CN101306405B - Full-automatic blood component preparation device and method - Google Patents
Full-automatic blood component preparation device and method Download PDFInfo
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- CN101306405B CN101306405B CN2008100121903A CN200810012190A CN101306405B CN 101306405 B CN101306405 B CN 101306405B CN 2008100121903 A CN2008100121903 A CN 2008100121903A CN 200810012190 A CN200810012190 A CN 200810012190A CN 101306405 B CN101306405 B CN 101306405B
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Abstract
The invention discloses a full automatic blood component preparation device and a preparation method thereof. The centrifuge rotating crankshaft of the preparation device is installed in the cavity of the centrifuge fixed base, the rotating crankshaft is hollowed, a cell interface detector is arranged in the cavity in the rotating crankshaft, and a blood gathering bag tray with a squeezing mechanism and a collecting bag tray are installed on the rotating crankshaft; a gas pipeline connects all control clamps and all extrusion units with an air pump through an unwinding cavity and an air pump control valve to form a control system with a microcomputer. The preparation method can automatically and synchronistically accomplish the fully closed operation flow of the blood centrifugation and separation and the blood component collection through the monitor signal sent out by the cell interface detector and the program control of the equipment microcomputer on a centrifuge, an air cell, the control clamps and the air pump control valve. The full automatic blood component preparation device and the preparation method has the advantages that the complete separation, the high purity and the pollution free of the blood components of blood plasma, blood platelet and red blood cell are realized; a whole blood single bag separation is realized, namely gathering is carried out instantly after collection, the device is miniaturized and portable; the preparation device and the preparation method are particularly suitable for the application in an emergency, in a blood collecting vehicle on site and in a room.
Description
Technical field
The invention belongs to blood component preparation device and preparation method field, be specifically related to a kind of full automatic blood component preparation device and preparation method.
Background technology
The whole blood that gather the blood station, main component is blood plasma, red blood cell, leucocyte and blood platelet, blood (preservation condition of each composition of blood is different) is preserved in the blood station, and blood transfusion all needs separation of whole blood is become blood constituent with clinical patients, and the time gap blood collection time that is prepared into blood constituent is short more good more, purity is high more good more, could effectively guarantee the validity of different blood constituents like this, make full use of valuable blood resource.But, be used for blood constituent and separate employed centrifuge and be main equipment, though be fit to concentrate blood in enormous quantities to separate, can't be used for blood-collecting car or blood sampling room, more can not guarantee the time and the purity of separating; The method that the blood station prepares blood constituent is earlier whole blood to be concentrated transportation blood back station, concentrates centrifugally, uses other device separates blood constituent after centrifugal the finishing again, centrifugal with separate and can not finish synchronously, blood collection is longer to the time that is separated into blood constituent.Particularly blood-collecting car blood sampling or on-the-spot emergency action blood sampling can not be to single bag of separations of whole blood, promptly adopt i.e. branch.Before this, the U.S. is centrifugal to single bag of whole blood, separate and realized finishing synchronously, but this equipment is to be improved by the blood cell wash mill to form, to blood collection bags when centrifugal, pockets such as collecting bag remain static, and both connections need be separated cyclone, and cost is higher, and the method that it adopts can't realize that pipeline truly is airtight, satisfies the blood safety demand.
Summary of the invention
The present invention discloses a kind of full automatic blood component preparation device and preparation method, solves above-mentioned technological deficiency problem.
The concrete technical scheme of preparation facilities of the present invention mainly comprises three parts:
The one, mechanical system, centrifuge rotation arbor is installed in the cavity of centrifuge firm banking, centrifugal arbor adopts the hollow rotating arbor, the middle part of rotation arbor cavity is position and top position on the lower side on the lower side, each settles a removable pulsed cell interface detector, with cell detector relative position axial wall on the device two apertures be 2mm
2～3mm
2Transparency window.Circular canopy shape blood collection bags pallet of rotation arbor bottom fixed installation, respectively there is a square restitope axisymmetric both sides on pallet; Rotation arbor middle part and top respectively are provided with a chute, and symmetry is installed two square collecting bag pallets (the surface area ratio collecting bag is bigger) in the chute, and restitope and pallet are in same vertical plane; Two chute fixture blocks have been fixed on the perpendicular position of vertical plane therewith in the chute inherence, make the collecting bag pallet that assigns in the chute can be around 90 ° of rotation arbor one-directional rotation.
Respectively there is a pallet flype canopy shape blood collection bags pallet restitope both sides of the edge and collecting bag pallet both sides of the edge, be connected with each pallet by folding shaft, pallet flype lower surface upwards is depression hole shape, can place extruding gasbag, the air bag upper surface normally is bonded in the lower surface depression hole of pallet flype, between canopy shape blood collection bags pallet and air bag, place blood collection bags, between collecting bag pallet and air bag, place collecting bag.
