CN101289469A - 一种从中药提取液中分离总生物碱的方法 - Google Patents
一种从中药提取液中分离总生物碱的方法 Download PDFInfo
- Publication number
- CN101289469A CN101289469A CN 200710014331 CN200710014331A CN101289469A CN 101289469 A CN101289469 A CN 101289469A CN 200710014331 CN200710014331 CN 200710014331 CN 200710014331 A CN200710014331 A CN 200710014331A CN 101289469 A CN101289469 A CN 101289469A
- Authority
- CN
- China
- Prior art keywords
- separating bio
- alkali according
- alkaloid
- bio alkali
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229930013930 alkaloid Natural products 0.000 title claims abstract description 80
- 238000000034 method Methods 0.000 title claims abstract description 58
- 239000003814 drug Substances 0.000 title claims description 32
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 48
- 239000011347 resin Substances 0.000 claims abstract description 46
- 229920005989 resin Polymers 0.000 claims abstract description 46
- 150000003797 alkaloid derivatives Chemical class 0.000 claims abstract description 44
- 239000003513 alkali Substances 0.000 claims abstract description 26
- 239000002253 acid Substances 0.000 claims abstract description 25
- 238000010828 elution Methods 0.000 claims abstract description 23
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000012535 impurity Substances 0.000 claims abstract description 10
- 239000003729 cation exchange resin Substances 0.000 claims abstract description 6
- 239000000243 solution Substances 0.000 claims abstract 11
- 239000012266 salt solution Substances 0.000 claims abstract 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 42
- 150000003839 salts Chemical class 0.000 claims description 35
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 17
- 239000000284 extract Substances 0.000 claims description 12
- 235000014347 soups Nutrition 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 8
- 239000003456 ion exchange resin Substances 0.000 claims description 6
- 229920003303 ion-exchange polymer Polymers 0.000 claims description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 4
- 238000007654 immersion Methods 0.000 claims description 4
- 230000001476 alcoholic effect Effects 0.000 claims description 3
- 238000011033 desalting Methods 0.000 claims description 3
- 238000011068 loading method Methods 0.000 claims description 3
- 230000002411 adverse Effects 0.000 claims description 2
- 239000011780 sodium chloride Substances 0.000 claims description 2
- 238000002791 soaking Methods 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
- 238000000605 extraction Methods 0.000 abstract description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 23
- 239000000706 filtrate Substances 0.000 abstract description 17
- 239000003960 organic solvent Substances 0.000 abstract description 16
- 238000001035 drying Methods 0.000 abstract description 13
- 238000004519 manufacturing process Methods 0.000 abstract description 7
- 239000002585 base Substances 0.000 abstract description 4
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 6
- 230000007547 defect Effects 0.000 abstract 1
- 238000006386 neutralization reaction Methods 0.000 abstract 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 39
- 239000007788 liquid Substances 0.000 description 24
- 238000001556 precipitation Methods 0.000 description 21
- 239000006228 supernatant Substances 0.000 description 21
- CGFYHILWFSGVJS-UHFFFAOYSA-N silicic acid;trioxotungsten Chemical compound O[Si](O)(O)O.O=[W]1(=O)O[W](=O)(=O)O[W](=O)(=O)O1.O=[W]1(=O)O[W](=O)(=O)O[W](=O)(=O)O1.O=[W]1(=O)O[W](=O)(=O)O[W](=O)(=O)O1.O=[W]1(=O)O[W](=O)(=O)O[W](=O)(=O)O1 CGFYHILWFSGVJS-UHFFFAOYSA-N 0.000 description 20
- 238000010612 desalination reaction Methods 0.000 description 14
- 230000000694 effects Effects 0.000 description 13
- 238000005516 engineering process Methods 0.000 description 12
