facilitation to the learning functionality of brain, shortens learning process, and the infringement of the learning and Memory function that can agonist drug causes, improves cerebral function.Selenium zinc causes learning and memory of little mouse dysfunction and the snperoxiaized protective effect better effects if of cephalopin to lead.The higher concentration fluorine can make the learning ability of mice damage, and can cause hippocampus CA
3District's PDM thickness significantly diminishes and the synaptic cleft width significantly strengthens, but give this effect of the selenium antagonism fluorine of debita spissitudo simultaneously for fluorine.
Another important feature of the present invention is to replenish brain nutrient nutrition zinc.The Aged Mice autonomic activities degree that lacks zinc reduces, and zinc can improve the wound repair function of DNA (DNA) in the body, and then influences the learning and memory ability of mouse.Female mouse pregnancy period lacks zinc and can cause sub-mouse encephalodysplasia, and scarce zinc can cause light film, drowsiness, movable minimizing, emotionally disturbed and lose weight etc.Zinc influences the process that cynapse is transmitted, and zinc has the rat of promotion memory impairments simultaneously, and zinc normally has important effect to brain growth and function thereof, and the shortage of zinc can influence the brain growth of young mouse and the metabolism of neurotransmitter, thereby causes its learning ability to descend.If but replenished the zinc agent in early days in time, could reverse during then this variation.Replenished if lack in the zinc process afterwards, body is then got back to the eubolism state, and is day after the fair if scarce zinc can not get compensating into, will produce serious influence to growth of children and intelligence.
Decrease of memory is that multiple factor causes, and the present invention is that the wherein main pathogenesis of basis adopts multiple function raw material to carry out the science compatibility.Taurine has the effect that promotes brain development; nutrition selenium can improve learning ability; nutrition zinc is the brain nutrient; the effect that they can play is made up by certain law; and by certain component proportion; make health food, make three kinds of raw materials in the process of improving memory, give full play to each self-applying, to reach the purpose of effective improvement memory.The present invention has the function of obvious auxiliary improvement of memory through the research of animal functional experiment and human clinical's test-meal evidence.
In addition, health food effective component of the present invention is clear and definite, and steady quality is easy to control.The raw material components that the present invention selects for use is few, flat flavor, and instant has no side effect.
The present invention is further illustrated below in conjunction with the specific embodiment and animal function test.
The specific embodiment
The present invention will be described below to enumerate specific embodiment.It is pointed out that embodiment only is used for that the invention will be further described, do not represent protection scope of the present invention, nonessential modification and adjustment that other people prompting according to the present invention is made still belong to protection scope of the present invention.
Embodiment 1
Active component and the weight content thereof of forming health food of the present invention are:
Taurine 65%
Zinc citrate 33%
Selenide of carragheen 2%.
Embodiment 2
Active component and the weight content thereof of forming health food of the present invention are:
Taurine 55%
Zinc acetate 42%
Sodium selenate 3%.
Embodiment 3
Active component and the weight content thereof of forming health food of the present invention are:
Taurine 70%
Zinc chloride 28%
Cereuisiae fermentum rich in selenoaminoacid 2%.
Embodiment 4
Active component and the weight content thereof of forming health food of the present invention are:
Taurine 45%
Zinc gluconate 50%
Selenomethionine 5%.
Embodiment 5
Active component and the weight content thereof of forming health food of the present invention are:
Taurine 70%
Zinc lactate 20%
Selenocysteine 10%.
The health food that is used for auxiliary improvement of memory of the foregoing description by common process, can be made said multiple formulation on the pharmacy, as capsule, tablet, powder, electuary, paste or granule.
Animal function test result
The capsule that adopts the foregoing description 1 prescription to make carries out the animal function test according to Ministry of Public Health's " health food check and assessment technique standard (2003 editions) " regulation, and content of the test is: the body weight influence; Step down test; Water maze test; Data are handled.
1. repeated test result
1.1 capsule of the present invention is to the influence of mouse body weight:
The diving tower experimental group sees Table 1, and the water maze laboratory group sees Table 2.Each phase body weight of each experimental group weight ratio in corresponding period with control group, difference there are no significant meaning (P＞0.05) shows that capsule of the present invention does not have obvious influence to the body weight of mouse.
Table 1 capsule of the present invention is to the influence of mouse body weight (n=12, x ± s)
Table 2 capsule of the present invention is to the influence of mouse body weight (n=12, x ± s)
1.2 capsule of the present invention is to the influence of mouse step down test latent time, errors number and wrong reaction rate:
By table 3, table 4 result as seen, when training test, high dose group animal errors number reduces than control group, and difference has highly significant meaning (P＜0.01).When 24h test, middle and high dosage treated animal errors number reduced than control group, and difference has conspicuousness meaning (P＜0.05).When experiment was disappeared in memory in the 5th day, middle and high dosage treated animal errors number reduced than control group, and difference all has conspicuousness meaning (P＜0.05); Middle and high dosage treated animal wrong reaction rate lowers than control group, and difference all has conspicuousness meaning (P＜0.05).The result shows: in the experiment of mouse diving tower, its memory is obtained capsule of the present invention and the maintenance process has facilitation.
