CN101301275A - 含烟碱的口服剂量形式的制备方法 - Google Patents
含烟碱的口服剂量形式的制备方法 Download PDFInfo
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- CN101301275A CN101301275A CNA2008101253651A CN200810125365A CN101301275A CN 101301275 A CN101301275 A CN 101301275A CN A2008101253651 A CNA2008101253651 A CN A2008101253651A CN 200810125365 A CN200810125365 A CN 200810125365A CN 101301275 A CN101301275 A CN 101301275A
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- Prior art keywords
- nicotine
- active substance
- lozenge
- dosage form
- melt
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- General Chemical & Material Sciences (AREA)
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- Biochemistry (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
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| CNA028073339A Pending CN1553771A (zh) | 2001-03-26 | 2002-03-22 | 含烟碱的口服剂量形式 |
Country Status (11)
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104132895A (zh) * | 2014-07-08 | 2014-11-05 | 国家烟草质量监督检验中心 | 适用于连续流动法测定烟草及烟草制品中总植物碱的缓冲体系 |
| CN104363768A (zh) * | 2012-04-17 | 2015-02-18 | R.J.雷诺兹烟草公司 | 重熔的可摄取产品 |
| CN115003281A (zh) * | 2020-01-15 | 2022-09-02 | 麦克内尔股份公司 | 锭剂 |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040253307A1 (en) * | 2003-02-04 | 2004-12-16 | Brian Hague | Sugar-free oral transmucosal solid dosage forms and uses thereof |
| IL155666A (en) | 2003-04-29 | 2013-12-31 | Neurim Pharma 1991 | Insomnia treatment |
| US9119846B2 (en) | 2003-04-29 | 2015-09-01 | Neurim Pharmaceuticals (1991) Ltd. | Method and composition for enhancing cognition in alzheimer's patients |
| PL2446881T3 (pl) * | 2003-07-24 | 2014-08-29 | Glaxosmithkline Llc | Folie rozpuszczające się w jamie ustnej |
| GB0320854D0 (en) | 2003-09-05 | 2003-10-08 | Arrow No 7 Ltd | Buccal drug delivery |
| US20070191815A1 (en) | 2004-09-13 | 2007-08-16 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery |
| US8627828B2 (en) | 2003-11-07 | 2014-01-14 | U.S. Smokeless Tobacco Company Llc | Tobacco compositions |
| AU2004289248B2 (en) | 2003-11-07 | 2012-05-03 | U.S. Smokeless Tobacco Company Llc | Tobacco compositions |
| RU2351148C2 (ru) * | 2004-08-11 | 2009-04-10 | КЭДБЕРИ АДАМС ЮЭсЭй ЭлЭлСи | Согревающие композиции и системы их доставки |
| US8252321B2 (en) | 2004-09-13 | 2012-08-28 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like |
| WO2008069921A2 (en) * | 2006-12-01 | 2008-06-12 | Cima Labs Inc. | Oral transmucosal nicotine dosage form |
| GB2468424B (en) * | 2007-04-02 | 2011-11-09 | Parkinson S Inst | Methods and compositions for reduction of side effects of therapeutic treatments |
| ES2521494T3 (es) | 2007-04-02 | 2014-11-12 | Parkinson's Institute | Métodos y composiciones para la reducción de los efectos secundarios de tratamientos terapéuticos |
| DE102008012015A1 (de) | 2008-03-01 | 2009-09-10 | Südzucker AG Mannheim/Ochsenfurt | Verbesserte Isomalt-haltige Komprimate und Verfahren zu ihrer Herstellung |
| CN102770138B (zh) * | 2010-02-18 | 2015-12-09 | J·V·达卡 | 含有尼古丁的软凝胶锭剂 |
| US20110274628A1 (en) * | 2010-05-07 | 2011-11-10 | Borschke August J | Nicotine-containing pharmaceutical compositions |
| UA112974C2 (uk) * | 2010-09-16 | 2016-11-25 | Джеі. Бі. Кемікалс Енд Фармасьютікалс Лімітид | Нікотиновмісна композиція (варіанти) |
| CA2841785A1 (en) | 2011-07-06 | 2013-01-10 | The Parkinson's Institute | Compositions and methods for treatment of symptoms in parkinson's disease patients |
| US9474303B2 (en) * | 2011-09-22 | 2016-10-25 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
| US9629392B2 (en) | 2011-09-22 | 2017-04-25 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
| US9084439B2 (en) | 2011-09-22 | 2015-07-21 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
| US20130078307A1 (en) | 2011-09-22 | 2013-03-28 | Niconovum Usa, Inc. | Nicotine-containing pharmaceutical composition |
| US9907748B2 (en) | 2011-10-21 | 2018-03-06 | Niconovum Usa, Inc. | Excipients for nicotine-containing therapeutic compositions |
| TW201507726A (zh) * | 2013-05-10 | 2015-03-01 | Glaxosmithkline Llc | 菸鹼菱形錠配製物 |