The 2nd, control system, blood collection bags pallet and collecting bag pallet and the inner gas pipeline that communicates that makes of rotation arbor, the gas pipeline of this end of pallet connects air bag and control folder, the gas pipeline of rotation arbor bottom by the chamber of untwisting, pass the seperator firm banking, the air pump control valve installed on each bar gas pipeline is connected with air pump, the air pump control valve is by the equipment microcomputerized control.
The 3rd, the blood bag system, use existing general blood sampling three linked blood bags, comprise blood collection bags, collecting bag (being also referred to as transfering bag) and red blood cell additive bag, the three must be positioned over centrifugal shaft homonymy pallet, connect with the transparent conduit that has the control folder, arbor is fixed and survey form over against cell near rotating.Place identical another set of simulation bag at the whirler axisymmetric position.
The preparation process of blood constituent, be to send pilot signal and equipment micro computer by the cell interface detector gentle pump control valve implementation procedure control is pressed from both sides in centrifuge, air bag, control, automatically finish the totally closed operation flow process of centrifugal blood, separation and blood component collection synchronously.
Full automatic blood component preparation device of the present invention is with the preparation method is totally-enclosed owing to adopting, fully automatic blood separates and blood is collected integration apparatus system and preparation technology, need not to change existing blood bag constructions, realized pollution-free, single bag of separation of whole blood (promptly adopt promptly and divide); Equipment miniaturization, portable realizes that blood plasma, blood platelet separate entirely with erythrocytic blood constituent, the purity height, is particularly suitable for using in emergency condition, the on-the-spot blood-collecting car (room).
Description of drawings
Below in conjunction with the drawings and specific embodiments the present invention is described in further detail.
Fig. 1 is full automatic blood component preparation device schematic diagram and rotation arbor cutaway view;
Fig. 2 is the full automatic blood component preparation device vertical view.
Figure labeling description: hollow rotating arbor 1, control folder 2, collecting bag 3, collecting bag pallet 4, chute 5, transparent conduit 6, pallet flype 7, air bag 8, folding shaft 9, transparency window 10,10 ', cell interface detector 11,11 ', blood collection bags 12, blood collection bags pallet 13, gas pipeline 14, centrifuge 15, support 16, air pump control valve 17, air pump 18, the chamber 19 of untwisting, chute fixture block 20.
The specific embodiment
As shown in Figure 1, preparation facilities of the present invention mainly comprises three parts.
Mechanical system part, centrifugal arbor adopt hollow rotating arbor 1, rotation arbor 1 hollow intracavitary unit cell interface detector 11,11 '; Cell interface detector 11,11 ' is passed into rotation arbor 1 fixed position by the vertical sounding rod along hollow space from upper opening, and detector bar then is fixed on the irrotational machine outer wall, can move up and down.The circular canopy shape of rotation arbor 1 bottom fixed installation one deck blood collection bags pallet 13, each square restitope of axisymmetric both sides, rotation arbor 1 middle part, top are equipped with each symmetry of chute 5 (see figure 2)s two square collecting bag pallets 4 (the surface area ratio collecting bag is bigger) are installed, and square restitope and square pallet are in same vertical plane; Two chute fixture blocks 20 have been fixed on the perpendicular position of vertical plane therewith in chute 5 inherences, make the collecting bag pallets 4 that assign in the chute 5 can be around 90 ° of rotation arbor 1 one-directional rotation; A portable cell interface detector 11,11 ' is respectively settled on middle part and top in rotation arbor 1 cavity, rotate arbor 1 with cell interface detector 11,11 ' relative position, installing the aperture respectively is 2mm
2～3mm
2Transparency window 10,10 '.
Respectively there is a pallet flype 7 canopy shape blood collection bags pallet 13 restitope both sides of the edge and collecting bag pallet 4 both sides of the edge, be connected with each pallet by folding shaft 9, pallet flype 7 lower surfaces upwards are depression hole shape, can place air bag 8, air bag 8 upper surfaces normally are bonded in the lower surface depression hole of pallet flype 7, place blood collection bags 12 between canopy shape blood collection bags pallet 13 and air bag 8; Between collecting bag pallet 4 and air bag 8, place collecting bag 3.
The control system part, blood collection bags pallet 13 and collecting bag pallet 4 and the rotation arbor 1 inner gas pipeline 14 that communicates that makes, and converge near the zonule the close cavity that rotates arbor 1 bottom surface, enter air pump 18 by the chamber 19 of untwisting separately again, each bar gas pipeline 14 is installed air pump control valve 17 respectively untwisting between chamber 19 and the air pump 18; The control of blood collection bags 12 and collecting bag 3 folder 2 communicates with gas pipeline 14, and the equipment micro computer presss from both sides 2 gentle pump control valves 17 by the 18 control controls of control air pump.