- 238000007689 inspection Methods 0.000 description 11
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 10
- 241000219784 Sophora Species 0.000 description 10
- 239000012141 concentrate Substances 0.000 description 10
- 229910052739 hydrogen Inorganic materials 0.000 description 10
- 239000001257 hydrogen Substances 0.000 description 10
- 239000001110 calcium chloride Substances 0.000 description 9
- 229910001628 calcium chloride Inorganic materials 0.000 description 9
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 8
- DPDMMXDBJGCCQC-UHFFFAOYSA-N [Na].[Cl] Chemical compound [Na].[Cl] DPDMMXDBJGCCQC-UHFFFAOYSA-N 0.000 description 8
- 150000002431 hydrogen Chemical class 0.000 description 8
- 238000000926 separation method Methods 0.000 description 8
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 7
- -1 alkaloid ion Chemical class 0.000 description 6
- 238000009835 boiling Methods 0.000 description 6
- 238000000746 purification Methods 0.000 description 6
- 238000010992 reflux Methods 0.000 description 6
- 230000001105 regulatory effect Effects 0.000 description 6
- 239000003463 adsorbent Substances 0.000 description 5
- 239000000470 constituent Substances 0.000 description 5
- 238000007598 dipping method Methods 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- 239000001117 sulphuric acid Substances 0.000 description 5
- 235000011149 sulphuric acid Nutrition 0.000 description 5
- 241000931913 Cephalotaxus fortunei Species 0.000 description 4
- 241000218176 Corydalis Species 0.000 description 4
- 241000935235 Fritillaria meleagris Species 0.000 description 4
- 240000001090 Papaver somniferum Species 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- 235000019270 ammonium chloride Nutrition 0.000 description 4
- 235000011114 ammonium hydroxide Nutrition 0.000 description 4
- 229960001701 chloroform Drugs 0.000 description 4
- 150000002500 ions Chemical class 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 241001501111 Erycibe Species 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 241001330502 Stephania Species 0.000 description 3
- 241000489520 Veratrum album Species 0.000 description 3
- 241000863480 Vinca Species 0.000 description 3
- 229940126678 chinese medicines Drugs 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 3
- 238000005342 ion exchange Methods 0.000 description 3
- 238000002955 isolation Methods 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 241000736253 Berberis bealei Species 0.000 description 2
- 241001656898 Buxus microphylla Species 0.000 description 2
- 235000002566 Capsicum Nutrition 0.000 description 2
- 240000008574 Capsicum frutescens Species 0.000 description 2
- 240000001829 Catharanthus roseus Species 0.000 description 2
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 2
- 241000723369 Cocculus trilobus Species 0.000 description 2
- 240000007154 Coffea arabica Species 0.000 description 2
- 241000189665 Colchicum autumnale Species 0.000 description 2
- 235000002991 Coptis groenlandica Nutrition 0.000 description 2
- 244000247747 Coptis groenlandica Species 0.000 description 2
- 241000208296 Datura Species 0.000 description 2
- 240000007175 Datura inoxia Species 0.000 description 2
- 240000008853 Datura stramonium Species 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 240000006890 Erythroxylum coca Species 0.000 description 2
- 244000267607 Galega officinalis Species 0.000 description 2
- 235000007025 Galega officinalis Nutrition 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 241000208280 Hyoscyamus niger Species 0.000 description 2
- 240000007890 Leonurus cardiaca Species 0.000 description 2
- 235000000802 Leonurus cardiaca ssp. villosus Nutrition 0.000 description 2
- 235000010648 Lupinus luteus Nutrition 0.000 description 2
- 244000045959 Lupinus luteus Species 0.000 description 2
