CN101292942A - Dermatologic preparation composition containing gamma-oryzanol - Google Patents
Dermatologic preparation composition containing gamma-oryzanol Download PDFInfo
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Abstract
The purpose of the invention is to provide a skin external use agent compound which comprises gamma-oryzanol in oil phase and inhibits discoloration with time. The invention provides the skin external use agent compound comprising the gamma-oryzanol and sodium bisulfate.
Description
Technical field
The present invention relates to a kind of through the time the repressed Dermatologic preparation composition that contains gamma oryzanol of variable color.
Background technology
Gamma oryzanol is the material that exists in Testa oryzae oil, rice germ oil, Semen Maydis oil, other frumentum rice oil, is the mixture (non-patent literature 1) of ferulic acid (3-methoxyl group-4-hydroxycinnamic acid) ester of triterpene alcohol.Pharmacological action about gamma oryzanol has various report, it has abirritation, gonad stimulation, sebum secretion facilitation, blood flow facilitation, skin temperature effect of increasing, antioxidation, ultra-violet absorption effect, tyrosinase activity inhibitory action of growth-promoting effect, autonomic ataxia disease etc., and is safe material.Therefore, as pharmaceuticals, cosmetics, food additive, also, in broad range, be used as the growth promoter of animal.For example, as the skin preparations for extenal use that contains gamma oryzanol, known have to contain the skin preparations for extenal use that carbamide and refining gamma oryzanol are feature (patent documentation 1).
In addition, because gamma oryzanol is fat-soluble, so, in preparationization, carried out various investigations, for example, the also known technology (patent documentation 2) of making the form of aqueous solution and supplying with.
Gamma oryzanol is fat-soluble, and it is dissolved in oil phase, uses on skin with forms such as emulsification composition and oiliness ointment, and is favourable at aspects such as Percutaneously absorbable, stability.But clear and definite, when manufacturing contains the Dermatologic preparation composition of gamma oryzanol, when perhaps in oil phase, cooperating gamma oryzanol, the oil phase that obtains take place through the time ground variable color be xanchromatic problem.The variable color of Dermatologic preparation composition descends its commodity value greatly.
Patent documentation 1: No. 3493459 communique of patent
Patent documentation 2: Japanese kokai publication hei 07-258165 communique
Non-patent literature 1:FRAGRANCE JOURNAL, 3, P71-P77,1998
Summary of the invention
Therefore, the object of the present invention is to provide a kind of in oil phase, contain gamma oryzanol, through the time the repressed Dermatologic preparation composition of variable color.
Therefore, the present inventor to Dermatologic preparation composition through the time variable color suppress to have carried out various researchs, found that, though antioxidants such as hydrogenated soya phosphatide matter, BHA (BHA), dibutyl paracresol (BHT), tocopheryl acetate do not have effect, but, only in gamma oryzanol, select the combination sodium sulfite and when cooperating, can access long-time non-discoloring stable Dermatologic preparation composition, thereby finish the present invention.
That is, the invention provides a kind of Dermatologic preparation composition that contains gamma oryzanol and sodium sulfite.
The effect of invention
Dermatologic preparation composition of the present invention contains the gamma oryzanol with various pharmacological actions, physiological action in oil phase, and long-time invariant color and stablize the commodity value height.
In addition, except that gamma oryzanol and sodium sulfite, also contain the ester (below be also referred to as " senior representative examples of saturated aliphatic carboxylic ester ") of senior representative examples of saturated aliphatic carboxylic and aliphatic monobasic alcohol and/or the Dermatologic preparation composition of the present invention of green-fruity class spice, not only long-time invariant color and stablizing, and be suppressed from the unhappy stink of sodium sulfite, commodity value is higher.Particularly beyond gamma oryzanol and sodium sulfite, at least the Dermatologic preparation composition of the present invention that contains the ester of senior representative examples of saturated aliphatic carboxylic and aliphatic monobasic alcohol, not only long-time invariant color and stablizing, and be suppressed from the unhappy stink of sodium sulfite, and,, be not clamminess although contain the oiliness composition yet, usability excellence, commodity value are high especially.At this moment, when Dermatologic preparation composition of the present invention is emulsification composition, can provide through the time separate Dermatologic preparation composition repressed, appearance stablity.
The specific embodiment
" gamma oryzanol " of Shi Yonging in the present invention, be that kind Pi Dengzhong from rice (Oryza sativa L.) obtains, mainly contain the gamma oryzanol of ferulic acid (3-methoxyl group-4-hydroxycinnamic acid) ester of triterpene alcohol, there is no particular limitation for raw material, process for purification, manufacture method etc., but the gamma oryzanol of preferred record in medicine part outer article raw material specification 2006.As the commercially available product of gamma oryzanol, for example, can enumerate gamma oryzanol " reason is ground " (production of RIKEN VITAMIN society), gamma oryzanol (ORYZA OIL ﹠amp; CHEMICAL society produces), gamma oryzanol-C (Gang peace shop society produces) etc.