Table 3 capsule of the present invention is to the influence of mouse step down test latent time and errors number (n=12, x ± s)
Annotate: * represents that comparing P＜0.05 * * with control group represents to compare P＜0.01 with control group
Table 4 capsule of the present invention is to the disappear influence (x ± s) of experimental result of mouse step down test
Annotate: * represents that comparing P＜0.05 * * with control group represents to compare P＜0.01 with control group
1.3 capsule of the present invention is to the influence of reactivity (5 days aggregate result) of reaching home in time, errors number and the 2min of reaching home of mouse water maze test:
By table 5, table 6 result as seen, in 5 days duration of test, middle and high dosage treated animal is reached home the time all less than control group, and difference all has conspicuousness meaning (P＜0.05); The high dose group animal errors number of reaching home is compared minimizing with control group, and difference has highly significant meaning (P＜0.01).Memory is disappeared in the test after 5 days, animal ratio and the control group comparison of reaching home in time, errors number and the 2min of reaching home of each dosage treated animal, difference there are no significant meaning (P＞0.05).The result shows: in the mouse water maze laboratory, capsule of the present invention has facilitation to the mouse memory procurement process.
Table 5 capsule of the present invention is to the reach home influence of time and errors number of mouse water maze test
(result added up in 5 days, x ± s)
Annotate: * represents that comparing P＜0.05 * * with control group represents to compare P＜0.01 with control group
Table 6 capsule of the present invention is to the disappear influence (x ± s) of experimental result of mouse water maze
2. conclusion:
Give capsule 0.08,0.17 of the present invention, 0.50g/kg BW every day respectively to the Kunming mouse per os, be equivalent to recommend 5,10,30 times of day dosing, totally 4 weeks, the result shows: in the diving tower experiment, capsule of the present invention obtains and maintains the improvement effect to the memory of mouse passive avoidance response ability; In water maze laboratory, capsule of the present invention obtains to have the improvement effect to the memory of mouse spatial discrimination.Repeated test result is with result of the test is consistent first.
Evaluation criterion according to the auxiliary improving memory function method of inspection in " health food check and assessment technique standard " judges that capsule of the present invention has the function of improving memory.
Claims (6)
1, a kind of health food that is used for auxiliary improvement of memory is characterized in that active component and the weight content thereof of forming this health food are:
Taurine 15～85%
Nutrition zinc 13～80%
Nutrition selenium 0.01～10%.
2, the health food that is used for auxiliary improvement of memory according to claim 1 is characterized in that the weight content of each active component is:
Taurine 30～70%
Nutrition zinc 25～65%
Nutrition selenium 1～5%.
3, the health food that is used for auxiliary improvement of memory according to claim 1 and 2 is characterized in that described taurine is meant taurine or the artificial synthetic taurine that extracts from biology.
4, the health food that is used for auxiliary improvement of memory according to claim 1 and 2 is characterized in that described nutrition zinc is meant employed zinc citrate, zinc acetate, zinc carbonate, zinc chloride, zinc gluconate, zinc lactate, zinc sulfate or zinc oxide in drug additive, food additives and health food nutrient.
5, the health food that is used for auxiliary improvement of memory according to claim 1 and 2 is characterized in that described nutrition selenium is meant employed selenide of carragheen, selenocysteine, cereuisiae fermentum rich in selenoaminoacid, sodium selenate, sodium selenite or selenomethionine in drug additive, food additives and health food nutrient.
6, the health food that is used for auxiliary improvement of memory according to claim 1 and 2, the formulation that it is characterized in that described health food is capsule, tablet, powder, electuary, paste or granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200810028968XA CN101313751A (en) | 2008-06-23 | 2008-06-23 | Health food for auxiliary improvement of memory |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200810028968XA CN101313751A (en) | 2008-06-23 | 2008-06-23 | Health food for auxiliary improvement of memory |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101313751A true CN101313751A (en) | 2008-12-03 |
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ID=40105007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA200810028968XA Pending CN101313751A (en) | 2008-06-23 | 2008-06-23 | Health food for auxiliary improvement of memory |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102077943A (en) * | 2010-09-20 | 2011-06-01 | 王强 | Seafood for special dietary uses for hypomnesia patients |
| CN108936669A (en) * | 2018-09-25 | 2018-12-07 | 泓博元生命科技（深圳）有限公司 | Improve the composition and the preparation method and application thereof of memory |
| CN109170891A (en) * | 2018-09-25 | 2019-01-11 | 泓博元生命科技（深圳）有限公司 | A kind of composition and the preparation method and application thereof improving memory |
-
2008
- 2008-06-23 CN CNA200810028968XA patent/CN101313751A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102077943A (en) * | 2010-09-20 | 2011-06-01 | 王强 | Seafood for special dietary uses for hypomnesia patients |
| CN102077943B (en) * | 2010-09-20 | 2013-04-24 | 王强 | Seafood for special dietary uses for hypomnesia patients |
| CN108936669A (en) * | 2018-09-25 | 2018-12-07 | 泓博元生命科技（深圳）有限公司 | Improve the composition and the preparation method and application thereof of memory |
| CN109170891A (en) * | 2018-09-25 | 2019-01-11 | 泓博元生命科技（深圳）有限公司 | A kind of composition and the preparation method and application thereof improving memory |
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Application publication date: 20081203 |