- 241001633628 Lycoris Species 0.000 description 2
- 240000007849 Macleaya cordata Species 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 235000008753 Papaver somniferum Nutrition 0.000 description 2
- LOUPRKONTZGTKE-WZBLMQSHSA-N Quinine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-WZBLMQSHSA-N 0.000 description 2
- 244000269722 Thea sinensis Species 0.000 description 2
- 244000299461 Theobroma cacao Species 0.000 description 2
- 235000009470 Theobroma cacao Nutrition 0.000 description 2
- 241000863486 Vinca minor Species 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 2
- 239000000920 calcium hydroxide Substances 0.000 description 2
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 230000002526 effect on cardiovascular system Effects 0.000 description 2
- 239000003480 eluent Substances 0.000 description 2
- ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 208000019423 liver disease Diseases 0.000 description 2
- 238000000874 microwave-assisted extraction Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000007670 refining Methods 0.000 description 2
- 238000000638 solvent extraction Methods 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 2
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 2
- LTTQKYMNTNISSZ-MWTRTKDXSA-N (2S)-(-)-kurarinone Chemical class C1([C@H]2OC=3C(C[C@@H](CC=C(C)C)C(C)=C)=C(O)C=C(C=3C(=O)C2)OC)=CC=C(O)C=C1O LTTQKYMNTNISSZ-MWTRTKDXSA-N 0.000 description 1
- MUKYLHIZBOASDM-UHFFFAOYSA-N 2-[carbamimidoyl(methyl)amino]acetic acid 2,3,4,5,6-pentahydroxyhexanoic acid Chemical compound NC(=N)N(C)CC(O)=O.OCC(O)C(O)C(O)C(O)C(O)=O MUKYLHIZBOASDM-UHFFFAOYSA-N 0.000 description 1
- WTQYWNWRJNXDEG-UHFFFAOYSA-N 6-Hydroxy-hyoscyamin Natural products CN1C(C2)CC(O)C1CC2OC(=O)C(CO)C1=CC=CC=C1 WTQYWNWRJNXDEG-UHFFFAOYSA-N 0.000 description 1
- 244000161999 Acacia greggii Species 0.000 description 1
- 241000173607 Aconitum anthora Species 0.000 description 1
- 241000553739 Aconitum carmichaelii var. truppelianum Species 0.000 description 1
- 241000553759 Aconitum coreanum Species 0.000 description 1
- 244000130463 Alangium chinense Species 0.000 description 1
- 241000512005 Alstonia Species 0.000 description 1
- 240000005369 Alstonia scholaris Species 0.000 description 1
- 241000572624 Alstonia yunnanensis Species 0.000 description 1
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 241001419717 Anisodus luridus Species 0.000 description 1
- 235000006226 Areca catechu Nutrition 0.000 description 1
- 244000080767 Areca catechu Species 0.000 description 1
- 241001106067 Atropa Species 0.000 description 1
- 241001465356 Atropa belladonna Species 0.000 description 1
- 241001407408 Berberis fortunei Species 0.000 description 1
- 241001407382 Berberis julianae Species 0.000 description 1
- 235000008671 Calycanthus floridus Nutrition 0.000 description 1
- 244000025311 Calycanthus occidentalis Species 0.000 description 1
- 235000008670 Calycanthus occidentalis Nutrition 0.000 description 1
- 241000759905 Camptotheca acuminata Species 0.000 description 1
- 235000002568 Capsicum frutescens Nutrition 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 235000001258 Cinchona calisaya Nutrition 0.000 description 1
- 241000005787 Cistanche Species 0.000 description 1
- 241000221751 Claviceps purpurea Species 0.000 description 1
- 235000007460 Coffea arabica Nutrition 0.000 description 1
- 241001573498 Compacta Species 0.000 description 1
- 244000028602 Crotalaria sessiliflora Species 0.000 description 1
- 240000000774 Cunila origanoides Species 0.000 description 1
- 235000018274 Cunila origanoides Nutrition 0.000 description 1
- 244000301850 Cupressus sempervirens Species 0.000 description 1
- 244000052363 Cynodon dactylon Species 0.000 description 1
- 241001523681 Dendrobium Species 0.000 description 1
- 244000132440 Dendrobium dixanthum Species 0.000 description 1