From pharmacological effect, physiologic effect and Dermatologic preparation composition through the time variable color the aspect of inhibition, gamma oryzanol content in the Dermatologic preparation composition of the present invention is with respect to the Dermatologic preparation composition all-mass, be preferably 0.01～5 quality %, more preferably 0.1～3 quality % is preferably 0.5～2 quality % especially.In addition, the content of gamma oryzanol can be quantitative by for example HPLC method (UV detects).
Employed in the present invention " sodium sulfite " is with chemical formula NaHSO
3The inorganic compound of expression preferably corrects the sodium sulfite of record in the version at Japanese Pharmacopoeia the 15.Sodium sulfite is known to preservative agent, is unknown but also use with gamma oryzanol.
From suppress Dermatologic preparation composition through the time variable color the aspect, the content of the sodium sulfite in the Dermatologic preparation composition of the present invention is with respect to the all-mass of Dermatologic preparation composition, be preferably 0.05～0.5 quality %, more preferably 0.1～0.5 quality % is preferably 0.1～0.3 quality % especially.
From suppress Dermatologic preparation composition through the time variable color the aspect, gamma oryzanol with respect to 1 mass parts, the content ratio of gamma oryzanol and sodium sulfite is preferably 0.01～1 mass parts, and more preferably 0.05～0.5 mass parts is preferably 0.1～0.3 mass parts especially.
If cooperate sodium sulfite in order to suppress to contain the Dermatologic preparation composition variable color of gamma oryzanol, then when coating, produce unhappy stink from sodium sulfite, therefore, in Dermatologic preparation composition of the present invention, in order to suppress this unhappiness stink, preferred ester and/or the green-fruity class spice that further cooperates senior representative examples of saturated aliphatic carboxylic and aliphatic monobasic alcohol.In addition, the ester of senior representative examples of saturated aliphatic carboxylic and aliphatic monobasic alcohol and/or green-fruity class spice suppresses the unhappy stink from sodium sulfite, is unknown before this.
" ester of senior representative examples of saturated aliphatic carboxylic and aliphatic monobasic alcohol " that can be adapted at cooperating in the Dermatologic preparation composition of the present invention, refer to the chemical compound that senior representative examples of saturated aliphatic carboxylic and aliphatic monobasic alcohol form by the ester bond combination, in the present invention, this chemical compound can use a kind of or be used in combination two or more.
In the present invention, as the senior representative examples of saturated aliphatic carboxylic that constitutes senior representative examples of saturated aliphatic carboxylic ester, for example, can enumerate the representative examples of saturated aliphatic carboxylic of carbon number 6～24.
The carbochain of senior representative examples of saturated aliphatic carboxylic can be any one of straight or branched, but be preferably straight chain.The carbon number of senior representative examples of saturated aliphatic carboxylic is preferably 6～24, and more preferably 6～20, more preferably 8～18, be preferably 10～16 especially.The carboxyl number of senior representative examples of saturated aliphatic carboxylic is preferably 1～2, is preferably 1 especially.
As so senior representative examples of saturated aliphatic carboxylic, for example, can enumerate straight chain representative examples of saturated aliphatic monocarboxylic acids such as caproic acid, sad, capric acid, lauric acid, myristic acid, Palmic acid, stearic acid; Side chain representative examples of saturated aliphatic monocarboxylic acids such as different Palmic acid, isostearic acid; Straight chain representative examples of saturated aliphatic dicarboxylic acids such as adipic acid, 1,5-pentanedicarboxylic acid., suberic acid, Azelaic Acid, decanedioic acid etc.
In the present invention, the carbochain that constitutes the aliphatic monobasic alcohol of senior representative examples of saturated aliphatic carboxylic ester can be any one of straight or branched, but is preferably side chain.The carbochain of aliphatic monobasic alcohol both can be saturated also can be undersaturated, but be preferably saturated.The carbon number of aliphatic monobasic alcohol is preferably 1～20, and more preferably 2～20, be preferably 3～20 especially.
As such aliphatic monobasic alcohol, for example, can enumerate the representative examples of saturated aliphatic monohydric alcohol of straight chains such as methanol, ethanol, 1-propanol, 1-butanols, 1-amylalcohol, 1-hexanol, 1-enanthol, 1-capryl alcohol, myristyl alcohol, hexadecanol, cetostearyl alcohol; Side chain representative examples of saturated aliphatic monohydric alcohols such as isopropyl alcohol, isobutanol, different tridecyl alcohol, different three stearyl alcohols, 2-octyldodecanol, 2-hexyldecanol, 2-heptyl tip-nip etc.