The transfusion system part is placed blood collection bags 12 and collecting bag 3 on each of symmetrical the same side layer pallet, blood collection bags 12 and two collecting bags 3 are tightly connected, and transparent connecting duct 7 must be through the transparency window 10 and 10 ' on the rotation arbor 1.Symmetry is placed fixing simulation blood bag on the opposite side pallet, puts in advance in the analog acquisition bag 12 and 200 milliliters or the 400 milliliters liquid with whole blood equivalent, plays balanced action when centrifugal; Other connected mode is also identical with the blood bag, and the control and the separation process of blood bag of each layer air bag 8, gas pipeline 14 and transparent conduit 6 control folders 2 are synchronous.
Preparation process of the present invention, mainly be to centrifuge 15, air bag 8, the 2 gentle pump control valve 17 implementation procedures controls of control folder by cell interface detector 11,11 ' monitoring and equipment micro computer, realize that fully automatic blood is centrifugal, high accuracy is separated and the blood component collection flow process, and flow process is in the totally-enclosed system.
Prepare before the preparation: in the same side of blood collection bags pallet 13 and collecting bag pallet 4, the blood collection bags 12 of interior dress whole blood is placed on lower floor's blood collection bags pallet 13, respectively place collecting bag 3 on middle level collecting bag pallet 4 and the upper strata collecting bag pallet 4, dress red blood cell additive in the collecting bag 3 of upper strata collecting bag pallet 4; Lower floor's blood collection bags 12 of a relative side is put into and 200 milliliters or the 400 milliliters liquid with whole blood equivalent in advance.Six sacks all will export upwards, tilt to place, and each outlet is connected with transfusion transparent conduit 6 by control folder 2.
The preparation beginning, micro computer starts centrifuge 15, rotates rotation arbor 1, drives blood collection bags pallet 13 and collecting bag pallet 4 and rotates synchronously.Begin the light eccentric phase, the whole blood in the blood collection bags 12 is pressed platelet rich plasma and red blood cell ordering layering by outlet side to the bag bottom side.The equipment micro computer starts corresponding air pump control valve 17, open the control folder 2 of both sides lower floor and middle level collecting bag 3, open lower floor's air bag 8 simultaneously and make its inflation, squeezes blood collection bag 12, the liquid that is rich in hematoblastic blood plasma and opposite side is risen through transfusion transparent conduit 6 respectively enter middle level collecting bag 3, rise to transparency window 10 until red blood cell.It is centrifugal to begin weight subsequently, and the blood plasma of heavy centrifugal generation is squeezed in the middle level collecting bag 3; Because synchronously heavy centrifugal, under heavy centrifugal action, be settled down to middle level collecting bag 3 bottoms at the light blood platelet that enters middle level collecting bag 3 when centrifugal.Close middle level control folder 2 and lower floor's air bag 8, open upper strata control folder 2 and air bag 8, the red blood cell additive is squeezed in lower floor's blood collection bags 12.Close lower floor's control folder 2 and upper strata air bag 8, open middle level control folder 2 and air bag 8, the blood plasma in the middle level collecting bag 3 is squeezed in the upper strata collecting bag 3, when cell interface detector 11 ' detects the blood platelet interface, close all control folder 2 and air bags 8, stop centrifuge 15.Being blood plasma in the upper strata collecting bag 3 then, is blood platelet in the middle level collecting bag 3, is red cell suspension in lower floor's collection bag 12.Separation process finishes, can take off the collecting bag 3 that blood plasma is housed from upper tray, afterwards upper strata collecting bag pallet 4 is rotated 90 °, raise the pallet flype 8 of middle level collecting bag pallet 4 again, take off from pallet hematoblastic collecting bag 3 is housed, afterwards middle level collecting bag pallet 4 is rotated 90 °, raise the pallet flype 8 of lower floor's blood collection bags pallet 13 again, take off the blood collection bags 12 that red cell suspension is housed from pallet.
Can prepare preceding preparation afterwards next time.
Claims (6)
1. full automatic blood component preparation device, use existing general blood sampling three linked blood bags, comprising blood collection bags and collecting bag, and with having the transparent conduit connection that control is pressed from both sides, it is characterized in that: centrifuge rotation arbor is installed in the cavity of centrifuge firm banking, rotation arbor hollow, middle part in cavity is position and top position on the lower side on the lower side, each settles a removable pulsed cell interface detector, with the axial wall of cell interface detector relative position on two apertures of device be 2mm
2～3mm
2Transparency window; On the rotation arbor blood collection bags pallet and the collecting bag pallet that has extrusion is installed; By gas pipeline each control folder, each extrusion are connected with air pump, air pump connects the air pump control valve, and equipment microcomputerized control air pump control valve constitutes control system thus.