- 240000004638 Dendrobium nobile Species 0.000 description 1
- 241001076416 Dendrobium tosaense Species 0.000 description 1
- 235000014866 Dictamnus albus Nutrition 0.000 description 1
- 241001074093 Echinopsis Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241001465251 Ephedra sinica Species 0.000 description 1
- 241000123862 Fibraurea recisa Species 0.000 description 1
- 241001113926 Gelsemium Species 0.000 description 1
- 241000246500 Gentianella aspera Species 0.000 description 1
- 235000011201 Ginkgo Nutrition 0.000 description 1
- 235000008100 Ginkgo biloba Nutrition 0.000 description 1
- 244000194101 Ginkgo biloba Species 0.000 description 1
- 241000983397 Holarrhena pubescens Species 0.000 description 1
- 241001626188 Hunteria zeylanica Species 0.000 description 1
- 241001504070 Huperzia Species 0.000 description 1
- ZQPQGKQTIZYFEF-WCVJEAGWSA-N Huperzine Natural products C1([C@H]2[C@H](O)C(=O)N[C@H]2[C@@H](O)C=2C=CC=CC=2)=CC=CC=C1 ZQPQGKQTIZYFEF-WCVJEAGWSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 235000004520 Lindera benzoin Nutrition 0.000 description 1
- 235000008262 Lindera benzoin var. benzoin Nutrition 0.000 description 1
- 241001113846 Loganiaceae Species 0.000 description 1
- 241000927897 Lycopodium japonicum Species 0.000 description 1
- 241001654189 Lycoris aurea Species 0.000 description 1
- 241000319062 Lycoris radiata Species 0.000 description 1
- 241000218378 Magnolia Species 0.000 description 1
- 244000179291 Mahonia aquifolium Species 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- QMGVPVSNSZLJIA-UHFFFAOYSA-N Nux Vomica Natural products C1C2C3C4N(C=5C6=CC=CC=5)C(=O)CC3OCC=C2CN2C1C46CC2 QMGVPVSNSZLJIA-UHFFFAOYSA-N 0.000 description 1
- 235000011096 Papaver Nutrition 0.000 description 1
- 235000005126 Peganum harmala Nutrition 0.000 description 1
- 240000005523 Peganum harmala Species 0.000 description 1
- 239000006002 Pepper Substances 0.000 description 1
- 241000418088 Physostigma Species 0.000 description 1
- 241000418087 Physostigma venenosum Species 0.000 description 1
- 235000016761 Piper aduncum Nutrition 0.000 description 1
- 240000003889 Piper guineense Species 0.000 description 1
- 235000017804 Piper guineense Nutrition 0.000 description 1
- 235000008184 Piper nigrum Nutrition 0.000 description 1
- 241001250596 Pleione Species 0.000 description 1
- 208000000474 Poliomyelitis Diseases 0.000 description 1
- 241000218206 Ranunculus Species 0.000 description 1
- 235000002226 Ranunculus ficaria Nutrition 0.000 description 1
- 244000081426 Ranunculus ficaria Species 0.000 description 1
- 244000061121 Rauvolfia serpentina Species 0.000 description 1
- 244000036029 Saint Ignatius beans Species 0.000 description 1
- 241000209056 Secale Species 0.000 description 1
- 241000867909 Securinega Species 0.000 description 1
- 241000132346 Securinega suffruticosa Species 0.000 description 1
- 241001146213 Senecio nemorensis Species 0.000 description 1
- 241000520352 Senecio sylvaticus Species 0.000 description 1
- 206010039966 Senile dementia Diseases 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- 235000000208 Solanum incanum Nutrition 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 241001671204 Stemona Species 0.000 description 1
- 241001643405 Stephania cephalantha Species 0.000 description 1
- 244000244920 Stephania japonica Species 0.000 description 1
- 241001369613 Stephania tetrandra Species 0.000 description 1
- 244000107975 Strychnos nux-vomica Species 0.000 description 1
- 241000511964 Tabernaemontana Species 0.000 description 1
- 235000006468 Thea sinensis Nutrition 0.000 description 1
- 241000246091 Thermopsis Species 0.000 description 1
- 241000673328 Thermopsis barbata Species 0.000 description 1
- 241001533104 Tribulus terrestris Species 0.000 description 1
- 241000830536 Tripterygium wilfordii Species 0.000 description 1