Employed senior representative examples of saturated aliphatic carboxylic ester among the present invention, the ester of the representative examples of saturated aliphatic monocarboxylic acid of preferred carbon number 6～24 and the aliphatic monobasic alcohol of carbon number 1～20, the perhaps ester of the aliphatic monobasic alcohol of the representative examples of saturated aliphatic dicarboxylic acids of carbon number 6～24 and carbon number 1～20, the more preferably ester of the aliphatic monobasic alcohol of the representative examples of saturated aliphatic monocarboxylic acid of carbon number 6～24 and carbon number 2～20, the perhaps ester of the aliphatic monobasic alcohol of the representative examples of saturated aliphatic dicarboxylic acids of carbon number 6～24 and carbon number 2～20, the ester of the aliphatic monobasic alcohol of the ester of the representative examples of saturated aliphatic monocarboxylic acid of preferred especially carbon number 6～24 and the aliphatic monobasic alcohol of carbon number 3～20 or the representative examples of saturated aliphatic dicarboxylic acids of carbon number 6～24 and carbon number 3～20.
The total number of carbon atoms of senior representative examples of saturated aliphatic carboxylic ester is preferably 8～40, and more preferably 10～40.
In addition, when senior representative examples of saturated aliphatic carboxylic has a plurality of carboxyl, in senior representative examples of saturated aliphatic carboxylic ester, both can it all form ester bond with aliphatic monobasic alcohol, also can its part and aliphatic monobasic alcohol form ester bond, but preferred all carboxyls and aliphatic monobasic alcohol formation ester bond.
Ester as the aliphatic monobasic alcohol of the representative examples of saturated aliphatic monocarboxylic acid of carbon number 6～24 and carbon number 1～20, for example, can enumerate sad hexadecanol ester, sad stearic alcohol ester, lauric acid hexanol ester, Palmic acid isopropyl alcohol ester, Palmic acid isooctadecanol ester, hexadecyl palmitate, myristic acid methanol ester, myristic acid isopropyl alcohol ester, the myristic acid isotridecanol, myristic acid Semen Myristicae alcohol ester, myristic acid hexadecanol ester, octyl dodecyl myristate, myristic acid hexyldecanol ester, the stearic acid butyl alcohol ester, stearic acid hexyldecanol ester, isostearic acid hexyldecanol ester, isostearic acid octyl group decyl ester etc.
Ester as the aliphatic monobasic alcohol of the representative examples of saturated aliphatic dicarboxylic acids of carbon number 6～24 and carbon number 1～20, for example, can enumerate adipic acid diisopropyl alcohol ester, adipic acid two isobutyl alcohol esters, adipic acid two isooctanol esters, decanedioic acid diisopropyl alcohol ester, decanedioic acid diethyl alcohol ester etc.
Wherein, be preferably selected from octyl dodecyl myristate, the diisopropyl adipate more than a kind, preferred especially octyl dodecyl myristate.
From suppressing from the unhappy stink of sodium sulfite, the usability of Dermatologic preparation composition and the viewpoint of appearance stability, the content of the senior representative examples of saturated aliphatic carboxylic ester in the Dermatologic preparation composition of the present invention is preferably 0.5～20 quality %, more preferably 1～15 quality % is preferably 2～10 quality % especially.
From suppressing viewpoint from the unhappy stink of sodium sulfite, with respect to the sodium sulfite of 1 mass parts, the content ratio of sodium sulfite and senior representative examples of saturated aliphatic carboxylic ester is preferably 2～200 mass parts, and more preferably 5～100 mass parts are preferably 10～50 mass parts especially.
" green-fruity class spice " that can in Dermatologic preparation composition of the present invention, be fit to cooperation, so long as have the spice of both fragrance characteristics of the fragrance (making it picture leaf and green fragrance) of green class spice and the fragrance of fruity class spice (citrus fruit sample in addition fragrant and sweet) concurrently, then there is no particular limitation, can not distinguish monomer perfume, compound perfume and use.That is, both can cooperate the spice of the fragrance of the fragrance that has green class spice concurrently and fruity class spice separately, also can and with green class spice and fruity class spice.Object lesson as green-fruity class spice, can enumerate blending be selected from as employed monomer perfume in the blending of green class spice known suitable-the 3-hexanol, sec-n-octyl alcohol, propargyl alcohol, isopropyl benzyl methanol, suitable-the 3-hexanal, instead-the 2-hexanal, isocyclocitral, 1-methyl-3-isohesyl-1,2,5,6-tetrahydrochysene benzaldehyde, the 4-methyl isophthalic acid, 2,5,6-tetrahydrochysene benzaldehyde, 2,4-dimethyl-1,2,5,6-tetrahydrochysene benzaldehyde, 