CN101297896B - Method for extracting antipyretic and detoxicated oral liquid using cellulase - Google Patents
Method for extracting antipyretic and detoxicated oral liquid using cellulase Download PDFInfo
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- CN101297896B CN101297896B CN2008100526420A CN200810052642A CN101297896B CN 101297896 B CN101297896 B CN 101297896B CN 2008100526420 A CN2008100526420 A CN 2008100526420A CN 200810052642 A CN200810052642 A CN 200810052642A CN 101297896 B CN101297896 B CN 101297896B
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Abstract
The invention discloses a method for extracting antipyretic and antitoxic oral solution by using cellulase which aims at providing a method for extracting oral solution with simple operating technology, safety and energy saving. The method of the invention includes the following steps that materials required to prepare 100L antipyretic and antitoxic oral solution are added into 200 to 700L purified water to be then evenly blended; 0.2 to 5kg cellulase is then added into the purified water and evenly mixed, and the obtained mixture then stands still under the room temperature for 15 to 72 hours to realize the full reaction; the mixture after the full reaction is then filtered to collect the filtrate which is condensed to 100L and the pH value of which is adjusted to be 4.3 to 6.0 so as to obtain the antipyretic and antitoxic oral solution. By utilizing the unique activity, the mechanism of functioning under the room temperature and the function of exclusively decomposing plant cellulose of the cellulase and determining the dosage of the cellulase and the technology conditions under the room temperature, the production method of the invention prepares the antipyretic and antitoxic oral solution through a certain period of treatment, filtration and condensation and has the advantages of simple operation, safety, energy saving, less environmental pollution and reduction of the production cost.
Description
Technical field
The present invention relates to a kind of extracting method of oral liquid, in particular, relate to a kind of method of utilizing cellulase to extract antipyretic and detoxicated oral liquid.
Background technology
Antipyretic and detoxicated oral liquid is a kind of antiviral Chinese medicine oral liquid, has heat-clearing and toxic substances removing, cures mainly fever caused by exogenous pathogens, be used for more pestilence from the beginning of.Can be used for virosiss such as fowl newcastle, fabricius bursa and viral respiratory disease, chronic respiratory tract disease etc., utilize in the process at veterinary drug to be widely used.
Traditional handicraft is extracted antipyretic and detoxicated oral liquid, and need to decoct twice, and filter, concentrate, refilter and obtain through adding purified water, complicated process of preparation, the preparation cost height, equipment has high input, use coal resource and purified water resource that need be a large amount of.And the workman scalds easily in process of production, fire-prone in the heating process.
Summary of the invention
The present invention is in order to overcome weak point of the prior art, the method for simple, safe, the energy-conservation extraction antipyretic and detoxicated oral liquid of a kind of operating procedure to be provided.
The present invention is achieved through the following technical solutions:
A kind of method of utilizing cellulase to extract antipyretic and detoxicated oral liquid is characterized in that, comprises the steps:
(1) will prepare the required raw material of 100L antipyretic and detoxicated oral liquid and join in 200～700L water and stir, the cellulase that adds 0.2～5kg again stirs, and at room temperature places 15～72 hours, and fully reaction is filtered and discarded filtering residue, collects filtrate;
(2) above-mentioned filtrate is concentrated into 100L, regulates pH value to 4.3～6.0, obtain antipyretic and detoxicated oral liquid.Acid or alkali can be added when regulating pH value, sodium hydroxide or hydrochloric acid etc. can be used.
The preferred range of the antipyretic and detoxicated oral liquid raw material of preparation 100L is: the needed raw material of preparation 100L antipyretic and detoxicated oral liquid, water 250～600L, cellulase 0.3～4kg; At room temperature the time of Fang Zhiing is 18～48 hours.
The raw materials used optimum of antipyretic and detoxicated oral liquid of preparation 100L is: the needed raw material of preparation 100L antipyretic and detoxicated oral liquid, water 400L, cellulase 1kg; At room temperature the time of Fang Zhiing is 36 hours.
The water that uses in the above-mentioned preparation method preferably adopts purified water.Wherein prepare the needed raw material of 100L antipyretic and detoxicated oral liquid according to the national standard formulation ratio.