- 241001170744 Veratrum nigrum Species 0.000 description 1
- 240000003248 Zanthoxylum nitidum Species 0.000 description 1
- 238000002479 acid--base titration Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- WYTGDNHDOZPMIW-RCBQFDQVSA-N alstonine Natural products C1=CC2=C3C=CC=CC3=NC2=C2N1C[C@H]1[C@H](C)OC=C(C(=O)OC)[C@H]1C2 WYTGDNHDOZPMIW-RCBQFDQVSA-N 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- WTQYWNWRJNXDEG-LEOABGAYSA-N anisodamine Chemical compound C1([C@@H](CO)C(=O)O[C@@H]2C[C@H]3[C@@H](O)C[C@@H](C2)N3C)=CC=CC=C1 WTQYWNWRJNXDEG-LEOABGAYSA-N 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000003260 anti-sepsis Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- YBHILYKTIRIUTE-UHFFFAOYSA-N berberine Chemical compound C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 YBHILYKTIRIUTE-UHFFFAOYSA-N 0.000 description 1
- 229940093265 berberine Drugs 0.000 description 1
- QISXPYZVZJBNDM-UHFFFAOYSA-N berberine Natural products COc1ccc2C=C3N(Cc2c1OC)C=Cc4cc5OCOc5cc34 QISXPYZVZJBNDM-UHFFFAOYSA-N 0.000 description 1
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 description 1
- 239000001390 capsicum minimum Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 235000004608 catclaw acacia Nutrition 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 description 1
- 229940073500 citrus aurantium fruit extract Drugs 0.000 description 1
- 235000008957 cocaer Nutrition 0.000 description 1
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 229960002179 ephedrine Drugs 0.000 description 1
- 238000003810 ethyl acetate extraction Methods 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002213 flavones Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229960003980 galantamine Drugs 0.000 description 1
- 229930182494 ginsenoside Natural products 0.000 description 1
- 229940089161 ginsenoside Drugs 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 208000002672 hepatitis B Diseases 0.000 description 1
- 239000012676 herbal extract Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000005374 membrane filtration Methods 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 235000006502 papoula Nutrition 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229910052573 porcelain Inorganic materials 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 229960000948 quinine Drugs 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 235000015398 thunder god vine Nutrition 0.000 description 1
- 238000002137 ultrasound extraction Methods 0.000 description 1
- 229940038779 valerian root extract Drugs 0.000 description 1
- 239000001192 valeriana officinalis l. rhizome/root Substances 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Description
Claims (16)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 200710014331 CN101289469B (zh) | 2007-04-18 | 2007-04-18 | 一种从中药提取液中分离总生物碱的方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 200710014331 CN101289469B (zh) | 2007-04-18 | 2007-04-18 | 一种从中药提取液中分离总生物碱的方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101289469A true CN101289469A (zh) | 2008-10-22 |
CN101289469B CN101289469B (zh) | 2013-04-17 |
Family
ID=40033937
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 200710014331 Expired - Fee Related CN101289469B (zh) | 2007-04-18 | 2007-04-18 | 一种从中药提取液中分离总生物碱的方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN101289469B (zh) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101966228B (zh) * | 2009-07-27 | 2012-02-22 | 中国科学院成都生物研究所 | 一种厚朴生物碱的用途 |
CN102614149A (zh) * | 2012-03-30 | 2012-08-01 | 湖南正清制药集团股份有限公司 | 一种制备盐酸青藤碱胶囊剂的方法 |
CN102631414A (zh) * | 2012-04-25 | 2012-08-15 | 成都煜泉绿健科技有限公司 | 地不容总生物碱提取纯化工艺 |
CN104415573A (zh) * | 2013-09-10 | 2015-03-18 | 中国科学院大连化学物理研究所 | 一种延胡索提取物中叔胺碱和季铵碱的分类制备方法 |
CN106074668A (zh) * | 2016-08-03 | 2016-11-09 | 刘石磊 | 用于神经退行性疾病或神经再生的中药制剂 |
CN108379431A (zh) * | 2018-04-09 | 2018-08-10 | 陕西师范大学 | 一种采用超声提取法提取藜芦中总生物碱的方法 |