1,2,5,6-tetrahydrochysene cinnamic aldehyde, hydrogenation tropine aldehyde (Ha イ De ロ ト ロ パ ア Le デ ヒ De), to hydrogenated methyl tropine aldehyde (p-メ チ Le Ha イ De ロ ト ロ パ ア Le デ ヒ De), p-tolyl acetaldehyde, to the tert-amyl benzene oxy-aldehyde, acetaldehyde methyl citronellyl acetal, acetaldehyde ethyl citronellyl acetal, acetaldehyde ethylphenyl ethyl acetals, acetaldehyde diphenyl-ethyl acetal, the hexanal dimethylacetal, the enanthaldehyde diethyl acetal, dihydro citronellal dimethylacetal, phenyl acetaldehyde diethyl acetal, the methyl hexyl ether, the methyl heptyl ether, the methyl citronellyl ether, methyl Mang cattle ether, ethyl Mang cattle ether, the vinyl citronellyl ether, vinyl Mang cattle ether, the hexyl heptyl ether, carbonic acid ethyl-3-methyl butine ester, carbonic acid butyl-3-methyl butine ester, isobutyl carbonate butyl-3-methyl butine ester, isobutyl carbonate amyl group pentyne ester, carbonic acid methyl hexin ester, carbonic acid ethyl hexin ester, carbonic acid ethyl heptyne ester, isobutyl carbonate butyl heptyne ester, isobutyl carbonate amyl group heptyne ester, carbonic acid pi-allyl heptyne ester, carbonic acid ethyl-6-methyl heptyne ester, carbonic acid methyl octyne ester, isobutyl carbonate amyl group octyne ester, acetic acid is suitable-4-heptene ester, isopulegyl acetate, the caproic acid heptyl ester, nonyl acetate, citronellyl formate, geranyl formate, in butyl sulfide and two-pentenyl, four thioethers more than a kind or 2 kinds; Be selected from as the known 1-butoxy of employed monomer perfume-1-Ethyl Methyl Ether in the blending of fruity class spice with mediation, 1-ethyoxyl-1-hexyl oxo ethane, 1-ethyoxyl-1-Ethyl Methyl Ether, 1-ethyoxyl-1-propoxyl group ethane, hexanol, instead-the 2-hexenol, the 2-methyl butanol, ethanol, propanol, butanols, isobutanol, amylalcohol, isoamyl alcohol, suitable-the 3-hexenol, formaldehyde, acetaldehyde, propionic aldehyde, butyraldehyde, valeral, hexanal, instead-the 2-hexenoic aldehyde, suitable-the 3-hexenoic aldehyde, aldehyde C-9, pentyl acetate, butyl acetate, butyl butyrate, butyl propionate, benzyl isovalerate, cinnamyl isovalerate, citronellyl isovalerate, allyl butyrate, valeric acid pi-allyl cyclohexyl, cyclohexyl acetate, cyclohexyl butyrate, ethyl acetate, ethyl n-butyrate., ethyl caprilate, ethyl valerate, Exceed 600, n-hexyl butyrate, hexyl propionate, methyl butyrate, benzyl butyrate, propyl acetate, propyl butyrate, propyl valerate, propyl propionate, allyl isovalerate, amyl butyrate, amyl valerate, methyl caproate, methallyl butyrate, verdox, acetic acid, propanoic acid, butanoic acid, valeric acid, isovaleric acid, and in the caproic acid more than a kind or 2 kinds and the compound perfume that obtains.As the green among the present invention-fruity class spice, can use commercially available product, particularly, for example, can enumerate GREEN FRUITY Z061340 (production of Feng Yu spice society) etc.
In addition, in the affirmation of the green in Dermatologic preparation composition-fruity class spice, for example, can use the GC method of hearing of smelling, detect the composition of the speciality that in Dermatologic preparation composition, has green class spice and fruity class spice fragrance concurrently, perhaps detect the composition of the speciality that in Dermatologic preparation composition, has green class spice fragrance and composition, can confirm the existence of the green-fruity class spice in Dermatologic preparation composition thus with speciality of fruity class spice fragrance.
Viewpoint from the unhappy stink that suppresses Dermatologic preparation composition, the relative Dermatologic preparation composition all-mass of content of the green in the Dermatologic preparation composition of the present invention-fruity class spice, be preferably 0.0005～2.5 quality %, more preferably 0.001～1 quality % is preferably 0.0025～0.5 quality % especially.In addition, the content of green-fruity class spice for example can be by the HPLC standard measure.
Viewpoint from the unhappy stink that suppresses Dermatologic preparation composition, sodium bisulfate with respect to 1 mass parts, the content ratio of sodium sulfite and green-fruity class spice is preferably 0.01～10 mass parts, and more preferably 0.05～2 mass parts is preferably 0.1～1 mass parts especially.
From suppressing from the unhappy stink of sodium sulfite, the usability of Dermatologic preparation composition and the viewpoint of appearance stability, in Dermatologic preparation composition of the present invention, especially preferably contain senior representative examples of saturated aliphatic carboxylic ester and green-fruity class spice simultaneously.At this moment, senior representative examples of saturated aliphatic carboxylic ester and green-fruity class spice in Dermatologic preparation composition content and and the content of sodium sulfite than same as described above.