| WO2016123406A1 (en) | 2015-01-28 | 2016-08-04 | Chrono Therapeutics Inc. | Drug delivery methods and systems |
| CA2977814A1 (en) | 2015-03-12 | 2016-09-15 | Chrono Therapeutics Inc. | Craving input and support system |
| WO2018129304A1 (en) | 2017-01-06 | 2018-07-12 | Chrono Therapeutics Inc. | Transdermal drug delivery devices and methods |
| SE541358C2 (en) * | 2017-05-30 | 2019-08-13 | Enorama Pharma Ab | Nicotine-containing chewing gum compositions |
| AU2019279884B2 (en) | 2018-05-29 | 2025-01-30 | Morningside Venture Investments Limited | Drug delivery methods and systems |
| MA54245A (fr) | 2018-11-16 | 2022-02-23 | Morningside Venture Investments Ltd | Système d'administration transdermique de médicaments à régulation thermique |
| WO2020244725A1 (en) * | 2019-06-07 | 2020-12-10 | Ncp Nextgen A/S | Nicotine pouch product |
| USD1081739S1 (en) | 2021-04-06 | 2025-07-01 | Altria Client Services Llc | Die for gum forming |
| US20220313678A1 (en) * | 2021-04-06 | 2022-10-06 | Altria Client Services Llc | Spray dried nicotine for inclusion in oral products |
| US12295412B2 (en) | 2022-01-28 | 2025-05-13 | Altria Client Services Llc | Oral pouch product |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9310412D0 (en) * | 1993-05-20 | 1993-07-07 | Danbiosyst Uk | Nasal nicotine system |
| US5549906A (en) * | 1993-07-26 | 1996-08-27 | Pharmacia Ab | Nicotine lozenge and therapeutic method for smoking cessation |
| US5362496A (en) * | 1993-08-04 | 1994-11-08 | Pharmetrix Corporation | Method and therapeutic system for smoking cessation |
| DE19536394A1 (de) * | 1995-09-29 | 1997-04-03 | Basf Ag | Feste Arzneiformen, erhältlich durch Extrusion einer Isomalt enthaltenden Polymer-Wirkstoff-Schmelze |
| DE19639342C2 (de) * | 1996-09-25 | 1998-07-16 | Suedzucker Ag | Kaugummi, enthaltend ein Süßungsmittel |
| US6322806B1 (en) * | 1999-04-06 | 2001-11-27 | Wm. Wrigley Jr. Company | Over-coated chewing gum formulations including tableted center |
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2002
- 2002-03-22 AR ARP020101068A patent/AR033444A1/es unknown
- 2002-03-22 WO PCT/US2002/008914 patent/WO2002076211A1/en active IP Right Grant
- 2002-03-22 AU AU2002252470A patent/AU2002252470B2/en not_active Ceased
- 2002-03-22 JP JP2002574739A patent/JP2004525928A/ja active Pending
- 2002-03-22 CN CNA028073339A patent/CN1553771A/zh active Pending
- 2002-03-22 NZ NZ528167A patent/NZ528167A/en not_active IP Right Cessation
- 2002-03-22 CA CA002440713A patent/CA2440713A1/en not_active Abandoned
- 2002-03-22 MX MXPA03008762A patent/MXPA03008762A/es active IP Right Grant
- 2002-03-22 CN CNA2008101253651A patent/CN101301275A/zh active Pending
- 2002-03-22 PL PL02364621A patent/PL364621A1/xx not_active Application Discontinuation
- 2002-03-22 EP EP02721544A patent/EP1372392A4/en not_active Withdrawn
- 2002-03-22 BR BR0208382-5A patent/BR0208382A/pt not_active IP Right Cessation
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104363768A (zh) * | 2012-04-17 | 2015-02-18 | R.J.雷诺兹烟草公司 | 重熔的可摄取产品 |
| JP2015516153A (ja) * | 2012-04-17 | 2015-06-11 | アール・ジエイ・レイノルズ・タバコ・カンパニー | 再融解摂取製品 |
| CN104363768B (zh) * | 2012-04-17 | 2018-03-16 | R.J.雷诺兹烟草公司 | 重熔的可摄取产品 |
| US10517818B2 (en) | 2012-04-17 | 2019-12-31 | R.J. Reynolds Tobacco Company | Remelted ingestible products |
| CN104132895A (zh) * | 2014-07-08 | 2014-11-05 | 国家烟草质量监督检验中心 | 适用于连续流动法测定烟草及烟草制品中总植物碱的缓冲体系 |
| CN104132895B (zh) * | 2014-07-08 | 2017-08-25 | 国家烟草质量监督检验中心 | 适用于连续流动法测定烟草及烟草制品中总植物碱的缓冲体系 |
| CN115003281A (zh) * | 2020-01-15 | 2022-09-02 | 麦克内尔股份公司 | 锭剂 |
Also Published As
| Publication number | Publication date |
|---|---|
| PL364621A1 (en) | 2004-12-13 |
| AU2002252470B2 (en) | 2008-05-22 |
| BR0208382A (pt) | 2004-06-15 |
| CN1553771A (zh) | 2004-12-08 |
| WO2002076211A1 (en) | 2002-10-03 |
| NZ528167A (en) | 2005-04-29 |
| EP1372392A1 (en) | 2004-01-02 |
| AR033444A1 (es) | 2003-12-17 |
| CA2440713A1 (en) | 2002-10-03 |
| MXPA03008762A (es) | 2004-02-18 |
| EP1372392A4 (en) | 2004-06-23 |
| JP2004525928A (ja) | 2004-08-26 |
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