The present invention has following technique effect:
Production method of the present invention is utilized the function of the unique activity of cellulase and mechanism that plays a role and single-minded decomposition plant cellulose under normal temperature condition, under normal temperature condition, by determining to the use amount of cellulase and process conditions, processing through certain hour, filter, concentrate and obtain antipyretic and detoxicated oral liquid, that method of the present invention has is simple to operate, safe, energy-conservation, the joint purified water, reduce environmental pollution, save the advantage of non-renewable resource.Simultaneously, can reduce energy consumption and purified water resource consumption, increase the safety of production operation, reduce production cost.Investment of production equipment is little.
The specific embodiment
Below in conjunction with specific embodiment to the detailed description of the invention.
Embodiment 1
To prepare the needed raw material of 100L antipyretic and detoxicated oral liquid and press the standard recipe proportioning, it is standby to pulverize the 24# sieve.Above-mentioned ready raw material is added the 600L purified water stir, add the cellulase of 0.5kg again, stir, at room temperature placed 18 hours, filter and discard filtering residue, collect filtrate.The filtrate of collecting is concentrated into 100L, and hydro-oxidation sodium is regulated pH value to 4.3～6.0 and is obtained antipyretic and detoxicated oral liquid.
Embodiment 2
To prepare the needed raw material of 100L antipyretic and detoxicated oral liquid and press the standard recipe proportioning, it is standby to pulverize the 24# sieve.Above-mentioned ready raw material is added the 200L purified water stir, add the cellulase of 5kg again, stir, at room temperature placed 15 hours, filter and discard filtering residue, collect filtrate.The filtrate of collecting is concentrated into 100L, adds hydrochloric acid adjusting pH value to 4.3～6.0 and obtain antipyretic and detoxicated oral liquid.
Embodiment 3
To prepare the needed raw material of 100L antipyretic and detoxicated oral liquid and press the standard recipe proportioning, it is standby to pulverize the 24# sieve.Above-mentioned ready raw material is added the 250L purified water stir, add the cellulase of 4kg again, stir, at room temperature placed 72 hours, filter and discard filtering residue, collect filtrate.The filtrate of collecting is concentrated into 100L, and hydro-oxidation sodium is regulated pH value to 4.3～6.0 and is obtained antipyretic and detoxicated oral liquid.
Embodiment 4
To prepare the needed raw material of 100L antipyretic and detoxicated oral liquid and press the standard recipe proportioning, it is standby to pulverize the 24# sieve.Above-mentioned ready raw material is added the 700L purified water stir, add the cellulase of 0.3kg again, stir, at room temperature placed 30 hours, filter and discard filtering residue, collect filtrate.The filtrate of collecting is concentrated into 100L, adds hydrochloric acid adjusting pH value to 4.3～6.0 and obtain antipyretic and detoxicated oral liquid.
Embodiment 5
To prepare the needed raw material of 100L antipyretic and detoxicated oral liquid and press the standard recipe proportioning, it is standby to pulverize the 24# sieve.Above-mentioned ready raw material is added the 300L purified water stir, add the cellulase of 0.2kg again, stir, at room temperature placed 48 hours, filter and discard filtering residue, collect filtrate.The filtrate of collecting is concentrated into 100L, and hydro-oxidation sodium is regulated pH value to 4.3～6.0 and is obtained antipyretic and detoxicated oral liquid.
Embodiment 6
To prepare the needed raw material of 100L antipyretic and detoxicated oral liquid and press the standard recipe proportioning, it is standby to pulverize the 24# sieve.Above-mentioned ready raw material is added the 400L purified water stir, add the cellulase of 1kg again, stir, at room temperature placed 36 hours, filter and discard filtering residue, collect filtrate.The filtrate of collecting is concentrated into 100L, and hydro-oxidation sodium is regulated pH value to 4.3～6.0 and is obtained antipyretic and detoxicated oral liquid.
Experimental check and technology contrast
By second check of standard " the veterinary drug provincial standard rises national standard "
Extract by traditional handicraft, up to specification
Extract with cellulase, up to specification
Traditional handicraft and preparation technology's of the present invention comparative result is as shown in table 1.