As the oiliness composition in the Dermatologic preparation composition of the present invention; so long as in Dermatologic preparation compositions such as emulsification composition and oiliness ointment compositions as the composition that constitutes oil phase and by normally used composition; then there is no particular limitation; for example; can enumerate hydro carbons (white vaseline; liquid paraffin; squalane etc.); wax class (cera alba; Brazil wax; candelilla wax; lanoline etc.); oils (soybean oil; stearic; Semen Ricini oil; olive oil; triacylglycerol etc.); alcohols (hexadecanol; stearyl alcohol; oleyl alcohol; cholesterol etc.); fatty acid (Palmic acid; stearic acid; oleic acid etc.); silicone oil (methyl polysiloxane etc.); vitamin derivative class (palmitic retinol; tocopheryl acetates etc.), these compositions can use or make up two or more uses separately.Deliquescent aspect from gamma oryzanol, in Dermatologic preparation composition of the present invention, these oiliness compositions preferably contain 1～1000 mass parts with respect to the gamma oryzanol of 1 mass parts, more preferably contain 5～500 mass parts, especially preferably contain 7.5～200 mass parts.
In Dermatologic preparation composition of the present invention, except that mentioned component, according to various conditions such as the application target of Dermatologic preparation composition, forms, as required, can contain emulsifying agent, water composition, antiseptic, antioxidant, other active ingredient, water etc.
As emulsifying agent; for example; can enumerate polyoxyethylene alkyl ether (Polyoxyethylene cetyl ether; polyoxyethylene octadecyl ether etc.); polyoxyethylene alkyl phenyl ether (polyoxyethylene nonylplenyl ether; NONIN HS 240 etc.); polyoxyethylene polyoxy-propylene (polyoxyethylene polyoxypropylene cetyl ether etc.); Polyoxyethylene Sorbitol Fatty Acid Esters (mono laurate polyoxyethylene sorbitan ester etc.); polyoxyethylene sorbitan fatty acid ester (single oleic acid polyoxyethylene sorbitol acid anhydride ester; three stearic acid polyoxyethylene sorbitan esters; Polysorbate etc.); the polyoxyethylene Semen Ricini oil; polyoxyethylene sclerosis Semen Ricini oil; the polyoxyethylene sorbitol Cera Flava; sucrose fatty acid ester; monoacylglycerol ester (glyceryl monostearate etc.); DG ester (distearin etc.); polyglyceryl fatty acid ester (monostearate two glyceride etc.); Wool wax alcohols,ethoxylated; polyoxyethylene lanolin alcohol; the polyoxyethylene sterol; polyoxyethylene fatty acid amide (polyoxyethylene 8 stearate amide etc.); lecithin; cithrol (mono laurate macrogol ester etc.); methyl glycol fatty acid ester (propylene glycolmonostearate); sorbitan fatty acid ester (sorbitan monostearate etc.); alkyl sodium sulfate (sodium lauryl sulphate etc.); polyoxyethylene alkyl ether phosphate (Polyoxyethylene cetyl ether sodium phosphate; polyoxyethylene lauryl ether sodium phosphates etc.) etc., these emulsifying agents can use or make up two or more uses separately.
From the dissolubility and the skin irritant aspect of gamma oryzanol, in Dermatologic preparation composition of the present invention, these emulsifying agents preferably contain 0.5～10 quality %, more preferably contain 1～5 quality %, especially preferably contain 1.5～4 quality %.
As water composition, for example, can enumerate lower alcohols (ethanol, isopropyl alcohol etc.), polyalcohols (1,3-butanediol, glycerol, propylene glycol, Polyethylene Glycol etc.), water soluble polymer class (methylcellulose, ethyl cellulose, CVP Carbopol ETD2050, xanthan gum, polyvinylpyrrolidone, water solublity collagen, hyaluronic acid etc.), amino acids (glycine, alanine etc.), other (citric acid, phosphoric acid, lactic acid, sodium lactate, sodium chloride etc.) etc., these water compositions can use or make up two or more uses separately.
As antiseptic, for example, can enumerate methyl parahydroxybenzoate, propyl p-hydroxybenzoate, butyl p-hydroxybenzoate etc., these antiseptic can use or make up two or more uses separately.
As antioxidant, for example, can enumerate dibenzylatiooluene, tocopherol etc., these antioxidants can use or make up two or more uses separately.
As other active ingredient, for example, with antipruritic is purpose, can cooperate hydryllin (diphenhydramine, chlorphenamine maleate etc.), local anesthetic (benzocaine, lignocaine etc.), local anti-inflammatory anti-itch agent (Camphora, menthol etc.), other (crotamiton, enoxolone) etc., these active ingredient can use or make up two or more uses separately.In addition, to preserve moisture is purpose, can cooperate polyalcohols (1,3-butanediol, glycerol, propylene glycol, Polyethylene Glycol etc.), aminoacid (glycine, alanine etc.), acid mucopolysaccharides (hyaluronic acid, heparin class material etc.), sugar alcohol (Sorbitol, trehalose etc.), other (carbamide, lactic acid, sodium lactate, pyrrolidone carboxylic acid salt etc.) etc., these compositions can use or make up two or more uses separately.
From the stability of gamma oryzanol and irritating aspect of preparation composition for external use, the pH of Dermatologic preparation composition of the present invention is preferably 4～9, and more preferably 5～8.