CN110003197A (zh) * | 2019-04-23 | 2019-07-12 | 南京久安源环保科技有限公司 | 一种莨菪烷类生物碱的提取工艺 |
CN112402519A (zh) * | 2020-12-14 | 2021-02-26 | 武汉惠尔生物科技有限公司 | 一种缬草总生物碱提取物及其制备方法 |
-
2007
- 2007-04-18 CN CN 200710014331 patent/CN101289469B/zh not_active Expired - Fee Related
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101966228B (zh) * | 2009-07-27 | 2012-02-22 | 中国科学院成都生物研究所 | 一种厚朴生物碱的用途 |
CN102614149A (zh) * | 2012-03-30 | 2012-08-01 | 湖南正清制药集团股份有限公司 | 一种制备盐酸青藤碱胶囊剂的方法 |
CN102614149B (zh) * | 2012-03-30 | 2013-10-16 | 湖南正清制药集团股份有限公司 | 一种制备盐酸青藤碱胶囊剂的方法 |
CN102631414A (zh) * | 2012-04-25 | 2012-08-15 | 成都煜泉绿健科技有限公司 | 地不容总生物碱提取纯化工艺 |
CN102631414B (zh) * | 2012-04-25 | 2013-09-25 | 成都煜泉绿健科技有限公司 | 地不容总生物碱提取纯化工艺 |
CN104415573B (zh) * | 2013-09-10 | 2017-03-22 | 中国科学院大连化学物理研究所 | 一种延胡索提取物中叔胺碱和季铵碱的分类制备方法 |
CN104415573A (zh) * | 2013-09-10 | 2015-03-18 | 中国科学院大连化学物理研究所 | 一种延胡索提取物中叔胺碱和季铵碱的分类制备方法 |
CN106074668A (zh) * | 2016-08-03 | 2016-11-09 | 刘石磊 | 用于神经退行性疾病或神经再生的中药制剂 |
CN106074668B (zh) * | 2016-08-03 | 2019-09-27 | 黑龙江中医药大学 | 用于神经退行性疾病或神经再生的中药制剂 |
CN108379431A (zh) * | 2018-04-09 | 2018-08-10 | 陕西师范大学 | 一种采用超声提取法提取藜芦中总生物碱的方法 |
CN110003197A (zh) * | 2019-04-23 | 2019-07-12 | 南京久安源环保科技有限公司 | 一种莨菪烷类生物碱的提取工艺 |
CN110003197B (zh) * | 2019-04-23 | 2021-08-06 | 南京久安源环保科技有限公司 | 一种莨菪烷类生物碱的提取工艺 |
CN112402519A (zh) * | 2020-12-14 | 2021-02-26 | 武汉惠尔生物科技有限公司 | 一种缬草总生物碱提取物及其制备方法 |
CN112402519B (zh) * | 2020-12-14 | 2022-06-07 | 武汉惠尔生物科技有限公司 | 一种缬草总生物碱提取物及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN101289469B (zh) | 2013-04-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101289469B (zh) | 一种从中药提取液中分离总生物碱的方法 | |
CN101647828B (zh) | 一种用离子交换树脂分离中药总生物碱的方法 | |
CN101491619A (zh) | 一种从中药提取物中分离莨菪碱类总生物碱的方法 | |
CN101698059A (zh) | 一种用离子交换树脂分离石斛总生物碱的方法 | |
CN101491596A (zh) | 一种从中药提取物中分离小檗碱类总生物碱的方法 | |
CN102172361A (zh) | 一种用离子交换树脂分离中药总生物碱的方法 | |
CN101289472A (zh) | 一种从中药提取物中分离苦参碱类总生物碱的方法 | |
CN101698057A (zh) | 一种用离子交换树脂分离金线莲总生物碱的方法 | |
CN101697983A (zh) | 一种用离子交换树脂分离骆驼蓬总生物碱的方法 | |
CN101491589A (zh) | 一种分离白屈菜、血水草或飞龙掌血总生物碱的方法 | |
CN101697984A (zh) | 一种用离子交换树脂分离角蒿总生物碱的方法 | |
CN102172366A (zh) | 一种用离子交换树脂分离益母草总生物碱的方法 | |
CN101697986B (zh) | 一种用离子交换树脂分离长春花总生物碱的方法 | |
CN101697982B (zh) | 一种用离子交换树脂分离喜树总生物碱的方法 | |
CN101491554A (zh) | 一种从中药角蒿提取液中分离角蒿总生物碱的方法 | |
CN101698003B (zh) | 一种用离子交换树脂分离延胡索总生物碱的方法 | |
CN101289471A (zh) | 一种从中药夏天无提取液中分离夏天无总生物碱的方法 | |
CN101697992A (zh) | 一种用离子交换树脂分离千层塔总生物碱的方法 | |
CN101647854B (zh) | 一种用离子交换树脂分离苦参总生物碱的方法 | |
CN101697999A (zh) | 一种用离子交换树脂分离马钱子总生物碱的方法 | |
CN101396434A (zh) | 一种用离子交换树脂分离紫金龙总生物碱的方法 | |
CN101698022B (zh) | 一种用离子交换树脂分离辣椒总生物碱的方法 | |
CN101491587A (zh) | 一种从中药博落回提取液中分离博落回总生物碱的方法 | |
CN101698031B (zh) | 一种用离子交换树脂分离石蒜总生物碱的方法 | |
CN101289470A (zh) | 一种从中药提取物中分离总生物碱的方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
DD01 | Delivery of document by public notice |
Addressee: Feng Xingang Document name: Notification of Patent Invention Entering into Substantive Examination Stage |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20150930 Address after: 266071 Hongkong East Road, Laoshan District, Shandong, China, No. 23, No. Patentee after: Qingdao Haiyang biological medicine academy limited company Address before: 250002, Ji'nan City, Shandong province sunshine Shun City six district 2-903 Patentee before: Dai Long |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20171229 Address after: 251200 in Shandong province (Yucheng) Dezhou national hi tech Industrial Development Zone, the ideal space innovation incubator tower 8 floor Patentee after: Shandong Yu Ze Pharmaceutical Technology Co., Ltd. Address before: 266071 Hongkong East Road, Laoshan District, Shandong, China, No. 23, No. Patentee before: Qingdao Haiyang biological medicine academy limited company |
|
CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130417 Termination date: 20180418 |