Table 1
| Project | The tradition method is extracted (100L) | Cellulase extracts (100L) |
| Raw material | Antipyretic and detoxicated oral liquid raw material (pulverizing or decoction pieces), basic adjuvant. | Antipyretic and detoxicated oral liquid raw material (pulverizing), |
| Adjuvant | 1400L purified water, 2 tons of standard coals (, concentration process more) than cellulase | 400L purified water, 1kg cellulase |
| Operation | Heating extraction, leave standstill put cold, filter, concentrate, refilter | Room temperature is extracted, and leaves standstill, filters, concentrates, refilters in 36 hours |
| Dangerous | Heating extraction leaves standstill the fire hazard of the dangerous and heating process of the scald of putting in cold | -- |
| Cost relatively | Many artificial, 2 tons of standard coals with 1000L purified water and Duo Yue 800L purification evaporation of water | The 1kg cellulase |
| Equipment | Firing equipment | -- |
| Environmental pollution | 2 tons of waste gas that coal produced burn | -- |
Conclusion:
As seen technology by table 1 contrast, and cellulase extracts antipyretic and detoxicated oral liquid, than traditional handicraft extracting method tangible advantage is arranged.
Claims (4)
1. a method of utilizing cellulase to extract antipyretic and detoxicated oral liquid is characterized in that, comprises the steps:
(1) will prepare the required raw material of 100L antipyretic and detoxicated oral liquid and join in 200～700L water and stir, the cellulase that adds 0.2～5kg again stirs, and at room temperature places 15～72 hours, and fully reaction is filtered and discarded filtering residue, collects filtrate;
(2) above-mentioned filtrate is concentrated into 100L, regulates pH value to 4.3～6.0, obtain antipyretic and detoxicated oral liquid.
2. the method for utilizing cellulase to extract antipyretic and detoxicated oral liquid according to claim 1, it is characterized in that, the antipyretic and detoxicated oral liquid of every 100L is made by following raw material: the needed raw material of preparation 100L antipyretic and detoxicated oral liquid, water 250～600L, cellulase 0.3～4kg; At room temperature the time of Fang Zhiing is 18～48 hours.
3. the method for utilizing cellulase to extract antipyretic and detoxicated oral liquid according to claim 1, it is characterized in that, the antipyretic and detoxicated oral liquid of every 100L is made by following raw material: the needed raw material of preparation 100L antipyretic and detoxicated oral liquid, water 400L, cellulase 1kg; At room temperature the time of Fang Zhiing is 36 hours.
4. the method for utilizing cellulase to extract antipyretic and detoxicated oral liquid according to claim 1 is characterized in that, adds acid or alkali adjusting pH value in the step (2).
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| CN101297896B true CN101297896B (en) | 2011-02-02 |
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| CN103919914B (en) * | 2014-04-15 | 2016-06-08 | 河南牧翔动物药业有限公司 | A kind of preparation method of antipyretic and detoxicated oral liquid for animals |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1843438A (en) * | 2006-02-10 | 2006-10-11 | 天津生机集团有限公司 | Plague-clearing toxin-removing oral liquid for treating infectious bursa of Fabricius disease of livestock and fowl, and its preparation method |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1843438A (en) * | 2006-02-10 | 2006-10-11 | 天津生机集团有限公司 | Plague-clearing toxin-removing oral liquid for treating infectious bursa of Fabricius disease of livestock and fowl, and its preparation method |
Non-Patent Citations (1)
| Title |
|---|
| 杨吉霞等.纤维素酶在中药成分提取中的应用.《中药材》.2005,第28卷(第1期),第64-66页. * |
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Assignee: Tianjin Jimingsheng Biological Technology Co., Ltd. Assignor: Tianjin Shengji Group Co., Ltd. Contract record no.: 2011120000013 Denomination of invention: Method for extracting antipyretic and detoxicated oral liquid using cellulase Granted publication date: 20110202 License type: Exclusive license, sub license Open date: 20081105 Record date: 20110321 |