Dermatologic preparation composition of the present invention, both can in oil phase, contain gamma oryzanol, also can in for example emulsification composition and/or oiliness ointment compositions, contain gamma oryzanol, but from aspects such as usabilities, preferred emulsification composition, preferred especially O/W emulsion composition.As the preferred configuration of emulsification composition, can enumerate emulsifiable paste, emulsion, lotion etc.
Dermatologic preparation composition of the present invention can be by the usual method manufacturing, can make with same operation such as common emulsification composition, ointment.As its using method, preferably use in the local skin coating.
Embodiment
Below, the present invention will be described in more detail to enumerate embodiment, but the present invention is not subjected to any qualification of these embodiment.
Embodiment 1
Become in the Purified Water of amount of 100g in the gross weight that is equivalent to make lotion, add 0.1g sodium sulfite (production of sheet mountain chemical industry society), 0.25g CVP Carbopol ETD2050,0.3g xanthan gum, 3g glycine and be equivalent to make the pH of lotion to become the sodium hydroxide of 7 amount, 70 ℃ of heating, mix, with it as water.On the other hand, add 1g gamma oryzanol (oryzanol-C: Gang peace shop society produces), 2g white vaseline, 0.5g stearyl alcohol, 5g squalane, 3g octyl dodecyl myristate, 0.24g polysorbate 60,0.9g polyoxyethylene sclerosis Semen Ricini oil 50 and 0.82g sorbitan monostearate, in 70 ℃ of heating, mixing, with its oil phase.Add oil phase at aqueous phase, stir down at 70 ℃, mix, below the emulsifying postcooling to 40 ℃, having made total amount is the lotion of the present invention of 100g.
Embodiment 2,3
Operate equally with embodiment 1,, made lotion of the present invention according at the component shown in the table 1.
Comparative example 1
The lotion that to mismatch sodium sulfite in embodiment 1 is 1 lotion and making as a comparative example.
Comparative example 2～5
To in comparative example 1, replace sodium sulfite and cooperate the lotion of known hydrogenated soya phosphatide, BHA, BHT, tocopheryl acetate to distinguish 2,3,4,5 lotion as a comparative example as antioxidant.
Test example 1
At the lotion of in embodiment 1～3 and comparative example 1～5, making, estimate according to following assessment item.
(through the time variable color the evaluation of inhibition)
Variable color is estimated by the variation of the tone of visual tone after 40 ℃, dark place are preserved 2 months after with respect to firm modulation.Tone is indeclinable to be zero, variable color be xanchromatic for *.
The result is illustrated in the table 1.
[table 1]
As shown in Table 1, when only in containing the lotion of gamma oryzanol, cooperating sodium sulfite, through the time variable color be suppressed.On the other hand, when adding hydrogenated soya phosphatide as known antioxidant, BHA, BHT, tocopheryl acetate, gamma oryzanol through the time variable color can not be suppressed.By this result of the test as can be known, containing the long-time invariant color of Dermatologic preparation composition of the present invention of gamma oryzanol and sodium sulfite, is stable Dermatologic preparation composition.
Embodiment 4
In the Purified Water of the amount that is equivalent to make the lotion total amount become 100g, add 0.2g sodium sulfite (production of sheet mountain chemical industry society), 0.25g CVP Carbopol ETD2050 and be equivalent to make the pH of lotion to become the sodium hydroxide of 7 amount, 70 ℃ of heating, mix, with it as water.On the other hand, add 1g gamma oryzanol (oryzanol-C: Gang peace shop society produces), 2g white vaseline, 0.5g stearyl alcohol, 5g squalane, 3g octyl dodecyl myristate (EXCEPARL OD-M, flower king (strain) production), 1g polyoxyethylene sclerosis Semen Ricini oil 50 and 1g sorbitan monostearate, 70 ℃ of heating, mix, with it as oil phase.Add oil phase at aqueous phase, in 70 ℃ of stirring, mixing, below the emulsifying postcooling to 40 ℃, having made total amount is the lotion of the present invention of 100g.
Comparative example 6
The lotion that to mismatch octyl dodecyl myristate in embodiment 4 is 6 lotion and making as a comparative example.
Test example 2
At the lotion of in embodiment 4 and comparative example 6, making, estimate according to following assessment item.
(through the time variable color the evaluation of inhibition)
Variable color is estimated by the variation of the tone of visual tone after 40 ℃, dark place are preserved 2 months after with respect to firm modulation.Tone is indeclinable to be zero, variable color be xanchromatic for *.
(from the evaluation of the inhibition of the unhappy stink of sodium sulfite)
Test and estimate by the fragrance of lotion (fragrance after the coating just) being carried out sense.The fragrance is here represented the inhibition effect from the unhappy stink of sodium sulfite.The unhappy stink of imperceptible sodium sulfite be zero, feel sodium sulfite unhappy stink for *.
(evaluation of usability)
Carrying out sense by the usability to lotion tests and estimates.
The sense test is implemented by 7 participants.The evaluation of usability was estimated with following 3 stages.