2. according to the described full automatic blood component preparation device of claim 1, it is characterized in that: circular canopy shape blood collection bags pallet of bottom fixed installation of described rotation arbor, respectively there is a square restitope axisymmetric both sides on pallet; Rotation arbor middle part and top respectively are provided with a chute, each symmetrical erection space two piece square collecting bag pallets more bigger in the chute than collecting bag area, and restitope and pallet are in same vertical plane; Two chute fixture blocks have been fixed on the perpendicular position of vertical plane therewith in the chute inherence, make the collecting bag pallet that assigns in the chute can be around 90 ° of rotation arbor one-directional rotation.
3. according to claim 1 or 2 described full automatic blood component preparation devices, it is characterized in that: the extrusion of described blood collection bags pallet and collecting bag pallet mainly is an air bag; Respectively there is a pallet flype canopy shape blood collection bags pallet restitope both sides of the edge and collecting bag pallet both sides of the edge, be connected with each pallet by folding shaft, pallet flype lower surface upwards is depression hole shape, can place air bag, the air bag upper surface normally is bonded in the lower surface depression hole of pallet flype, between canopy shape blood collection bags pallet and air bag, place blood collection bags, between collecting bag pallet and air bag, place collecting bag.
4. according to the described full automatic blood component preparation device of claim 1, it is characterized in that: described control system is at blood collection bags pallet and collecting bag pallet and the inner gas pipeline that communicates that makes of rotation arbor, the gas pipeline of this end of pallet connects air bag and control folder, the gas pipeline of rotation arbor bottom by the chamber of untwisting, pass the seperator firm banking, the air pump control valve installed on each bar gas pipeline is connected with air pump, the air pump control valve is by the equipment microcomputerized control.
5. according to the described full automatic blood component preparation device of claim 1, it is characterized in that: described three linked blood bags, must be positioned over rotation arbor homonymy pallet, transparent conduit connects upper and lower three sacks through each layer control folder, near rotating that arbor is fixed and over against described transparency window; Place identical another set of simulation bag at the whirler axisymmetric position.
6. preparation method who utilizes the described full automatic blood component preparation device of claim 1, it is characterized in that: the preparation process of described blood constituent, be to send pilot signal and equipment micro computer by the cell interface detector gentle pump control valve implementation procedure control is pressed from both sides in centrifuge, air bag, control, automatically finish the totally closed operation flow process of centrifugal blood, separation and blood component collection synchronously.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008100121903A CN101306405B (en) | 2008-07-04 | 2008-07-04 | Full-automatic blood component preparation device and method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008100121903A CN101306405B (en) | 2008-07-04 | 2008-07-04 | Full-automatic blood component preparation device and method |
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| CN101306405A CN101306405A (en) | 2008-11-19 |
| CN101306405B true CN101306405B (en) | 2011-04-06 |
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Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101444763B (en) * | 2008-11-25 | 2010-12-08 | 康炜 | Full automatic blood component preparation device and preparation method |
| CN101607232B (en) * | 2009-07-14 | 2011-04-27 | 潘凌子 | Single-layer fully-automatic device for preparing blood components |
| DE102009040525B4 (en) * | 2009-09-08 | 2015-02-05 | Andreas Hettich Gmbh & Co. Kg | Centrifuge for separating whole blood into blood components, and fluidically communicating containers for insertion into the centrifuge, and methods for obtaining a highly enriched platelet concentrate from whole blood |
| US8469871B2 (en) * | 2010-11-19 | 2013-06-25 | Kensey Nash Corporation | Centrifuge |
| CN105597179B (en) * | 2016-02-24 | 2018-01-05 | 江苏摩科特医疗科技有限公司 | Blood irradiator, dose monitoring system and irradiation dose measuring method |
| EP3548108B1 (en) * | 2016-12-02 | 2024-01-31 | Terumo BCT, Inc. | Composite fluid separation |
| CN110152895B (en) * | 2019-06-10 | 2021-06-04 | 甘肃龙腾科技有限责任公司 | Serum extraction centrifugal separation device |
| CN111420813B (en) * | 2020-04-06 | 2022-01-28 | 四川大学华西医院 | PRP centrifugal sleeve, PRP centrifugal machine and PRP preparation method |
| CN114289194A (en) * | 2021-12-30 | 2022-04-08 | 昕慕(江苏)生物医药科技有限公司 | Blood component separator and use method |
| CN115025893B (en) * | 2022-08-11 | 2022-11-04 | 广州知力医学诊断技术有限公司 | Blood low-temperature centrifuge, whole blood separating method and erythrocyte washing method |
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