Well: do not feel to be clamminess
Common: as to feel to be clamminess a little
Difference: feel to be clamminess
(through the time isolating inhibition evaluation)
In order to study the appearance stability of lotion, be respectively charged into vial (2K bottle), confirm after 60 ℃ of 1 weeks of preservation, to have or not separation.Have or not separation to estimate by visual.Can not confirm isolating is zero, take place isolatingly to be *.
The result of test example 2 is illustrated in the table 2.
[table 2]
As shown in Table 2, except that gamma oryzanol, sodium sulfite, the lotion of embodiment 4 of octyl dodecyl myristate that cooperates the ester of the senior representative examples of saturated aliphatic carboxylic of conduct of itself odorless and aliphatic monobasic alcohol, through the time variable color be suppressed, and, be suppressed from the unhappy stink of sodium sulfite.And the lotion of embodiment 4 is not clamminess, the usability excellence, be through the time separate the lotion of repressed appearance stablity.By this result of the test as can be known, the Dermatologic preparation composition of the present invention that except that gamma oryzanol and sodium sulfite, also contains the ester of senior representative examples of saturated aliphatic carboxylic and aliphatic monobasic alcohol, not only long-time invariant color, stable, and be suppressed from the unhappy stink of sodium sulfite, and,, be not clamminess although contain the oiliness composition yet, the usability excellence, and be the Dermatologic preparation composition of appearance stablity.
Embodiment 5
In the Purified Water of the amount that is equivalent to make the lotion total amount become 100g, add 0.2g sodium sulfite (production of sheet mountain chemical industry society), 0.25g CVP Carbopol ETD2050 and be equivalent to make the pH of lotion to become the sodium hydroxide of 7 amount, 70 ℃ of heating, mix, with it as water.On the other hand, add 1g gamma oryzanol (oryzanol-C: shop, Tongan City society produces), 2g white vaseline, 0.5g stearyl alcohol, 5g squalane, 1g polyoxyethylene sclerosis Semen Ricini oil 50 and 1g sorbitan monostearate, 70 ℃ of heating, mix, with it as oil phase.Add oil phase at aqueous phase, in 70 ℃ of stirrings, mixing, below emulsifying postcooling to 40 ℃, stir, mix 0.02g green-fruity class spice (GREEN FRUITY Z061340 (Feng Yu spice (strain) production)), having made total amount is the lotion of the present invention of 100g.
Comparative example 7
The lotion that to mismatch green-fruity class spice in embodiment 5 is 7 lotion and making as a comparative example.
Test example 3
At the lotion of in embodiment 5 and comparative example 7, making, estimate according to following assessment item.
(through the time variable color the evaluation of inhibition)
Variable color is estimated by the variation of the tone of visual tone after 40 ℃, dark place are preserved 2 months after with respect to firm modulation.Tone is indeclinable to be zero, variable color be xanchromatic for *.
(from the evaluation of the inhibition of the unhappy stink of sodium sulfite)
Test and estimate by the fragrance of lotion (fragrance after the coating just) being carried out sense.The fragrance is here represented the inhibition effect from the unhappy stink of sodium sulfite.The unhappy stink of imperceptible sodium sulfite be zero, feel sodium sulfite unhappy stink for *.
The result of test example 3 is illustrated in the table 3.
[table 3]
As shown in Table 3, except that gamma oryzanol, sodium sulfite, cooperated the lotion of the embodiment 5 of green-fruity class spice, through the time variable color be suppressed, and be suppressed from the unhappy stink of sodium sulfite.By this result of the test as can be known, the Dermatologic preparation composition of the present invention that except that gamma oryzanol and sodium sulfite, also contains green-fruity class spice, not only long-time invariant color, stable, and be the repressed Dermatologic preparation composition of unhappy stink from sodium sulfite.
Embodiment 6
The lotion that will append the 3g octyl dodecyl myristate again in the oil phase in the lotion of embodiment 5 and cooperate is as the lotion of embodiment 6 and make.
Test example 4
At the lotion of in embodiment 6, making, estimate according to following assessment item.
(through the time variable color the evaluation of inhibition)
Variable color is estimated by the variation of the tone of visual tone after 40 ℃, dark place are preserved 2 months after with respect to firm modulation.Tone is indeclinable to be zero, variable color be xanchromatic for *.
(from the evaluation of the inhibition of the unhappy stink of sodium sulfite)
Test and estimate by the fragrance of lotion (fragrance after the coating just) being carried out sense.The fragrance is here represented the inhibition effect from the unhappy stink of sodium sulfite.The unhappy stink of imperceptible sodium sulfite be zero, feel sodium sulfite unhappy stink for *.
(evaluation of usability)
Carrying out sense by the usability to lotion tests and estimates.
The sense test is implemented by 7 participants.The evaluation of usability was estimated with following 3 stages.
Well: do not feel to be clamminess
Common: as to feel to be clamminess a little
Difference: feel to be clamminess
(through the time isolating inhibition evaluation)
In order to study the appearance stability of lotion, be respectively charged into vial (2K bottle), confirm after 60 ℃ of 1 weeks of preservation, to have or not separation.Have or not separation to estimate by visual.Can not confirm isolating is zero, take place isolatingly to be *.
The result of test example 4 is illustrated in the table 4.
[table 4]
As shown in Table 4, be combined with the lotion of the embodiment 6 of the octyl dodecyl myristate of ester of the senior representative examples of saturated aliphatic carboxylic of conduct of gamma oryzanol, sodium sulfite, itself odorless and aliphatic monobasic alcohol and green-fruity class spice, affirmation through the time variable color be suppressed, and the unhappy stink from sodium sulfite is suppressed, and be not clamminess, the usability excellence, be through the time separate the Dermatologic preparation composition of repressed appearance stablity.Particularly to unhappy stink from sodium sulfite, even the lotion of the present invention that only contains octyl dodecyl myristate of embodiment 4 and the lotion of the present invention that only contains green-fruity class spice of embodiment 5 are compared, also have more excellent inhibitory action.By this result of the test as can be known, except that gamma oryzanol and sodium sulfite, also contain the ester of senior representative examples of saturated aliphatic carboxylic and aliphatic monobasic alcohol and the Dermatologic preparation composition of the present invention of green-fruity class spice, not only long-time invariant color, stable, and be suppressed from the unhappy stink of sodium sulfite, and, although contain the oiliness composition, but be not clamminess yet, the usability excellence, and be the Dermatologic preparation composition of appearance stablity.
Claims (8)
1. Dermatologic preparation composition is characterized in that:
Contain gamma oryzanol and sodium sulfite.
2. Dermatologic preparation composition as claimed in claim 1 is characterized in that:
The content of sodium sulfite is 0.01～1 mass parts with respect to the gamma oryzanol of 1 mass parts.
3. Dermatologic preparation composition as claimed in claim 1 is characterized in that:
The ester and/or the green-fruity class spice that also contain senior representative examples of saturated aliphatic carboxylic and aliphatic monobasic alcohol.
4. Dermatologic preparation composition as claimed in claim 3 is characterized in that:
Senior representative examples of saturated aliphatic carboxylic is the representative examples of saturated aliphatic carboxylic of carbon number 6～24.
5. Dermatologic preparation composition as claimed in claim 3 is characterized in that:
The ester of senior representative examples of saturated aliphatic carboxylic and aliphatic monobasic alcohol is an octyl dodecyl myristate.
6. Dermatologic preparation composition as claimed in claim 3 is characterized in that:
The content of the ester of senior representative examples of saturated aliphatic carboxylic and aliphatic monobasic alcohol is 2～200 mass parts with respect to the sodium sulfite of 1 mass parts.
7. Dermatologic preparation composition as claimed in claim 3 is characterized in that:
The content of green-fruity class spice is 0.01～10 mass parts with respect to the sodium sulfite of 1 mass parts.
8. as each described Dermatologic preparation composition in the claim 1～7, it is characterized in that: it is emulsification composition.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007115065 | 2007-04-25 | ||
| JP2007-115065 | 2007-04-25 | ||
| JP2007-309563 | 2007-11-30 | ||
| JP2008-097321 | 2008-04-03 |
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| Publication Number | Publication Date |
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| CN101292942A true CN101292942A (en) | 2008-10-29 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008100955229A Pending CN101292942A (en) | 2007-04-25 | 2008-04-23 | Dermatologic preparation composition containing gamma-oryzanol |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104546688A (en) * | 2014-12-25 | 2015-04-29 | 郑州瑞龙制药股份有限公司 | Cream for treating beriberi and preparation method for cream |
| CN105902418A (en) * | 2016-05-19 | 2016-08-31 | 重庆苗秀生物科技股份有限公司 | Imitated sebum matrix, external preparation including imitated sebum matrix and application thereof |
| CN109568201A (en) * | 2018-11-21 | 2019-04-05 | 上海中翊日化有限公司 | Inhibit color-changing composition, preparation for external application to skin and application |
| CN111840301A (en) * | 2019-04-24 | 2020-10-30 | 太阳星光齿磨公司 | Application of gamma-oryzanol and application of liposome containing gamma-oryzanol |
-
2008
- 2008-04-23 CN CNA2008100955229A patent/CN101292942A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104546688A (en) * | 2014-12-25 | 2015-04-29 | 郑州瑞龙制药股份有限公司 | Cream for treating beriberi and preparation method for cream |
| CN105902418A (en) * | 2016-05-19 | 2016-08-31 | 重庆苗秀生物科技股份有限公司 | Imitated sebum matrix, external preparation including imitated sebum matrix and application thereof |
| CN109568201A (en) * | 2018-11-21 | 2019-04-05 | 上海中翊日化有限公司 | Inhibit color-changing composition, preparation for external application to skin and application |
| CN109568201B (en) * | 2018-11-21 | 2022-02-11 | 上海中翊日化有限公司 | Discoloration-inhibiting composition, skin external preparation and application |
| CN111840301A (en) * | 2019-04-24 | 2020-10-30 | 太阳星光齿磨公司 | Application of gamma-oryzanol and application of liposome containing gamma-oryzanol |
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